Inverted-U-shaped dopamine actions on human working memory and cognitive control

Biological Psychiatry

Volumn 69, Issue 12, 2011, Pages

  Cools, Roshan ^a,b   D'Esposito, Mark ^c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cognitive control; dopamine (DA); functional magnetic resonance imaging (fMRI); prefrontal cortex; striatum; working memory

Indexed keywords

BROMOCRIPTINE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; PERGOLIDE;

BEHAVIOR; BRAIN; COGNITION; CORPUS STRIATUM; EXECUTIVE FUNCTION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; NERVE CELL; NONHUMAN; PARKINSON DISEASE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SINGLE DRUG DOSE; WORKING MEMORY;

ANIMALS; COGNITION; CORPUS STRIATUM; DOPAMINE; DOPAMINE AGENTS; HUMANS; INDIVIDUALITY; MEMORY, SHORT-TERM; MODELS, BIOLOGICAL; PREFRONTAL CORTEX; PSYCHOMOTOR PERFORMANCE;

EID: 79958138448     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.03.028     Document Type: Review

References (167)

1. J. Cohen, T. Braver, and J. Brown Computational perspectives in dopamine function in prefrontal cortex Curr Opin Neurobiol 12 2002 223 229 (Pubitemid 34518344)
2. R. Bilder, K. Volavka, H. Lachman, and A. Grace The catechol-O- methyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes Neuropsychopharmacology 29 2004 1943 1961 (Pubitemid 39486546)
3. M. D'Esposito From cognitive to neural models of working memory Philos Trans R Soc Lond B Biol Sci 362 2007 761 772 (Pubitemid 47056808)
4. J. Fuster The Prefrontal Cortex 1989 Raven New York
5. E. Miller, and J. Cohen An integrative theory of prefrontal cortex function Annu Rev Neurosci 24 2001 167 202 (Pubitemid 32695227)
6. L. Chao, and R. Knight Human prefrontal lesions increase distractibility to irrelevant sensory inputs Neuroreport 6 1995 1605 1610
7. T. Shallice From Neuropsychology to Mental Structure 1988 Cambridge University Press Cambridge, England
8. Goldman-Rakic Cellular and circuit basis of working memory in prefrontal cortex of nonhuman primates H.B.M. Uylings, C.G.V. Eden, J.P.C. DeBruin, M.A. Corner, M.G.P. Feenstra, Progress in Brain Research 1990 Elsevier Science Publishers Amsterdam 325 336
9. P. Goldman-Rakic Dopamine-mediated mechanisms of the prefrontal cortex Semin Neurosci 4 1992 109 118
10. P. Goldman-Rakic Cellular basis of working memory Neuron 14 1995 477 485
11. T.W. Robbins Chemical neuromodulation of frontal-executive functions in humans and other animals Exp Brain Res 133 2000 130 138 (Pubitemid 30411664)
12. A.F.T. Arnsten Catecholamine modulation of prefrontal cortical cognitive function Trends Cogn Sci 2 1998 436 446
13. R. Cools, and T.W. Robbins Chemistry of the adaptive mind Philos Transact A Math Phys Eng Sci 362 2004 2871 2888 (Pubitemid 40004422)
14. R. Cools, and M. D'Esposito Dopaminergic modulation of flexible control in humans A. Bjorklund, S.B. Dunnett, L.L. Iversen, S.D. Iversen, Dopamine Handbook 2009 Oxford University Press Oxford
15. S.B. Floresco, and O. Magyar Mesocortical dopamine modulation of executive functions: Beyond working memory Psychopharmacology (Berl) 188 2006 567 585 (Pubitemid 46758962)
16. M.J. Bannon, and R.H. Roth Pharmacology of mesocortical dopamine neurons Pharmacol Rev 35 1983 53 68 (Pubitemid 13001289)
17. D. Shohamy, and R.A. Adcock Dopamine and adaptive memory Trends Cogn Sci 14 2010 464 472
18. R.M. Brown, A.M. Crane, and P.S. Goldman Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: Concentrations and in vitro synthesis rates Brain Res 168 1979 133 150 (Pubitemid 9164942)
19. T.J. Brozoski, R. Brown, H.E. Rosvold, and P.S. Goldman Cognitive deficit caused by regional depletion of dopamine in the prefrontal cortex of rhesus monkeys Science 205 1979 929 931
20. A.F. Arnsten, J.X. Cai, B.L. Murphy, and P.S. Goldman-Rakic Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys Psychopharmacology (Berl) 116 1994 143 151 (Pubitemid 24317040)
