Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders

Medical Science Monitor

Volumn 17, Issue 9, 2011, Pages

  Ptáček, Radek ^a   Kuželová, Hana ^a   Stefano, George B ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

ADHD; Dopamine receptor gene; DRD4; Psychiatric disorders

Indexed keywords

DOPAMINE 4 RECEPTOR; METHYLPHENIDATE; NEUROLEPTIC AGENT;

ALCOHOLISM; ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; DEVELOPMENTAL DISORDER; DNA POLYMORPHISM; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; IMPULSIVENESS; MENTAL DISEASE; META ANALYSIS (TOPIC); PERSONALITY DISORDER; PHARMACOGENETICS; POSTTRAUMATIC STRESS DISORDER; PROBLEM SOLVING; SIDE EFFECT; STRESS; SUBSTANCE ABUSE; TEMPERAMENT; TREATMENT RESPONSE;

EID: 80054026319     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.881925     Document Type: Article

References (108)

1. Arai M: Increased plasma arginine vasopressin levels in dopamine agonist-treated Parkinson's disease patients. Neuro Endocrinol Lett, 2011; 32(1): 39-43
2. Ugrumov MV, Saifetyarova JY, Lavrentieva AV, Sapronova AY: Developing brain as an endocrine organ: Secretion of dopamine. Mol Cell Endocrinol, 2011; [Epub ahead of print]
3. Huang Y, Qiu AW, Peng YP et al: Roles of dopamine receptor subtypes in mediating modulation of T lymphocyte function. Neuro Endocrinol Lett, 2010; 31(6): 782-91
4. Huang S, Wang H, Xu Y et al: The protective action of topiramate on dopaminergic neurons. Med Sci Monit, 2010; 16(9): BR307-12
5. Hu K, Zhou H, Zhang G et al: The effect of chemical sympathectomy and stress on bone remodeling in adult rats. Neuro Endocrinol Lett, 2010; 31(6): 807-13
6. Kasahara M, Groenink L, Olivier B, Sarnyai Z: Corticotropin-releasing factor (CRF) over-expression down-regulates hippocampal dopamine receptor protein expression and CREB activation in mice. Neuro Endocrinol Lett, 2011; 32(2) [Epub ahead of print]
7. Matalka KZ, Attallah LJ, Qinna NA, Alhussainy T: Dopamine selectively modulates lipopolysaccharide-induced TNF-alpha, IFN-gamma and IL-10 within mice tissues. Neuro Endocrinol Lett, 2011; 32(2) [Epub ahead of print]
8. Markianos M, Panas M, Kalfakis N et al: Neuroendocrine evidence of normal hypothalamus-pituitary dopaminergic function in Huntington's disease. Neuro Endocrinol Lett, 2010; 31(3): 359-62
9. Xiong NX, Pu JZ, Zhao HY, Zhang FC: Effect of Nogo-A gene inhibition on dopamine release in PC12 cells. Neuro Endocrinol Lett, 2008; 29(6): 884-88
10. Esch T, Stefano GB: The neurobiology of stress management. Neuro Endocrinol Lett, 2010; 31(1): 19-39
11. van Tol HH, Wu CM, Guan HC et al: Multiple dopamine D4 receptor variants in the human population. Nature, 1992; 358(6382): 149-52
12. Ding YC, Chi HC, Grady DL et al: Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci USA, 2002; 99: 309-14
13. Chang FM, Kidd JR, Livak KJ et al: The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet, 1996; 98(1): 91-101
14. Chen D, Liu F, Shang Q et al: Association between polymorphisms of DRD2 and DRD4 and opioid dependence: Evidence from the current studies. Am J Med Genet B Neuropsychiatr Genet, 2011; [Epub ahead of print]
15. Kaplan AS, Levitan RD, Yilmaz Z et al: A DRD4/BDNF gene-gene interaction associated with maximum BMI in women with bulimia ner-vosa. Int J Eat Disord, 2008; 41(1): 22-28
