A methylation-switchable conformational probe for the sensitive and selective detection of RNA demethylase activity

Chemical Communications

Volumn 52, Issue 36, 2016, Pages 6181-6184

  Yang, Tianming ^a   Cheong, Adeline ^a   Mai, Xiangrui ^a   Zou, Shui ^a   Woon, Esther C Y ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROMETRY; METHYLATION; RNA PROBE; CHEMISTRY; CIRCULAR DICHROISM; CONFORMATION; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; TRANSITION TEMPERATURE;

ALKB PROTEIN; DOUBLE STRANDED RNA; RNA;

ALKB ENZYMES; BASE SEQUENCE; CIRCULAR DICHROISM; FLUOROMETRY; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; NUCLEIC ACID CONFORMATION; RNA; RNA, DOUBLE-STRANDED; TRANSITION TEMPERATURE;

EID: 84967046594     PISSN: 13597345     EISSN: 1364548X     Source Type: Journal    
DOI: 10.1039/c6cc01045h     Document Type: Article

References (35)

1. Y. Fu D. Dominissini G. Rechavi C. He Nat. Rev. Genet. 2014 15 293
2. K. D. Meyer S. R. Jaffrey Nat. Rev. Mol. Cell Biol. 2014 15 313
3. H. Grosjean, Fine-Tuning of RNA Functions by Modification and Editing, Springer, Heidelberg, 2005
4. B. S. Zhao C. He Genome Biol. 2015 16 43
5. S. C. Wu Y. Zhang Nat. Rev. Mol. Cell Biol. 2010 11 607
6. H. Grosjean, DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution, CRC Press, 2009
7. J. A. Law S. E. Jacobsen Nat. Rev. Genet. 2010 11 204
8. Y. Motorin M. Helm RNA 2011 2 611
9. C. J. Schofield and R. P. Hausinger, 2-Oxoglutarate-Dependent Oxygenases, Royal Society of Chemistry, 2015
10. F. Lyko R. Brown J. Natl. Cancer Inst. 2005 97 1498
11. J. Fischer L. Koch C. Emmerling J. Vierkotten T. Peters J. C. Bruning U. Ruther Nature 2009 458 894
12. M. Camp B. F. Eichman Mol. Cell 2011 44 343
13. B. Sedgwick Nat. Rev. Mol. Cell Biol. 2004 5 148
14. B. I. Fedeles V. Singh J. C. Delaney D. Li J. M. Essigmann J. Biol. Chem. 2015 290 20734
15. T. W. Roy A. S. Bhagwat Nucleic Acids Res. 2007 35 147
16. G. Jia C. He et al. Nat. Chem. Biol. 2011 7 885
17. J. D. W. Toh Y. G. Gao E. C. Y. Woon et al. Chem. Sci. 2015 6 112
18. M. Ma H. P. Harding S. O'Rahilly D. Ron G. S. Yeo Biochem. J. 2012 444 183
19. B. Chen C. G. Yang et al. J. Am. Chem. Soc. 2012 134 17963
20. S. C. Trewick T. F. Henshaw R. P. Hausinger T. Lindahl B. Sedgwick Nature 2002 419 174
21. D. H. Lee T. R. O'Connor et al. J. Biol. Chem. 2005 280 39448
22. J. C. Delaney et al. Nat. Struct. Mol. Biol. 2005 12 855
23. E. C. Y. Woon et al. J. Med. Chem. 2012 55 2173
24. M. Behe G. Felsenfeld Proc. Natl. Acad. Sci. U. S. A. 1981 78 1619
25. R. Micura W. Pils C. Höbartner K. Grubmayr M. O. Ebert B. Jaun Nucleic Acids Res. 2001 29 3997
26. C. Roost S. R. Lynch P. J. Batista K. Qu H. Y. Chang E. T. Kool J. Am. Chem. Soc. 2015 137 2107
27. J. D. Engel P. H. von Hippel J. Biol. Chem. 1978 253 927
28. F. H. Niesen et al. Nat. Protoc. 2007 2 2212
29. C. M. Rodriguez Lopez B. Guzman Asenjo A. J. Lloyd M. J. Wilkinson Anal. Chem. 2010 82 9100
30. S. H. Chou P. Flynn B. Reid Biochemistry 1989 28 2422
31. E. N. Nikolova E. Kim A. A. Wise P. J. O'Brien I. Andricioaei H. M. Al-Hashimi Nature 2011 470 498
32. L. Lu C. Yi X. Jian G. Zheng C. He Nucleic Acids Res. 2010 38 4415
33. H. Yang Y. Zhan D. Fenn L. M. Chi S. L. Lam FEBS Lett. 2008 582 1629
34. J. D. Engel Biochem. Biophys. Res. Commun. 1975 64 581
35. N. R. Rose E. C. Y. Woon et al. J. Med. Chem. 2012 55 6639