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Volumn 35, Issue 4, 2014, Pages 168-177

Insights into drug discovery from natural medicines using reverse pharmacokinetics

Author keywords

gut microbiota; multiple component and multiple target drugs; remote target; target identification; translational medicine

Indexed keywords

NATURAL PRODUCT;

EID: 84898809667     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2014.02.001     Document Type: Review
Times cited : (84)

References (86)
  • 1
    • 33847381100 scopus 로고    scopus 로고
    • A decade of fragment-based drug design: Strategic advances and lessons learned
    • P.J. Hajduk, and J. Greer A decade of fragment-based drug design: strategic advances and lessons learned Nat. Rev. Drug Discov. 6 2007 211 219
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 211-219
    • Hajduk, P.J.1    Greer, J.2
  • 2
    • 67650436176 scopus 로고    scopus 로고
    • Drug discovery and natural products: End of an era or an endless frontier?
    • J.W. Li, and J.C. Vederas Drug discovery and natural products: end of an era or an endless frontier? Science 325 2009 161 165
    • (2009) Science , vol.325 , pp. 161-165
    • Li, J.W.1    Vederas, J.C.2
  • 3
    • 52049109838 scopus 로고    scopus 로고
    • Natural products in drug discovery
    • A.L. Harvey Natural products in drug discovery Drug Discov. Today 13 2008 894 901
    • (2008) Drug Discov. Today , vol.13 , pp. 894-901
    • Harvey, A.L.1
  • 4
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
    • D.J. Newman Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J. Med. Chem. 51 2008 2589 2599
    • (2008) J. Med. Chem. , vol.51 , pp. 2589-2599
    • Newman, D.J.1
  • 5
    • 14944383798 scopus 로고    scopus 로고
    • The evolving role of natural products in drug discovery
    • F.E. Koehn, and G.T. Carter The evolving role of natural products in drug discovery Nat. Rev. Drug Discov. 4 2005 206 220
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 206-220
    • Koehn, F.E.1    Carter, G.T.2
  • 6
    • 67651232559 scopus 로고    scopus 로고
    • Traditional medicine-inspired approaches to drug discovery: Can Ayurveda show the way forward?
    • B. Patwardhan, and R.A. Mashelkar Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug Discov. Today 14 2009 804 811
    • (2009) Drug Discov. Today , vol.14 , pp. 804-811
    • Patwardhan, B.1    Mashelkar, R.A.2
  • 7
    • 33744902836 scopus 로고    scopus 로고
    • Angiogenesis: From plants to blood vessels
    • T.P. Fan et al. Angiogenesis: from plants to blood vessels Trends Pharmacol. Sci. 27 2006 297 309
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 297-309
    • Fan, T.P.1
  • 8
    • 58849156821 scopus 로고    scopus 로고
    • Where is the hope for drug discovery? Let history tell the future
    • D.X. Kong et al. Where is the hope for drug discovery? Let history tell the future Drug Discov. Today 14 2009 115 119
    • (2009) Drug Discov. Today , vol.14 , pp. 115-119
    • Kong, D.X.1
  • 9
    • 34548279788 scopus 로고    scopus 로고
    • Molecular understanding and modern application of traditional medicines: Triumphs and trials
    • T.W. Corson, and C.M. Crews Molecular understanding and modern application of traditional medicines: triumphs and trials Cell 130 2007 769 774
    • (2007) Cell , vol.130 , pp. 769-774
    • Corson, T.W.1    Crews, C.M.2
  • 10
    • 34250702156 scopus 로고    scopus 로고
    • Revisiting the ancient concept of botanical therapeutics
    • B.M. Schmidt et al. Revisiting the ancient concept of botanical therapeutics Nat. Chem. Biol. 3 2007 360 366
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 360-366
    • Schmidt, B.M.1
  • 11
    • 59349120231 scopus 로고    scopus 로고
    • Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets
    • B.B. Aggarwal, and B. Sung Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets Trends Pharmacol. Sci. 30 2009 85 94
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 85-94
    • Aggarwal, B.B.1    Sung, B.2
  • 12
    • 84867869761 scopus 로고    scopus 로고
    • Target-based selection of flavonoids for neurodegenerative disorders
    • Q.R. Jones et al. Target-based selection of flavonoids for neurodegenerative disorders Trends Pharmacol. Sci. 33 2012 602 610
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 602-610
    • Jones, Q.R.1
  • 13
    • 45749089694 scopus 로고    scopus 로고
    • Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease
    • A.N. Begum et al. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease J. Pharmacol. Exp. Ther. 326 2008 196 208
    • (2008) J. Pharmacol. Exp. Ther. , vol.326 , pp. 196-208
    • Begum, A.N.1
  • 14
    • 84858072552 scopus 로고    scopus 로고
    • The pharmacology of curcumin: Is it the degradation products?
