Contributions of the Basal Ganglia to Temporal Processing: Evidence from Parkinson's Disease

Timing and Time Perception

Volumn 2, Issue 1, 2014, Pages 87-127

  Jones, Catherine R G ^a   Jahanshahi, Marjan ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

basal ganglia; dopamine; motor timing; Parkinson's disease; perceptual timing; temporal processing

Indexed keywords

EID: 84979641520     PISSN: 2213445X     EISSN: 22134468     Source Type: Journal    
DOI: 10.1163/22134468-00002009     Document Type: Article

References (129)

1. Alexander, G. E., DeLong, M. R., &Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci., 9, 357-381
2. Allman, M. J., &Meck, W. H. (2012). Pathophysiological distortions in time perception and timed performance. Brain, 135, 656-677
3. Artieda, J., Pastor, M. A., Lacruz, F., &Obeso, J. A. (1992). Temporal discrimination is abnormal in Parkinson's disease. Brain, 115, 199-210
4. BareŜ, M., Lungu, O. V., Husárová, I., &Gescheidt, T. (2010). Predictive motor timing performance dissociates between early diseases of the cerebellum and Parkinson's disease. Cerebellum, 9, 124-135
5. Brown, R. G., &Marsden, C. D. (1991). Dual task performance and processing resources in normal subjects and patients with Parkinson's disease. Brain, 114, 215-231
6. Buhusi, C. V., &Meck, W. H. (2005). What makes us tick? Functional and neural mechanisms of interval timing. Nat. Rev. Neurosci., 6, 755-765
7. Cerasa, A., Hagberg, G. E., Peppe, A., Bianciardi, M., Gioia, M., Costa, A., Castriota-Scanderbeg, A., Caltagirone, C., &Sabatini, U. (2006). Functional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson's disease. Brain Res. Bull., 71, 259-269
8. Chaudhuri, K. R., Healy, D. G., &Schapira, A. H. (2006). Non-motor symptoms of Parkinson's disease: Diagnosis and management. Lancet Neurol., 5, 235-245
9. Chaudhuri, K. R., &Schapira, A. H. (2009). Non-motor symptoms of Parkinson's disease: Dopaminergic pathophysiology and treatment. Lancet Neurol., 8, 464-474
10. Cheng, R. K., Ali, Y. M., &Meck, W. H. (2007). Ketamine "unlocks" the reduced clock-speed effect of cocaine following extended training: Evidence for dopamine-glutamate interactions in timing and time perception. Neurobiol. Learn. Mem., 88, 149-159
11. Claassen, D. O., Jones, C. R., Yu, M., Dirnberger, G.,Malone, T., Parkinson,M., Giunti, P., Kubovy, M., &Jahanshahi, M. (2013). Deciphering the impact of cerebellar and basal ganglia dysfunction in accuracy and variability of motor timing. Neuropsychologia, 51, 267-274
12. Collier, G. L., &Ogden, R. T. (2001). Variance decomposition of tempo drift in isochronous rhythmic tapping. Ann. NY Acad. Sci., 930, 405-408
13. Conte, A., Modugno, N., Lena, F., Dispenza, S., Gandolfi, B., Iezzi, E., Fabbrini, G., &Berardelli, A. (2010). Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinson's disease. Brain, 133, 2656-2663
14. Cools, R., Barker, R. A., Sahakian, B. J., &Robbins, T.W. (2001). Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands. Cereb. Cortex, 11, 1136-1143
15. Coull, J. T., Cheng, R. K., &Meck, W. H. (2011). Neuroanatomical and neurochemical substrates of timing. Neuropsychopharmacology, 36, 3-25
16. Coull, J. T., Hwang, H. J., Leyton, M., &Dagher, A. (2012). Dopamine precursor depletion impairs timing in healthy volunteers by attenuating activity in putamen and supplementary motor area. J. Neurosci., 32, 16704-16715
17. Coull, J. T., &Nobre, A. C. (2008). Dissociating explicit timing from temporal expectation with fMRI. Curr. Opin. Neurobiol., 18, 137-144