21. P. Collins, A.C. Roberts, R. Dias, B.J. Everitt, and T.W. Robbins Perseveration and strategy in a novel spatial self-ordered sequencing task for nonhuman primates: Effects of excitotoxic lesions and dopamine depletions of the prefrontal cortex J Cogn Neurosci 10 1998 332 354 (Pubitemid 28247946)
22. T. Sawaguchi, and P.S. Goldman-Rakic D1 dopamine receptors in prefrontal cortex: Involvement in working memory Science 251 1991 947 950 (Pubitemid 21926192)
23. T. Sawaguchi, M. Matsumura, and K. Kubota Effects of dopamine antagonists on neuronal activity related to a delayed response task in monkey prefrontal cortex J Neurophysiol 63 1990 1401 1412 (Pubitemid 20217476)
24. M. Luciana, R.A. Depue, P. Arbisi, and A. Leon Facilitation of working memory in humans by a D2 dopamine receptor agonist J Cogn Neurosci 4 1992 58 68
25. H. Simon Dopaminergic A10 neurons and the frontal system J Physiol 77 1981 81 95 (Pubitemid 11104025)
26. R. Elliott, B.J. Sahakian, K. Matthews, A. Bannerjea, J. Rimmer, and T.W. Robbins Effects of methylphenidate on spatial working memory and planning in healthy young adults Psychopharmacology 131 1997 196 206 (Pubitemid 27261609)
27. R.D. Rogers, A.J. Blackshaw, H.C. Middleton, K. Matthews, K. Hawtin, and C. Crowley Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: Implications for the monoaminergic basis of impulsive behaviour Psychopharmacology 146 1999 482 491 (Pubitemid 29513289)
28. Y. Chudasama, and T.W. Robbins Functions of frontostriatal systems in cognition: Comparative neuropsychopharmacological studies in rats, monkeys and humans Biol Psychol 73 2006 19 38 (Pubitemid 43732470)
29. D.Y. Kimberg, M. D'Esposito, and M.J. Farah Effects of bromocriptine on human subjects depend on working memory capacity Neuroreport 8 1997 3581 3585 (Pubitemid 27497487)
30. M. Luciana, and P. Collins Dopaminergic modulation of working memory for spatial but not object cues in normal volunteers J Cogn Neurosci 9 1997 330 347 (Pubitemid 27273526)
31. M.A. Mehta, R. Swainson, A.D. Ogilvie, B.J. Sahakian, and T.W. Robbins Improved short-term spatial memory but impaired reversal learning following the dopamine D2 agonist bromocriptine in human volunteers Psychopharmacology 159 2001 10 20 (Pubitemid 34031245)
32. D.Y. Kimberg, and M. D'Esposito Cognitive effects of the dopamine receptor agonist pergolide Neuropsychologia 41 2003 1020 1027 (Pubitemid 36349393)
33. U. Muller, D.Y. von Cramon, and S. Pollman D1- versus D2-receptor modulation of visuospatial working memory in humans J Neurosci 18 1998 2720 2728 (Pubitemid 28141817)
34. M.A. Mehta, B.J. Sahakian, P.J. McKenna, and T.W. Robbins Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson's disease Psychopharmacology (Berl) 146 1999 162 174 (Pubitemid 29474208)
35. M.A. Mehta, F.F. Manes, G. Magnolfi, B.J. Sahakian, and T.W. Robbins Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers Psychopharmacology (Berl) 176 2004 331 342 (Pubitemid 40012740)
36. M.J. Frank, L.C. Seeberger, and R.C. O'Reilly By carrot or by stick: Cognitive reinforcement learning in parkinsonism Science 306 2004 1940 1943 (Pubitemid 39627859)
37. R. Cools, R.A. Barker, B.J. Sahakian, and T.W. Robbins Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands Cereb Cortex 11 2001 1136 1143 (Pubitemid 33108240)
38. S.E. Gibbs, and M. D'Esposito Individual capacity differences predict working memory performance and prefrontal activity following dopamine receptor stimulation Cogn Affect Behav Neurosci 5 2005 212 221 (Pubitemid 44252016)
39. V.S. Mattay, J.H. Callicot, A. Bertolino, I. Heaton, J.A. Frank, and R. Coppola Effects of dextroamphetamine on cognitive performance and cortical activation Neuroimage 12 2000 268 275
40. M. Mehta, P. Calloway, and B. Sahakian Amelioration of specific working memory deficits by methylphenidate in a case of adult attention deficit/hyperactivity disorder J Psychopharm 14 2000 299 302