    • L. Shen, and H.F. Ji The pharmacology of curcumin: is it the degradation products? Trends Mol. Med. 18 2012 138 144
    • (2012) Trends Mol. Med. , vol.18 , pp. 138-144
    • Shen, L.1    Ji, H.F.2
  • 15
    • 40549135974 scopus 로고    scopus 로고
    • The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
    • T. Morimoto et al. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats J. Clin. Invest. 118 2008 868 878
    • (2008) J. Clin. Invest. , vol.118 , pp. 868-878
    • Morimoto, T.1
  • 16
    • 84860540855 scopus 로고    scopus 로고
    • Resveratrol in medicinal chemistry: A critical review of its pharmacokinetics, drug-delivery, and membrane interactions
    • A.R. Neves et al. Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions Curr. Med. Chem. 19 2012 1663 1681
    • (2012) Curr. Med. Chem. , vol.19 , pp. 1663-1681
    • Neves, A.R.1
  • 17
    • 84863011114 scopus 로고    scopus 로고
    • Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    • S.J. Park et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases Cell 148 2012 421 433
    • (2012) Cell , vol.148 , pp. 421-433
    • Park, S.J.1
  • 18
    • 84874974106 scopus 로고    scopus 로고
    • 21st century natural product research and drug development and traditional medicines
    • L.T. Ngo et al. 21st century natural product research and drug development and traditional medicines Nat. Prod. Rep. 30 2013 584 592
    • (2013) Nat. Prod. Rep. , vol.30 , pp. 584-592
    • Ngo, L.T.1
  • 19
    • 84861907787 scopus 로고    scopus 로고
    • Pharmacokinetics-pharmacology disconnection of herbal medicines and its potential solutions with cellular pharmacokinetic-pharmacodynamic strategy
    • J. Zhang et al. Pharmacokinetics-pharmacology disconnection of herbal medicines and its potential solutions with cellular pharmacokinetic- pharmacodynamic strategy Curr. Drug Metab. 13 2012 558 576
    • (2012) Curr. Drug Metab. , vol.13 , pp. 558-576
    • Zhang, J.1
  • 20
    • 67649407501 scopus 로고    scopus 로고
    • Curcumin in clinical practice: Myth or reality?