18. Domellöf, M. E., Elgh, E., Forsgren, L. (2011). The relation between cognition and motor dysfunction in drug-naive newly diagnosed patients with Parkinson's disease. Movement Disord., 26, 2183-2189
19. Domellöf, M. E., Forsgren, L., &Elgh, E. (in press). Persistence of associations between cognitive impairment and motor dysfunction in the early phase of Parkinson's disease. J. Neurol
20. Drew, M. R., Fairhurst, S., Malapani, C., Horvitz, J. C., &Balsam, P. D. (2003). Effects of dopamine antagonists on the timing of two intervals. Pharmacol. Biochem. Behav., 75, 9-15
21. Duchek, J. M., Balota, D. A., &Ferraro, F. R. (1994). Component analysis of a rhythmic finger tapping task in individuals with senile dementia of the Alzheimer type and in individuals with Parkinson's disease. Neuropsychology, 8, 218-226
22. DuŜek, P., Jech, R., Sieger, T., Vymazal, J., Růžička, E.,Wackermann, J., &Mueller, K. (2012). Abnormal activity in the precuneus during time perception in Parkinson's disease: An fMRI study. PLoSOne, 7, e29635. doi:10.1371/journal.pone.0029635
23. Elsinger, C. L., Rao, S., Zimbelman, J. L., Reynolds, N. C., Blindauer, K. A., &Hoffmann, R. G. (2003). Neural basis for impaired time reproduction in Parkinson's disease: An fMRI study. J. Int. Neuropsychol. Soc., 9, 1088-1098
24. Fahn, S., Elton, R. L., (1987). Unified Parkinson's Disease rating scale. In S. Fahn, C. D. Marsden, D. B. Calne, &M. Goldstein (Eds.), Recent developments in Parkinson's disease (pp. 153-164). Florham Park, NJ, USA: Macmillan Healthcare Information
25. Filippopoulos, P. C., Hallworth, P., Lee, S., Wearden, J. H. (in press). Interference between auditory and visual duration judgments suggests a common code for time. Psychol. Res
26. Fiorio, M., Stanzani, C., Rothwell, J. C., Bhatia, K. P., Moretto, G., Fiaschi, A., &Tinazzi, M. (2007). Defective temporal discrimination of passive movements in Parkinson's disease. Neurosci. Lett., 417, 312-315
27. Follett, K. A.,Weaver, F. M., Stern,M., Hur, K.,Harris, C. L., Luo, P.,Marks,W. J. Jr., Rothlind, J., Sagher, O., Moy, C., Pahwa, R., Burchiel,K., Hogarth, P., Lai, E.C., Duda, J. E.,Holloway,K., Samii,A., Horn, S., Bronstein, J. M., Stoner, G., Starr, P. A., Simpson, R., Baltuch, G., De Salles, A., Huang, G. D., Reda, D. J., &CSP 468 Study Group (2012). Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. New Engl. J. Med., 362, 2077-2091
28. Freeman, J. S., Cody, F.W., Schady,W. (1993). The influence of external timing cues upon the rhythm of voluntary movements in Parkinson's disease. J. Neurol. Neurosurg. Psychiat., 56, 1078-1084
29. Gibbon, J. (1977). Scalar expectancy theory andWeber's law in animal timing. Psychol. Rev., 84, 279-325
30. Gibbon, J., Church, R. M., &Meck, W. H. (1984). Scalar timing in memory. Ann. NY Acad. Sci., 423, 52-77
31. Gibbon, J., Malapani, C., Dale, C. L., &Gallistel, C. R. (1997). Toward a neurobiology of temporal cognition: Advances and challenges. Curr. Opin. Neurobiol., 7, 170-184
32. Gotham, A. M., Brown, R. G., &Marsden, C. D. (1988). Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa. Brain, 111, 299-321
33. Graham, J.M., Sagar,H. J. (1999). A data-driven approach to the study of heterogeneity in idiopathic Parkinson's disease: Identification of three distinct syptypes. Movement Disord., 14, 10-20
34. Grahn, J. A., &Brett, M. (2009). Impairment of beat-based rhythm discrimination in Parkinson's disease. Cortex, 45, 54-61
