Clock Speed as a Window into Dopaminergic Control of Emotion and Time Perception

Timing and Time Perception

Volumn 4, Issue 1, 2016, Pages 99-122

  Cheng, Ruey Kuang ^a   Tipples, Jason ^b   Narayanan, Nandakumar S ^c,d   Meck, Warren H ^e  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b UNIVERSITY OF HULL   (United Kingdom)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e DUKE UNIVERSITY   (United States)

Author keywords

cortico striatal circuits; Fear; interval timing; medial prefrontal cortex; pleasure; striatal beat frequency model

Indexed keywords

EID: 84980391575     PISSN: 2213445X     EISSN: 22134468     Source Type: Journal    
DOI: 10.1163/22134468-00002064     Document Type: Article

References (201)

1. Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Hunag, Y., Hwang, D.-R., Keilp, J., Kochan, L., Van Heertum, R., Gorman, J. M., & Larueele, M. (2002). Prefrontal dopamine D1 receptors and working memory in schizophrenia. J. Neurosci., 22, 3708-3719.
2. Agostino, P. V., & Cheng, R-K. (2016). Contributions of dopaminergic signaling to timing accuracy and precision. Curr. Opin. Behav. Sci., 8, 153-160.
3. Agostino, P. V., Peryer, G., & Meck, W. H. (2008). How music fills our emotions and helps us keep time. Behav. Brain Sci., 31, 575-576.
4. Agostino, P. V., Golombek, D. A., & Meck, W. H. (2011). Unwinding the molecular basis of interval and circadian timing. Front. Integr. Neurosci., 5, 64. doi: 10.3389/fnint.2011.00064.
5. Agostino, P. V., Cheng, R. K., Williams, C. L., West, A. E., & Meck, W. H. (2013). Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. Genes Brain Behav., 12, 633-644.
6. Akdoǧan, B., & Balci, F. (2016). Stimulus probability effects on temporal bisection performance of mice (Mus musculus). Anim. Cogn., 19, 15-30.
7. Allan, L. G., & Gibbon, J. (1991). Human bisection at the geometric mean. Learn. Motiv., 22, 39-58.
8. Allman, M. J., & Meck, W. H. (2012). Pathophysiological distortions in time perception and timed performance. Brain, 135, 656-677.
9. Allman, M. J., Yin, B., & Meck, W. H. (2014a). Time in the psychopathological mind. In V. Arstila & D. Lloyd (Eds), Subjective time: The philosophy, psychology, and neuroscience of temporality (pp. 637-654). Cambridge, MA, USA: MIT Press.
10. Allman, M. J., Teki, S. Griffiths, T. D., & Meck, W. H. (2014b). Properties of the internal clock: First- and second-order principles of subjective time. Annu. Rev. Psychol. 65, 743-771.
11. Alzahrani, H., & Venneri, A. (2015). Cognitive and neuroanatomical correlates of neuropsychiatric symptoms in Parkinson's disease: A systematic review. J. Neurol. Sci., 356, 32-44.
12. Angrilli, A., Cherubini, P., Pavese, A., & Manfredini, S. (1997). The influence of affective factors on time perception. Percept. Psychophys., 59, 972-982.
13. Avlar, B., Kahn, J. B., Jensen, G., Kandel, E. R., Simpson, E. H., & Balsam, P. D. (2015). Improving temporal cognition by enhancing motivation. Behav. Neurosci., 129, 576-588.
14. Balci, F. (2014). Interval timing, dopamine, and motivation. Timing Time Percept., 2, 379-410.
15. Bar-Haim, Y., Kerem, A., Lamy, D., & Zakay, D. (2010). When time slows down: The influence of threat on time perception in anxiety. Cogn. Emot., 24, 255-263.
16. Barkley, R. A., Edwards, G., Laneri, M., Fletcher, K., & Metevia, L. (2001). Executive functioning, temporal discounting, and sense of time in adolescents with attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD). J. Abnorm. Child Psychol., 29, 541-556.
17. Bartholomew, A. J., Meck, W. H., & Cirulli, E. T. (2015). Analysis of genetic and non-genetic factors influencing timing and time perception. PLoS One, 10, e0143873. doi: 10.1371/journal.pone.0143873.
18. Berridge, K. C., & Kringlebach, M. L. (2013). Neuroscience of affect: Brain mechanisms of pleasure and displeasure. Curr. Opin. Neurobiol., 23, 294-303.
19. Buetti, S., & Lleras, A. (2012). Perceiving control over aversive and fearful events can alter how we experience those events: An investigation of time perception in spider-fearful individuals. Front. Psychol., 3, 337. doi: 10.3389/fpsyg.2012.00337.
20. Buhusi, C.V. (2003) Dopaminergic effects of methamphetamine and haloperidol on the control of an internal clock. In W. H. Meck (Ed.), Functional and neural mechanisms of interval timing (pp. 317-338). Boca Raton, FL, USA: CRC Press.
21. Buhusi, C. V., & Meck, W. H. (2002). Differential effects of methamphetamine and haloperidol on the control of an internal clock. Behav. Neurosci., 116, 291-297.
22. Buhusi, C. V., & Meck, W. H. (2005). What makes us tick? Functional and neural mechanisms of interval timing. Nat. Rev. Neurosci., 6, 755-765.
23. Buhusi, C. V., & Meck, W. H. (2006). Interval timing with gaps and distracters: Evaluation of the ambiguity, switch, and time-sharing hypotheses. J. Exp. Psychol. Anim. Behav. Process., 32, 329-338.