16. Emanuele E, Boso M, Cassola F et al: Increased dopamine DRD4 receptor mRNA expression in lymphocytes of musicians and autistic individuals: bridging the music-autism connection. Neuro Endocrinol Lett, 2010; 31(1): 122-25
17. Lung FW, Yang MC, Shu BC: The interleukin 10 promoter haplotype ACA and the long-form variant of the DRD4 uVNTR polymorphism are associated with vulnerability to schizophrenia. Psychiatry Res, 2011; 188(2): 294-96
18. Lee KY, Joo EJ, Ji YI et al: Associations between DRDs and schizophrenia in a Korean population: multi-stage association analyses. Exp Mol Med, 2011; 43(1): 44-52
19. Vrajová M, Peková S, Horacek J, Höschl C: The effects of siRNA-medi-ated RGS4 gene silencing on the whole genome transcription profle: implications for schizophrenia. Neuro Endocrinol Lett, 2011; 32(3): 246-52
20. Hohmann S, Becker K, Fellinger J et al: Evidence for epistasis between the 5-HTTLPR and the dopamine D4 receptor polymorphisms in externalizing behavior among 15-year-olds. J Neural Transm, 2009; 116(12): 1621-29
21. Dmitrieva J, Chen C, Greenberger E et al: Gender-specifc expression of the DRD4 gene on adolescent delinquency, anger and thrill seeking. Soc Cogn Affect Neurosci, 2011; 6(1): 82-89
22. Kang JI, Namkoong K, Kim SJ: Association of DRD4 and COMT polymorphisms with anger and forgiveness traits in healthy volunteers. Neurosci Lett, 2008; 430(3): 252-57
23. Kranzler HR, Edenberg HJ: Pharmacogenetics of alcohol and alcohol dependence treatment. Curr Pharm Des, 2010; 16(19): 2141-48
24. Tsuchimine S, Yasui-Furukori N, Kaneda A et al: Minor genetic variants of the dopamine D4 receptor (DRD4) polymorphism are associated with novelty seeking in healthy Japanese subjects. Prog Neuropsychopharmacol Biol Psychiatry, 2009; 33(7): 1232-35
25. Inukai K, Shinada M, Tanida S et al: Salivary alpha-amylase levels and big fve personality factors in adults. Neuro Endocrinol Lett, 2010; 31(6): 771-74
26. Flegr J, Príplatová L: Testosterone and cortisol levels in university students refect actual rather than estimated number of wrong answers on written exam. Neuro Endocrinol Lett, 2010; 31(4): 577-81
27. Vevera J, Stopkova R, Bes M et al: COMT polymorphisms in impulsively violent offenders with antisocial personality disorder. Neuro Endocrinol Lett, 2009; 30(6): 753-56
28. Ivorra JL, D'Souza UM, Jover M et al: Association between neonatal temperament, SLC6A4, DRD4 and a functional polymorphism located in TFAP2B. Genes Brain Behav, 2011 [Epub ahead of print]
29. Roussos P, Giakoumaki SG, Bitsios P: Cognitive and emotional processing in high novelty seeking associated with the L-DRD4 genotype. Neuropsychologia, 2009; 47(7): 1654-59
30. Kluger AN, Siegfried Z, Ebstein RP: A meta-analysis of the association between DRD4 polymorphism and novelty seeking. Molecular Psychiatry, 2002; 7: 712-17
31. De Luca A, Rizzardi M, Torrente I et al: Dopamine D4 receptor (DRD4) polymorphism and adaptability trait during infancy: a longitudinal study in 1- to 5-month-old neonates. Neurogenetics, 2001; 3: 79-82
32. De Luca A, Rizzardi M, Buccino A et al: Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants. Neurogenetics, 2003; 4: 207-12
33. Kuzelova H, Ptacek R, Macek M: The serotonin transporter gene (5-HTT) variant and psychiatric disorders: review of current literature. Neuro Endocrinol Lett, 2010; 31(1): 5