    • C. Mancuso, and E. Barone Curcumin in clinical practice: myth or reality? Trends Pharmacol. Sci. 30 2009 333 334
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 333-334
    • Mancuso, C.1    Barone, E.2
  • 21
    • 37549051274 scopus 로고    scopus 로고
    • Bioavailability of curcumin: Problems and promises
    • P. Anand et al. Bioavailability of curcumin: problems and promises Mol. Pharm. 4 2007 807 818
    • (2007) Mol. Pharm. , vol.4 , pp. 807-818
    • Anand, P.1
  • 22
    • 63149189848 scopus 로고    scopus 로고
    • Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG
    • A.K. Ghosh et al. Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG Clin. Cancer Res. 15 2009 1250 1258
    • (2009) Clin. Cancer Res. , vol.15 , pp. 1250-1258
    • Ghosh, A.K.1
  • 23
    • 38749109673 scopus 로고    scopus 로고
    • Curcumin as 'Curecumin': From kitchen to clinic
    • A. Goel et al. Curcumin as 'Curecumin': from kitchen to clinic Biochem. Pharmacol. 75 2008 787 809
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 787-809
    • Goel, A.1
  • 24
    • 83755183008 scopus 로고    scopus 로고
    • Curcumin inhibits interferon-gamma signaling in colonic epithelial cells
    • M.T. Midura-Kiela et al. Curcumin inhibits interferon-gamma signaling in colonic epithelial cells Am. J. Physiol. Gastrointest. Liver Physiol. 302 2012 G85 G96
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.302
    • Midura-Kiela, M.T.1
  • 25
    • 79955598016 scopus 로고    scopus 로고
    • Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism
    • A. Hassaninasab et al. Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism Proc. Natl. Acad. Sci. U.S.A. 108 2011 6615 6620
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 6615-6620
    • Hassaninasab, A.1
  • 26
    • 0036892994 scopus 로고    scopus 로고
    • Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice
    • K. Sugimoto et al. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice Gastroenterology 123 2002 1912 1922
    • (2002) Gastroenterology , vol.123 , pp. 1912-1922
    • Sugimoto, K.1
  • 27
    • 33845292957 scopus 로고    scopus 로고
    • Curcumin maintenance therapy for ulcerative colitis: Randomized, multicenter, double-blind, placebo-controlled trial
    • H. Hanai et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial Clin. Gastroenterol. Hepatol. 4 2006 1502 1506
    • (2006) Clin. Gastroenterol. Hepatol. , vol.4 , pp. 1502-1506
    • Hanai, H.1
  • 28
    • 79955804832 scopus 로고    scopus 로고
    • Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia
    • R.E. Carroll et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia Cancer Prev. Res. (Phila.) 4 2011 354 364
    • (2011) Cancer Prev. Res. (Phila.) , vol.4 , pp. 354-364
    • Carroll, R.E.1
  • 29
    • 67650333217 scopus 로고    scopus 로고
    • Principles and clinical implications of the brain-gut-enteric microbiota axis
    • S.H. Rhee et al. Principles and clinical implications of the brain-gut-enteric microbiota axis Nat. Rev. Gastroenterol. Hepatol. 6 2009 306 314
    • (2009) Nat. Rev. Gastroenterol. Hepatol. , vol.6 , pp. 306-314
    • Rhee, S.H.1
  • 30
    • 42549118500 scopus 로고    scopus 로고
    • Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production
    • P.Y. Wang et al. Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production Nature 452 2008 1012 1016
    • (2008) Nature , vol.452 , pp. 1012-1016
    • Wang, P.Y.1
  • 31
    • 84866546211 scopus 로고    scopus 로고
    • Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour
    • J.F. Cryan, and T.G. Dinan Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour Nat. Rev. Neurosci. 13 2012 701 712
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 701-712
    • Cryan, J.F.1    Dinan, T.G.2
  • 32
    • 84871454511 scopus 로고    scopus 로고
    • Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk
    • E. Holmes et al. Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk Cell Metab. 16 2012 559 564
    • (2012) Cell Metab. , vol.16 , pp. 559-564
    • Holmes, E.1
  • 33
    • 84861992769 scopus 로고    scopus 로고
    • Therapeutic modulation of microbiota-host metabolic interactions
    • E. Holmes et al. Therapeutic modulation of microbiota-host metabolic interactions Sci. Transl. Med. 4 2012 137rv136
