Improving temporal cognition by enhancing motivation

Behavioral Neuroscience

Volumn 129, Issue 5, 2015, Pages 576-588

  Avlar, Billur ^a   Kahn, Julia B ^a,e   Jensen, Greg ^a   Kandel, Eric R ^a,b   Simpson, Eleanor H ^a,c   Balsam, Peter D ^a,c,d  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Kavli Institute for Brain Science   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d Program on US Russia Relations at Columbia s Harriman Institute   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

5 HT2C receptor; Dopamine D2 receptor; Reward; Striatum; Time perception

Indexed keywords

6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; DOPAMINE 2 RECEPTOR; LIGAND; SEROTONIN 2C RECEPTOR; 6-CHLORO-5-METHYL-1-((2-(2-METHYLPYRID-3-YLOXY)PYRID-5-YL)CARBAMOYL)INDOLINE; AMINOPYRIDINE DERIVATIVE; INDOLE DERIVATIVE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; AROUSAL; ARTICLE; COGNITION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; MOTIVATION; MOUSE; NONHUMAN; OPERANT BEHAVIORAL TEST; PSYCHOMETRY; REWARD; TASK PERFORMANCE; TIME PERCEPTION; TRANSGENIC MOUSE; ANIMAL; CORPUS STRIATUM; GENE EXPRESSION PROFILING; INSTRUMENTAL CONDITIONING; METABOLISM; PHYSIOLOGY;

AMINOPYRIDINES; ANIMALS; COGNITION; CONDITIONING, OPERANT; CORPUS STRIATUM; FEMALE; GENE EXPRESSION PROFILING; INDOLES; MICE; MICE, TRANSGENIC; MOTIVATION; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, DOPAMINE D2; REWARD;

EID: 84942553770     PISSN: 07357044     EISSN: 19390084     Source Type: Journal    
DOI: 10.1037/bne0000083     Document Type: Article

References (65)

1. Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y.,. Laruelle, M. (2002). Prefrontal dopamine D1 receptors and working memory in schizophrenia. The Journal of Neuroscience, 22, 3708-3719.
2. Bäckman, L., Nyberg, L., Soveri, A., Johansson, J., Andersson, M., Dahlin, E.,. Rinne, J. O. (2011, August 5). Effects of working-memory training on striatal dopamine release. Science, 333, 718. http://dx.doi.org/10.1126/science.1204978.
3. Balci, F. (2014). Interval timing, dopamine, and motivation. Timing & Time Perception, 2, 379-410. http://dx.doi.org/10.1163/22134468-00002035.
4. Barch, D. M., & Dowd, E. C. (2010). Goal representations and motivational drive in schizophrenia: The role of prefrontal-striatal interactions. Schizophrenia Bulletin, 36, 919-934. http://dx.doi.org/10.1093/schbul/sbq068.
5. Barch, D. M., Treadway, M. T., & Schoen, N. (2014). Effort, anhedonia, and function in schizophrenia: Reduced effort allocation predicts amotivation and functional impairment. Journal of Abnormal Psychology, 123, 387-397. http://dx.doi.org/10.1037/a0036299.
6. Becker, J. B. (1999). Gender differences in dopaminergic function in striatum and nucleus accumbens. Pharmacology Biochemistry and Behavior, 64, 803-812. http://dx.doi.org/10.1016/S0091-3057(99)00168-9.
7. Berridge, K. C., & Kringelbach, M. L. (2013). Neuroscience of affect: Brain mechanisms of pleasure and displeasure. Current Opinion in Neurobiology, 23, 294-303. http://dx.doi.org/10.1016/j.conb.2013.01.017.
8. Bolger, N., & Laurenceau, J. P. (2013). Modelling categorical outcomes. In N. Bolger & J. P. Laurenceau (Eds.), Intensive longitudinal methods: An introduction to diary and experience sampling research (pp. 105-125). New York, NY: Guilford Press.
9. Boulougouris, V., Glennon, J. C., & Robbins, T. W. (2008). Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in rats. Neuropsychopharmacology, 33, 2007-2019. http://dx.doi.org/10.1038/sj.npp.1301584.
10. Boulougouris, V., & Robbins, T. W. (2010). Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific. The Journal of Neuroscience, 30, 930-938. http://dx.doi.org/10.1523/JNEUROSCI.4312-09.2010.
11. Boulougouris, V., & Tsaltas, E. (2008). Serotonergic and dopaminergic modulation of attentional processes. Progress in Brain Research, 172, 517-542.
12. Buhusi, C. V., & Meck, W. H. (2005). What makes us tick? Functional and neural mechanisms of interval timing. Nature Reviews Neuroscience, 6, 755-765. http://dx.doi.org/10.1038/nrn1764.
13. Choi, J., & Medalia, A. (2010). Intrinsic motivation and learning in a schizophrenia spectrum sample. Schizophrenia Research, 118, 12-19. http://dx.doi.org/10.1016/j.schres.2009.08.001.
14. Church, R. M., & Deluty, M. Z. (1977). Bisection of temporal intervals. Journal of Experimental Psychology: Animal Behavior Processes, 3, 216-228. http://dx.doi.org/10.1037/0097-7403.3.3.216.
15. Coull, J. T., Cheng, R. K., & Meck, W. H. (2011). Neuroanatomical and neurochemical substrates of timing. Neuropsychopharmacology, 36, 3-25. http://dx.doi.org/10.1038/npp.2010.113.
16. Coull, J. T., Hwang, H. J., Leyton, M., & Dagher, A. (2012). Dopamine precursor depletion impairs timing in healthy volunteers by attenuating activity in putamen and supplementary motor area. The Journal of Neuroscience, 32, 16704-16715. http://dx.doi.org/10.1523/JNEUROSCI.1258-12.2012.
17. Croxson, P. L., Walton, M. E., O'Reilly, J. X., Behrens, T. E., & Rushworth, M. F. (2009). Effort-based cost-benefit valuation and the human brain. The Journal of Neuroscience, 29, 4531-4541. http://dx.doi.org/10.1523/JNEUROSCI.4515-08.2009.
18. De Deurwaerdère, P., Navailles, S., Berg, K. A., Clarke, W. P., & Spampinato, U. (2004). Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. The Journal of Neuroscience, 24, 3235-3241. http://dx.doi.org/10.1523/JNEUROSCI.0112-04.2004.
