Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice

Nature Medicine

Volumn 22, Issue 9, 2016, Pages 1023-1032

  Lee, Jaemin ^a   Liu, Junli ^a   Feng, Xudong ^a   Hernández, Mario Andrés Salazar ^a   Mucka, Patrick ^a   Ibi, Dorina ^a   Choi, Jae Won ^a   Ozcan, Umut ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELASTROL; LEPTIN; WITHAFERIN A; GLUCOSE BLOOD LEVEL; STAT3 PROTEIN; STAT3 PROTEIN, MOUSE; TRIPTERINE; TRITERPENE; WITHANOLIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET INDUCED OBESITY; DRUG IDENTIFICATION; DRUG POTENCY; EMBRYO; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; GENE EXPRESSION PROFILING; GLUCOSE METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LIPID DIET; LIVER; METABOLISM; MOUSE MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; FATTY LIVER; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSE TOLERANCE TEST; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LEPTIN; LIVER; MICE; MICE, OBESE; OBESITY; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRITERPENES; WITHANOLIDES;

EID: 84980324243     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4145     Document Type: Article

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