    • (2012) Sci. Transl. Med. , vol.4
    • Holmes, E.1
  • 34
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: Multiple constituents and multiple actions
    • A.S. Attele et al. Ginseng pharmacology: multiple constituents and multiple actions Biochem. Pharmacol. 58 1999 1685 1693
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 1685-1693
    • Attele, A.S.1
  • 35
    • 84879699014 scopus 로고    scopus 로고
    • Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells
    • Y. Chen et al. Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells Blood 121 2013 3682 3691
    • (2013) Blood , vol.121 , pp. 3682-3691
    • Chen, Y.1
  • 36
    • 33846864682 scopus 로고    scopus 로고
    • Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation
    • H. Hao et al. Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation Curr. Drug Metab. 8 2007 137 149
    • (2007) Curr. Drug Metab. , vol.8 , pp. 137-149
    • Hao, H.1
  • 37
    • 84886945841 scopus 로고    scopus 로고
    • Towards a 'systems'-level understanding of the nervous system and its disorders
    • I.A. Qureshi, and M.F. Mehler Towards a 'systems'-level understanding of the nervous system and its disorders Trends Neurosci. 36 2013 674 684
    • (2013) Trends Neurosci. , vol.36 , pp. 674-684
    • Qureshi, I.A.1    Mehler, M.F.2
  • 38
    • 84877919797 scopus 로고    scopus 로고
    • Cancer cachexia: Malignant inflammation, tumorkines, and metabolic mayhem
    • M. Tsoli, and G. Robertson Cancer cachexia: malignant inflammation, tumorkines, and metabolic mayhem Trends Endocrinol. Metab. 24 2013 174 183
    • (2013) Trends Endocrinol. Metab. , vol.24 , pp. 174-183
    • Tsoli, M.1    Robertson, G.2
  • 39
    • 84863198809 scopus 로고    scopus 로고
    • Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus
    • B. Jiang et al. Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus Br. J. Pharmacol. 166 2012 1872 1887
    • (2012) Br. J. Pharmacol. , vol.166 , pp. 1872-1887
    • Jiang, B.1
  • 40
    • 84856229622 scopus 로고    scopus 로고
    • Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia
    • J. Zhu et al. Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia Neuroscience 202 2012 342 351
    • (2012) Neuroscience , vol.202 , pp. 342-351
    • Zhu, J.1
  • 41
    • 84862007373 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway
    • J. Wu et al. Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway Neuropharmacology 63 2012 349 361
    • (2012) Neuropharmacology , vol.63 , pp. 349-361
    • Wu, J.1
  • 42
    • 82355191863 scopus 로고    scopus 로고
    • Ginsenosides and their CNS targets
    • K. Radad et al. Ginsenosides and their CNS targets CNS Neurosci. Ther. 17 2011 761 768
    • (2011) CNS Neurosci. Ther. , vol.17 , pp. 761-768
    • Radad, K.1
  • 43
    • 84888089377 scopus 로고    scopus 로고
    • Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats
    • X. Zheng et al. Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats Neuroscience 256C 2013 210 222
    • (2013) Neuroscience , vol.256 C , pp. 210-222
    • Zheng, X.1
  • 44
    • 80051646543 scopus 로고    scopus 로고
    • Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy
    • A. Kang et al. Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy J. Neuroinflammation 8 2011 100
    • (2011) J. Neuroinflammation , vol.8 , pp. 100
    • Kang, A.1
  • 45
    • 71049183577 scopus 로고    scopus 로고
    • Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats
    • H. Liu et al. Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats Drug Metab. Dispos. 37 2009 2290 2298
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 2290-2298
    • Liu, H.1
  • 46
    • 79958021894 scopus 로고    scopus 로고
    • Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration
    • D. Zwilling et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration Cell 145 2011 863 874
    • (2011) Cell , vol.145 , pp. 863-874
    • Zwilling, D.1
  • 47
    • 77957263726 scopus 로고    scopus 로고
    • Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism
    • J.R. Clapper et al. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism Nat. Neurosci. 13 2010 1265 1270
    • (2010) Nat. Neurosci. , vol.13 , pp. 1265-1270
    • Clapper, J.R.1
  • 48
    • 79958293037 scopus 로고    scopus 로고