19. Di Matteo, V., Di Giovanni, G., Di Mascio, M., & Esposito, E. (1999). SB 242084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system. Neuropharmacology, 38, 1195-1205. http://dx.doi.org/10.1016/S0028-3908(99)00047-7.
20. Drew, M. R., Fairhurst, S., Malapani, C., Horvitz, J. C., & Balsam, P. D. (2003). Effects of dopamine antagonists on the timing of two intervals. Pharmacology Biochemistry and Behavior, 75, 9-15. http://dx.doi.org/10.1016/S0091-3057(03)00036-4.
21. Drew, M. R., Simpson, E. H., Kellendonk, C., Herzberg, W. G., Lipatova, O., Fairhurst, S.,. Balsam, P. D. (2007). Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing. The Journal of Neuroscience, 27, 7731-7739. http://dx.doi.org/10.1523/JNEUROSCI.1736-07.2007.
22. Droit-Volet, S. (2013). Time perception, emotions and mood disorders. Journal of Physiology-Paris, 107, 255-264. http://dx.doi.org/10.1016/j.jphysparis.2013.03.005.
23. Fervaha, G., Zakzanis, K. K., Foussias, G., Graff-Guerrero, A., Agid, O., & Remington, G. (2014). Motivational deficits and cognitive test performance in schizophrenia. Journal of the American Medical Association Psychiatry, 71, 1058-1065. http://dx.doi.org/10.1001/jamapsychiatry.2014.1105.
24. Galtress, T., & Kirkpatrick, K. (2010). The role of the nucleus accumbens core in impulsive choice, timing, and reward processing. Behavioral Neuroscience, 124, 26-43. http://dx.doi.org/10.1037/a0018464.
25. Gold, J. M., Hahn, B., Zhang, W. W., Robinson, B. M., Kappenman, E. S., Beck, V. M., & Luck, S. J. (2010). Reduced capacity but spared precision and maintenance of working memory representations in schizophrenia. Archives of General Psychiatry, 67, 570-577. http://dx.doi.org/10.1001/archgenpsychiatry.2010.65.
26. Gold, J. M., Waltz, J. A., Matveeva, T. M., Kasanova, Z., Strauss, G. P., Herbener, E. S.,. Frank, M. J. (2012). Negative symptoms and the failure to represent the expected reward value of actions: Behavioral and computational modeling evidence. Archives of General Psychiatry, 69, 129-138. http://dx.doi.org/10.1001/archgenpsychiatry.2011.1269.
27. Green, M. F., Hellemann, G., Horan, W. P., Lee, J., & Wynn, J. K. (2012). From perception to functional outcome in schizophrenia: Modeling the role of ability and motivation. JAMA Psychiatry, 69, 1216-1224. http://dx.doi.org/10.1001/archgenpsychiatry.2012.652.
28. Hart, G., Leung, B. K., & Balleine, B. W. (2014). Dorsal and ventral streams: The distinct role of striatal subregions in the acquisition and performance of goal-directed actions. Neurobiology of Learning and Memory, 108, 104-118. http://dx.doi.org/10.1016/j.nlm.2013.11.003.
29. Hutson, P. H., Barton, C. L., Jay, M., Blurton, P., Burkamp, F., Clarkson, R., & Bristow, L. J. (2000). Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT(2C/2B) receptor antagonists: Neurochemical and behavioural studies. Neuropharmacology, 39, 2318-2328. http://dx.doi.org/10.1016/S0028-3908(00)00089-7.
30. Kellendonk, C., Simpson, E. H., Polan, H. J., Malleret, G., Vronskaya, S., Winiger, V.,. Kandel, E. R. (2006). Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron, 49, 603-615. http://dx.doi.org/10.1016/j.neuron.2006.01.023.
31. Kim, J., Glahn, D. C., Nuechterlein, K. H., & Cannon, T. D. (2004). Maintenance and manipulation of information in schizophrenia: Further evidence for impairment in the central executive component of working memory. Schizophrenia Research, 68, 173-187. http://dx.doi.org/10.1016/S0920-9964(03)00150-6.
32. Kuepper, R., Skinbjerg, M., & Abi-Dargham, A. (2012). The dopamine dysfunction in schizophrenia revisited: New insights into topography and course. Handbook of Experimental Pharmacology, 212, 1-26. http://dx.doi.org/10.1007/978-3-642-25761-2_1.
33. Liu, X., Hairston, J., Schrier, M., & Fan, J. (2011). Common and distinct networks underlying reward valence and processing stages: A metaanalysis of functional neuroimaging studies. Neuroscience and Biobehavioral Reviews, 35, 1219-1236. http://dx.doi.org/10.1016/j.neubiorev.2010.12.012.