24. Buhusi, C. V., & Meck, W. H. (2007). Effect of clozapine on interval timing and working memory for time in the peak-interval procedure with gaps. Behav. Process., 74, 159-167.
25. Buhusi, C. V., & Meck, W. H. (2009a). Relativity theory and time perception: Single or multiple clocks? PLoS One, 4:e6268. doi: 10.1371/journal.pone.0006268.
26. Buhusi, C. V., & Meck, W. H. (2009b). Relative time sharing: New findings and an extension of the resource allocation model of temporal processing. Philos. Trans. R. Soc. B, 364, 1875-1885.
27. Buhusi, C. V., & Oprisan, S. A. (2013). Time-scale invariance as an emergent property in a perceptron with realistic, noisy neurons. Behav. Process., 95, 60-70.
28. Campbell, L. A., & Bryant, R. A. (2007). How time flies: A study of novice skydivers. Behav. Res. Ther., 45, 1389-1392.
29. Chaudhuri, K. R., & Sauerbier, A. (2016). Parkinson disease: Unraveling the nonmotor mysteries of Parkinson disease. Nat. Rev. Neurol., 12, 10-11.
30. Chaudhuri, K. R., & Schapira, A. H. (2009). Non-motor symptoms of Parkinsons disease: Dopaminergic pathophysiology and treatment. Lancet Neurol., 8, 464-474.
31. Cheng, R. K., MacDonald, C. J., & Meck, W. H. (2006). Differential effects of cocaine and ketamine on time estimation: Implications for neurobiological models of interval timing. Pharmacol. Biochem. Behav., 85, 114-122.
32. Cheng, R. K., Ali, Y. M., & Meck, W. H. (2007a). Ketamine "unlocks" the reduced clock-speed effect of cocaine following extended training: Evidence for dopamine-glutamate interactions in timing and time perception. Neurobiol. Learn. Mem., 88, 149-159.
33. Cheng, R. K., Hakak, O. L., & Meck, W. H. (2007b). Habit formation and the loss of control of an internal clock: Inverse relationship between the level of baseline training and the clock-speed enhancing effects of methamphetamine. Psychopharmacology, 193, 351-362.
34. Church, R. M. (2003). A concise introduction to scalar timing theory. In W. H. Meck (Ed.), Functional and neural mechanisms of interval timing. (pp. 3-22). Boca Raton, FL: CRC Press.
35. Ciullo, V., Spalletta, G., Caltagirone, C., Jorge, R. E., & Piras, F. (2016). Explicit time deficit in schizophrenia: Systematic review and meta-analysis indicate it is primary and not domain specific. Schizophr. Bull. 42, 505-518.
36. Conners, C. K., Levin, E. D., Sparrow, E., Hinton, S. C., Erhardt, D., Meck, W. H., Rose, J. E., & March, J. (1996). Nicotine and attention in adult attention deficit hyperactivity disorder (ADHD). Psychopharmacol. Bull., 32, 67-73.
37. Cools, R., & D'Esposito, M. (2011). Inverted-U-shaped dopamine actions on human working memory and cognitive control. Biol. Psychiatry, 69, e113-e125.
38. Coull, J. T., & Nobre, A. C. (1998). Where and when to pay attention: The neural systems for directing attention to spatial locations and to time intervals as revealed by both PET and fMRI. J. Neurosci., 18, 7426-7435.
39. Coull, J. T., Cheng, R. K., & Meck, W. H. (2011). Neuroanatomical and neurochemical substrates of timing. Neuropsychopharmacology Rev., 36, 3-25.
40. Coull, J. T., Vidal, F., & Burle, B. (2016). When to act, or not to act: that's the SMA's question. Curr. Opin. Behav. Sci., 8, 14-21.
41. Cravo, A. M., Rohenkohl, G., Wyart, V., & Nobre, A. C. (2013). Temporal expectation enhances contrast sensitivity by phase entrainment of low-frequency oscillations in visual cortex. J. Neurosci., 33, 40002-4010.
42. Dreyer, J. K., Herrik, K. F., Berg, R. W., & Hounsgaard, J. D. (2010). Influence of phasic and tonic dopamine release on receptor activation. J. Neurosci., 30, 14273-14283.
43. Droit-Volet, S. (2013). Time perception, emotions and mood disorders. J. Physiol., 107, 255-264.
44. Droit-Volet, S., & Meck, W. H. (2007). How emotions colour our perception of time. Trends Cogn. Sci., 11, 504-513.
45. Droit-Volet, S., Brunot, S., & Niedenthal, P. M. (2004). Perception of the duration of emotional events. Cogn. Emot., 18, 849-858.
46. Droit-Volet, S., Mermillod, M., Cocenas-Silva, R., & Gil, S. (2010). The effect of expectancy of a threatening event on time perception in human adults. Emotion, 10, 908-914.
47. Droit-Volet, S., Fayolle, S. L. & Gil, S. (2011). Emotion and time perception: Mood elicited by films. Front. Integr. Neurosci., 5, 33. doi: 10.3389/fnint.2011.00033.
48. Droit-Volet, S., Fayolle, S., Lamotte, M. & Gil, S. (2013). Time, emotion and the embodiment of timing. Timing Time Percept., 1, 99-126.
49. Escoffier, N., Sheng, D. Y. J., & Schirmer, A. (2010). Unattended musical beats enhance visual processing. Acta Psychol. (Amst.), 135, 12-16.
