Apelin targets gut contraction to control glucose metabolism via the brain

Gut

Volumn 66, Issue 2, 2017, Pages 258-269

  Fournel, Audren ^a,b   Drougard, Anne ^a,b   Duparc, Thibaut ^a,c   Marlin, Alysson ^a,b   Brierley, Stuart M ^d,e,f   Castro, Joel ^d   Le Gonidec, Sophie ^a,b   Masri, Bernard ^g   Colom, André ^a,b   Lucas, Alexandre ^a,b   Rousset, Perrine ^b,h   Cenac, Nicolas ^b,h   Vergnolle, Nathalie ^b,h   Valet, Philippe ^a,b   Cani, Patrice D ^a,c   Knauf, Claude ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d UNIVERSITY OF ADELAIDE   (Australia)

^e ROYAL ADELAIDE HOSPITAL   (Australia)

^f UNIVERSITY OF ADELAIDE   (Australia)

^g CHU RANGUEIL   (France)

^h CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; APELIN RECEPTOR; GLUCOSE; NITRIC OXIDE; ADIPOCYTOKINE; APLN PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GLUCOSE MONITORING; BRAIN; CONTROLLED STUDY; DUODENUM MOTILITY; GLUCOSE ABSORPTION; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; INTESTINE CONTRACTION; INTESTINE INNERVATION; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; NUTRITIONAL STATUS; OB/OB MOUSE; PEPTIDE ANALYSIS; PROTEIN FUNCTION; TELEMETRY; TRANSCYTOSIS; ANIMAL; C57BL MOUSE; DIABETES MELLITUS; DRUG EFFECTS; DUODENUM; GASTROINTESTINAL MOTILITY; GENETIC PROCEDURES; HOMEOSTASIS; METABOLISM; MUSCLE CONTRACTION; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; SMOOTH MUSCLE;

ADIPOKINES; ANIMALS; BIOSENSING TECHNIQUES; DIABETES MELLITUS; DUODENUM; ENTERIC NERVOUS SYSTEM; GASTROINTESTINAL MOTILITY; GLUCOSE; HOMEOSTASIS; HYPOTHALAMUS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NITRIC OXIDE; OBESITY; TELEMETRY;

EID: 85011423348     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2015-310230     Document Type: Article

References (33)

