Role of manganese superoxide dismutase on growth and invasive properties of human estrogen-independent breast cancer cells

Breast Cancer Research and Treatment

Volumn 108, Issue 2, 2008, Pages 203-215

  Kattan, Zilal ^a   Minig, Vanessa ^a   Leroy, Pierre ^b   Dauça, Michel ^a   Becuwe, Philippe ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b Laboratoire de Chimie Physique et Microbiologie pour l'Environnement   (France)

Author keywords

Breast cancer; Cell growth; Invasiveness; Manganese superoxide dismutase; Matrix metalloproteinases; Metastasis; Reactive oxygen species

Indexed keywords

CATALASE; COMPLEMENTARY RNA; ESTROGEN; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; METALLOPROTEINASE; METALLOPROTEINASE 9; PEROXIREDOXIN; PEROXIREDOXIN 3; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL GROWTH; CELL INVASION; CELL STRAIN MCF 7; CELL THERAPY; COLONY FORMATION; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; ENZYME REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE; TUMOR GROWTH; UPREGULATION;

EID: 39749193830     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-007-9597-5     Document Type: Article

References (53)

1. 1. JM Matés 2000 Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology Toxicology 153 83 104 11090949 10.1016/S0300-483X(00)00306-1 Matés JM (2000) Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153:83–104
2. 2. DK St Clair XS Wan TD Oberley KE Muse WH St Clair 1992 Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase Mol Carcinog 6 238 242 1485915 10.1002/mc.2940060404 1:STN:280:ByyC3srotF0%3D St Clair DK, Wan XS, Oberley TD, Muse KE, St Clair WH (1992) Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase. Mol Carcinog 6:238–242
3. 3. KK Kiningham TD Oberley S Lin CA Mattingly DK St Clair 1999 Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death FASEB J 13 1601 1610 10463952 1:CAS:528:DyaK1MXmtVWis7w%3D Kiningham KK, Oberley TD, Lin S, Mattingly CA, St Clair DK (1999) Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death. FASEB J 13:1601–1610
4. 4. RM Lebovitz H Zhang H Vogel J Cartwright Jr L Dionne N Lu S Huang MM Matzuk 1996 Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice Proc Natl Acad Sci USA 93 9782 9787 8790408 10.1073/pnas.93.18.9782 1:CAS:528:DyaK28XlsFehtr8%3D Lebovitz RM, Zhang H, Vogel H, Cartwright J Jr, Dionne L, Lu N, Huang S, Matzuk MM (1996) Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci USA 93:9782–9787
5. 5. LA Ridnour TD Oberley LW Oberley 2004 Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal Antioxid Redox Signal 6 501 512 15130277 10.1089/152308604773934260 1:CAS:528:DC%2BD2cXjslahu78%3D Ridnour LA, Oberley TD, Oberley LW (2004) Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal. Antioxid Redox Signal 6:501–512
6. 6. A Bravard L Sabatier F Hoffschir M Ricoul C Luccioni B Dutrillaux 1992 SOD2: a new type of tumor-suppressor gene? Int J Cancer 51 476 480 1592538 10.1002/ijc.2910510323 1:CAS:528:DyaK38Xlt1Grsrs%3D Bravard A, Sabatier L, Hoffschir F, Ricoul M, Luccioni C, Dutrillaux B (1992) SOD2: a new type of tumor-suppressor gene? Int J Cancer 51:476–480
7. 7. SL Church JW Grant LA Ridnour LW Oberley PE Swanson PS Meltzer JM Trent 1993 Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells Proc Natl Acad Sci USA 90 3113 3117 8464931 10.1073/pnas.90.7.3113 1:CAS:528:DyaK3sXisFans7s%3D Church SL, Grant JW, Ridnour LA, Oberley LW, Swanson PE, Meltzer PS, Trent JM (1993) Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc Natl Acad Sci USA 90:3113–3117
