메뉴 건너뛰기




Volumn 25, Issue 6, 2016, Pages 326-336

Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype

Author keywords

[No Author keywords available]

Indexed keywords

MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PROTEIN; REACTIVE OXYGEN METABOLITE; SIRTUIN 3; LYSINE; SUPEROXIDE DISMUTASE; TUMOR MARKER;

EID: 84982281641     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2016.6641     Document Type: Review
Times cited : (39)

References (90)
  • 2
    • 7444264020 scopus 로고    scopus 로고
    • The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer
    • Allred DC, Brown P, and Medina D. The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer. Breast Cancer Res 6: 240-245, 2004.
    • (2004) Breast Cancer Res , vol.6 , pp. 240-245
    • Allred, D.C.1    Brown, P.2    Medina, D.3
  • 4
    • 84908289874 scopus 로고    scopus 로고
    • Manganese superoxide dismutase in breast cancer: From molecular mechanisms of gene regulation to biological and clinical significance
    • Becuwe P, Ennen M, Klotz R, Barbieux C, and Grandemange S. Manganese superoxide dismutase in breast cancer: from molecular mechanisms of gene regulation to biological and clinical significance. Free Radic Biol Med 77: 139-151, 2014.
    • (2014) Free Radic Biol Med , vol.77 , pp. 139-151
    • Becuwe, P.1    Ennen, M.2    Klotz, R.3    Barbieux, C.4    Grandemange, S.5
  • 5
    • 79959819034 scopus 로고    scopus 로고
    • SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production
    • Bell EL, Emerling BM, Ricoult SJ, and Guarente L. SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Oncogene 30: 2986-2996, 2011.
    • (2011) Oncogene , vol.30 , pp. 2986-2996
    • Bell, E.L.1    Emerling, B.M.2    Ricoult, S.J.3    Guarente, L.4
  • 7
    • 0020730787 scopus 로고
    • Electrostatic facilitation of the reaction catalyzed by the manganesecontaining and the iron-containing superoxide dismutases
    • Benovic J, Tillman T, Cudd A, and Fridovich I. Electrostatic facilitation of the reaction catalyzed by the manganesecontaining and the iron-containing superoxide dismutases. Arch Biochem Biophys 221: 329-332, 1983.
    • (1983) Arch Biochem Biophys , vol.221 , pp. 329-332
    • Benovic, J.1    Tillman, T.2    Cudd, A.3    Fridovich, I.4
  • 9
    • 9144261127 scopus 로고    scopus 로고
    • Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity
    • Bisht KS, Bradbury CM, Mattson D, Kaushal A, Sowers A, Markovina S, Ortiz KL, Sieck LK, Isaacs JS, Brechbiel MW, Mitchell JB, Neckers LM, and Gius D. Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. Cancer Res 63: 8984-8995, 2003.
    • (2003) Cancer Res , vol.63 , pp. 8984-8995
    • Bisht, K.S.1    Bradbury, C.M.2    Mattson, D.3    Kaushal, A.4    Sowers, A.5    Markovina, S.6    Ortiz, K.L.7    Sieck, L.K.8    Isaacs, J.S.9    Brechbiel, M.W.10    Mitchell, J.B.11    Neckers, L.M.12    Gius, D.13
  • 12
    • 79957979314 scopus 로고    scopus 로고
    • Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS
    • Chen Y, Zhang J, Lin Y, Lei Q, Guan KL, Zhao S, and Xiong Y. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep 12: 534-541, 2011.
    • (2011) EMBO Rep , vol.12 , pp. 534-541
    • Chen, Y.1    Zhang, J.2    Lin, Y.3    Lei, Q.4    Guan, K.L.5    Zhao, S.6    Xiong, Y.7
  • 14
    • 84866756366 scopus 로고    scopus 로고
    • The molecular profile of luminal B breast cancer
    • Creighton CJ. The molecular profile of luminal B breast cancer. Biologics 6: 289-297, 2012.
    • (2012) Biologics , vol.6 , pp. 289-297
    • Creighton, C.J.1
  • 15
    • 79951705085 scopus 로고    scopus 로고
    • Fulvestrant: A review of its use in the management of hormone receptor-positive metastatic breast cancer in postmenopausal women
    • Croxtall JD and McKeage K. Fulvestrant: a review of its use in the management of hormone receptor-positive metastatic breast cancer in postmenopausal women. Drugs 71: 363-380, 2011.