35. Gu, B.-M., Jurkowski, A. J.,Lake, J. I.,Malapani, C.,Meck,W. H. (inpress). Bayesianmodels of interval timing and distortions in temporal memory as a function of Parkinson's disease and dopaminerelated error processing. In A. Vatakis &M. J. Allman (Eds.), Time distortions in mind: temporal processing in clinical populations. Leiden, The Netherlands: Brill
36. Guehl, D., Burbaud, P., Lorenzi, C., Ramos, C., Bioulac, B., Semal, C., &Demany, L. (2008). Auditory temporal processing in Parkinson's disease. Neuropsychologia, 46, 2326-2335
37. Harrington, D. L., Castillo, G. N., Greenberg, P. A., Song, D. D., Lessig, S., Lee, R. R., &Rao, S. M. (2011). Neurobehavioural mechanisms of temporal processing deficits in Parkinson's disease. PLoS One, 6, e17461. doi:10.1371/journal.pone.0017461
38. Harrington,D. L.,Haaland, K. Y., Hermanowicz, N. (1998). Temporal processing in the basal ganglia. Neuropsychology, 12, 3-12
39. Hellström, A., Lang, H., Portin, R., &Rinne, J. (1997). Tone duration discrimination in Parkinson's disease. Neuropsychologia, 35, 737-740
40. Hinton, S. C., Harrington, D. L., Binder, J. R., Durgerian, S., &Rao, S. M. (2004). Neural systems supporting timing and chronometric counting: An fMRI study. Cognitive Brain Res., 21, 183-192
41. Hinton, S. C.,Meck,W.H. (2004). Frontal-striatal circuitry activated by human peak-interval timing in the supra-seconds range. Cognitive Brain Res., 21, 171-182
42. Hinton, S. C., &Rao, S. M. (2004). One-thousand one. one-thousand two.": Chronometric countring violates the scalar property in interval timing. Psychonom. Bull. Rev., 11, 24-30
43. Hoehn, M., &Yahr, M. (1967). Parkinsonism: Onset, progression and mortality. Neurology, 17, 427-442
44. Husárová, I., Lungu, O. V., Mareček, R., Mikl, M., Gescheidt, T., Krupa, P., &BareŜ, M. (2011). Functional imaging of the cerebellum and basal ganglia duringmotor predictive motor timing in early Parkinson's disease. J. Neuroimaging. doi:10.1111/j.1552-6569.2011.00663.x
45. Ivry, R. B. (1996). The representation of temporal information in perception andmotor control. Curr. Opin. Neurobiol., 6, 851-857
46. Ivry, R. B., &Keele, S.W. (1989). Timing functions of the cerebellum. J. Cognitive Neurosci., 1, 136-152
47. Jahanshahi, M., Jones, C. R. G., Dirnberger, G., &Frith, C. D. (2006). The substantia nigra pars compacta and temporal processing. J. Neurosci., 26, 12266-12273
48. Jahanshahi,M., Wilkinson, L.,Gahir,H., Dharminda, A., Lagnado,D. A. (2010a). Medication impairs probailistic classification learning in Parkinson's disease. Neuropsychologia, 48, 1096-1103
49. Jahanshahi, M., Jones, C. R. G., Zijlmans, J., Katzenschlager, R., Lee, L., Quinn,N., Frith, C. D., &Lees, A. J. (2010b). Dopaminergic modulation of striato-frontal connectivity during motor timing in Parkinson's disease. Brain, 133, 727-745
50. Jäncke, L., Specht, K., Mirzazade, S., Loose, R., Himmelbach, M., Lutz, K., &Shah, N. J. (1998). A parametric analysis of the 'rate effect' in the sensorimotor cortex: A functional magnetic resonance imaging analysis in human subjects. Neurosci. Lett., 252, 37-40
51. Jankovic, J.,McDermott,M., Carter, J., Gauthier,S., Goetz, C.,Golbe,L.,Huber,S., Koller,W., Olanow,C., Shoulson, I., Stern, M., Tanner, C.,Weiner, A., Parkinson Study Group (1990). Variable expression of Parkinson's disease: A base-line analysis of the DATATOP cohort. Neurology, 40, 1529-1534
52. Jones, C. R. G., Claassen, D. O., Minhong, Y., Spies, J. R., Malone, T., Dirnberger, G., Jahanshahi, M., &Kubovy, M. (2011). Modeling accuracy and variability of motor timing in treated and untreated Parkinson's disease and healthy controls. Frontiers Integrat. Neurosci., 5, 81. doi:10.3389/fnint.2011.00081