8. 8. N Li TD Oberley LW Oberley W Zhong 1998 Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype Prostate 35 221 233 9582091 10.1002/(SICI)1097-0045(19980515)35:3<221::AID-PROS8>3.0.CO;2-J 1:CAS:528:DyaK1cXjtVKlt78%3D Li N, Oberley TD, Oberley LW, Zhong W (1998) Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype. Prostate 35:221–233
9. 9. KH Kim AM Rodriguez PM Carrico JA Melendez 2001 Potential mechanisms for the inhibition of tumor cell growth by manganese superoxide dismutase Antiox Redox Signal 3 361 373 10.1089/15230860152409013 1:CAS:528:DC%2BD3MXlt1Ghsrg%3D Kim KH, Rodriguez AM, Carrico PM, Melendez JA (2001) Potential mechanisms for the inhibition of tumor cell growth by manganese superoxide dismutase. Antiox Redox Signal 3:361–373
10. 10. JJ Cullen C Weydert MM Hinkhouse J Ritchie FE Domann D Spitz LW Oberley 2003 The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma Cancer Res 63 1297 1303 12649190 1:CAS:528:DC%2BD3sXit1Sgtb0%3D Cullen JJ, Weydert C, Hinkhouse MM, Ritchie J, Domann FE, Spitz D, Oberley LW (2003) The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma. Cancer Res 63:1297–1303
11. 11. S Nishida F Akai H Iwasaki K Hosokawa T Kusunoki K Suzuki N Taniguchi S Hashimoto TT Tamura 1993 Manganese superoxide dismutase content and localization in human thyroid tumours J Pathol 169 341 345 8492227 10.1002/path.1711690311 1:CAS:528:DyaK3sXktVKjtbw%3D Nishida S, Akai F, Iwasaki H, Hosokawa K, Kusunoki T, Suzuki K, Taniguchi N, Hashimoto S, Tamura TT (1993) Manganese superoxide dismutase content and localization in human thyroid tumours. J Pathol 169:341–345
12. 12. CS Cobbs DS Levi K Aldape MA Israel 1996 Manganese superoxide dismutase expression in human central nervous system tumors Cancer Res 56 3192 3195 8764104 1:CAS:528:DyaK28XktlaqsLc%3D Cobbs CS, Levi DS, Aldape K, Israel MA (1996) Manganese superoxide dismutase expression in human central nervous system tumors. Cancer Res 56:3192–3195
13. 13. AM Janssen CB Bosman W Duijn van MM Oostendorp-van Ruit de FJ Kubben G Griffioen CB Lamers JH Krieken van CJ Velde van de HW Verspaget 2000 Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer Clin Cancer Res 6 3183 3192 10955802 1:CAS:528:DC%2BD3cXmsVOmtrY%3D Janssen AM, Bosman CB, van Duijn W, Oostendorp-van de Ruit MM, Kubben FJ, Griffioen G, Lamers CB, van Krieken JH, van de Velde CJ, Verspaget HW (2000) Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer. Clin Cancer Res 6:3183–3192
14. 14. T Nishiura K Suzuki T Kawaguchi H Nakao N Kawamura M Taniguchi Y Kanayama T Yonezawa S Iizuka N Taniguchi 1992 Elevated serum manganese superoxide dismutase in acute leukemias Cancer Lett 62 211 215 1596865 10.1016/0304-3835(92)90098-G 1:CAS:528:DyaK38XitFajur8%3D Nishiura T, Suzuki K, Kawaguchi T, Nakao H, Kawamura N, Taniguchi M, Kanayama Y, Yonezawa T, Iizuka S, Taniguchi N (1992) Elevated serum manganese superoxide dismutase in acute leukemias. Cancer Lett 62:211–215
15. 15. M Malafa J Margenthaler B Webb L Neitzel M Christophersen 2000 MnSOD expression is increased in metastatic gastric cancer J Surg Res 88 130 134 10644478 10.1006/jsre.1999.5773 1:CAS:528:DC%2BD3cXls1ekug%3D%3D Malafa M, Margenthaler J, Webb B, Neitzel L, Christophersen M (2000) MnSOD expression is increased in metastatic gastric cancer. J Surg Res 88:130–134
