Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 9, 2004, Pages 3224-3229

  Lee, Wyan Ching Mimi ^a   Yoshihara, Motojiro ^a   Littleton, J Troy ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 3; HTT Q0 PROTEIN; HTT Q128 PROTEIN; HUNTINGTIN; POLYGLUTAMINE; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DEGENERATIVE DISEASE; DROSOPHILA; HUNTINGTON CHOREA; LARVA; LIFESPAN; LOCOMOTION; MOTOR COORDINATION; NERVE DEGENERATION; NERVE FIBER TRANSPORT; NEURITE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; SYNAPSE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONAL TRANSPORT; AXONS; CYTOPLASM; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; ELECTRORETINOGRAPHY; HUMANS; HUNTINGTON DISEASE; LARVA; MUSCLE, SKELETAL; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PEPTIDES;

ANIMALIA; ATAXIA;

EID: 1542267796     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0400243101     Document Type: Article

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