50. Escoffier, N., Herrmann, C. S., & Schirmer, A. (2015). Auditory rhythms entrain visual processes in the human brain: Evidence from evoked oscillations and event-related potentials. Neuroimage, 111, 267-276.
51. Failing, M., & Theeuwes, J. (2015). Reward alters the perception of time. Cognition, 148, 19-26.
52. Fayolle, S., Gil, S., & Droit-Volet, S. (2015). Fear and time: Fear speeds up the internal clock. Behav. Process., 120, 135-140.
53. Folta-Schoofs, K., Wolf, O. T., Treue, S., & Schoofs, D. (2014). Perceptual complexity, rather than valence or arousal accounts for distractor-induced overproductions of temporal durations. Acta Psychologica, 147, 51-59.
54. Gable, P. A., & Poole, B. D. (2012). Time flies when you're having approach-motivated fun effects of motivational intensity on time perception. Psychol. Sci., 23, 879-886.
55. Gil, S., & Droit-Volet, S. (2011). "Time flies in the presence of angry faces" ⋯ depending on the temporal task used! Acta Psychologica, 136, 354-362.
56. Gil, S., & Droit-Volet, S. (2012). Emotional time distortions: The fundamental role of arousal. Cogn. Emot., 26, 847-862.
57. Goldman-Rakic, P. S., Castner, S. A., Svensson, T. H., Siever, L. J., & Williams, G. V. (2004). Targeting the dopamine D1 receptor in schizophrenia: Insights for cognitive dysfunction. Psychopharmacology, 174, 3-16.
58. Gu, B.-M., Cheng, R. K., Yin, B., & Meck, W. H. (2011). Quinpirole-induced sensitization to noisy/sparse periodic input: Temporal synchronization as a component of obsessive-compulsive disorder. Neuroscience, 179, 143-150.
59. Gu, B.-M., Jurkowski, A. J., Lake, J. I., Malapani, C., & Meck, W. H. (2015a). Bayesian models of interval timing and distortions in temporal memory as a function of Parkinson's disease and dopamine-related error processing. In A. Vatakis & M.J. Allman (Eds), Time distortions in mind: Temporal processing in clinical populations (pp. 284-329). Boston, MA, UISA: Brill Academic Publishers.
60. Gu, B.-M., Van Rijn, H., & Meck, W. H. (2015b). Oscillatory multiplexing of neural population codes for interval timing and working memory. Neurosci. Biobehav. Rev., 48, 160-185.
61. Harrington, D. L., & Rao, S. M. (2015). Timing in neurogenerative disorders of the basal ganglia. In A. Vatakis & M. J. Allman (Eds), Time distortions in mind: Temporal processing in clinical populations (pp. 190-225). Boston, MA, USA: Brill Academic Publishers.
62. Harrington, D. L., Castillo, G. N., Reed, J. D., Song, D. D., Litvan, I., & Lee, R. R. (2014). Dissociation of neural mechanisms for intersensory timing deficits in Parkinson's disease. Timing Time Percept., 2, 145-168.
63. Hashimoto, Y., & Yotsumoto, Y. (2015). Effect of temporal frequency spectra of flicker on time perception: Behavioral testing and simulations using a striatal beat frequency model. Timing Time Percept., 3, 201-222.
64. Hass, J., & Durstewitz, D. (2014). Neurocomputational models of time perception. Adv. Exp. Med. Biol., 828, 49-71.
65. Heilbronner, S. R., & Meck, W. H. (2014). Dissociations between interval timing and intertemporal choice following administration of fluoxetine, cocaine, or methamphetamine. Behav. Process., 101, 123-134.
66. Henry, M. J., & Herrmann, B. (2014). Low-frequency neural oscillations support dynamic attending in temporal context. Timing Time Percept., 2, 62-86.
67. Hinton, S. C., & Meck, W. H. (1996). Increasing the speed of an internal clock: The effects of nicotine on interval timing. Drug Dev. Res., 38, 204-211.
68. Hinton, S. C., & Meck, W. H. (1997a). How time flies: Functional and neural mechanisms of interval timing. In C. M. Bradshaw & E. Szabadi (Eds), Time and behaviour: Psychological and neurobiological analyses (pp. 409-457). New York, NY, USA: Elsevier.
69. Hinton, S. C., & Meck, W. H. (1997b). The "internal clocks" of circadian and interval timing. Endeavour, 21, 82-87.
70. Howland, R. H. (2012). The use of dopaminergic and stimulant drugs for the treatment of depression. J. Psychosoc. Nurs. Ment. Health Serv., 50, 11-14.
71. Hwang-Gu, S.-L., & Gau, S. S.-F. (2015). Interval timing deficits assessed by time reproduction dual tasks as cognitive endophenotypes for attention-deficit/hyperactivity disorder. PLoS One,10, e0127157. doi: 10.1371/journal.pone.0127157.
72. Ilango, A., Kesner, A. J., Keller, K. L., Stuber, G. D., Bonci, A., & Ikemoto, S. (2014). Similar roles of substnatia nigra and ventral tegmental dopamine neurons in reward and aversion. J. Neurosci., 34, 817-822.
73. Jahanshahi, M., Jones, C. R. G., Dirnberger, G., & Frith, C. D. (2006). The substantia nigra pars compacta and temporal processing. J. Neurosci., 26, 12266-12273.
74. Jones, C. R. G., & Jahanshahi, M. (2014). Contributions of the basal ganglia to temporal processing: Evidence from Parkinson's disease. Timing Time Percept., 2, 87-127.