53. Jones, C. R. G., &Jahanshahi, M. (2009). The substantia nigra, the basal ganglia, dopamine and temporal processing. J. Neural Transm., 73, 161-171
54. Jones, C. R. G., &Jahanshahi,M. (2011). Dopamine modulates striato-frontal functioning during temporal processing. Frontiers Integrat. Neurosci., 5, 70. doi:10.3389/fnint.2011.00070
55. Jones, C. R. G., Malone, T. J., Dirnberger, G., Edwards, M., &Jahanshahi, M. (2008). Basal ganglia, dopamine and temporal processing: Performance on three timing tasks on and off medication in Parkinson's disease. Brain Cognition, 68, 30-41
56. Joundi, R. A.,Brittain, J. S.,Green, A. L.,Aziz, T. Z., &Jenkinson, N. (2012).High-frequency stimulation of the subthalamic nucleus selectively decreases central variance of rhythmic finger tapping in Parkinson's disease. Neuropsychologia, 50, 2460-2466
57. Keele, S.W., Pokorny, R. A., Corcos,D.M., Ivry, R. (1985). Do perception andmotor production share common timing mechanisms: A correctional analysis. Acta Psychol., 60, 173-191
58. Kehagia, A. A., Barker, R. A., Robbins, T.W. (2010). Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease. Lancet Neurol., 9, 1200-1213
59. Kessler, J., Markowitsch, H. J., Denzler, P. (2000). Mini-Mental-Status-Test (MMST). Göttingen: Beltz-Test GmbH
60. Koch, G., Brusa, L., Caltagirone, C., Oliveri, M., Peppe, A., Tiraboschi, P., &Stanzione, P. (2004). Subthalamic deep brain stimulation improves time perception in Parkinson's disease. NeuroReport, 15, 1071-1073
61. Koch, G., Brusa, L., Oliveri, M., Stanzione, P., &Caltagirone, C. (2005). Memory for time intervals is impaired in left hemi-Parkinson patients. Neuropsychologia, 43, 1163-1167
62. Koch, G., Costa,A., Brusa, L., Peppe, A.,Gatto, I., Torriero, S., Lo Gerfo, E., Salerno, S., Oliveri, M., Carlesimo, G. A., Caltagrione, C. (2008). Impaired reproduction of second but notmillisecond time intervals in Parkinson's disease. Neuropsychologia, 46, 1305-1313
63. Lake, J. I., &Meck, W. H. (2013). Differential effects of amphetamine and haloperidol on temporal reproduction: Dopaminergic regulation of attention and clock speed. Neuropsychologia, 51, 284-292
64. Lange, K. W., Tucha, O., Steup, A., Gsell, W., &Naumann, M. (1995). Subjective time estimation in Parkinson's disease. J. Neural Transm. Suppl., 46, 433-438
65. Lee, M. S., Kim, H. S., &Lyoo, C. H. (2005). "Off" gait freezing and temporal discrimination threshold in patients with Parkinson disease. Neurology, 64, 670-674
66. Lewis, S. J., Cools, R., Robbins, T. W., Dove, A., Barker, R. A., &Owen, A.M. (2003). Using executive heterogeneity to explore the nature of working memory deficits in Parkinson's disease. Neuropsychologia, 41, 645-654
67. Lewis, S. J., Foltynie, T., Blackwell, A. D., Robbins, T. W., Owen, A. M., &Barker, R. A. (2005). Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach. J. Neurol. Neurosurg. Psychiat., 76, 343-348
68. Lewis, P. A., &Miall, R. C. (2003). Distinct systems for automatic and cognitively controlled time measurement: Evidence from neuroimaging. Curr. Opin. Neurobiol., 13, 250-255
69. Logigian, E.,Hefter, H., Reiners, K., Freund, H. J. (1991). Does tremor pace repetitive voluntarymotor behavior in Parkinson's disease? Ann. Neurol., 30, 172-179
70. Lustig, C., Matell, M. S., &Meck, W. H. (2005). Not "just" a coincidence: Frontal-striatal interactions in working memory and interval timing. Memory, 13, 441-448
71. Lustig, C., &Meck, W. H. (2005). Chronic treatment with haloperidol induces working memory deficits in feedback effects of interval timing. Brain Cognition, 58, 9-16