    • (2011) Drugs , vol.71 , pp. 363-380
    • Croxtall, J.D.1    McKeage, K.2
  • 16
    • 0027768899 scopus 로고
    • The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling
    • Dauvois S, White R, and Parker MG. The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J Cell Sci 106(Pt 4): 1377-1388, 1993.
    • (1993) J Cell Sci , vol.106 , pp. 1377-1388
    • Dauvois, S.1    White, R.2    Parker, M.G.3
  • 17
    • 84898783930 scopus 로고    scopus 로고
    • Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer
    • Desouki MM, Doubinskaia I, Gius D, and Abdulkadir SA. Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer. Hum Pathol 45: 1071-1077, 2014.
    • (2014) Hum Pathol , vol.45 , pp. 1071-1077
    • Desouki, M.M.1    Doubinskaia, I.2    Gius, D.3    Abdulkadir, S.A.4
  • 18
    • 84861628788 scopus 로고    scopus 로고
    • Manganese superoxide dismutase regulation and cancer
    • Dhar SK and St Clair DK. Manganese superoxide dismutase regulation and cancer. Free Radic Biol Med 52: 2209-2222, 2012.
    • (2012) Free Radic Biol Med , vol.52 , pp. 2209-2222
    • Dhar, S.K.1    St Clair, D.K.2
  • 19
    • 77953257025 scopus 로고    scopus 로고
    • Aging and disease: Connections to sirtuins
    • Donmez G and Guarente L. Aging and disease: connections to sirtuins. Aging Cell 9: 285-290, 2010.
    • (2010) Aging Cell , vol.9 , pp. 285-290
    • Donmez, G.1    Guarente, L.2
  • 20
    • 85203363507 scopus 로고    scopus 로고
    • Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Patient-level meta-analysis of randomised trials
    • Early Breast Cancer Trialists' Collaborative Group, Davies C, Godwin J, Gray R, Clarke M, Cutter D, Darby S, McGale P, Pan HC, Taylor C, Wang YC, Dowsett M, Ingle J, and Peto R. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet 378: 771-784, 2011.
    • (2011) Lancet , vol.378 , pp. 771-784
    • Davies, C.1    Godwin, J.2    Gray, R.3    Clarke, M.4    Cutter, D.5    Darby, S.6    McGale, P.7    Pan, H.C.8    Taylor, C.9    Wang, Y.C.10    Dowsett, M.11    Ingle, J.12    Peto, R.13
  • 21
    • 0030854406 scopus 로고    scopus 로고
    • Aging and cancer: Issues of basic and clinical science
    • Ershler WB and Longo DL. Aging and cancer: issues of basic and clinical science. J Natl Cancer Inst 89: 1489-1497, 1997.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1489-1497
    • Ershler, W.B.1    Longo, D.L.2
  • 22
    • 0030922887 scopus 로고    scopus 로고
    • The biology of aging: The current research agenda
    • Ershler WB and Longo DL. The biology of aging: the current research agenda. Cancer 80: 1284-1293, 1997.
    • (1997) Cancer , vol.80 , pp. 1284-1293
    • Ershler, W.B.1    Longo, D.L.2
  • 23
    • 84933545260 scopus 로고    scopus 로고
    • Evaluation of targeted therapies in advanced breast cancer: The need for large-scale molecular screening and transformative clinical trial designs
    • Epub ahead of print
    • Fadoukhair Z, Zardavas D, Chad MA, Goulioti T, Aftimos P, and Piccart M. Evaluation of targeted therapies in advanced breast cancer: the need for large-scale molecular screening and transformative clinical trial designs. Oncogene 2015. [Epub ahead of print]; DOI: 10.1038/onc .2015.249.
    • (2015) Oncogene
    • Fadoukhair, Z.1    Zardavas, D.2    Chad, M.A.3    Goulioti, T.4    Aftimos, P.5    Piccart, M.6
  • 24
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel T, Deng CX, and Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 460: 587-591, 2009.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 26
    • 84982302826 scopus 로고    scopus 로고
    • This reference has been deleted
    • This reference has been deleted.
  • 27
    • 84865576222 scopus 로고    scopus 로고
    • Metabolic regulation by SIRT3: Implications for tumorigenesis
    • Finley LW and Haigis MC. Metabolic regulation by SIRT3: implications for tumorigenesis. Trends Mol Med 18: 516-523, 2012.