16. 16. Y Toh S Kuninaka T Oshiro Y Ikeda H Nakashima H Baba S Kohnoe T Okamura M Mori K Sugimachi 2000 Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas Int J Oncol 17 107 112 10853026 1:CAS:528:DC%2BD3cXksV2ru7s%3D Toh Y, Kuninaka S, Oshiro T, Ikeda Y, Nakashima H, Baba H, Kohnoe S, Okamura T, Mori M, Sugimachi K (2000) Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas. Int J Oncol 17:107–112
17. 17. JJ Li LW Oberley DK St Clair LA Ridnour TD Oberley 1995 Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase Oncogene 10 1989 2000 7761099 1:CAS:528:DyaK2MXmtVGrtrs%3D Li JJ, Oberley LW, St Clair DK, Ridnour LA, Oberley TD (1995) Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase. Oncogene 10:1989–2000
18. 18. LW Oberley 2005 Mechanism of the tumor suppressive effect of MnSOD overexpression Biomed Pharmacother 59 143 148 15862707 10.1016/j.biopha.2005.03.006 1:CAS:528:DC%2BD2MXjs1Kmtrk%3D Oberley LW (2005) Mechanism of the tumor suppressive effect of MnSOD overexpression. Biomed Pharmacother 59:143–148
19. 19. E Tsanou E Ioachim E Briasoulis K Damala A Charchanti V Karavasilis N Pavlidis NJ Agnantis 2004 Immunohistochemical expression of superoxide dismutase (MnSOD) anti-oxidant enzyme in invasive breast carcinoma Histol Histopathol 19 807 813 15168344 1:CAS:528:DC%2BD2cXntVygtbk%3D Tsanou E, Ioachim E, Briasoulis E, Damala K, Charchanti A, Karavasilis V, Pavlidis N, Agnantis NJ (2004) Immunohistochemical expression of superoxide dismutase (MnSOD) anti-oxidant enzyme in invasive breast carcinoma. Histol Histopathol 19:807–813
20. 20. M Bortoli De C Dati S Antoniotti P Maggiora ML Sapei 1992 Hormonal regulation of c-erbB-2 oncogene expression in breast cancer cells J Steroid Biochem Mol Biol 43 21 25 1356014 10.1016/0960-0760(92)90183-J De Bortoli M, Dati C, Antoniotti S, Maggiora P, Sapei ML (1992) Hormonal regulation of c-erbB-2 oncogene expression in breast cancer cells. J Steroid Biochem Mol Biol 43:21–25
21. 21. A Bianchi P Becuwe P Franck M Dauca 2002 Induction of MnSOD gene by arachidonic acid is mediated by reactive oxygen species and p38 MAPK signaling pathway in human HepG2 hepatoma cells Free Radic Biol Med 32 1132 1142 12031898 10.1016/S0891-5849(02)00834-1 1:CAS:528:DC%2BD38XjvVehu7w%3D Bianchi A, Becuwe P, Franck P, Dauca M (2002) Induction of MnSOD gene by arachidonic acid is mediated by reactive oxygen species and p38 MAPK signaling pathway in human HepG2 hepatoma cells. Free Radic Biol Med 32:1132–1142
22. 22. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275 14907713 1:CAS:528:DyaG38XhsVyrsw%3D%3D Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275
23. 23. UK Laemmli 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 680 685 5432063 10.1038/227680a0 1:CAS:528:DC%2BD3MXlsFags7s%3D Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685
24. 24. H Towbin T Staehelin J Gordon 1979 Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications Proc Natl Acad Sci USA 76 4350 4354 388439 10.1073/pnas.76.9.4350 1:CAS:528:DyaE1MXmtVKltLw%3D Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350–4354
25. 25. F El Bouhtoury JM Keller S Colin RM Parache M Dauça 1992 Peroxisomal enzymes in normal and tumoral human breast J Pathol 166 27 35 1538272 10.1002/path.1711660106 1:STN:280:By2C28nptFE%3D El Bouhtoury F, Keller JM, Colin S, Parache RM, Dauça M (1992) Peroxisomal enzymes in normal and tumoral human breast. J Pathol 166:27–35