75. Jones, C. R. G., and Jahanshahi, M. (2015). Striatal and frontal pathology: Parkinson's disease and patients with lesions of the basal ganglia and frontal cortex. In A. Vatakis & M. J. Allman (Eds), Time distortions in mind: Temporal processing in clinical populations (pp. 250-280). Boston, MA, USA: Brill Academic Publishers.
76. Kim, J., Jung, A. H., Byun, J., Jo, S., & Jung, M. W. (2009). Inactivation of medial prefrontal cortex impairs time interval discrimination in rats. Front. Behav. Neurosci., 3, 38. doi: 10.3389/neuro.08.038.2009.
77. Kim, J., Ghim, J.-W., Lee, J. H., & Jung, M. W. (2013). Neural correlates of interval timing in rodent prefrontal cortex. J. Neurosci., 33, 13834-13847.
78. Kliegl, K. M., Watrin, L., & Huckauf, A. (2015). Duration perception of emotional stimuli: Using evaluative conditioning to avoid sensory confounds. Cogn. Emot., 29, 1350-1367.
79. Kononowicz, T. W. (2015). Dopamine-dependent oscillations in frontal cortex index "start-gun" signal in interval timing. Front. Hum. Neurosci., 9, 331. doi: 10.3389/fnhum.2015.00331.
80. Kononowicz, T. W., & Penney, T. B. (2016). The contigent negative variation (CNV): timing isn't everything. Curr. Opin. Behav. Sci., 8, doi: 10.1016/j.cobeha.2016.02.022.
81. Kononowicz, T. W., & Van Rijn, H. (2014). Decoupling interval timing and climbing neural activity: A dissociation between CNV and N1P2 amplitudes. J. Neurosci., 34, 2931-2939.
82. Kononowicz, T. W., & Van Rijn, H. (2015). Single trial beta oscillations index time estimation. Neuropsychologia, 75, 381-389.
83. Kononowicz, T. W., Sander, T., & Van Rijn, H. (2015). Neuroelectromagnetic signatures of the reproduction of supra-second durations. Neuropsychologia, 75, 201-213.
84. Kopec, C. D., & Brody, C. D. (2010). Human performance on the temporal bisection task. Brain Cogn., 74, 262-272.
85. Kring, A. M., & Caponigro, J. M. (2010). Emotion in schizophrenia: Where feeling meets thinking. Curr. Dir. Psychol. Sci., 19, 255-259.
86. Lake, J. I. (2016). Recent advances in understanding emotion-driven temporal distortions. Curr. Opin. Behav. Sci., 8, 214-219.
87. Lake, J. I., & Meck, W. H. (2013). Differential effects of amphetamine and haloperidol on temporal reproduction: Dopaminergic regulation of attention and clock speed. Neuropsychologia, 51, 284-292.
88. Lake, J. I., LaBar, K. S., & Meck, W. H. (2014). Hear it playing low and slow: How pitch level differentially influences time perception. Acta Psychologica, 149, 169-177.
89. Lake, J. I., LaBar, K. S., & Meck, W. H. (in press). Emotional modulation of interval timing and time perception. Neurosci. Biobehav. Rev.
90. Lake, J. I., Meck, W. H., & LaBar, K. S. (2016). Discriminative fear learners are resilient to temporal distortions during threat anticipation. Timing Time Percept, 4, 63-78.
91. Land, B. B., Narayanan, N. S., Liu, R. J., Gianessi, C. A., Brayton, C. E., Grimaldi, D. M., Sarhan, M., Guarnieri, D. J., Deisseroth, K., Aghajanian, G. K., & DiLeone, R. J. (2014). Medial prefrontal D1 dopamine neurons control food intake. Nat. Neurosci. 17, 248-253.
92. Langer, J., Wapner, S., & Werner, H. (1961). The effect of danger upon the experience of time. Am. J. Psychol., 74, 94-97.
93. Laubach, M., Caetano, M. S., & Narayanan, N. S. (2015). Mistakes were made: Neural mechanisms for the adaptive control of action initiation by the medial prefrontal cortex. J. Physiol. Paris, 109, 104-117.
94. Levin, E. D., Conners, C. K., Sparrow, E., Hinton, S. C., Erhardt, D., Meck, W. H., Rose, J. E., & March, J. (1996). Nicotine effects on adults with attention-deficit/hyperactivity disorder. Psychopharmacology, 123, 55-63.
95. Levin, E. D., Conners, C. K., Silva, D., Hinton, S. C., Meck, W. H., March, J., & Rose, J. E. (1998). Transdermal nicotine effects on attention. Psychopharmacology, 140, 135-141.
96. Linazasoro, G., & van Blercom, N. (2007). Severe stuttering and motor tics responsive to cocaine. Parkinsonism Relat. Disord., 13, 57-58.
97. Lui, M. A., Penney, T. B., Schirmer, A. (2011). Emotion effects on timing: Attention versus pacemaker accounts. PLoS One, 6, e21829. doi: 10.1371/journal.pone.0021829.
98. Lustig, C., & Meck, W. H. (2005). Chronic treatment with haloperidol induces deficits in working memory and feedback effects of interval timing. Brain Cogn., 58, 9-16.
99. Lustig, C., Matell, M. S., & Meck, W. H. (2005). Not "just" a coincidence: Frontal-striatal synchronization in working memory and interval timing. Memory, 13, 441-448.