34. Ptáček R, Kuzelova H, Paclt I et al: Anthropometric changes in non-medicated ADHD boys. Neuro Endocrinol Lett, 2009; 30(3): 377-73
35. Ptacek R, Kuzelova H, Paclt I et al: ADHD and growth: anthropometric changes in medicated and non-medicated ADHD boys. Med Sci Monit, 2009; 15(12): CR595-99
36. Prihodova I, Paclt I, Kemlink D et al: Sleep disorders and daytime sleepiness in children with attention-defcit/hyperactivity disorder: A two-night polysomnographic study with a multiple sleep latency test. Sleep Medicine, 2010; 11(9): 922-28
37. Paclt I, Drtilkova I, Kopeckova M et al: The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years. Neuro Endocrinol Lett, 2010; 31(1): 131-36
38. Paclt I, Koudelová J, Pacltova D, Kopeckova M: Dopamine beta hy-droxylase (DBH) plasma activity in childhood mental disorders. Neuro Endocrinol Lett, 2009; 30(5): 604-9
39. Langley K: Association of the dopamine D4 receptor gene 7-repeat al-lele with neuropsychological test performance of children with ADHD. Am J Psychiatry, 2004; 161(1): 133-38
40. Faraone SV et al: 2001, Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder. Am J Psychiatry, 2001; 158(7): 1052-57
41. Auerbach JG, Faroy M, Ebstein R et al: The association of the dopa-mine D4 receptor gene (DRD4) and the serotonin transporter promoter gene (5-HTTLPR) with temperament in 12-month-old infants. J Child Psychol Psychiatry, 2001; 42(6): 777-83
42. Bellgrove MA, Hawi Z, Lowe N et al: DRD4 gene variants and sustained attention in attention defcit hyperactivity disorder (ADHD): effects of associated alleles at the VNTR and -521 SNP. Am J Med Genet B Neuropsychiatr Genet, 2005; 136B(1): 81-86
43. Foltin V, Foltinova J, Neu E et al: Placenta - organ important for fetus and interesting for the rise of the Attention Defcit Hyperactivity Disorder Syndrome - interdisciplinary study. Neuro Endocrinol Lett, 2011; 32(1): 44-50
44. Reiersen AM, Todorov AA: Association between DRD4 genotype and Autistic Symptoms in DSM-IV ADHD. J Can Acad Child Adolesc Psychiatry, 2011; 20(1): 15-21
45. Takagishi H, Takahashi T, Yamagishi T et al: Salivary testosterone levels and autism-spectrum quotient in adults. Neuro Endocrinol Lett, 2010; 31(6): 837-41
46. Emanuele E, Colombo R, Martinelli V et al: Elevated urine levels of bu-fotenine in patients with autistic spectrum disorders and schizophrenia. Neuro Endocrinol Lett, 2010; 31(1): 117-21
47. Kelemenova S, Ostatnikova D: Neuroendocrine pathways altered in autism. Special role of reelin. Neuro Endocrinol Lett, 2009; 30(4): 429-36
48. Kałuzna-Czaplinska J, Michalska M, Rynkowski J: Determination of tryp-tophan in urine of autistic and healthy children by gas chromatogra-phy/mass spectrometry. Med Sci Monit, 2010; 16(10): CR488-92
49. Calahorro F, Alejandre E, Anaya N et al: A preliminary study of gene polymorphisms involved in the neurotransmitters metabolism of a homogeneous Spanish autistic group Research in Autism Spectrum Disorders, 2009; 3: 438-43
50. Grady DL, Harxhi A, Smith M et al: Sequence Variants of the DRD4 Gene in Autism: Further Evidence That Rare DRD4 7R Haplotypes Are ADHD Specifc American Journal of Medical Genetics Part B (Neuropsychiatric Genetics), 2005; 136B: 33-35
51. Filbey FM, Claus ED, Morgan M et al: Dopaminergic genes modulate response inhibition in alcohol abusing adults. Addict Biol, 2011; [Epub ahead of print]
