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Volumn 21, Issue 8, 2016, Pages 1284-1290

Treatment of insulin resistance: straight from the gut

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

EID: 84979665351     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2016.06.016     Document Type: Review
Times cited : (12)

References (71)
  • 1
    • 33751161267 scopus 로고    scopus 로고
    • The adipocyte-myocyte axis in insulin resistance
    • Sell, H., et al. The adipocyte-myocyte axis in insulin resistance. Trends Endocrinol. Metab. 17 (2006), 416–422.
    • (2006) Trends Endocrinol. Metab. , vol.17 , pp. 416-422
    • Sell, H.1
  • 2
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • Perry, R.J., et al. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510 (2014), 84–91.
    • (2014) Nature , vol.510 , pp. 84-91
    • Perry, R.J.1
  • 3
    • 84887347937 scopus 로고    scopus 로고
    • Cooperation between brain and islet in glucose homeostasis and diabetes
    • Schwartz, M.W., et al. Cooperation between brain and islet in glucose homeostasis and diabetes. Nature 503 (2013), 59–66.
    • (2013) Nature , vol.503 , pp. 59-66
    • Schwartz, M.W.1
  • 4
    • 33747618036 scopus 로고    scopus 로고
    • Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
    • Dumas, M.E., et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 12511–12516.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 12511-12516
    • Dumas, M.E.1
  • 5
    • 84874045511 scopus 로고    scopus 로고
    • The origins and drivers of insulin resistance
    • Johnson, A.M., Olefsky, J.M., The origins and drivers of insulin resistance. Cell 152 (2013), 673–684.
    • (2013) Cell , vol.152 , pp. 673-684
    • Johnson, A.M.1    Olefsky, J.M.2
  • 6
    • 84892814749 scopus 로고    scopus 로고
    • Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits
    • De Vadder, F., et al. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 156 (2014), 84–96.
    • (2014) Cell , vol.156 , pp. 84-96
    • De Vadder, F.1
  • 7
    • 84875879626 scopus 로고    scopus 로고
    • The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders
    • Silvestri, C., Di Marzo, V., The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders. Cell Metab. 17 (2013), 475–490.
    • (2013) Cell Metab. , vol.17 , pp. 475-490
    • Silvestri, C.1    Di Marzo, V.2
  • 8
    • 84931397732 scopus 로고    scopus 로고
    • Gut serotonin is a regulator of obesity and metabolism
    • Young, R.L., et al. Gut serotonin is a regulator of obesity and metabolism. Gastroenterology 149 (2015), 253–255.
    • (2015) Gastroenterology , vol.149 , pp. 253-255
    • Young, R.L.1
  • 9
    • 84904742368 scopus 로고    scopus 로고
    • Beyond intestinal soap-bile acids in metabolic control
    • Kuipers, F., et al. Beyond intestinal soap-bile acids in metabolic control. Nat. Rev. Endocrinol. 10 (2014), 488–498.
    • (2014) Nat. Rev. Endocrinol. , vol.10 , pp. 488-498
    • Kuipers, F.1
  • 10
    • 84940721356 scopus 로고    scopus 로고
    • Glucoregulatory relevance of small intestinal nutrient sensing in physiology, bariatric surgery, and pharmacology
    • Duca, F.A., et al. Glucoregulatory relevance of small intestinal nutrient sensing in physiology, bariatric surgery, and pharmacology. Cell Metab. 22 (2015), 367–380.
    • (2015) Cell Metab. , vol.22 , pp. 367-380
    • Duca, F.A.1
  • 11
    • 84891852494 scopus 로고    scopus 로고
    • Jejunal leptin-PI3K signaling lowers glucose production
    • Rasmussen, B.A., et al. Jejunal leptin-PI3K signaling lowers glucose production. Cell Metab. 19 (2014), 155–161.
    • (2014) Cell Metab. , vol.19 , pp. 155-161
    • Rasmussen, B.A.1
  • 12
    • 84898051705 scopus 로고    scopus 로고
    • FXR is a molecular target for the effects of vertical sleeve gastrectomy
    • Ryan, K.K., et al. FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature 509 (2014), 183–188.
    • (2014) Nature , vol.509 , pp. 183-188
    • Ryan, K.K.1
  • 13
    • 84929177057 scopus 로고    scopus 로고
    • Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats
    • Duca, F.A., et al. Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat. Med. 21 (2015), 506–511.