26. 26. C Beauchamp I Fridovich 1971 Superoxide dismutase: improved assays and an assay applicable to acrylamide gels Anal Biochem 44 276 287 4943714 10.1016/0003-2697(71)90370-8 1:CAS:528:DyaE38XjtFKhsg%3D%3D Beauchamp C, Fridovich I (1971) Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 44:276–287
27. 27. P Fossati L Prencipe G Berti 1980 Use of 3,5-dichloro-2-hydroxybenzenesulfonic acid/4-aminophenazone chromogenic system in direct enzymic assay of uric acid in serum and urine Clin Chem 26 227 231 7353268 1:CAS:528:DyaL3cXhsValtbw%3D Fossati P, Prencipe L, Berti G (1980) Use of 3,5-dichloro-2-hydroxybenzenesulfonic acid/4-aminophenazone chromogenic system in direct enzymic assay of uric acid in serum and urine. Clin Chem 26:227–231
28. 28. L Flohe WA Gunzler 1984 Assays of glutathione peroxidase Methods Enzymol 105 114 121 6727659 1:CAS:528:DyaL2cXltVKisbs%3D Flohe L, Gunzler WA (1984) Assays of glutathione peroxidase. Methods Enzymol 105:114–121
29. 29. P Leroy A Nicolas C Thioudellet T Oster M Wellman G Siest 1993 Rapid liquid chromatographic assay of glutathione in cultured cells Biomed Chromatogr 7 86 89 8485380 10.1002/bmc.1130070208 1:CAS:528:DyaK3sXit12nt70%3D Leroy P, Nicolas A, Thioudellet C, Oster T, Wellman M, Siest G (1993) Rapid liquid chromatographic assay of glutathione in cultured cells. Biomed Chromatogr 7:86–89
30. 30. F Sanger S Nicklen AR Coulson 1977 DNA sequencing with chain-terminating inhibitors Proc Natl Acad Sci USA 74 5463 5467 271968 10.1073/pnas.74.12.5463 1:CAS:528:DyaE1cXhtlaru7Y%3D Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463–5467
31. 31. RS Talhouk JR Chin EN Unemori Z Werb MJ Bissell 1991 Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture Development 112 439 449 1794314 1:CAS:528:DyaK3MXltlamtLY%3D Talhouk RS, Chin JR, Unemori EN, Werb Z, Bissell MJ (1991) Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. Development 112:439–449
32. 32. CR Merril D Goldman SA Sedman MH Ebert 1981 Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins Science 211 1437 1438 6162199 10.1126/science.6162199 1:CAS:528:DyaL3MXhsFaqtLY%3D Merril CR, Goldman D, Sedman SA, Ebert MH (1981) Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. Science 211:1437–1438
33. 33. Y Xu A Krishnan XS Wan H Majima CC Yeh G Ludewig EJ Kasarskis DK St Clair 1999 Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells Oncogene 18 93 102 9926924 10.1038/sj.onc.1202265 1:CAS:528:DyaK1MXhtVCms74%3D Xu Y, Krishnan A, Wan XS, Majima H, Yeh CC, Ludewig G, Kasarskis EJ, St Clair DK (1999) Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells. Oncogene 18:93–102
34. 34. Y Huang T He FE Domann 1999 Decreased expression of manganese superoxide dismutase in transformed cells is associated with increased cytosine methylation of the SOD2 gene DNA Cell Biol 18 643 652 10463060 10.1089/104454999315051 1:CAS:528:DyaK1MXlt1Kiur4%3D Huang Y, He T, Domann FE (1999) Decreased expression of manganese superoxide dismutase in transformed cells is associated with increased cytosine methylation of the SOD2 gene. DNA Cell Biol 18:643–652
35. 35. D Millikin E Meese B Vogelstein C Witkowski J Trent 1991 Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma Cancer Res 51 5449 5453 1680551 1:STN:280:By2D3crkslc%3D Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J (1991) Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma. Cancer Res 51:5449–5453
