Real-time imaging of Huntingtin aggregates diverting target search and gene transcription

eLife

Volumn 5, Issue AUGUST, 2016, Pages

  Li, Li ^a,b   Liu, Hui ^a   Dong, Peng ^a   Li, Dong ^a   Legant, Wesley R ^a   Grimm, Jonathan B ^a   Lavis, Luke D ^a   Betzig, Eric ^a   Tjian, Robert ^a,b   Liu, Zhe ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; TRANSCRIPTION FACTOR; HTT PROTEIN, MOUSE; MUTANT PROTEIN;

ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; BINDING SITE; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HUNTINGTON CHOREA; IMMUNOFLUORESCENCE TEST; MICROSCOPY; PROTEIN AGGREGATION; PROTEIN STABILITY; STOCHASTIC MODEL; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; MOUSE; MOUSE EMBRYONIC STEM CELL; NERVE CELL; PATHOLOGY; PROTEINOSIS; SINGLE MOLECULE IMAGING; VISUAL CORTEX;

ANIMALS; CELLS, CULTURED; HUNTINGTIN PROTEIN; MICE; MOUSE EMBRYONIC STEM CELLS; MUTANT PROTEINS; NEURONS; PROTEIN AGGREGATION, PATHOLOGICAL; SINGLE MOLECULE IMAGING; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VISUAL CORTEX;

EID: 84982835436     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.17056.001     Document Type: Article

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