72. Lyoo, C.H., Ryu, Y. H., Lee, M. J., Lee, M. S. (2012). Striatal dopamine loss and discriminative sensory dysfunction in Parkinson's disease. Acta Neurol. Scand., 126, 344-349
73. MacDonald, C. J., &Meck,W. H. (2005). Differential effects of clozapine and haloperidol on interval timing in the supraseconds range. Psychopharmacology (Berl.), 182, 232-244
74. MacDonald, A. A.,Monchi, O., Seergobin, K. N., Ganjavi, H., Tamjeedi, R., &MacDonald, P. A. (2013). Parkinson's disease duration determines effect of dopaminergic therapy on ventral striatum function. Movement Disord., 28, 153-160
75. Madison, G. (2001). Variability in isochronous tapping: Higher order dependencies as a function of intertap interval. J. Exp. Psychol.-Human, 27, 411-422
76. Malapani, C., Deweer, B., &Gibbon, J. (2002). Separating storage from retrieval dysfunction of temporal memory in Parkinson's disease. J. Cognitive Neurosci., 14, 311-322
77. Malapani, C., Rakitin, B., Levy, R., Meck, W. H., Deweer, B., Dubois, B., &Gibbon, J. (1998). Coupled temporalmemories in Parkinson's disease:Adopamine-related dysfunction. J. CognitiveNeurosci., 10, 316-331
78. Matell, M. S., Bateson, M., &Meck, W. H. (2006). Single-trials analyses demonstrate that increases in clock speed contribute to the methamphetamine-induced horizontal shifts in peak-interval timing functions. Psychopharmacology (Berl.), 188, 201-212
79. Matell, M. S., King, G. R., &Meck, W. H. (2004). Differential adjustment of interval timing by the chronic administation of intermittent or continuous cocaine. Behav. Neurosci., 118, 150-156
80. Matell, M. S., &Meck, W. H. (2000). Neuropsychological mechanisms of interval timing behaviour. Bioessays, 22, 94-103
81. Matell, M. S., &Meck,W. H. (2004). Cortico-striatal circuits and interval timing: Coincidence detection of oscillatory processes. Cognitive Brain Res., 21, 139-170
82. Mattis, S. (1988). Dementia rating scale. Odessa F: Psychological Assessment Resources
83. McNab, F., Klingberg, T. (2008). Prefrontal cortex and basal ganglia control access toworking memory. Nat. Neurosci., 11, 103-107
84. Meck,W. H. (1983). Selective adjustment of the speed of internal clock and memory processes. J. Exp. Psychol.-Anim. Behav. Proc., 9, 171-201
85. Meck,W.H. (1986). Affinity for the dopamineD2 receptor predicts neuroleptic potency in decreasing the speed of an internal clock. Pharmacol. Biochem. Behav., 25, 1185-1189
86. Meck,W. H. (1996). Neuropharmacology of timing and time perception. Cognitive Brain Res., 3, 227-242
87. Meck, W. H. (2006). Neuroanatomical localization of an internal clock: A functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems. Brain Res., 1109, 93-107
88. Meck, W. H., &Benson, A. M. (2002). Dissecting the brain's internal clock: How frontal-striatal circuitry keeps time and shifts attention. Brain Cognition, 48, 195-211
89. Meck, W. H., Cheng, R. K., MacDonald, C. J., Gainetdinov, R. R., Caron, M. G., &Çevik,M. Ö. (2012). Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice. Neuropharmacology, 62, 1221-1229
90. Merchant, H., Harrington, D. L., &Meck,W. H. (2013). Neural basis of the perception and estimation of time. Annu. Rev. Neurosci., 36, 313-336
91. Merchant, H., Luciana, M., Hooper, C., Majestic, S., &Tuite, P. (2008). Interval timing and Parkinson's disease: Heterogeneity in temporal performance. Exp. Brain Res., 184, 233-248
92. Moreau, C., Ozsancak, C., Blatt, J. L., Derambure, P., Destee, A., &Defebvre, L. (2007). Oral festination in Parkinson's disease: Biomechanical analysis and correlation with festination and freezing of gait. Movement Disord., 22, 1503-1506