34. Mann, C. L., Footer, O., Chung, Y. S., Driscoll, L. L., & Barch, D. M. (2013). Spared and impaired aspects of motivated cognitive control in schizophrenia. Journal of Abnormal Psychology, 122, 745-755. http://dx.doi.org/10.1037/a0033069.
35. Maricq, A. V., & Church, R. M. (1983). The differential effects of haloperidol and methamphetamine on time estimation in the rat. Psychopharmacology, 79, 10-15. http://dx.doi.org/10.1007/BF00433008.
36. Maricq, A. V., Roberts, S., & Church, R. M. (1981). Methamphetamine and time estimation. Journal of Experimental Psychology: Animal Behavior Processes, 7, 18-30. http://dx.doi.org/10.1037/0097-7403.7.1.18.
37. Markou, A., Salamone, J. D., Bussey, T. J., Mar, A. C., Brunner, D., Gilmour, G., & Balsam, P. (2013). Measuring reinforcement learning and motivation constructs in experimental animals: Relevance to the negative symptoms of schizophrenia. Neuroscience & Biobehavioral Reviews, 37 (9, Pt. B), 2149-2165. http://dx.doi.org/10.1016/j.neubiorev.2013.08.007.
38. Mayford, M., Bach, M. E., Huang, Y. Y., Wang, L., Hawkins, R. D., & Kandel, E. R. (1996, December 6). Control of memory formation through regulated expression of a CaMKII transgene. Science, 274, 1678-1683. http://dx.doi.org/10.1126/science.274.5293.1678.
39. McNab, F., Varrone, A., Farde, L., Jucaite, A., Bystritsky, P., Forssberg, H., & Klingberg, T. (2009, February 6). Changes in cortical dopamine D1 receptor binding associated with cognitive training. Science, 323, 800-802. http://dx.doi.org/10.1126/science.1166102.
40. Meck, W. H. (1986). Affinity for the dopamine D2 receptor predicts neuroleptic potency in decreasing the speed of an internal clock. Pharmacology Biochemistry and Behavior, 25, 1185-1189. http://dx.doi.org/10.1016/0091-3057(86)90109-7.
41. Munro, C. A., McCaul, M. E., Wong, D. F., Oswald, L. M., Zhou, Y., Brasic, J.,. Wand, G. S. (2006). Sex differences in striatal dopamine release in healthy adults. Biological Psychiatry, 59, 966-974. http://dx.doi.org/10.1016/j.biopsych.2006.01.008.
42. Navailles, S., De Deurwaerdère, P., Porras, G., & Spampinato, U. (2004). In Vivo evidence that 5-HT2C receptor antagonist but not agonist modulates cocaine-induced dopamine outflow in the rat nucleus accumbens and striatum. Neuropsychopharmacology, 29, 319-326. http://dx.doi.org/10.1038/sj.npp.1300329.
43. Nelder, J. A., & Wedderburn, R. W. M. (1972). Generalized linear models. Journal of the Royal Statistical Society. Series A (General), 135, 370-384. http://dx.doi.org/10.2307/2344614.
44. Nieoullon, A. (2002). Dopamine and the regulation of cognition and attention. Progress in Neurobiology, 67, 53-83. http://dx.doi.org/10.1016/S0301-0082(02)00011-4.
45. Nowend, K. L., Arizzi, M., Carlson, B. B., & Salamone, J. D. (2001). D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption. Pharmacology Biochemistry and Behavior, 69, 373-382. http://dx.doi.org/10.1016/S0091-3057(01)00524-X.
46. Opal, M. D., Klenotich, S. C., Morais, M., Bessa, J., Winkle, J., Doukas, D.,. Dulawa, S. M. (2014). Serotonin 2C receptor antagonists induce fast-onset antidepressant effects. Molecular Psychiatry, 19, 1106-1114.
47. Randall, P. A., Lee, C. A., Podurgiel, S. J., Hart, E., Yohn, S. E., Jones, M.,. Salamone, J. D. (2015). Bupropion increases selection of high effort activity in rats tested on a progressive ratio/chow feeding choice procedure: Implications for treatment of effort-related motivational symptoms. International Journal of Neuropsychopharmacology, 18. http://dx.doi.org/10.1093/ijnp/pyu017.
48. Rao, S. M., Mayer, A. R., & Harrington, D. L. (2001). The evolution of brain activation during temporal processing. Nature Neuroscience, 4, 317-323. http://dx.doi.org/10.1038/85191.