52. van der Zwaluw CS, Larsen H, Engels RC: Best friends and alcohol use in adolescence: the role of the dopamine D4 receptor gene. Addict Biol, 2011; [Epub ahead of print]
53. Park A, Sher KJ, Todorov AA, Heath AC: Interaction between the DRD4 VNTR polymorphism and proximal and distal environments in alcohol dependence during emerging and young adulthood. J Abnorm Psychol, 2011; 120(3): 585-95
54. Das D, Tan X, Easteal S: Effect of model choice in genetic association studies: DRD4 exon III VNTR and cigarette use in young adults. Am J Med Genet B Neuropsychiatr Genet, 2011; 156B(3): 346-51
55. Ellis JA, Olsson CA, Moore E et al: A role for the DRD4 exon III VNTR in modifying the association between nicotine dependence and neu-roticism. Nicotine Tob Res, 2011; 13(2): 64-69
56. Nederhof E, Creemers HE, Huizink AC et al: L-DRD4 genotype not associated with sensation seeking, gambling performance and startle reactivity in adolescents: The TRAILS study. Neuropsychologia, 2011; 49(5): 1359-62
57. McGeary J: The DRD4 exon 3 VNTR polymorphism and addiction-related phenotypes: A review. Pharmacol Biochem Behav, 2009; 93: 222-29
58. Pietras T, Witusik A, Panek M et al: Anxiety, depression and methods of stress coping in patients with nicotine dependence syndrome. Med Sci Monit, 2011; 17(5): CR272-76
59. Emanuele E, Brondino N, Pesenti S et al: Genetic loading on human loving styles. Neuro Endocrinol Lett, 2007; 28(6): 815-21
60. Armbruster D, Mueller A, Moser DA et al: Interaction effect of D4 do-pamine receptor gene and serotonin transporter promoter polymorphism on the cortisol stress response. Behav Neurosci, 2009; 123(6): 1288-95
61. Bakermans-Kranenburg MJ, van Ijzendoorn MH, Caspers K, Philibert R: DRD4 genotype moderates the impact of parental problems on unresolved loss or trauma. Attach Hum Dev, 2011; 13(3): 253-69
62. Dragan WŁ, Oniszczenko W: The association between dopamine D4 receptor exon III polymorphism and intensity of PTSD symptoms among food survivors. Anxiety Stress Coping, 2009; 22(5): 483-95
63. Prasko J, Raszka M, Adamcova K et al: Predicting the therapeutic response to cognitive behavioural therapy in patients with pharmacore-sistant obsessive-compulsive disorder. Neuro Endocrinol Lett, 2009; 30(5): 615-23
64. Nikisch G: Involvement and role of antidepressant drugs of the hypo-thalamic-pituitary-adrenal axis and glucocorticoid receptor function. Neuro Endocrinol Lett, 2009; 30(1): 11-16
65. Komorousova J, Beran J, Rusavy Z, Jankovec Z: Glycemic control improvement through treatment of depression using antidepressant drugs in patients with diabetes mellitus type 1. Neuro Endocrinol Lett, 2010; 31(6): 801-6
66. Ceskova E, Kašpárek T, Dufek J et al: Individualized treatment of eating disorders. Neuro Endocrinol Lett, 2010; 31(6): 754-60
67. st century? Audit of 100 seizure-free patients, referred with the diagnosis of pharmacore-sistant epilepsy. Neuro Endocrinol Lett, 2010; 31(6): 818-22
68. Daansen PJ, Haffmans J: Reducing symptoms in women with chronic anorexia nervosa. A pilot study on the effects of bright light therapy. Neuro Endocrinol Lett, 2010; 31(3): 290-96
69. Turic D, Swanson J, Sonuga-Barke E: Drd 4 and dat 1 in ad hd: Functional neurobiology to pharmacogenetics. Pharmgenomics Pers Med, 2010; 3: 61-78