100. MacDonald, C. J., & Meck, W. H. (2005). Differential effects of clozapine and haloperidol on interval timing in the supraseconds range. Psychopharmacology, 182, 232-244.
101. MacDonald, C. J., Cheng, R. K., Williams, C. L., & Meck, W. H. (2007). Combined organizational and activational effects of short and long photoperiods on spatial and temporal memory in rats. Behav. Process., 74, 226-233.
102. MacDonald, C. J., Cheng, R. K., & Meck, W. H. (2012). Acquisition of "Start" and "Stop" response thresholds in peak-interval timing is differentially sensitive to protein synthesis inhibition in the dorsal and ventral striatum. Front. Integr. Neurosci., 6, 10. doi: 10.3389/fnint.2012.00010.
103. MacDonald, C. J., Fortin, N. J., Sakata, S., & Meck, W. H. (2014). Retrospective and prospective views on the role of the hippocampus in interval timing and memory for elapsed time. Timing & Time Percept., 2, 51-61.
104. Malapani, C., Rakitin, B., Levy, R., Meck, W. H., Deweer, B., Dubois, B., & Gibbon, J. (1998). Coupled temporal memories in Parkinson's disease: A dopamine-related dysfunction. J. Cogn. Neurosci., 10, 316-331.
105. Maricq, A. V., & Church, R. M. (1983). The differential effects of haloperidol and methamphetamine on time estimation in the rat. Psychopharmacology, 79, 10-15.
106. Maricq, A. V., Roberts, S., & Church, R. M. (1981). Methamphetamine and time estimation. J. Exp. Psychol. Anim. Behav. Process., 7, 18-30.
107. Matell, M. S., & Meck, W. H. (2000). Neuropsychological mechanisms of interval timing behaviour. BioEssays, 22, 94-103.
108. Matell, M. S., & Meck, W. H. (2004). Cortico-striatal circuits and interval timing: Coincidence-detection of oscillatory processes. Cogn. Brain Res., 21, 139-170.
109. Matell, M. S., King, G. R., & Meck, W. H. (2004). Differential modulation of clock speed by the chronic administration of intermittent versus continuous cocaine. Behav. Neurosci., 118, 150-156.
110. Matell, M. S., Bateson, M., & Meck, W. H. (2006). Single-trials analyses demonstrate that increases in clock speed contribute to the methamphetamine-induced horizontal shifts in peak-interval timing functions. Psychopharmacology, 188, 201-212.
111. Mathalon, D. H., & Sohal, V. S. (2016). Neural oscillations and synchrony in brain dysfunction and neuropsychiatric disorders: It's about time. JAMA Psychiatry, 72, 840-844.
112. Matthews, W. J., & Meck, W. H. (2014). Time perception: The bad news and the good. WIREs Cogn. Sci., 5, 429-446.
113. Matthews, W. J., Terhune, D. B., Van Rijn, H., Eagleman, D. M., Sommer, M. A., & Meck, W. H. (2014). Subjective duration as a signature of coding efficiency: Emerging links among stimulus repetition, prediction coding, and cortical GABA levels. Timing Time Percept. Rev., 1, 1-11.
114. Meck, W. H. (1983). Selective adjustment of the speed of internal clock and memory processes. J. Exp. Psychol. Anim. Behav. Process., 9, 171-201.
115. Meck, W. H. (1986). Affinity for the dopamine D2 receptor predicts neuroleptic potency in decreasing the speed of an internal clock. Pharmacol. Biochem. Behav., 25, 1185-1189.
116. Meck, W. H. (1996). Neuropharmacology of timing and time perception. Cogn. Brain Res., 3, 227-242.
117. Meck, W. H. (2005). Neuropsychology of timing and time perception. Brain Cogn., 58, 1-8.
118. Meck, W. H. (2006a). Neuroanatomical localization of an internal clock: A functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems. Brain Res., 1109, 93-107.
119. Meck, W. H. (2006b). Frontal cortex lesions eliminate the clock speed effect of dopaminergic drugs on interval timing. Brain Res., 1108, 157-167.
120. Meck, W. H. (2007). Acute ethanol potentiates the clock-speed enhancing effects of nicotine on timing and temporal memory. Alcohol Clin. Exp. Res., 31, 2106-2113.
121. Meck, W. H., & Benson, A. M. (2002). Dissecting the brain's internal clock: How frontal-striatal circuitry keeps time and shifts attention. Brain Cogn., 48, 195-211.
122. Meck, W. H., & MacDonald, C. J. (2007). Amygdala inactivation reverses fear's ability to impair divided attention and make time stand still. Behav. Neurosci., 121, 707-720.
123. Meck, W. H., Church, R. M., & Gibbon, J. (1985). Temporal integration in duration and number discrimination. J. Exp. Psychol. Anim. Behav. Process., 11, 591-597.
124. Meck, W. H., Cheng, R. K., MacDonald, C. J., Gainetdinov, R. R., Caron, M. G., & Çevik, M. Ö. (2012). Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice. Neuropharmacology, 62, 1221-1229.
125. Merchant, H., Harrington, D. L., & Meck, W. H. (2013a). Neural basis of the perception and estimation of time. Ann. Rev. Neurosci., 36, 313-336.
126. Merchant, H., Pérez, O., Zarco, W., & Gámez, J. (2013b). Interval tuning in the primate medial premotor cortex as a general timing mechanism. J. Neurosci., 33, 9082-9096.