93. Nakamura, R., Nagasaki, H., &Narabayashi, H. (1978). Disturbances of rhythm formation in patients with Parkinson's disease. Part I.Characteristics of tapping response to the periodic signals. Percept. Motor Skill., 46, 63-75
94. Nambu, A., Tokuno, H., &Takada, M. (2002). Functional significance of the cortico-sybthalamopallidal 'hyperdirect' pathway. Neurosci. Res., 43, 111-117
95. O'Boyle, D. J., Freeman, J. S., &Cody, F.W. (1996). The accuracy and precision of timing of self-paced, repetitive movements in subjects with Parkinson's disease. Brain, 119, 51-70
96. Oliveira, F. T., McDonald, J. J., &Goodman, D. (2007). Performance monitoring in the anterior cingulate is not all error related: Expectancy deviation and the represntation of action-outcome associations. J. Cognitive Neurosci., 19, 1-11
97. Pastor, M. A., Artieda, J., Jahanshahi, M., &Obeso, J. A. (1992a). Time estimation and reproduction is abnormal in Parkinson's disease. Brain, 115, 211-225
98. Pastor,M. A., Jahanshahi,M., Artieda, J., &Obeso, J. A. (1992b). Performance of repetitive wristmovements in Parkinson's disease. Brain, 115, 875-891
99. Perbal, S., Deweer, B., Pillon, B., Vidailhet, M., Dubois, B., &Pouthas, V. (2005). Effects of internal clock andmemorydisorders on duration reproductions and duration productions in patientswith Parkinson's disease. Brain Cognition, 58, 35-48
100. Post, B., Speelman, J. D., de Haan, R. J., &CARPA-study group (2008). Clinical heterogeneity in newly diagnosed Parkinson's disease. J. Neurol., 255, 716-722
101. Rakitin, B. C., Gibbon, J., Penney, T. B., Malapani, C., Hinton, S. C., &Meck, W. H. (1998). Scalar expectancy theory and peak-interval timing in humans. J. Exp. Psychol.-Anim. Behav. Proc., 24, 15-33
102. Rakshi, J. S.,Uema, T., Ito, K., Bailey,D. L.,Morrish, P. K., Ashburner, J.,Dagher,A., Jenkins, I. H., Friston, K. J., &Brooks, D. J. (1999). Frontal, midbrain and striatal dopaminergic function in early and advanced Parkinson's disease: A 3D [18F]dopa-PET study. Brain, 122, 1637-1650
103. Rascol, O., Goetz, C., Koller,W., Poewe,W., &Sampaio, C. (2002). Treatment interventions for Parkinson's disease: An evidence based assessment. Lancet, 359, 1589-1598
104. Rammsayer, T., &Classen,W. (1997). Impaired temporal discrimination in Parkinson's disease: Temporal processing of brief durations as an indicator of degeneration of dopaminergic neurons in the basal ganglia. Intl J. Neurosci., 91, 45-55
105. Riesen, J. M., &Schnider, A. (2001). Time estimation in Parkinson's disease: Normal long duration estimation despite impaired short duration discrimination. J. Neurol., 248, 27-35
106. Rocchi, L., Conte, A., Nardella, A., Li Voti, P., Di Biasio, F., Leodori, G., Fabbrini, G., &Berardelli, A. (2013). Somatosensory temporal discrimination threshold may help to differentiate patients with multiple system atrophy from patients with Parkinson's disease. Eur. J. Neurol., 20, 714-719
107. Sadato, N., Ibanez, V., Campbell, G., Deiber, M.-P., Le Bihan, D., &Hallett, M. (1997). Frequencydependent changes of regional cerebral blood flow during finger movements: Functional MRI compared to PET. J. Cerebr. Blood F. Met., 17, 670-679
108. Santi, A., Miki, A., Hornyak, S., &Eidse, J. (2005). The perception of empty and filled time intervals by rats. Behav. Proc., 70, 247-263
109. Schrag, A., Quinn, N. P., &Ben-Shlomo, Y. (2006). Heterogeneity of Parkinson's disease. J. Neurol., Neurosurg. Psychiat., 77, 275-276