41. D. Kimberg, G. Aguirre, J. Lease, and M. D'Esposito Cortical effects of bromocriptine, a D-2 dopamine receptor agonist, in human subjects, revealed by fMRI Hum Brain Mapp 12 2001 246 257 (Pubitemid 32238561)
42. M. Daneman, and P. Carpenter Individual differences in working memory and reading J Verbal Learning Verbal Behav 19 1980 450 466
43. T. Salthouse, and R. Babcock Decomposing adult age differences in working memory Dev Psychol 27 1991 762 766
44. M.J. Frank, and R.C. O'Reilly A mechanistic account of striatal dopamine function in human cognition: Psychopharmacological studies with cabergoline and haloperidol Behav Neurosci 120 2006 497 517 (Pubitemid 44050530)
45. R. Cools, M. Sheridan, E. Jacobs, and M. D'Esposito Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory J Neurosci 27 2007 5506 5514 (Pubitemid 46790174)
46. J. Wilder Paradoxic reactions to treatment N Y State J Med 57 1957 3348 3352
47. P. Dews Rate-dependency hypothesis Science 198 1977 1182 1183
48. P.B. Dews Studies on behavior IV. Stimulant actions of methamphetamine J Pharmacol Exp Ther 122 1958 137
49. S. Granon, F. Passetti, K.L. Thomas, J.W. Dalley, B.J. Everitt, and T. Robbins Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex J Neurosci 20 2000 1208 1215 (Pubitemid 30220477)
50. S. Floresco, and A. Phillips Delay-dependent modulation of memory retrieval by infusion of a dopamine D1 agonist into the rat medial prefrontal cortex Behav Neurosci 115 2001 934 939 (Pubitemid 32738339)
51. M.S. Lidow, P.O. Koh, and A.F. Arnsten D1 dopamine receptors in the mouse prefrontal cortex: Immunocytochemical and cognitive neuropharmacological analyses Synapse 47 2003 101 108 (Pubitemid 36020281)
52. A.F. Arnsten, and P.S. Goldman-Rakic Noise stress impairs prefrontal cortical cognitive function in monkeys Arch Gen Psychiatry 55 1998 362 368
53. J. Zahrt, J.R. Taylor, R.G. Mathew, and A.F.T. Arnsten Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance J Neurosci 17 1997 8528 8535 (Pubitemid 27461074)
54. J.X. Cai, and A.F. Arnsten Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys J Pharmacol Exp Ther 282 1997 1 7
55. T. Sawaguchi, M. Matsumura, and K. Kubota Dopamine enhances the neuronal activity of spatial short-term memory task in the primate prefrontal cortex Neurosci Res 5 1988 465 473
56. A. Phillips, S. Ahn, and S. Floresco Magnitude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response task J Neurosci 14 2004 547 553 (Pubitemid 38112388)
57. Y. Chudasama, and T.W. Robbins Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex Neuropsychopharmacology 29 2004 1628 1636 (Pubitemid 39150104)
58. J.K. Seamans, S.B. Floresco, and A.G. Phillips D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat J Neurosci 18 1998 1613 1621 (Pubitemid 28082442)
59. B.L. Murphy, A.F.T. Arnsten, P.S. Goldman-Rakic, and R.H. Roth Increasing dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys Proc Natl Acad Sci U S A 93 1996 1325 1329 (Pubitemid 26052888)
60. J.K. Seamans, and C.R. Yang The principal features and mechanisms of dopamine modulation in the prefrontal cortex Prog Neurobiol 74 2004 1 58
61. G.V. Williams, and P.S. Goldman-Rakic Modulation of memory fields by dopamine D1 receptors in prefrontal cortex Nature 376 1995 572 575
62. J. Seamans, D. Durstewitz, B. Christie, C. Stevens, and T. Sejnowski Dopamine D1/D5 receptor modulation of excitatory synaptic input to layer V prefrontal cortex neurons Proc Natl Acad Sci U S A 98 2001 301 306 (Pubitemid 32095904)
63. C.R. Yang, and J.K. Seamans Dopamine D1 receptor actions in layers VVI rat prefrontal cortex neurons in vitro: Modulation of dendritic-somatic signal integration J Neurosci 16 1996 1922 1935 (Pubitemid 26145968)