    • (2015) Nat. Med. , vol.21 , pp. 506-511
    • Duca, F.A.1
  • 14
    • 84929149035 scopus 로고    scopus 로고
    • Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network
    • Cote, C.D., et al. Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. Nat. Med. 21 (2015), 498–505.
    • (2015) Nat. Med. , vol.21 , pp. 498-505
    • Cote, C.D.1
  • 15
    • 84862017831 scopus 로고    scopus 로고
    • Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes
    • Breen, D.M., et al. Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes. Nat. Med. 18 (2012), 950–955.
    • (2012) Nat. Med. , vol.18 , pp. 950-955
    • Breen, D.M.1
  • 16
    • 84887960056 scopus 로고    scopus 로고
    • Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
    • Li, F., et al. Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat. Commun., 4, 2013, 2384.
    • (2013) Nat. Commun. , vol.4 , pp. 2384
    • Li, F.1
  • 17
    • 84949932843 scopus 로고    scopus 로고
    • Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
    • Jiang, C., et al. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat. Commun., 6, 2015, 10166.
    • (2015) Nat. Commun. , vol.6 , pp. 10166
    • Jiang, C.1
  • 18
    • 84928402947 scopus 로고    scopus 로고
    • Regulation of obesity-related insulin resistance with gut anti-inflammatory agents
    • Luck, H., et al. Regulation of obesity-related insulin resistance with gut anti-inflammatory agents. Cell Metab. 21 (2015), 527–542.
    • (2015) Cell Metab. , vol.21 , pp. 527-542
    • Luck, H.1
  • 19
    • 84944682179 scopus 로고    scopus 로고
    • Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine
    • Haghikia, A., et al. Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine. Immunity 43 (2015), 817–829.
    • (2015) Immunity , vol.43 , pp. 817-829
    • Haghikia, A.1
  • 20
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia, J., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482 (2012), 179–185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1
  • 21
    • 84879369738 scopus 로고    scopus 로고
    • Commensal bacteria at the interface of host metabolism and the immune system
    • Brestoff, J.R., Artis, D., Commensal bacteria at the interface of host metabolism and the immune system. Nat. Immunol. 14 (2013), 676–684.
    • (2013) Nat. Immunol. , vol.14 , pp. 676-684
    • Brestoff, J.R.1    Artis, D.2
  • 22
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • e917
    • Vrieze, A., et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143 (2012), 913–916 e917.
    • (2012) Gastroenterology , vol.143 , pp. 913-916
    • Vrieze, A.1
  • 23
    • 79953647671 scopus 로고    scopus 로고
    • The gut microbiome as therapeutic target
    • Cani, P.D., Delzenne, N.M., The gut microbiome as therapeutic target. Pharmacol. Ther. 130 (2011), 202–212.
    • (2011) Pharmacol. Ther. , vol.130 , pp. 202-212
    • Cani, P.D.1    Delzenne, N.M.2
  • 24
    • 84878709716 scopus 로고    scopus 로고
    • Gut metagenome in European women with normal, impaired and diabetic glucose control
    • Karlsson, F.H., et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498 (2013), 99–103.
    • (2013) Nature , vol.498 , pp. 99-103
    • Karlsson, F.H.1
  • 25
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin, J., et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490 (2012), 55–60.
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1
  • 26
    • 84908325271 scopus 로고    scopus 로고
    • Artificial sweeteners induce glucose intolerance by altering the gut microbiota
    • Suez, J., et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 514 (2014), 181–186.
    • (2014) Nature , vol.514 , pp. 181-186
    • Suez, J.1
  • 27
    • 84924301510 scopus 로고    scopus 로고
    • Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
    • Chassaing, B., et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519 (2015), 92–96.
    • (2015) Nature , vol.519 , pp. 92-96
    • Chassaing, B.1
  • 28
    • 84923545804 scopus 로고    scopus 로고
    • Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula
    • Xu, J., et al. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula. ISME J. 9 (2015), 552–562.
    • (2015) ISME J. , vol.9 , pp. 552-562
    • Xu, J.1
  • 29
    • 84897960120 scopus 로고    scopus 로고
    • An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    • Shin, N.R., et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut 63 (2014), 727–735.
    • (2014) Gut , vol.63 , pp. 727-735
    • Shin, N.R.1
  • 30
    • 84932640924 scopus 로고    scopus 로고
    • Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
    • Chang, C.J., et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat. Commun., 6, 2015, 7489.