70. Polanczyk G, Bigarella MP, Hutz MH, Rohde LA: Pharmacogenetic approach for a better drug treatment in children. Curr Pharm Des, 2010; 16(22): 2462-73
71. Ptáček R, Kuželová H, Macek M: Farmakogenetika ADHD. Ces a Slov Psych, 2010; 106(4): 226-29
72. Hwu HG, Hong CJ, Lee YL et al: Dopamine D4 receptor gene polymorphisms and neuroleptic response in schizophrenia. Biol Psychiatry, 1998; 44(6): 483-87
73. Bicikova M, Hampl R, Hill M et al: Neuro- and immunomodulatory steroids and other biochemical markers in drug-naive schizophrenia patients and the effect of treatment with atypical antipsychotics. Neuro Endocrinol Lett, 2011; 32(2): 141-47
74. Hroudova J, Fisar Z: Activities of respiratory chain complexes and citrate synthase infuenced by pharmacologically different antidepres-sants and mood stabilizers. Neuro Endocrinol Lett, 2010; 31(3): 336-42
75. Bares M, Novak T, Kopecek M et al: Is combined treatment more effective than switching to monotherapy in patients with resistant depression? A retrospective study. Neuro Endocrinol Lett, 2009; 30(6): 723-28
76. Zyss T, Zieba A, Hese RT et al: Magnetic seizure therapy (MST) - a safer method for evoking seizure activity than current therapy with a confrmed antidepressant effcacy. Neuro Endocrinol Lett, 2010; 31(4): 425-37
77. Kovaru H, Pav M, Kovaru F et al: Cell signalling in CNS and immune system in depression and during antidepressant treatment: focus on gli-al and natural killer cells. Neuro Endocrinol Lett, 2009; 30(4): 421-28
78. Nogal P, Pniewska-Siark B, Lewiński A: Analysis of treatment effcacy in girls with anorexia nervosa (III). Neuro Endocrinol Lett, 2009; 30(1): 32-38
79. Prikryl R, Ustohal L, Kucerova HP, Ceskova E: Paliperidon mediated modifcation of cortical inhibition. Neuro Endocrinol Lett, 2009; 30(3): 396-99
80. Hruby R, Hasto J, Minarik P: Attachment in integrative neuroscientif-ic perspective. Neuro Endocrinol Lett, 2011; 32(2): 111-20
81. Hruby R, Nosalova G, Hruba S: Predictive signifcance of TCI-R for an-tidepressant treatment. Med Sci Monit, 2010; 16(8): CR383-88
82. Das D, Cherbuin N, Tan X et al: DRD4-exonIII-VNTR Moderates the Effect of Childhood Adversities on Emotional Resilience in Young-Adults. PLoS One, 2011; 6(5): e20177
83. Glatt SJ, Faraone SV, Tsuang MT: Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a me-ta-analysis. Biol Psychiatry, 2003; 54(6): 629-35
84. López León S, Croes EA, Sayed-Tabatabaei FA et al: The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: a meta-analysis. Biol Psychiatry, 2005; 57(9): 999-1003
85. Millet B, Chabane N, Delorme R et al: Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2003; 116B(1): 55-59
86. Camarena B, Loyzaga C, Aguilar A et al: Association study between the dopamine receptor D4 gene and obsessive-compulsive disorder. Eur Neuropsychopharmacol, 2007; 17(6-7): 406-9
87. Barnes JJ, Dean AJ, Nandam LS et al: The Molecular Genetics of Executive Function: Role of Monoamine System Genes. Biol Psychiatry, 2011 [Epub ahead of print]
88. Galecki P, Szemraj J, Zboralski K et al: Relation between functional polymorphism of catalase gene (-262C>T) and recurrent depressive disorder. Neuro Endocrinol Lett, 2009; 30(3): 357-62
89. Melkersson K, Hulting AL: Serotonin receptor 2A gene polymorphisms and schizophrenia: association with family history, diagnostic subtype and height in patients. Neuro Endocrinol Lett, 2009; 30(3): 343-51