64. J. Seamans, N. Gorelova, D. Durstewitz, and C. Yang Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons J Neurosci 21 2001 3628 3638 (Pubitemid 32422827)
65. D. Servan-Schreiber, H. Printz, and J. Cohen A network model of catecholamine effects: Gain, signal-to-noise ratio, and behavior Science 249 1990 892 895
66. S. Kroener, L.J. Chandler, P.E. Phillips, and J.K. Seamans Dopamine modulates persistent synaptic activity and enhances the signal-to-noise ratio in the prefrontal cortex PLoS One 4 2009 e6507
67. D. Durstewitz, and J. Seamans The dual-state theory of prefrontal cortex dopamine function with relevance to catechol-o-methyltransferase genotypes and schizophrenia Biol Psychiatry 64 2008 739 749
68. S. Vijayraghavan, M. Wang, S. Birnbaum, G. Williams, and A. Arnsten Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory Nat Neurosci 10 2007 176 184
69. R. Cools, E. Stefanova, R.A. Barker, T.W. Robbins, and A.M. Owen Dopaminergic modulation of high-level cognition in Parkinson's disease: The role of the prefrontal cortex revealed by PET Brain 125 2002 584 594 (Pubitemid 34194413)
70. V.S. Mattay, A. Tessitore, J.H. Callicott, A. Bertonlino, T.E. Goldberg, and T.N. Chase Dopaminergic modulation of cortical function in patients with Parkinson's disease Ann Neurol 58 2002 630 635
71. V. Mattay, T. Goldberg, F. Fera, A. Hariri, A. Tessitore, and M. Egan Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine Proc Natl Acad Sci U S A 100 2003 6186 6191 (Pubitemid 36576952)
72. M.J. Frank, and J.A. Fossella Neurogenetics and pharmacology of learning, motivation, and cognition Neuropsychopharmacology 36 2011 133 152
73. M. Slifstein, B. Kolachana, E.H. Simpson, P. Tabares, B. Cheng, and M. Duvall COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET Mol Psychiatry 13 2008 821 827 (Pubitemid 352032110)
74. J.A. Gogos, M. Morgan, V. Luine, M. Santha, S. Ogawa, and D. Pfaff Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior Proc Natl Acad Sci U S A 95 1998 9991 9996 (Pubitemid 28415282)
75. E. Tunbridge, D. Bannerman, T. Sharp, and P. Harrison Catechol-O-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex J Neurosci 24 2004 5331 5335 (Pubitemid 38747674)
76. M.F. Egan, T.E. Goldberg, B.S. Kolachana, J.H. Callicott, C.M. Mazzanti, and R.E. Straub Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia Proc Natl Acad Sci U S A 98 2001 6917 6922 (Pubitemid 32538317)
77. A. Diamond, L. Briand, J. Fossella, and L. Gehlbach Genetic and neurochemical modulation of prefrontal cognitive functions in children Arch Gen Psychiatry 161 2004 125 132 (Pubitemid 38419317)
78. A. Meyer-Lindenberg, P.D. Kohn, B. Kolachana, S. Kippenhan, A. McInerney-Leo, and R. Nussbaum Midbrain dopamine and prefrontal function in humans: Interaction and modulation by COMT genotype Nat Neurosci 8 2005 594 596 (Pubitemid 40594200)
79. B. Milner Effects of different brain lesions on card sorting: The role of the frontal lobes Arch Neurol 9 1963 90 100
80. J. Barnett, P. Jones, T. Robbins, and U. Muller Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: A meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls Mol Psychiatry 12 2007 502 509 (Pubitemid 46656086)
81. M. Ullsperger Genetic association studies of performance monitoring and learning from feedback: The role of dopamine and serotonin Neurosci Biobehav Rev 34 2010 649 659
82. M.J. Frank, A.A. Moustafa, H.M. Haughey, T. Curran, and K.E. Hutchison Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning Proc Natl Acad Sci U S A 104 2007 16311 16316 (Pubitemid 350099356)
83. M.J. Frank, B.B. Doll, J. Oas-Terpstra, and F. Moreno Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation Nat Neurosci 12 2009 1062 1068
84. D. Mier, P. Kirsch, and A. Meyer-Lindenberg Neural substrates of pleiotropic action of genetic variation in COMT: A meta-analysis Mol Psychiatry 15 2010 918 927