127. Meyer-Lindenberg, A., Miletich, R. S., Kohn, P. D., Esposito, G., Carson, R. E., Quarantelli, M., Weinberger, D. R., & Berman, K. F. (2002). Reduced prefrontal activity predicts exaggerated striatal dopamergic function in schizophrenia. Nat. Neurosci., 5, 267-271.
128. Muller, T., & Nobre, A. C. (2014). Perceiving the passage of time: Neural possibilities. Ann. NY Acad. Sci., 1326, 60-71.
129. Murai, Y., Whitaker, D., & Yotsumoto, Y. (2016). The centralized and distributed nature of adaptation-induced misjudgments of time. Curr. Opin. Behav. Sci., 8, 117-123.
130. Narayanan, N. S. (2016). Ramping activity is a cortical mechanism of temporal control of behavior. Curr. Opin. Behav. Sci., 8, 226-230.
131. Narayanan, N. S., & Laubach, M. (2006). Top-down control of motor cortex ensembles by dorsomedial prefrontal cortex. Neuron, 52, 921-931.
132. Narayanan, N. S., & Laubach, M. (2009). Delay activity in rodent frontal cortex during a simple reaction time task. J. Neurophysiol., 101, 2859-2871.
133. Narayanan, N. S., Land, B. B., Solder, J. E., Deisseroth, K., & DiLeone, R. J. (2012). Prefrontal D1 dopamine signaling is required for temporal control. Proc. Natl Acad. Sci. USA, 109, 20726-20731.
134. Narayanan, N. S., Cavanagh, J. F., Frank, M. J., & Laubach, M. (2013). Common medial frontal mechanisms of adaptive control in humans and rodents. Nat. Neurosci., 16, 1888-1895.
135. Nesse, R. M. (2005). Natural selection and the regulation of defenses. Evol. Hum. Behav., 26, 88-105.
136. Niki, H., & Watanabe, M. (1979). Prefrontal and cingulate unit activity during timing behavior in the monkey. Brain Res., 171, 213-224.
137. Noreika, V., Falter, C. M., & Rubia, K. (2013). Timing deficits in attention-deficit/hyperactivity disorder (ADHD): Evidence from neurocognitive and neuroimaging studies. Neuropsychologia, 51, 235-266.
138. Noulhiane, M., Mella, N., Samson, S., Ragot, R., & Pouthas, V. (2007). How emotional auditory stimuli modulate time perception. Emotion, 7, 697-704.
139. Ogden, R. S., Moore, D., Redfern, L., & McGlone, F. (2014). The effect of pain and the anticipation of pain on temporal perception: A role for attention and arousal. Cogn. Emot., 29(5), 910-922.
140. Ohman, A., & Mineka, S. (2001). Fears, phobias, and preparedness: Toward an evolved module of fear and fear learning. Psychol. Rev., 108, 483-522.
141. Oprisan, S. A., & Buhusi, C. V. (2011). Modeling pharmacological clock and memory patterns of interval timing in a striatal beat- frequency model with realistic, noisy neurons. Front. Integr. Neurosci. 5, 52. doi: 10.3389/fnint.2011.00052.
142. Oprisan, S. A., & Buhusi, C. V. (2013). How noise contributes to time-scale invariance of interval timing. Phys. Rev. E Stat. Nonlin. Soft Matter. Phys., 87, 052717. doi: 10.1103/PhysRevE.87.052717.
143. Oprisan, S. A., & Buhusi, C. V. (2014). What is all the noise about in interval timing? Phil. Trans. R. Soc. B, 369, 20120459. doi: 10.1098/rstb.2012.0459.
144. Oprisan, S. A., Dix, S., & Buhusi, C. V. (2014). Phase resetting and its implications for interval timing with intruders. Behav. Process., 101, 146-153.
145. Parker, K. L., Lamichhane, D., Caetano, M. S., & Narayanan, N. S. (2013). Executive dysfunction in Parkinson's disease and timing deficits. Front. Integr. Neurosci., 7, 75. doi: 10.3389/fnint.2013.00075.
146. Parker, K. L., Chen, K-H., Kingyon, J. R., Cavanagh, J. F., & Narayanan, N. S. (2014). D1-dependent 4 Hz oscillations and ramping activity in rodent medial frontal cortex during interval timing. J. Neurosci., 34, 16774-16783.
147. Parker, K. L., Chen, K-H., Kingyon, J. R., Cavanagh, J. F., & Narayanan, N. S. (2015a). Medial frontal ∼4-Hz activity in humans and rodents is attenuated in PD patients and in rodents with cortical dopamine depletion. J. Neurophysiol., 114, 1310-1320.
148. Parker, K. L., Ruggiero, R. N., and Narayanan, N. S. (2015b). Infusion of D1 dopamine receptor agonist into medial frontal cortex disrupts neural correlates of interval timing. Front. Behav. Neurosci., 9:294. doi: 10.3389/fnbeh.2015.00294.
149. Penney, T. B., Holder, M. D., & Meck, W. H. (1996). Clonidine-induced antagonism of norepinephrine modulates the attentional processes involved in peak-interval timing. Exp. Clin. Psychopharm., 4, 82-92.
150. Penney, T. B., Gibbon, J., & Meck, W. H. (2000). Differential effects of auditory and visual signals on clock speed and temporal memory. J. Exp. Psychol. Hum. Percept. Perform., 26, 1770-1787.
151. Penney, T. B., Gibbon, J., & Meck, W. H. (2008). Categorical scaling of duration bisection in pigeons (Columba livia), mice (Mus musculus), and humans (Homo sapiens). Psychol. Sci., 19, 1103-1109.