90. Melkersson K, Persson B, Hongslo T: The insulin receptor substrate-4 (IRS-4) gene and schizophrenia: no evidence for a main genetic factor, however one report of a single schizophrenia patient with a mutation. Neuro Endocrinol Lett, 2011; 32(1): 52-58
91. Maes M, Kubera M, Obuchowiczwa E et al: Depression's multiple co-morbidities explained by (neuro)infammatory and oxidative & nitro-sative stress pathways. Neuro Endocrinol Lett, 2011; 32(1): 7-24
92. Maes M, Mihaylova I, Kubera M et al: Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encepha-lomyelitis/chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression. Neuro Endocrinol Lett, 2011; 32(2): 133-40
93. Ondicova K, Pecenák J, Mravec B: The role of the vagus nerve in depression. Neuro Endocrinol Lett, 2010; 31(5): 602-8
94. Rackova S, Janu L, Kabickova H: Borna disease virus circulating immu-nocomplex positivity and psychopathology in psychiatric patients in the Czech Republic. Neuro Endocrinol Lett, 2009; 30(3): 414-20
95. Brandao PP, Garcia-Souza EP, Neves FA et al: Leptin/adiponectin ratio in obese women with and without binge eating disorder. Neuro Endocrinol Lett, 2010; 31(3): 353-58
96. Maes M, Galecki P, Verkerk R, Rief W: Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2,3-dioxygenase and lowered kynurenine aminotransferase activity. Neuro Endocrinol Lett, 2011; 32(3): 264-73
97. Janocha A, Bolanowski M, Pilecki W et al: Cognitive disorders in type 2 diabetic patients with recognized depression. Neuro Endocrinol Lett, 2010; 31(3): 399-405
98. Pastucha P, Prasko J, Grambal A et al: Panic disorder and dissociation - comparison with healthy controls. Neuro Endocrinol Lett, 2009; 30(6): 774-78
99. Raszka M, Prasko J, Koprivová J et al: Psychological dissociation in obsessive-compulsive disorder is associated with anxiety level but not with severity of obsessive-compulsive symptoms. Neuro Endocrinol Lett, 2009; 30(5): 624-28
100. Croonenberghs J, Van Grieken S, Wauters A et al: Serum testosterone concentration in male autistic youngsters. Neuro Endocrinol Lett, 2010; 31(4): 483-88
101. Celedova L, Cevela R, Kalita Z et al: Assessment of State of Health and Capacity for Work in Post-Stroke Patients - Case Reports. Ceska a slov-enska neurologie a neurochirurgie. 2010; 73(6): 728-33
102. Gu Y, Yun L, Tian Y, Hu Z: Association between COMT gene and Chinese male schizophrenic patients with violent behavior. Med Sci Monit, 2009; 15(9): CR484-89
103. Emanuele E, Bertona M, Minoretti P, Geroldi D: An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress. Neuro Endocrinol Lett, 2010; 31(5): 663-66
104. Geier DA, Kern JK, Davis G et al: A prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disorders. Med Sci Monit, 2011; 17(6): PI15-23
105. Prikryl R: Repetitive transcranial magnetic stimulation and treatment of negative symptoms of schizophrenia. Neuro Endocrinol Lett, 2011; 32(2): 121-26
106. Li Q, Sun J, Guo L et al: Increased fractional anisotropy in white matter of the right frontal region in children with attention-defcit/hyper-activity disorder: a diffusion tensor imaging study. Neuro Endocrinol Lett, 2010; 31(6): 747-53
107. th Word conf on clicical pharmacology and therapeutics. 1989; 3: 15-1990
108. st Antal psychopharmacology meeting. Activitas Nevrosa Superior, 1989; 31(4): 291-93