M1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs

Nature Structural and Molecular Biology

Volumn 23, Issue 9, 2016, Pages 803-810

  Zhou, Huiqing ^a   Kimsey, Isaac J ^a   Nikolova, Evgenia N ^b   Sathyamoorthy, Bharathwaj ^a,g   Grazioli, Gianmarc ^c   McSally, James ^c   Bai, Tianyu ^a   Wunderlich, Christoph H ^d   Kreutz, Christoph ^e   Andricioaei, Ioan ^c   Al Hashimi, Hashim M ^a,f  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Bachem Holding AG   (Switzerland)

^e UNIVERSITY OF INNSBRUCK   (Austria)

^f DUKE UNIVERSITY   (United States)

^g INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH BHOPAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

A RNA; DEOXYGUANOSINE; DNA B; DOUBLE STRANDED DNA; N 1 METHYLDEOXYADENOSINE; N 1 METHYLDEOXYGUANOSINE; RNA; UNCLASSIFIED DRUG; ADENOSINE; DOUBLE STRANDED RNA; GUANOSINE;

ARTICLE; BASE PAIRING; CHEMICAL MODIFICATION; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DNA HELIX; GENE DISRUPTION; GENOMIC INSTABILITY; HYDROGEN BOND; INTRON; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RNA PROCESSING; RNA STRUCTURE; TETRAHYMENA THERMOPHILA; CHEMISTRY; INVERTED REPEAT; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; RNA STABILITY;

ADENOSINE; BASE PAIRING; BASE SEQUENCE; GUANOSINE; HYDROGEN BONDING; INVERTED REPEAT SEQUENCES; MODELS, MOLECULAR; RNA; RNA STABILITY; RNA, DOUBLE-STRANDED;

EID: 84980347770     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.3270     Document Type: Article

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