85. J.A. Apud, V. Mattay, J. Chen, B.S. Kolachana, J.H. Callicott, and R. Rasetti Tolcapone improves cognition and cortical information processing in normal human subjects Neuropsychopharmacology 32 2007 1011 1020 (Pubitemid 46631983)
86. P. Roussos, S.G. Giakoumaki, and P. Bitsios Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O- methyltransferase rs4818c/g polymorphism Biol Psychiatry 66 2009 997 1004
87. M.X. Cohen, A. Krohn-Grimberghe, C.E. Elger, and B. Weber Dopamine gene predicts the brain's response to dopaminergic drug Eur J Neurosci 26 2007 3652 3660 (Pubitemid 350243518)
88. T. Pohjalainen, J.O. Rinne, K. Nagren, P. Lehikoinen, K. Anttila, and E.K. Syvalahti The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers Mol Psychiatry 3 1998 256 260 (Pubitemid 28266335)
89. Y. Zhang, A. Bertolino, L. Fazio, G. Blasi, A. Rampino, and R. Romano Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory Proc Natl Acad Sci U S A 104 2007 20552 20557
90. R. Cools, S. Gibbs, A. Miyakawa, W. Jagust, and M. D'Esposito Working memory capacity predicts dopamine synthesis capacity in the human striatum J Neurosci 28 2008 1208 1212 (Pubitemid 351186336)
91. S.M. Landau, R. Lal, J.P. O'Neil, S. Baker, and W.J. Jagust Striatal dopamine and working memory Cereb Cortex 19 2009 445 454
92. R. Cools, M. Frank, S. Gibbs, A. Miyakawa, W. Jagust, and M. D'Esposito Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration J Neurosci 29 2009 1538 1543
93. G. Alexander, M. DeLong, and P. Strick Parallel organization of functionally segregated circuits linking basal ganglia and cortex Annu Rev Neurosci 9 1986 357 381 (Pubitemid 16055790)
94. D.L. Wallace, J.J. Vytlacil, E.M. Nomura, S.E. Gibbs, and M. D'Esposito The dopamine agonist bromocriptine differentially affects fronto-striatal functional connectivity during working memory Front Hum Neurosci 5 2011 32
95. M.S. Lidow, P.S. Goldman-Rakic, D.W. Gallager, and P. Rakic Distribution of dopaminergic receptors in the primate cerebral cortex: Quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390 Neuroscience 40 1991 657 671
96. M. Camps, R. Cortes, B. Gueye, A. Probst, and J. Palacios Dopamine receptors in human brain: Autoradiographic distribution of D2 sites Neuroscience 28 1989 275
97. P. Goldman-Rakic, M. Lidow, J. Smiley, and M. Williams The anatomy of dopamine in monkey and human prefrontal cortex J Neural Transm Suppl 36 1992 163 177
98. G. Sedvall, L. Farde, and F.A. Wiesel Quantitative determination of D2 dopamine receptor characteristics in healthy human subjects and psychiatric patients Life Sci 41 1987 813 816 (Pubitemid 17102884)
99. A.C. Roberts, M.A. De Salvia, L.S. Wilkinson, P. Collins, J.L. Muir, and B.J. Everitt 6-hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: Possible interactions with subcortical dopamine J Neurosci 14 1994 2531 2544 (Pubitemid 24140883)
100. H.S. Crofts, J.W. Dalley, J.C.M. Van Denderen, B.J. Everitt, T.W. Robbins, and A.C. Roberts Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set Cereb Cortex 11 2001 1015 1026 (Pubitemid 33021232)
101. T.S. Braver, and J.D. Cohen On the control of control: The role of dopamine in regulating prefrontal function and working memory S. Monsell, J. Driver, Control of Cognitive Processes Attention and Performance vol XVIII 2000 MIT Press Cambridge, Massachusetts 713 737
102. M.J. Frank, B. Loughry, and R.C. O'Reilly Interactions between frontal cortex and basal ganglia in working memory: A computational model Cogn Affect Behav Neurosci 1 2001 137 160 (Pubitemid 38392490)
103. S. Lewis, A. Dove, T. Robbins, R. Barker, and A. Owen Striatal contributions to working memory: A functional magnetic resonance imaging study in humans Eur J Neurosci 19 2004 755 760 (Pubitemid 38241314)
104. A. Leber, N. Turk-Browne, and M. Chun Neural predictors of moment-to-moment fluctuations in cognitive flexibility Proc Natl Acad Sci U S A 105 2008 13592 13597