36. 36. H Nakshatri P Bhat-Nakshatri DA Martin RJ Goulet Jr GW Sledge Jr 1998 Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth Mol Cell Biol 17 3629 3639 Nakshatri H, Bhat-Nakshatri P, Martin DA, Goulet RJ Jr, Sledge GW Jr (1998) Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. Mol Cell Biol 17:3629–3639
37. 37. D Bernard B Quatannens A Begue B Vandenbunder C Abbadie 2001 Antiproliferative and antiapoptotic effects of crel may occur within the same cells via the up-regulation of manganese superoxide dismutase Cancer Res 61 2656 2664 11289144 1:CAS:528:DC%2BD3MXisVSksLw%3D Bernard D, Quatannens B, Begue A, Vandenbunder B, Abbadie C (2001) Antiproliferative and antiapoptotic effects of crel may occur within the same cells via the up-regulation of manganese superoxide dismutase. Cancer Res 61:2656–2664
38. 38. TD Oberley W Zhong LI Szweda LW Oberley 2000 Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium Prostate 44 144 155 10881024 10.1002/1097-0045(20000701)44:2<144::AID-PROS7>3.0.CO;2-G 1:CAS:528:DC%2BD3cXltFOmtLo%3D Oberley TD, Zhong W, Szweda LI, Oberley LW (2000) Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium. Prostate 44:144–155
39. 39. RS Esworthy MA Baker FF Chu 1995 Expression of selenium-dependent glutathione peroxidase in human breast tumor cell lines Cancer Res 55 957 962 7850813 1:CAS:528:DyaK2MXjsleltb8%3D Esworthy RS, Baker MA, Chu FF (1995) Expression of selenium-dependent glutathione peroxidase in human breast tumor cell lines. Cancer Res 55:957–962
40. 40. PA Cerutti 1985 Prooxidant states and tumor promotion Science 227 375 381 2981433 10.1126/science.2981433 1:CAS:528:DyaL2MXntl2htg%3D%3D Cerutti PA (1985) Prooxidant states and tumor promotion. Science 227:375–381
41. 41. TS Chang CS Cho S Park S Yu SW Kang SG Rhee 2004 Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria J Biol Chem 279 41975 41984 15280382 10.1074/jbc.M407707200 1:CAS:528:DC%2BD2cXnvFWnsLg%3D Chang TS, Cho CS, Park S, Yu S, Kang SW, Rhee SG (2004) Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria. J Biol Chem 279:41975–41984
42. 42. Y Hu DG Rosen Y Zhou L Feng G Yang J Liu P Huang 2005 Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress J Biol Chem 280 39485 39492 16179351 10.1074/jbc.M503296200 1:CAS:528:DC%2BD2MXht1ems77M Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, Huang P (2005) Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem 280:39485–39492
43. 43. JQ Yang S Li FE Domann GR Buettner LW Oberley 1999 Superoxide generation in v-Ha-ras-transduced human keratinocyte HaCaT cells Mol Carcinog 26 180 188 10559793 10.1002/(SICI)1098-2744(199911)26:3<180::AID-MC7>3.0.CO;2-4 1:CAS:528:DyaK1MXnt1GqsLg%3D Yang JQ, Li S, Domann FE, Buettner GR, Oberley LW (1999) Superoxide generation in v-Ha-ras-transduced human keratinocyte HaCaT cells. Mol Carcinog 26:180–188
44. 44. S Grandemange P Seyer A Carazo P Becuwe L Pessemesse M Busson C Marsac P Roger F Casas G Cabello C Wrutniak-Cabello 2005 Stimulation of mitochondrial activity by p43 overexpression induces human dermal fibroblast transformation Cancer Res 65 4282 4291 15899820 10.1158/0008-5472.CAN-04-3652 1:CAS:528:DC%2BD2MXktlSmt7o%3D Grandemange S, Seyer P, Carazo A, Becuwe P, Pessemesse L, Busson M, Marsac C, Roger P, Casas F, Cabello G, Wrutniak-Cabello C (2005) Stimulation of mitochondrial activity by p43 overexpression induces human dermal fibroblast transformation. Cancer Res 65:4282–4291