152. Penney, T. B., Yim, E. N. K., & Ng, K. K. (2014). Distractor expectancy effects on interval timing. Timing Time Percept., 2, 1-19.
153. Péron, J., Frühholz, S., Vérin, M., & Grandjean, D. (2013). Subthalamic nucleus: A key structure for emotional component synchronization in humans. Neurosci. Biobehav. Rev., 37, 358-373.
154. Péron, J., Grandjean, D., Drapier, S., & Vérin, M. (2014). Effect of dopamine therapy on nonverbal affect burst recognition in Parkinson's disease. PLoS One, 9, e90092. doi: 10.1371/journal.pone.009009.
155. Picton T. W., Stuss, D. T., Shallice, T., Alexander, M. P., & Gillingham, S. (2006). Keeping time: Effects of focal frontal lesions. Neuropsychologia, 44, 1195-1209.
156. Ptáček, R., Kuželová, H., & Stefano, G. B. (2011). Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders. Med. Sci. Monit., 17: RA215-RA220.
157. Rammsayer, T. H. (1999). Neuropharmacological evidence for different timing mechanisms in humans. Q. J. Exp. Psychol. B, 52, 273-286.
158. Rammsayer, T. H. (2006). Effects of pharmacologically induced changes in NMDA receptor activity on human timing and sensorimotor performance. Brain Res., 1073-1074, 407-416.
159. Ray, R. D., & Zald, D. H. (2012). Anatomical insights into the interaction of emotion and cognition in the prefrontal cortex. Neurosci. Biobehav. Rev., 36, 479-501.
160. Reutimann, J., Yakovlev, V., Fusi, S., & Senn, W. (2004). Climbing neuronal activity as an event-based cortical representation of time. J. Neurosci. 24, 3295-3303.
161. Richard, J. M., & Berridge, K. C. (2011). Nucleus accumbens dopamine/glutamate interaction switches modes to generate desire versus dread: D1 alone for appetitive eating but D1 and D2 together for fear. J. Neurosci., 31, 12866-12879.
162. Rommelse, N. N., Arias-Vásquez, A., Altink, M. E., Buschgens, C. J., Fliers, E., Asherson, P., Faraone, S. V., Buitelaar. J. K., Sergeant. J. A., Oosterlaan, J., & Franke, B. (2008). Neuropsychological endophenotype approach to genome-wide linkage analysis identifies susceptibility loci for ADHD on 2q21.1 and 13q12.11. Am. J. Hum. Genet., 83, 99-105.
163. Samaha, J., Bauer, P., Cimaroli, S., & Postle, B. R. (2015). Top-down control of the phase of alpha-band oscillations as a mechanism for temporal prediction. Proc. Natl Acad. Sci. USA, 112, 8439-8444.
164. Schapira, A. H. V., Bezard, E., Brotchie, J., Calon, F., Collingridge, G. L., Ferger, B., Hengerer, B., Hirsch, E., Jenner, P., Le Novère, N., Obeso, J., Schwarzschild, M. A., Spampinato, U., & Davidai, G. (2006). Novel pharmacological targets for the treatment of Parkinson's disease. Nat. Rev. Drug Discov., 5, 845-854.
165. Schirmer, A. (2014). Emotion. Thousand Oaks, CA, USA: SAGE.
166. Schirmer, A., Escoffier, N., Cheng, X., Feng, Y., & Penney, T. B. (2016). Detecting temporal change in dynamic sounds: On the role of stimulus duration, speed, and emotion. Front. Psychol., 6, 2055. doi: 10.3389/fpsyg.2015.02055.
167. Shaw, P., Stringaris, A., Nigg, J., & Leibenluft, E. (2014). Emotion dysregulation in attention deficit hyperactivity disorder. Am. J. Psychiatry, 171, 276-293.
168. Shi, Z., Jia, L., & Müller, H. J. (2012). Modulation of tactile duration judgments by emotional pictures. Front. Integr. Neurosci., 6, 24. doi: 10.3389/fnint.2012.00024.
169. Shi, Z., Church, R. M., & Meck, W. H. (2013). Bayesian optimization of time perception. Trends Cogn. Sci., 17, 556-564.
170. Simen, P., Balci, F., de Souza, L., Cohen, J. D., & Holmes, P. (2011). A model of interval timing by neural integration. J. Neurosci., 31, 9238-9253.
171. Singer, H. S., Szymanski, S., Giuliano, J., Yokoi, F., Dogan, A. S., Brasic, J. R., Zhou, Y., Grace, A. A., & Wong, D. F. (2002). Elevated intrasynaptic dopamine release in Tourette's syndrome measured by PET. Am. J. Psychiatry, 159, 1329-1336.
172. Smith, S. D., McIver, T. A., Di Nella, M. S. J., & Crease, M. L. (2011). The effects of valence and arousal on the emotional modulation of time perception: Evidence for multiple stages of processing. Emotion, 11, 1305-1313.
173. Spencer, R. M. C. (2015). Timing in the cerebellum and cerebellar disorders. In A. Vatakis & M.J. Allman (Eds), Time distortions in mind: Temporal processing in clinical populations (pp. 226-249). Boston, MA, USA: Brill Academic Publishers.
174. Teki, S., Grube, M., & Griffiths, T. D. (2012). A unified model of time perception accounts for duration- based and beat-based timing mechanisms. Front. Integr. Neurosci., 5, 90. doi: 10.3389/fnint.2011.00090.