105. F. McNab, and T. Klingberg Prefrontal cortex and basal ganglia control access to working memory Nat Neurosci 11 2008 103 107
106. R. Cools, L. Clark, and T.W. Robbins Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance J Neurosci 24 2004 1129 1135 (Pubitemid 38177020)
107. M. Wang, S. Vijayraghavan, and P.S. Goldman-Rakic Selective D2 receptor actions on the functional circuitry of working memory Science 303 2004 853 856 (Pubitemid 38174667)
108. D. Durstewitz, J. Seamans, and T. Sejnowski Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex J Neurophysiol 83 2000 1733 1750 (Pubitemid 30159594)
109. T.E. Hazy, M.J. Frank, and R.C. O'Reilly Banishing the homunculus: Making working memory work Neuroscience 139 2006 105 118
110. C.M. Dodds, L. Clark, A. Dove, R. Regenthal, F. Baumann, and E. Bullmore The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memory Psychopharmacology (Berl) 207 2009 35 45
111. E. Dahlin, A.S. Neely, A. Larsson, L. Backman, and L. Nyberg Transfer of learning after updating training mediated by the striatum Science 320 2008 1510 1512 (Pubitemid 351929433)
112. P. Marklund, A. Larsson, E. Elgh, J. Linder, K.A. Riklund, and L. Forsgren Temporal dynamics of basal ganglia under-recruitment in Parkinson's disease: Transient caudate abnormalities during updating of working memory Brain 132 2009 336 346
113. P. Collins, L.S. Wilkinson, B.J. Everitt, T.W. Robbins, and A.C. Roberts The effect of dopamine depletion from the caudate nucleus of the common marmoset (Callithrix jacchus) on tests of prefrontal cognitive function Behav Neurosci 114 2000 3 17 (Pubitemid 30131582)
114. M.R. van Schouwenburg, H.E. den Ouden, and R. Cools The human basal ganglia modulate frontal-posterior connectivity during attention shifting J Neurosci 30 2010 9910 9918
115. C. Kellendonk, E. Simpson, H. Polan, G. Malleret, S. Vronskaya, and V. Winiger Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning Neuron 49 2006 603 615 (Pubitemid 43221894)
116. D.M. Haluk, and S.B. Floresco Ventral striatal dopamine modulation of different forms of behavioral flexibility Neuropsychopharmacology 34 2009 2041 2052
117. C.M. Dodds, U. Muller, L. Clark, A. van Loon, R. Cools, and T.W. Robbins Methylphenidate has differential effects on blood oxygenation level-dependent signal related to cognitive subprocesses of reversal learning J Neurosci 28 2008 5976 5982
118. P.L. Clatworthy, S.J. Lewis, L. Brichard, Y.T. Hong, D. Izquierdo, and L. Clark Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory J Neurosci 29 2009 4690 4696
119. R. Cools, S. Lewis, L. Clark, R. Barker, and T.W. Robbins L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease Neuropsychopharmacology 32 2007 180 189 (Pubitemid 44967796)
120. C.J. Pycock, R.W. Kerwin, and C.J. Carter Effect of lesion of cortical dopamine terminals on sub-cortical dopamine-receptors in rats Nature 286 1980 74 77 (Pubitemid 10061071)
121. A.F. Arnsten Stress signalling pathways that impair prefrontal cortex structure and function Nat Rev Neurosci 10 2009 410 422
122. M.J. Frank Dynamic dopamine modulation in the basal ganglia: A neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism J Cogn Neurosci 17 2005 51 72
123. M. Akil, B.S. Kolachana, D.A. Rothmond, T.M. Hyde, D.R. Weinberger, and J.E. Kleinman Catechol-O-methyltransferase genotype and dopamine regulation in the human brain J Neurosci 23 2003 2008 2013 (Pubitemid 36368887)
124. M. Mehta, S. McGowan, A. Lawrence, M. Aitken, A. Montgomery, and P. Grasby Systemic sulpiride modulates striatal blood flow: Relationships to spatial working memory and planning Neuroimage 20 2003 1982 1994 (Pubitemid 37543616)
125. S. Floresco, O. Magyar, S. Ghods-Sharifi, C. Vexelman, and M. Tse Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting Neuropsychopharmacology 31 2006 297 309 (Pubitemid 43113395)