110. Shidara, M., Aigner, T. G., &Richmond, B. J. (1998). Neuronal signals in the monkey ventral striatum related to progress through a predictable series of trials. J. Neurosci., 18, 2613-2625
111. Smith, J. G., Harper, D. N., Gittings, D., &Abernethy, D. (2007). The effect of Parkinson's disease on time estimation as a function of stimulus duration range and modality. Brain Cognition, 64, 130-143
112. Spencer, R. M., &Ivry, R. B. (2005). Comparison of patients with Parkinson's disease or cerebellar lesions in the production of periodicmovements involving event-based or emergent timing. Brain Cognition, 58, 84-93
113. Stegemöller, E. L., Simuni, T., &MacKinnon, C. (2009). Effect of movement frequency on repetitive finger movements in patients with Parkinson's disease. Movement Disord., 24, 1162-1169
114. Summers, J. J., &Anson, J. G. (2009). Current status of the motor program: Revisited. Hum. Movement Sci., 28, 566-577
115. Toma, K.,Mima, T., Matsuoka, T., Gerloff, C., Ohnishi, T., Koshy, B., Andres, F., &Hallett, M. (2002). Movement rate effect on activation and functional coupling ofmotor cortical areas. J. Neurophysiol., 88, 3377-3385
116. Torta, D. M., Castelli, L., Latini-Corazzini, L., Banche, A., Lopiano, L., &Geminiani, G. (2010). Dissociation between time reproduction of actions and of intervals in patients with Parkinson's disease. J. Neurol., 257, 3377-3385
117. Van Rooden, S.M., Colas, F.,Martínez-Martín, P., Visser, M., Verbaan, D., Marinus, J., Chaudhuri, R. K., Kok, J. N., &van Hilten, J. J. (2011). Clinical subtypes of Parkinson's disease. Movement Disord., 26, 51-58
118. Wearden, J. H., Todd, N. P., &Jones, L. A. (2006). When do auditory/visual differences in duration judgements occur? Q. J. Exp. Psychol., 59, 1709-1724
119. Wearden, J. H., Norton, R., Martin, S., &Montford-Bebb, O. (2007). Internal clock processes and the filled-duration illusion. J. Exp. Psychol.-Human, 33, 716-729
120. Wearden, J. H., Smith-Spark, J. H., Cousins, R., Edelstyn, N. M., Cody, F. W., &O'Boyle, D. J. (2008). Stimulus timing by people with Parkinson's disease. Brain Cognition, 67, 264-279
121. Webster, D. D. (1968). Critical analysis of the disability in Parkinson's disease. Mod. Treat., 5, 257-282
122. Wiener, M., Lohoff, F.W., &Coslett, H. B. (2011). Double dissociation of dopamine genes and timing in humans. J. Cognitive Neurosci., 23, 2811-2821
123. Wild-Wall, N.,Willemssen, R., Falkenstein,M., &Beste, C. (2008). Time estimation in healthy ageing and neurodegenerative basal ganglia disorders. Neuroscience Lett., 442, 34-38
124. Wing, A.M., &Kristofferson, A. B. (1973a). Timing of interresponse intervals. Percept. Psychophys., 13, 455-460
125. Wing, A. M., &Kristofferson, A. B. (1973b). Response delays and timing of discrete motor responses. Percept. Psychophys., 14, 5-12
126. Wojtecki, L., Elben, S., Timmermann, L., Reck, C., Maarouf, M., Jorgens, S., Ploner, M., Südmeyer, M., Groiss, S. J., Sturm,V.,Niedeggen,M., Schnitzler, A. (2011). Modulation ofhumantime processing by subthalamic deep brain stimulation. PLoS One, 6, 12
127. Yahalom,G., Simon, E. S., Thorne,R., Peretz,C., Giladi,N. (2004). Handrhythmic tapping and timing in Parkinson's disease. Parkinsonism Relat. D., 10, 143-148
128. Yu, H., Sternad, D., Corcos, D. M., &Vaillancourt, D. E. (2007). Role of hyperactive cerebellum and motor cortex in Parkinson's disease. NeuroImage, 35, 222-233
129. Zélanti, P. S., &Droit-Volet, S. (2012). Auditory and visual differences in time perception? An investigation from a developmental perspective with neuropsychological tests. J. Exp. Child Psychol., 112, 296-311