49. Roberts, S. (1981). Isolation of an internal clock. Journal of Experimental Psychology: Animal Behavior Processes, 7, 242-268. http://dx.doi.org/10.1037/0097-7403.7.3.242.
50. Rømer Thomsen, K., Whybrow, P. C., & Kringelbach, M. L. (2015). Reconceptualizing anhedonia: Novel perspectives on balancing the pleasure networks in the human brain. Frontiers in Behavioral Neuroscience, 9, 49.
51. Rubinow, D. R., Schmidt, P. J., & Roca, C. A. (1998). Estrogen-serotonin interactions: Implications for affective regulation. Biological Psychiatry, 44, 839-850. http://dx.doi.org/10.1016/S0006-3223(98)00162-0.
52. Salamone, J. D., & Correa, M. (2012). The mysterious motivational functions of mesolimbic dopamine. Neuron, 76, 470-485. http://dx.doi.org/10.1016/j.neuron.2012.10.021.
53. Schwarz, G. (1978). Estimating the dimension of a model. Annals of Statistics, 6, 461-464. http://dx.doi.org/10.1214/aos/1176344136.
54. Simpson, E. H., Kellendonk, C., Ward, R. D., Richards, V., Lipatova, O., Fairhurst, S.,. Balsam, P. D. (2011). Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia. Biological Psychiatry, 69, 928-935. http://dx.doi.org/10.1016/j.biopsych.2011.01.012.
55. Simpson, E. H., Waltz, J. A., Kellendonk, C., & Balsam, P. D. (2012). Schizophrenia in translation: Dissecting motivation in schizophrenia and rodents. [Research Support, N. I. H., Extramural Review]. Schizophrenia Bulletin, 38, 1111-1117. http://dx.doi.org/10.1093/schbul/sbs114.
56. Strauss, G. P., Wilbur, R. C., Warren, K. R., August, S. M., & Gold, J. M. (2011). Anticipatory vs. consummatory pleasure: What is the nature of hedonic deficits in schizophrenia? Psychiatry Research, 187(1-2), 36-41. http://dx.doi.org/10.1016/j.psychres.2011.01.012.
57. Waltz, J. A., Frank, M. J., Robinson, B. M., & Gold, J. M. (2007). Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction. Biological Psychiatry, 62, 756-764. http://dx.doi.org/10.1016/j.biopsych.2006.09.042.
58. Waltz, J. A., Frank, M. J., Wiecki, T. V., & Gold, J. M. (2011). Altered probabilistic learning and response biases in schizophrenia: Behavioral evidence and neurocomputational modeling. Neuropsychology, 25, 86-97. http://dx.doi.org/10.1037/a0020882.
59. Ward, R. D., Avlar, B., & Balsam, P. D. (2015). Interactions of timing and motivational impairments in schizophrenia. In A. Vatakis & M. J. Allman (Eds.), Time distortions in mind: Temporal processing in clinical populations (pp. 284-329). Boston, MA: Brill Academic Publishers.
60. Ward, R. D., Kellendonk, C., Kandel, E. R., & Balsam, P. D. (2012). Timing as a window on cognition in schizophrenia. [Review]. Neuropharmacology, 62, 1175-1181. http://dx.doi.org/10.1016/j.neuropharm.2011.04.014.
61. Ward, R. D., Kellendonk, C., Simpson, E. H., Lipatova, O., Drew, M. R., Fairhurst, S.,. Balsam, P. D. (2009). Impaired timing precision produced by striatal D2 receptor overexpression is mediated by cognitive and motivational deficits. Behavioral Neuroscience, 123, 720-730. http://dx.doi.org/10.1037/a0016503.
62. Ward, R. D., Simpson, E. H., Richards, V. L., Deo, G., Taylor, K., Glendinning, J. I.,. Balsam, P. D. (2012). Dissociation of hedonic reaction to reward and incentive motivation in an animal model of the negative symptoms of schizophrenia. Neuropsychopharmacology, 37, 1699-1707. http://dx.doi.org/10.1038/npp.2012.15.
63. Ward, R. D., Winiger, J., Higa, K. K., Kahn, B., Kandel, E. R., Balsam, P. D., & Simpson, E. H. (in press). The impact of motivation on cognitive performance in an animal model of the negative and cognitive symptoms of schizophrenia. Behavioral Neuroscience.
64. Wearden, J. H., & Ferrara, A. (1995). Stimulus spacing effects in temporal bisection by humans. The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology, 48, 289-310.
65. Ziauddeen, H., & Murray, G. K. (2010). The relevance of reward pathways for schizophrenia. Current Opinion in Psychiatry, 23, 91-96. http://dx.doi.org/10.1097/YCO.0b013e328336661b.