126. M. Camps, R. Corts, B. Gueye, A. Probst, and J.M. Palacios Dopamine receptors in human brain: Autoradiographic distribution of D1 sites Neuroscience 28 1989 275 290 (Pubitemid 19053074)
127. M. Camps, P. Kelly, and J. Palacios Autoradiographic localization of dopamine D1 and D2 receptors in the brain of several mammalian species J Neural Transm Gen Sect 80 1990 105 127 (Pubitemid 20056747)
128. K. Nolan, R. Bilder, H. Lachman, and K. Volavka Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: Differential effects of Val and Met alleles on cognitive stability and flexibility Am J Psychiatry 161 2004 359 361 (Pubitemid 38419288)
129. L.K. Krugel, G. Biele, P.N. Mohr, S.C. Li, and H.R. Heekeren Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions Proc Natl Acad Sci U S A 106 2009 17951 17956
130. L.S. Colzato, F. Waszak, S. Nieuwenhuis, D. Posthuma, and B. Hommel The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: Evidence for a role of dopamine in the control of task-switching Neuropsychologia 48 2010 2764 2768
131. S.E. Gibbs, and M. D'Esposito A functional magnetic resonance imaging study of the effects of pergolide, a dopamine receptor agonist, on component processes of working memory Neuroscience 139 2006 359 371
132. R. Cools Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease Neurosci Biobehav Rev 30 2006 1 23 (Pubitemid 41779404)
133. K.W. Lange, T.W. Robbins, C.D. Marsden, M. James, A.M. Owen, and G.M. Paul L-Dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction Psychopharmacology 107 1992 394 404
134. A.M. Owen, M. James, J.M. Leigh, B.A. Summers, C.D. Marsden, and N.P. Quinn Fronto-striatal cognitive deficits at different stages of Parkinson's disease Brain 115 1992 1727 1751 (Pubitemid 23054862)
135. A.M. Owen, B.J. Sahakian, J.R. Hodges, B.A. Summers, C.E. Polkey, and T.W. Robbins Dopamine-dependent frontostriatal planning deficits in early Parkinson's disease Neuropsychology 9 1995 126 140
136. R. Cools, R.A. Barker, B.J. Sahakian, and T.W. Robbins Mechanisms of cognitive set flexibility in Parkinson's disease Brain 124 2001 2503 2512 (Pubitemid 33134938)
137. R. Cools, R.A. Barker, B.J. Sahakian, and T.W. Robbins L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease Neuropsychologia 41 2003 1431 1441 (Pubitemid 36808816)
138. A.M. Gotham, R.G. Brown, and C.D. Marsden 'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa Brain 111 1988 299 321
139. J.A. Cooper, H.J. Sagar, M. Doherty, N. Jordan, P. Tidswell, and E.V. Sullivan Different effects of dopaminergic and anticholingergic therapies on cognitive and motor function in Parkinson's disease Brain 115 1992 1701 1725 (Pubitemid 23054861)
140. N. Fournet, O. Moreaud, J.L. Roulin, B. Naegele, and J. Pellat Working memory in medicated patients with Parkinson's disease: The central executive seems to work J Neurol Neurosurg Psychiatry 60 1996 313 317 (Pubitemid 26081145)
141. B.J. Sahakian, R.G. Morris, J.L. Evenden, A. Heald, R. Levy, M. Philpot, and T.W. Robbins A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease Brain 111 1988 695 718
142. R. Brown, and C. Marsden 'Subcortical dementia': The neuropsychological evidence Neurosci 25 1988 363 387
143. B. Dubois, B. Pillon, C. Malapani, B. Deweer, M. Verin, and A. Partiaud Subcortical dementia and Parkinson's disease: What are the cognitive functions of the basal ganglia? F. Boller, J. Grafman, Handbook of Neuropsychology 1995 Elsevier New York 195 240
144. A.M. Owen, A.C. Roberts, J.R. Hodges, B.A. Summers, C.E. Polkey, and T.W. Robbins Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson's disease Brain 116 1993 1159 1179
145. R. Cools, A. Miyakawa, M. Sheridan, and M. D'Esposito Enhanced frontal function in Parkinson's disease Brain 133 2010 225 233
146. A.M. Owen, J. Doyon, A. Dagher, A. Sadikot, and A.C. Evans Abnormal basal ganglia outflow in Parkinson's disease identified with PET Implications for higher cortical functions Brain 121 1998 949 965 (Pubitemid 28220900)