    • (2012) Trends Mol Med , vol.18 , pp. 516-523
    • Finley, L.W.1    Haigis, M.C.2
  • 28
    • 84857883360 scopus 로고    scopus 로고
    • Mitochondrial Acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice
    • Fritz KS, Galligan JJ, Hirschey MD, Verdin E, and Petersen DR. Mitochondrial Acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res 11: 1633-1643, 2012.
    • (2012) J Proteome Res , vol.11 , pp. 1633-1643
    • Fritz, K.S.1    Galligan, J.J.2    Hirschey, M.D.3    Verdin, E.4    Petersen, D.R.5
  • 29
    • 0032998598 scopus 로고    scopus 로고
    • Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1
    • Gius D, Botero A, Shah S, and Curry HA. Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1. Toxicol Lett 106: 93-106, 1999.
    • (1999) Toxicol Lett , vol.106 , pp. 93-106
    • Gius, D.1    Botero, A.2    Shah, S.3    Curry, H.A.4
  • 30
    • 0033137321 scopus 로고    scopus 로고
    • Transduced p16INK4a peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of Cdk2 complexes in late G1
    • Gius DR, Ezhevsky SA, Becker-Hapak M, Nagahara H, Wei MC, and Dowdy SF. Transduced p16INK4a peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of Cdk2 complexes in late G1. Cancer Res 59: 2577-2580, 1999.
    • (1999) Cancer Res , vol.59 , pp. 2577-2580
    • Gius, D.R.1    Ezhevsky, S.A.2    Becker-Hapak, M.3    Nagahara, H.4    Wei, M.C.5    Dowdy, S.F.6
  • 31
    • 79960980007 scopus 로고    scopus 로고
    • Strategies for subtypes- dealing with the diversity of breast cancer: Highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011
    • Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ, and Panel M. Strategies for subtypes- dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol 22: 1736-1747, 2011.
    • (2011) Ann Oncol , vol.22 , pp. 1736-1747
    • Goldhirsch, A.1    Wood, W.C.2    Coates, A.S.3    Gelber, R.D.4    Thurlimann, B.5    Senn, H.J.6    Panel, M.7
  • 33
    • 38649132337 scopus 로고    scopus 로고
    • Mitochondria-A nexus for aging, calorie restriction, and sirtuins?
    • Guarente L. Mitochondria-a nexus for aging, calorie restriction, and sirtuins? Cell 132: 171-176, 2008.
    • (2008) Cell , vol.132 , pp. 171-176
    • Guarente, L.1
  • 34
    • 0034626747 scopus 로고    scopus 로고
    • Genetic pathways that regulate ageing in model organisms
    • Guarente L and Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 408: 255-262, 2000.
    • (2000) Nature , vol.408 , pp. 255-262
    • Guarente, L.1    Kenyon, C.2
  • 35
    • 84861161546 scopus 로고    scopus 로고
    • SIRT3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis
    • Haigis MC, Deng CX, Finley LW, Kim HS, and Gius D. SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res 72: 2468-2472, 2012.
    • (2012) Cancer Res , vol.72 , pp. 2468-2472
    • Haigis, M.C.1    Deng, C.X.2    Finley, L.W.3    Kim, H.S.4    Gius, D.5
  • 36
    • 0027414927 scopus 로고
    • Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor
    • Hallahan DE, Gius D, Kuchibhotla J, Sukhatme V, Kufe DW, and Weichselbaum RR. Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor. J Biol Chem 268: 4903-4907, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 4903-4907
    • Hallahan, D.E.1    Gius, D.2    Kuchibhotla, J.3    Sukhatme, V.4    Kufe, D.W.5    Weichselbaum, R.R.6
  • 37
    • 33745931074 scopus 로고    scopus 로고
    • Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
    • Hallows WC, Lee S, and Denu JM. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A 103: 10230-10235, 2006.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10230-10235
    • Hallows, W.C.1    Lee, S.2    Denu, J.M.3
  • 40
    • 56049116207 scopus 로고    scopus 로고
    • Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells
    • Hitchler MJ, Oberley LW, and Domann FE. Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells. Free Radic Biol Med 45: 1573-1580, 2008.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1573-1580
    • Hitchler, M.J.1    Oberley, L.W.2    Domann, F.E.3
  • 41
    • 0032800406 scopus 로고    scopus 로고
    • Decreased expression of manganese superoxide dismutase in transformed cells is associated with increased cytosine methylation of the SOD2 gene
    • Huang Y, He T, and Domann FE. Decreased expression of manganese superoxide dismutase in transformed cells is associated with increased cytosine methylation of the SOD2 gene. DNA Cell Biol 18: 643-652, 1999.