175. Thönes , S., & Oberfeld, D. (2015). The perception in depression: A meta-analysis. J. Affect. Disord., 175, 359-372.
176. Tipples, J. (2008). Negative emotionality influences the effects of emotion on time perception. Emotion, 8, 127-131.
177. Tipples, J. (2010). Time flies when we read taboo words. Psychon. Bull. Rev., 17, 563-568.
178. Tipples, J. (2011). When time stands still: Fear-specific modulation of temporal bias due to threat. Emotion, 11, 74-80.
179. Tipples, J. (2015). Rapid temporal accumulation in spider fear: Evidence from hierarchical drift diffusion modelling. Emotion, 15, 742-751.
180. Tipples, J., Brattan, V., & Johnston, P. (2013). Neural bases for individual differences in the subjective experience of short durations (less than 2 seconds). PLoS One, 8, e54669. doi: 10.1371/journal.pone.0054669.
181. Tipples, J., Brattan, V., & Johnston, P. (2015). Facial emotion modulates the neural mechanisms responsible for short interval time perception. Brain Topogr., 28, 104-112.
182. Tomasi, D., Wang, G.-J., Studentsova, Y., & Volkow, N. D. (2015). Dissecting neural responses to temporal prediction, attention, and memory: Effects of reward learning and interoception on time perception. Cereb. Cortex, 25, 3856-3867.
183. Trih, J. V., Nehrenberg, D. L., Jacobsen, J. P., Caron, M. G., & Wetsel, W. C. (2003). Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice. Neuroscience, 118, 297-310.
184. Tseng, K. Y., & O'Donnell, P. (2004). Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms. J. Neurosci., 24, 5131-5139.
185. Van Rijn, H., Kononowicz, T. W., Meck, W. H., Ng, K. K., & Penney, T. B. (2011). Contingent negative variation and its relation to time estimation: A theoretical evaluation. Front. Integr. Neurosci., 5, 91. doi: 10.3389/fnint.2011.00091.
186. Van Rijn, H., Gu, B.-M., & Meck, W. H. (2014). Dedicated clock/timing-circuit theories of time perception and timed performance. Adv. Exp. Med. Biol., 829, 75-99.
187. Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., & Arnsten, A. F. T. (2007). Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nat. Neurosci., 10, 376-384.
188. Vinogradov, S., & Hermann, A. (2016). Psychiatric illnesses as oscillatory connectomopathies. Neuropsychopharmacology, 41, 387-388.
189. Volkinburg, H. V., & Balsam, P. (2014). Effects of emotional valence and arousal on time perception. Timing Time Percept., 2, 360-378.
190. Ward, R. D., Kellendonk, C., Simpson, E. H., Lipatova, O., Drew, M. R., Fairhurst, S., Kandel, E. R., & Balsam, P.D. (2009). Impaired timing precision produced by striatal D2 receptor overexpression is mediated by cognitive and motivational deficits. Behav. Neurosci., 123, 720-730.
191. Ward, R. D., Kellendonk, C., Kandel, E. R., & Balsam, P.D. (2012). Timing as a window on cognition in schizophrenia. Neuropharmacology, 62, 1175-1181.
192. Watts, F., & Sharrock, R. (1984). Fear and time-estimation. Percept. Mot. Skills, 59(2), 597-598.
193. Williams, S. M., & Goldman-Rakic, P. S. (1998). Widespread origin of the primate mesofrontal dopamine system. Cereb. Cortex, 8, 321-345.
194. Williamson, L. L., Cheng, R. K., Etchegaray, M., & Meck, W. H. (2008). "Speed" warps time: Methamphetamine's interactive roles in drug abuse, habit formation, and the biological clocks of circadian and interval timing. Curr. Drug Abuse Rev., 1, 203-212.
195. Wittmann, M. (2015). Modulations of the experience of self and time. Consc. Cogn., 38, 172-181.
196. Wittmann, M., & Van Wassenhove, V. (2009). The experience of time: Neural mechanisms and the interplay of emotion, cognition and embodiment. Philos. Trans. R. Soc. Lond. B Biol. Sci., 364(1525), 1809-1813.
197. Wittmann, M., Leland, D. S., Churan, J., & Paulus, M. P. (2007). Impaired time perception and motor timing in stimulant-dependent subjects. Drug Alcohol Depend., 90(2-3), 183-192.
198. Xu, M., Zhang, S.-Y., Dan, Y., & Poo, M.-M. (2014). Representation of interval timing by temporally scalable firing patterns in rat prefrontal cortex. Proc. Natl Acad. Sci. USA, 111, 480-485.
199. Yin, B., & Meck, W. H. (2014). Comparison of interval timing behaviour in mice following dorsal or ventral hippocampal lesions with mice having δ opioid receptor gene deletion. Philos. Trans. R. Soc. B, 369, 20120466. doi: 10.1098/rstb.2012.0466.
200. Yin, B., Lusk, N. A., & Meck, W. H. (in press). Interval-timing protocols and their relevancy to the study of temporal cognition and neurobehavioral genetics. In V. Tucci (Ed.) Neuro-phenome: Cutting-edge approaches and technologies in neurobehavioral genetics. Hoboken, NJ, USA: Wiley-Blackwell.
201. Yoshioka, M., Matsumoto, M., Togashi, H., & Saito, H. (1996). Effects of conditioned fear stress on dopamine release in the rat prefrontal cortex. Neurosci. Lett., 209, 201-203.