147. S. Lewis, A. Dove, T. Robbins, R. Barker, and A. Owen Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry J Neurosci 23 2003 6351 6356 (Pubitemid 36875637)
148. I. Monchi, M. Petrides, J. Doyon, R. Postuma, K. Worsley, and A. Dagher Neural bases of set-shifting deficits in Parkinson's disease J Neurosci 24 2004 702 710 (Pubitemid 38166496)
149. S.J. Kish, K. Shannak, and O. Hornykiewicz Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease N Engl J Med 318 1988 876 880 (Pubitemid 18090271)
150. Y. Agid, M. Ruberg, F. Javoy-Agid, E. Hirsch, R. Raisman-Vozari, and S. Vyas Are dopaminergic neurons selectively vulnerable to Parkinson's disease? Adv Neurol 60 1993 148 164
151. N. Sawamoto, P. Piccini, G. Hotton, N. Pavese, K. Thielemans, and D. Brooks Cognitive deficits and striato-frontal dopamine release in Parkinson's disease Brain 131 2008 1294 1302
152. J. Rakshi, T. Uema, K. Ito, D. Bailey, P. Morrish, and J. Ashburner Frontal, midbrain and striatal dopamergic function in early and advanced Parkinson's disease A 3D [(18)F]dopa-PET study Brain 122 1999 1637 1650 (Pubitemid 29425668)
153. V. Kaasinen, E. Nurmi, A. Bruck, O. Eskola, J. Bergman, and O. Solin Increased frontal [(18)F]fluorodopa uptake in early Parkinson's disease: Sex differences in the prefrontal cortex Brain 124 2001 1125 1130 (Pubitemid 32510380)
154. F.P. Bowen, R.S. Kamienny, M.M. Burns, and M.D. Yahr Parkinsonism: Effects of levodopa treatment on concept formation Neurology 25 1975 701 704
155. A.J. Lees, and E. Smith Cognitive deficits in the early stages of Parkinson's disease Brain 106 1983 257 270 (Pubitemid 13098511)
156. A.E. Taylor, J.A. Saint-Cyr, and A.E. Lang Frontal lobe dysfunction in Parkinson's disease The cortical focus of neostriatal outflow Brain 109 1986 845 883 (Pubitemid 17175608)
157. A.R. Cools, J.H. van den Bercken, M.W. Horstink, K.P. van Spaendonck, and H.J. Berger Cognitive and motor shifting aptitude disorder in Parkinson's disease J Neurol Neurosurg Psychiatry 47 1984 443 453 (Pubitemid 14145492)
158. A.E. Hayes, M.C. Davidson, S.W. Keele, and R.D. Rafal Towards a functional analysis of the basal ganglia J Cogn Neurosci 10 1998 178 198 (Pubitemid 28182189)
159. A.F. Arnsten Catecholamine and second messenger influences on prefrontal cortical networks of "representational knowledge": A rational bridge between genetics and the symptoms of mental illness Cereb Cortex 17 suppl 1 2007 i6 i15
160. J.B. Becker Oestrogen effects on dopaminergic function in striatum Novartis Found Symp 230 2000 134 145 discussion: 145154
161. E. Jacobs, and M. D'Esposito Estrogen shapes dopamine-dependent cognitive processes: implications for women's health J Neurosci 31 2011 5286 5293
162. M.E. Hasselmo, and M. Sarter Modes and models of forebrain cholinergic neuromodulation of cognition Neuropsychopharmacology 36 2011 52 73
163. P.R. Corlett, G.D. Honey, J.H. Krystal, and P.C. Fletcher Glutamatergic model psychoses: Prediction error, learning, and inference Neuropsychopharmacology 36 2011 294 315
164. G. Aston-Jones, and J.D. Cohen An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance Annu Rev Neurosci 28 2005 403 450 (Pubitemid 41098911)
165. J.W. Dalley, A.C. Mar, D. Economidou, and T.W. Robbins Neurobehavioral mechanisms of impulsivity: Fronto-striatal systems and functional neurochemistry Pharmacol Biochem Behav 90 2008 250 260
166. D.M. Eagle, A. Bari, and T.W. Robbins The neuropsychopharmacology of action inhibition: Cross-species translation of the stop-signal and go/no-go tasks Psychopharmacology (Berl) 199 2008 439 456
167. R.C. O'Reilly, and M.J. Frank Making working memory work: A computational model of learning in the prefrontal cortex and basal ganglia Neural Comput 18 2006 283 328 (Pubitemid 43543839)