1. Blouet C, Schwartz GJ. Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats. PLoS ONE 2012;7:e51898.
2. Knauf C, Cani PD, Kim DH, et al. Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing. Diabetes 2008;57:2603-12.
3. Clapham JC. Central control of thermogenesis. Neuropharmacology 2012;63:111-23.
4. Coll AP, Yeo GS. The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis. Curr Opin Pharmacol 2013;13:970-6.
5. Breen DM, Rasmussen BA, Cote CD, et al. Nutrient-sensing mechanisms in the gut as therapeutic targets for diabetes. Diabetes 2013;62:3005-13.
6. Duparc T, Naslain D, Colom A, et al. Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus. Antioxid Redox Signal 2011;14:415-23.
7. Rasmussen BA, Breen DM, Duca FA, et al. Jejunal leptin-PI3K signaling lowers glucose production. Cell Metab 2014;19:155-61.
8. Castan-Laurell I, Dray C, Knauf C, et al. Apelin, a promising target for type 2 diabetes treatment Trends Endocrinol Metab 2012;23:234-41.
9. Duparc T, Colom A, Cani PD, et al. Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice. Antioxid Redox Signal 2011;15:1477-96.
10. Dray C, Knauf C, Daviaud D, et al. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab 2008;8:437-45.
11. Dray C, Sakar Y, Vinel C, et al. The intestinal glucose-apelin cycle controls carbohydrate absorption in mice. Gastroenterology 2013;144:771-80.
12. Chandrasekharan B, Srinivasan S. Diabetes and the enteric nervous system. Neurogastroenterol Motil 2007;19:951-60.
13. Reichardt F, Krueger D, Schemann M. Leptin excites enteric neurons of guinea-pig submucous and myenteric plexus. Neurogastroenterol Motil 2011;23:e165-70.
14. Bjerknes M, Cheng H. Modulation of specific intestinal epithelial progenitors by enteric neurons. Proc Natl Acad Sci USA 2001;98:12497-502.
15. Sababi M, Bengtsson UH. Enhanced intestinal motility influences absorption in anaesthetized rat. Acta Physiol Scand 2001;172:115-22.
16. Masri B, Salahpour A, Didriksen M, et al. Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics. Proc Natl Acad Sci USA 2008;105:13656-61.
17. Knauf C, Cani PD, Perrin C, et al. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest 2005;115:3554-63.
18. Cammisotto PG, Gingras D, Bendayan M. Transcytosis of gastric leptin through the rat duodenal mucosa. Am J Physiol Gastrointest Liver Physiol 2007;293: G773-9.
19. Zizzo MG, Mule F, Serio R. Duodenal contractile activity in dystrophic (mdx) mice: reduction of nitric oxide influence. Neurogastroenterol Motil 2003;15:559-65.
20. Zizzo MG, Mule F, Serio R. Inhibitory responses to exogenous adenosine in murine proximal and distal colon. Br J Pharmacol 2006;148:956-63.
21. Postorino A, Mancinelli R, Racanicchi C, et al. Spontaneous electromechanical activity in the rat duodenum in vitro. Arch Int Physiol Biochim 1990;98:35-40.
22. Riesenfeld G, Sklan D, Bar A, et al. Glucose absorption and starch digestion in the intestine of the chicken. J Nutr 1980;110:117-21.
23. Camacho RC, Denny JC, Pencek RR, et al. Portal venous hyperinsulinemia does not stimulate gut glucose absorption in the conscious dog. Metabolism 2004;53:1290-5.
24. Kim HR, Park SW, Cho HJ, et al. Comparative gene expression profiles of intestinal transporters in mice, rats and humans. Pharmacol Res 2007;56:224-36.
25. Lohrenz AK, Duske K, Schonhusen U, et al. Glucose transporters and enzymes related to glucose synthesis in small intestinal mucosa of mid-lactation dairy cows fed 2 levels of starch. J Dairy Sci 2011;94:4546-55.
26. Pfannkuche H, Gabel G. Glucose, epithelium, and enteric nervous system: dialogue in the dark. J Anim Physiol Anim Nutr (Berl) 2009;93:277-86.
27. Shirazi-Beechey SP, Moran AW, Batchelor DJ, et al. Glucose sensing and signalling; regulation of intestinal glucose transport. Proc Nutr Soc 2011;70:185-93.
28. Cabou C, Cani PD, Campistron G, et al. Central insulin regulates heart rate and arterial blood flow: an endothelial nitric oxide synthase-dependent mechanism altered during diabetes. Diabetes 2007;56:2872-7.
29. Drougard A, Duparc T, Brenachot X, et al. Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes. Antioxid Redox Signal 2014;20:557-73.
30. Clarke KJ, Whitaker KW, Reyes TM. Diminished metabolic responses to centrally-administered apelin-13 in diet-induced obese rats fed a high-fat diet. J Neuroendocrinol 2009;21:83-9.
31. Carrier GO, Aronstam RS. Increased muscarinic responsiveness and decreased muscarinic receptor content in ileal smooth muscle in diabetes. J Pharmacol Exp Ther 1990;254:445-9.
32. Everard A, Cani PD. Gut microbiota and GLP-1. Rev Endocr Metab Disord 2014;15:189-96.
33. Sandoval D, Dunki-Jacobs A, Sorrell J, et al. Impact of intestinal electrical stimulation on nutrient-induced GLP-1 secretion in vivo. Neurogastroenterol Motil 2013;25:700-5.