    • (1999) DNA Cell Biol , vol.18 , pp. 643-652
    • Huang, Y.1    He, T.2    Domann, F.E.3
  • 42
    • 84937142690 scopus 로고    scopus 로고
    • The role of ovarian suppression in premenopausal women with hormone receptor-positive early-stage breast cancer
    • Jain S, Santa-Maria CA, and Gradishar WJ. The role of ovarian suppression in premenopausal women with hormone receptor-positive early-stage breast cancer. Oncology (Williston Park) 29: 473-478, 481, 2015.
    • (2015) Oncology (Williston Park) , vol.29 , pp. 473-478
    • Jain, S.1    Santa-Maria, C.A.2    Gradishar, W.J.3
  • 43
    • 80052291180 scopus 로고    scopus 로고
    • Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
    • Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, and Kahn CR. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A 108: 14608-14613, 2011.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 14608-14613
    • Jing, E.1    Emanuelli, B.2    Hirschey, M.D.3    Boucher, J.4    Lee, K.Y.5    Lombard, D.6    Verdin, E.M.7    Kahn, C.R.8
  • 44
    • 42349117302 scopus 로고    scopus 로고
    • Manganese superoxide dismutase modulates hypoxiainducible factor-1 alpha induction via superoxide
    • Kaewpila S, Venkataraman S, Buettner GR, and Oberley LW. Manganese superoxide dismutase modulates hypoxiainducible factor-1 alpha induction via superoxide. Cancer Res 68: 2781-2788, 2008.
    • (2008) Cancer Res , vol.68 , pp. 2781-2788
    • Kaewpila, S.1    Venkataraman, S.2    Buettner, G.R.3    Oberley, L.W.4
  • 45
    • 39749193830 scopus 로고    scopus 로고
    • Role of manganese superoxide dismutase on growth and invasive properties of human estrogen-independent breast cancer cells
    • Kattan Z, Minig V, Leroy P, Dauca M, and Becuwe P. Role of manganese superoxide dismutase on growth and invasive properties of human estrogen-independent breast cancer cells. Breast Cancer Res Treat 108: 203-215, 2008.
    • (2008) Breast Cancer Res Treat , vol.108 , pp. 203-215
    • Kattan, Z.1    Minig, V.2    Leroy, P.3    Dauca, M.4    Becuwe, P.5
  • 49
    • 0034654011 scopus 로고    scopus 로고
    • Acetylation: A regulatory modification to rival phosphorylation?
    • Kouzarides T. Acetylation: a regulatory modification to rival phosphorylation? EMBO J 19: 1176-1179, 2000.
    • (2000) EMBO J , vol.19 , pp. 1176-1179
    • Kouzarides, T.1
  • 50
    • 0029032567 scopus 로고
    • Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase
    • Li JJ, Oberley LW, St Clair DK, Ridnour LA, and Oberley TD. Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase. Oncogene 10: 1989-2000, 1995.
    • (1995) Oncogene , vol.10 , pp. 1989-2000
    • Li, J.J.1    Oberley, L.W.2    St Clair, D.K.3    Ridnour, L.A.4    Oberley, T.D.5
  • 51
    • 33845967865 scopus 로고    scopus 로고
    • Downregulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats
    • Li M, Chiu JF, Mossman BT, and Fukagawa NK. Downregulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats. J Biol Chem 281: 40429-40439, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 40429-40439
    • Li, M.1    Chiu, J.F.2    Mossman, B.T.3    Fukagawa, N.K.4
  • 53
    • 75249094454 scopus 로고    scopus 로고
    • Calorie restriction and cancer prevention: Metabolic and molecular mechanisms
    • Longo VD and Fontana L. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci 31: 89-98, 2010.
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 89-98
    • Longo, V.D.1    Fontana, L.2
  • 55
    • 84966275803 scopus 로고    scopus 로고
    • Current medical treatment of estrogen receptor-positive breast cancer
    • Lumachi F, Santeufemia DA, and Basso SM. Current medical treatment of estrogen receptor-positive breast cancer. World J Biol Chem 6: 231-239, 2015.