    • (2015) Nat. Commun. , vol.6 , pp. 7489
    • Chang, C.J.1
  • 31
    • 84910131419 scopus 로고    scopus 로고
    • Microbial modulation of insulin sensitivity
    • Khan, M.T., et al. Microbial modulation of insulin sensitivity. Cell Metab. 20 (2014), 753–760.
    • (2014) Cell Metab. , vol.20 , pp. 753-760
    • Khan, M.T.1
  • 32
    • 84941879755 scopus 로고    scopus 로고
    • Short-chain fatty acids in control of body weight and insulin sensitivity
    • Canfora, E.E., et al. Short-chain fatty acids in control of body weight and insulin sensitivity. Nat. Rev. Endocrinol. 11 (2015), 577–591.
    • (2015) Nat. Rev. Endocrinol. , vol.11 , pp. 577-591
    • Canfora, E.E.1
  • 33
    • 84910133100 scopus 로고    scopus 로고
    • Specialized metabolites from the microbiome in health and disease
    • Sharon, G., et al. Specialized metabolites from the microbiome in health and disease. Cell Metab. 20 (2014), 719–730.
    • (2014) Cell Metab. , vol.20 , pp. 719-730
    • Sharon, G.1
  • 34
    • 84947610783 scopus 로고    scopus 로고
    • Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders
    • Fiorucci, S., Distrutti, E., Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders. Trends Mol. Med. 21 (2015), 702–714.
    • (2015) Trends Mol. Med. , vol.21 , pp. 702-714
    • Fiorucci, S.1    Distrutti, E.2
  • 35
    • 84924070363 scopus 로고    scopus 로고
    • Gut chemosensing mechanisms
    • Psichas, A., et al. Gut chemosensing mechanisms. J. Clin. Invest. 125 (2015), 908–917.
    • (2015) J. Clin. Invest. , vol.125 , pp. 908-917
    • Psichas, A.1
  • 36
    • 84925507991 scopus 로고    scopus 로고
    • Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
    • Fang, S., et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat. Med. 21 (2015), 159–165.
    • (2015) Nat. Med. , vol.21 , pp. 159-165
    • Fang, S.1
  • 37
    • 84923261268 scopus 로고    scopus 로고
    • Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status
    • Everard, A., et al. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. Nat. Commun., 5, 2014, 5648.
    • (2014) Nat. Commun. , vol.5 , pp. 5648
    • Everard, A.1
  • 38
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper, L.V., et al. Interactions between the microbiota and the immune system. Science 336 (2012), 1268–1273.
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1
  • 39
    • 84927131694 scopus 로고    scopus 로고
    • Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
    • Yano, J.M., et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell 161 (2015), 264–276.
    • (2015) Cell , vol.161 , pp. 264-276
    • Yano, J.M.1
  • 40
    • 84871451681 scopus 로고    scopus 로고
    • Gut-derived serotonin is a multifunctional determinant to fasting adaptation
    • Sumara, G., et al. Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab. 16 (2012), 588–600.
    • (2012) Cell Metab. , vol.16 , pp. 588-600
    • Sumara, G.1
  • 41
    • 84923212941 scopus 로고    scopus 로고
    • Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis
    • Crane, J.D., et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat. Med. 21 (2015), 166–172.
    • (2015) Nat. Med. , vol.21 , pp. 166-172
    • Crane, J.D.1
  • 42
    • 85011423348 scopus 로고    scopus 로고
    • Apelin targets gut contraction to control glucose metabolism via the brain
    • Fournel, A., et al. Apelin targets gut contraction to control glucose metabolism via the brain. Gut, 2015, 10.1136/gutjnl-2015-310230.
    • (2015) Gut
    • Fournel, A.1
  • 43
    • 84937675715 scopus 로고    scopus 로고
    • Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
    • Flynn, C.R., et al. Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery. Nat. Commun., 6, 2015, 7715.
    • (2015) Nat. Commun. , vol.6 , pp. 7715
    • Flynn, C.R.1
  • 44
    • 84929429661 scopus 로고    scopus 로고
    • Rapid and body weight-independent improvement of endothelial and high-density lipoprotein function after Roux-en-Y gastric bypass: role of glucagon-like peptide-1
    • Osto, E., et al. Rapid and body weight-independent improvement of endothelial and high-density lipoprotein function after Roux-en-Y gastric bypass: role of glucagon-like peptide-1. Circulation 131 (2015), 871–881.