45. 45. L Chang M Karin 2001 Mammalian MAP kinase signalling cascades Nature 410 37 40 11242034 10.1038/35065000 1:CAS:528:DC%2BD3MXhvVSgs7k%3D Chang L, Karin M (2001) Mammalian MAP kinase signalling cascades. Nature 410:37–40
46. 46. M Karin E Shaulian 2001 AP-1: linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death IUBMB Life 52 17 24 11795587 1:CAS:528:DC%2BD38Xmt12ksw%3D%3D Karin M, Shaulian E (2001) AP-1: linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death. IUBMB Life 52:17–24
47. 47. N Li Y Zhai TD Oberley 1999 Two distinct mechanisms for inhibition of cell growth in human prostate carcinoma cells with antioxidant enzyme imbalance Free Radic Biol Med 26 1554 1568 10401622 10.1016/S0891-5849(99)00024-6 1:STN:280:DyaK1MzivFyltw%3D%3D Li N, Zhai Y, Oberley TD (1999) Two distinct mechanisms for inhibition of cell growth in human prostate carcinoma cells with antioxidant enzyme imbalance. Free Radic Biol Med 26:1554–1568
48. 48. EW Lam R Zwacka EA Seftor DR Nieva BL Davidson JF Engelhardt MJ Hendrix LW Oberley 1999 Effects of antioxidant enzyme overexpression on the invasive phenotype of hamster cheek pouch carcinoma cells Free Radic Biol Med 27 572 579 10490277 10.1016/S0891-5849(99)00109-4 1:CAS:528:DyaK1MXls12ntLw%3D Lam EW, Zwacka R, Seftor EA, Nieva DR, Davidson BL, Engelhardt JF, Hendrix MJ, Oberley LW (1999) Effects of antioxidant enzyme overexpression on the invasive phenotype of hamster cheek pouch carcinoma cells. Free Radic Biol Med 27:572–579
49. 49. N Ramos-DeSimone E Hahn-Dantona J Sipley H Nagase DL French JP Quigley 1999 Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion J Biol Chem 274 13066 13076 10224058 10.1074/jbc.274.19.13066 1:CAS:528:DyaK1MXjtFOlsrw%3D Ramos-DeSimone N, Hahn-Dantona E, Sipley J, Nagase H, French DL, Quigley JP (1999) Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J Biol Chem 274:13066–13076
50. 50. HJ Zhang W Zhao S Venkataraman ME Robbins GR Buettner KC Kregel LW Oberley 2002 Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species J Biol Chem 277 20919 20926 11929863 10.1074/jbc.M109801200 1:CAS:528:DC%2BD38XkslWnsL8%3D Zhang HJ, Zhao W, Venkataraman S, Robbins ME, Buettner GR, Kregel KC, Oberley LW (2002) Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species. J Biol Chem 277:20919–20926
51. 51. KK Nelson AC Ranganathan J Mansouri AM Rodriguez KM Providence JL Rutter K Pumiglia JA Bennett JA Melendez 2003 Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis Clin Cancer Res 9 424 432 12538496 1:CAS:528:DC%2BD3sXnt1Oqug%3D%3D Nelson KK, Ranganathan AC, Mansouri J, Rodriguez AM, Providence KM, Rutter JL, Pumiglia K, Bennett JA, Melendez JA (2003) Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis. Clin Cancer Res 9:424–432
52. 52. S Rajagopalan XP Meng S Ramasamy DG Harrison ZS Galis 1996 Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability J Clin Invest 98 2572 2579 8958220 1:CAS:528:DyaK28XnsVWnt78%3D 10.1172/JCI119076 Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS (1996) Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 98:2572–2579
53. 53. H Sato M Seiki 1993 Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells Oncogene 8 395 405 8426746 1:CAS:528:DyaK3sXhtF2rur4%3D Sato H, Seiki M (1993) Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 8:395–405