    • (2015) World J Biol Chem , vol.6 , pp. 231-239
    • Lumachi, F.1    Santeufemia, D.A.2    Basso, S.M.3
  • 56
    • 84887114555 scopus 로고    scopus 로고
    • The HER2 receptor in breast cancer: Pathophysiology, clinical use, and new advances in therapy
    • Mitri Z, Constantine T, and O'Regan R. The HER2 receptor in breast cancer: pathophysiology, clinical use, and new advances in therapy. Chemother Res Pract 2012: 743193, 2012.
    • (2012) Chemother Res Pract , vol.2012 , pp. 743193
    • Mitri, Z.1    Constantine, T.2    O'Regan, R.3
  • 57
    • 0036807501 scopus 로고    scopus 로고
    • The evolving role of aromatase inhibitors in breast cancer
    • Mokbel K. The evolving role of aromatase inhibitors in breast cancer. Int J Clin Oncol 7: 279-283, 2002.
    • (2002) Int J Clin Oncol , vol.7 , pp. 279-283
    • Mokbel, K.1
  • 58
    • 84956957726 scopus 로고    scopus 로고
    • Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress
    • Nie H, Chen G, He J, Zhang F, Li M, Wang Q, Zhou H, Lyu J, and Bai Y. Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress. Mitochondrion 26: 104-112, 2016.
    • (2016) Mitochondrion , vol.26 , pp. 104-112
    • Nie, H.1    Chen, G.2    He, J.3    Zhang, F.4    Li, M.5    Wang, Q.6    Zhou, H.7    Lyu, J.8    Bai, Y.9
  • 59
    • 84904664964 scopus 로고    scopus 로고
    • Roles of oxidative stress in the development and progression of breast cancer
    • Nourazarian AR, Kangari P, and Salmaninejad A. Roles of oxidative stress in the development and progression of breast cancer. Asian Pac J Cancer Prev 15: 4745-4751, 2014.
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 4745-4751
    • Nourazarian, A.R.1    Kangari, P.2    Salmaninejad, A.3
  • 60
    • 0018749490 scopus 로고
    • Role of superoxide dismutase in cancer: A review
    • Oberley LW and Buettner GR. Role of superoxide dismutase in cancer: a review. Cancer Res 39: 1141-1149, 1979.
    • (1979) Cancer Res , vol.39 , pp. 1141-1149
    • Oberley, L.W.1    Buettner, G.R.2
  • 63
    • 84930686091 scopus 로고    scopus 로고
    • Co-expression of p16, Ki67 and COX-2 is associated with basal phenotype in high-grade ductal carcinoma in situ of the breast
    • Perez AA, Balabram D, Rocha RM, da Silva Souza A, and Gobbi H. Co-expression of p16, Ki67 and COX-2 is associated with basal phenotype in high-grade ductal carcinoma in situ of the breast. J Histochem Cytochem 63: 408-416, 2015.
    • (2015) J Histochem Cytochem , vol.63 , pp. 408-416
    • Perez, A.A.1    Balabram, D.2    Rocha, R.M.3    Da Silva Souza, A.4    Gobbi, H.5
  • 65
    • 78649521247 scopus 로고    scopus 로고
    • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    • Qiu X, Brown K, Hirschey MD, Verdin E, and Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 12: 662-667, 2010.
    • (2010) Cell Metab , vol.12 , pp. 662-667
    • Qiu, X.1    Brown, K.2    Hirschey, M.D.3    Verdin, E.4    Chen, D.5
  • 67
    • 84982938339 scopus 로고    scopus 로고
    • Changing treatment paradigms in metastatic breast cancer: Lessons learned
    • quiz 549
    • Santa-Maria CA and Gradishar WJ. Changing treatment paradigms in metastatic breast cancer: lessons learned. JAMA Oncol 1: 528-534, 2015; quiz 549.
    • (2015) JAMA Oncol , vol.1 , pp. 528-534
    • Santa-Maria, C.A.1    Gradishar, W.J.2
  • 71
    • 79952523493 scopus 로고    scopus 로고
    • SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF
    • Schumacker PT. SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF. Cancer Cell 19: 299-300, 2011.
    • (2011) Cancer Cell , vol.19 , pp. 299-300
    • Schumacker, P.T.1
  • 72
    • 33745889628 scopus 로고    scopus 로고
    • Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
    • Schwer B, Bunkenborg J, Verdin RO, Andersen JS, and Verdin E. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A 103: 10224-10229, 2006.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10224-10229
    • Schwer, B.1    Bunkenborg, J.2    Verdin, R.O.3    Andersen, J.S.4    Verdin, E.5
  • 74
    • 0028171376 scopus 로고
    • The metabolism of 17 beta-estradiol by lactoperoxidase: A possible source of oxidative stress in breast cancer
    • Sipe HJ, Jr., Jordan SJ, Hanna PM, and Mason RP. The metabolism of 17 beta-estradiol by lactoperoxidase: a possible source of oxidative stress in breast cancer. Carcinogenesis 15: 2637-2643, 1994.