    • (2015) Circulation , vol.131 , pp. 871-881
    • Osto, E.1
  • 45
    • 84876139394 scopus 로고    scopus 로고
    • Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity
    • Liou, A.P., et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci. Transl. Med., 5, 2013, 178ra141.
    • (2013) Sci. Transl. Med. , vol.5 , pp. 178ra141
    • Liou, A.P.1
  • 46
    • 84938559816 scopus 로고    scopus 로고
    • Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation
    • Tremaroli, V., et al. Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation. Cell Metab. 22 (2015), 228–238.
    • (2015) Cell Metab. , vol.22 , pp. 228-238
    • Tremaroli, V.1
  • 47
    • 84926318323 scopus 로고    scopus 로고
    • Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients
    • Magalhaes, I., et al. Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients. J. Clin. Invest. 125 (2015), 1752–1762.
    • (2015) J. Clin. Invest. , vol.125 , pp. 1752-1762
    • Magalhaes, I.1
  • 48
    • 84927694747 scopus 로고    scopus 로고
    • Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice
    • Wang, J., et al. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J. 9 (2015), 1–15.
    • (2015) ISME J. , vol.9 , pp. 1-15
    • Wang, J.1
  • 49
    • 84964696945 scopus 로고    scopus 로고
    • Dietary polyphenols promote growth of the gut bacterium Akkermansia muciniphila and attenuate high-fat diet-induced metabolic syndrome
    • Roopchand, D.E., et al. Dietary polyphenols promote growth of the gut bacterium Akkermansia muciniphila and attenuate high-fat diet-induced metabolic syndrome. Diabetes 64 (2015), 2847–2858.
    • (2015) Diabetes , vol.64 , pp. 2847-2858
    • Roopchand, D.E.1
  • 50
    • 84894331103 scopus 로고    scopus 로고
    • Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics
    • Geurts, L., et al. Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics. Benef. Microbes 5 (2014), 3–17.
    • (2014) Benef. Microbes , vol.5 , pp. 3-17
    • Geurts, L.1
  • 51
    • 84873453907 scopus 로고    scopus 로고
    • Gut microbiota in 2012: toward understanding and manipulating the gut microbiota
    • Aitken, J.D., Gewirtz, A.T., Gut microbiota in 2012: toward understanding and manipulating the gut microbiota. Nat. Rev. Gastroenterol. Hepatol. 10 (2013), 72–74.
    • (2013) Nat. Rev. Gastroenterol. Hepatol. , vol.10 , pp. 72-74
    • Aitken, J.D.1    Gewirtz, A.T.2
  • 52
    • 84938989766 scopus 로고    scopus 로고
    • Dietary modulation of the gut microbiota-a randomised controlled trial in obese postmenopausal women
    • Brahe, L.K., et al. Dietary modulation of the gut microbiota-a randomised controlled trial in obese postmenopausal women. Br. J. Nutr. 114 (2015), 406–417.
    • (2015) Br. J. Nutr. , vol.114 , pp. 406-417
    • Brahe, L.K.1
  • 53
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
    • Sayin, S.I., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 17 (2013), 225–235.
    • (2013) Cell Metab. , vol.17 , pp. 225-235
    • Sayin, S.I.1
  • 54
    • 85041189038 scopus 로고    scopus 로고
    • Diabetes: a closer look at the mechanisms of action of colesevelam in humans
    • Osorio, J., Diabetes: a closer look at the mechanisms of action of colesevelam in humans. Nat. Rev. Endocrinol., 8, 2012, 128.
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 128
    • Osorio, J.1
  • 55
    • 84958116472 scopus 로고    scopus 로고
    • Endocannabinoids – at the crossroads between the gut microbiota and host metabolism
    • Cani, P.D., et al. Endocannabinoids – at the crossroads between the gut microbiota and host metabolism. Nat. Rev. Endocrinol. 12 (2016), 133–143.
    • (2016) Nat. Rev. Endocrinol. , vol.12 , pp. 133-143
    • Cani, P.D.1
  • 56
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • Everard, A., et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 9066–9071.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 9066-9071
    • Everard, A.1
  • 57
    • 84908311821 scopus 로고    scopus 로고
    • Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
    • Wang, X., et al. Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes. Nature 514 (2014), 237–241.
    • (2014) Nature , vol.514 , pp. 237-241
    • Wang, X.1
  • 58
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker, D.J., Nauck, M.A., The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368 (2006), 1696–1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 59
    • 84927645989 scopus 로고    scopus 로고
    • Fibroblast growth factor 19-targeted therapies for the treatment of metabolic disease
    • Rysz, J., et al. Fibroblast growth factor 19-targeted therapies for the treatment of metabolic disease. Expert Opin. Investig. Drugs 24 (2015), 603–610.
    • (2015) Expert Opin. Investig. Drugs , vol.24 , pp. 603-610
    • Rysz, J.1
  • 60
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • e571
    • Mudaliar, S., et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 145 (2013), 574–582 e571.
    • (2013) Gastroenterology , vol.145 , pp. 574-582
    • Mudaliar, S.1
  • 61
    • 56349143943 scopus 로고    scopus 로고
    • N-acylphosphatidylethanolamine, a gut-derived circulating factor induced by fat ingestion, inhibits food intake
    • Gillum, M.P., et al. N-acylphosphatidylethanolamine, a gut-derived circulating factor induced by fat ingestion, inhibits food intake. Cell 135 (2008), 813–824.
    • (2008) Cell , vol.135 , pp. 813-824
    • Gillum, M.P.1
  • 62
    • 84905495117 scopus 로고    scopus 로고
    • Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity
    • Chen, Z., et al. Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity. J. Clin. Invest. 124 (2014), 3391–3406.
    • (2014) J. Clin. Invest. , vol.124 , pp. 3391-3406
    • Chen, Z.1
  • 63
    • 84898809667 scopus 로고    scopus 로고
    • Insights into drug discovery from natural medicines using reverse pharmacokinetics
    • Hao, H., et al. Insights into drug discovery from natural medicines using reverse pharmacokinetics. Trends Pharmacol. Sci. 35 (2014), 168–177.
    • (2014) Trends Pharmacol. Sci. , vol.35 , pp. 168-177
    • Hao, H.1
  • 64
    • 84952762385 scopus 로고    scopus 로고
    • Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?
    • Chen, F., et al. Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?. J. Ethnopharmacol. 179 (2016), 253–264.
    • (2016) J. Ethnopharmacol. , vol.179 , pp. 253-264
    • Chen, F.1
  • 65
    • 84926022212 scopus 로고    scopus 로고
    • Obesity and diabetes: FXR and JAK step up to BAT
    • Cully, M., Obesity and diabetes: FXR and JAK step up to BAT. Nat. Rev. Drug Discov., 14, 2015, 91.
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 91
    • Cully, M.1
  • 66
    • 84901849274 scopus 로고    scopus 로고
    • Combating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes
    • Scheen, A.J., Van Gaal, L.F., Combating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes. Lancet Diabetes Endocrinol. 2 (2014), 911–922.
    • (2014) Lancet Diabetes Endocrinol. , vol.2 , pp. 911-922
    • Scheen, A.J.1    Van Gaal, L.F.2
  • 67
    • 84949255269 scopus 로고    scopus 로고
    • Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling
    • Levy, M., et al. Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling. Cell 163 (2015), 1428–1443.
    • (2015) Cell , vol.163 , pp. 1428-1443
    • Levy, M.1
  • 68
    • 84872112919 scopus 로고    scopus 로고
    • Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity
    • Murphy, E.F., et al. Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity. Gut 62 (2013), 220–226.
    • (2013) Gut , vol.62 , pp. 220-226
    • Murphy, E.F.1
  • 69
    • 84949553094 scopus 로고    scopus 로고
    • Linking microbiota to human diseases: a systems biology perspective
    • Wu, H., et al. Linking microbiota to human diseases: a systems biology perspective. Trends Endocrinol. Metab. 26 (2015), 758–770.
    • (2015) Trends Endocrinol. Metab. , vol.26 , pp. 758-770
    • Wu, H.1
  • 70
    • 84924350477 scopus 로고    scopus 로고
    • Drugging the gut microbiome
    • Garber, K., Drugging the gut microbiome. Nat. Biotechnol. 33 (2015), 228–231.
    • (2015) Nat. Biotechnol. , vol.33 , pp. 228-231
    • Garber, K.1
  • 71
    • 79957880120 scopus 로고    scopus 로고
    • From probiotics to therapeutics: another step forward?
    • Ghishan, F.K., Kiela, P.R., From probiotics to therapeutics: another step forward?. J. Clin. Invest. 121 (2011), 2149–2152.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2149-2152
    • Ghishan, F.K.1    Kiela, P.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.