    • (1994) Carcinogenesis , vol.15 , pp. 2637-2643
    • Sipe, H.J.1    Jordan, S.J.2    Hanna, P.M.3    Mason, R.P.4
  • 75
    • 78651468722 scopus 로고    scopus 로고
    • Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    • Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, and Prolla TA. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 143: 802-812, 2010.
    • (2010) Cell , vol.143 , pp. 802-812
    • Someya, S.1    Yu, W.2    Hallows, W.C.3    Xu, J.4    Vann, J.M.5    Leeuwenburgh, C.6    Tanokura, M.7    Denu, J.M.8    Prolla, T.A.9
  • 76
    • 3042736846 scopus 로고    scopus 로고
    • Metabolic oxidation/ reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology
    • Spitz DR, Azzam EI, Li JJ, and Gius D. Metabolic oxidation/ reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Rev 23: 311-322, 2004.
    • (2004) Cancer Metastasis Rev , vol.23 , pp. 311-322
    • Spitz, D.R.1    Azzam, E.I.2    Li, J.J.3    Gius, D.4
  • 77
    • 0025174861 scopus 로고
    • Heat-induced cytotoxicity in H2O2-resistant Chinese hamster fibroblasts
    • Spitz DR and Li GC. Heat-induced cytotoxicity in H2O2-resistant Chinese hamster fibroblasts. J Cell Physiol 142: 255-260, 1990.
    • (1990) J Cell Physiol , vol.142 , pp. 255-260
    • Spitz, D.R.1    Li, G.C.2
  • 79
    • 84895744576 scopus 로고    scopus 로고
    • Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis
    • Tao R, Vassilopoulos A, Parisiadou L, Yan Y, and Gius D. Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis. Antioxid Redox Signal 20: 1646-1654, 2014.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 1646-1654
    • Tao, R.1    Vassilopoulos, A.2    Parisiadou, L.3    Yan, Y.4    Gius, D.5
  • 84
    • 78649328799 scopus 로고    scopus 로고
    • Sirtuin regulation of mitochondria: Energy production, apoptosis, and signaling
    • Verdin E, Hirschey MD, Finley LW, and Haigis MC. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci 35: 669-675, 2010.
    • (2010) Trends Biochem Sci , vol.35 , pp. 669-675
    • Verdin, E.1    Hirschey, M.D.2    Finley, L.W.3    Haigis, M.C.4
  • 86
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 123: 309-314, 1956.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 88
    • 77956551895 scopus 로고    scopus 로고
    • Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts
    • Zhang Y, Zhang HM, Shi Y, Lustgarten M, Li Y, Qi W, Zhang BX, and Van Remmen H. Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts. Free Radic Biol Med 49: 1255-1262, 2010.
    • (2010) Free Radic Biol Med , vol.49 , pp. 1255-1262
    • Zhang, Y.1    Zhang, H.M.2    Shi, Y.3    Lustgarten, M.4    Li, Y.5    Qi, W.6    Zhang, B.X.7    Van Remmen, H.8
  • 89
    • 84864398931 scopus 로고    scopus 로고
    • Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity
    • Zhu Y, Park SH, Ozden O, Kim HS, Jiang H, Vassilopoulos A, Spitz DR, and Gius D. Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity. Free Radic Biol Med 53: 828-833, 2012.
    • (2012) Free Radic Biol Med , vol.53 , pp. 828-833
    • Zhu, Y.1    Park, S.H.2    Ozden, O.3    Kim, H.S.4    Jiang, H.5    Vassilopoulos, A.6    Spitz, D.R.7    Gius, D.8
  • 90
    • 84909641972 scopus 로고    scopus 로고
    • SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis
    • Zhu Y, Yan Y, Principe DR, Zou X, Vassilopoulos A, and Gius D. SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. Cancer Metab 2: 15, 2014.
    • (2014) Cancer Metab , vol.2 , pp. 15
    • Zhu, Y.1    Yan, Y.2    Principe, D.R.3    Zou, X.4    Vassilopoulos, A.5    Gius, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.