    • Treating the periphery to ameliorate neurodegenerative diseases
    • P.H. Reinhart, and J.W. Kelly Treating the periphery to ameliorate neurodegenerative diseases Cell 145 2011 813 814
    • (2011) Cell , vol.145 , pp. 813-814
    • Reinhart, P.H.1    Kelly, J.W.2
  • 49
    • 77957276458 scopus 로고    scopus 로고
    • Endocannabinoids rein in pain outside the brain
    • D.M. Lovinger Endocannabinoids rein in pain outside the brain Nat. Neurosci. 13 2010 1155 1156
    • (2010) Nat. Neurosci. , vol.13 , pp. 1155-1156
    • Lovinger, D.M.1
  • 50
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • C. Iadecola, and J. Anrather The immunology of stroke: from mechanisms to translation Nat. Med. 17 2011 796 808
    • (2011) Nat. Med. , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 51
    • 70349838221 scopus 로고    scopus 로고
    • Taking advantage of the systemic immune system to cure brain diseases
    • V.W. Yong, and S. Rivest Taking advantage of the systemic immune system to cure brain diseases Neuron 64 2009 55 60
    • (2009) Neuron , vol.64 , pp. 55-60
    • Yong, V.W.1    Rivest, S.2
  • 52
    • 84893695424 scopus 로고    scopus 로고
    • Inflammatory pathways of seizure disorders
    • N. Marchi et al. Inflammatory pathways of seizure disorders Trends Neurosci. 37 2014 55 65
    • (2014) Trends Neurosci. , vol.37 , pp. 55-65
    • Marchi, N.1
  • 53
    • 0041379639 scopus 로고    scopus 로고
    • The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption
    • G.Y. Pan et al. The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption Planta Med. 69 2003 632 636
    • (2003) Planta Med. , vol.69 , pp. 632-636
    • Pan, G.Y.1
  • 54
    • 19944374769 scopus 로고    scopus 로고
    • Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
    • W. Kong et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins Nat. Med. 10 2004 1344 1351
    • (2004) Nat. Med. , vol.10 , pp. 1344-1351
    • Kong, W.1
  • 55
    • 77957130129 scopus 로고    scopus 로고
    • Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats
    • Y.T. Liu et al. Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats Drug Metab. Dispos. 38 2010 1779 1784
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 1779-1784
    • Liu, Y.T.1
  • 56
    • 84864560961 scopus 로고    scopus 로고
    • Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats
    • X. Zhang et al. Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats PLoS ONE 7 2012 e42529
    • (2012) PLoS ONE , vol.7 , pp. 42529
    • Zhang, X.1
  • 57
    • 84861978076 scopus 로고    scopus 로고
    • Host-gut microbiota metabolic interactions
    • J.K. Nicholson et al. Host-gut microbiota metabolic interactions Science 336 2012 1262 1267
    • (2012) Science , vol.336 , pp. 1262-1267
    • Nicholson, J.K.1
  • 58
    • 84866973849 scopus 로고    scopus 로고
    • Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b
    • D. Wang et al. Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b Circ. Res. 111 2012 967 981
    • (2012) Circ. Res. , vol.111 , pp. 967-981
    • Wang, D.1
  • 59
    • 84876323190 scopus 로고    scopus 로고
    • Structural changes of gut microbiota in a rat non-alcoholic fatty liver disease model treated with a Chinese herbal formula
    • X. Yin et al. Structural changes of gut microbiota in a rat non-alcoholic fatty liver disease model treated with a Chinese herbal formula Syst. Appl. Microbiol. 36 2013 188 196
    • (2013) Syst. Appl. Microbiol. , vol.36 , pp. 188-196
    • Yin, X.1
  • 60
    • 84878183914 scopus 로고    scopus 로고
    • Where do health benefits of flavonoids come from? Insights from flavonoid targets and their evolutionary history
    • M.F. Lu et al. Where do health benefits of flavonoids come from? Insights from flavonoid targets and their evolutionary history Biochem. Biophys. Res. Commun. 434 2013 701 704
    • (2013) Biochem. Biophys. Res. Commun. , vol.434 , pp. 701-704
    • Lu, M.F.1
  • 61
    • 34948835721 scopus 로고    scopus 로고
    • Metabolic regulatory network alterations in response to acute cold stress and ginsenoside intervention
    • X. Wang et al. Metabolic regulatory network alterations in response to acute cold stress and ginsenoside intervention J. Proteome Res. 6 2007 3449 3455
    • (2007) J. Proteome Res. , vol.6 , pp. 3449-3455
    • Wang, X.1
  • 62
    • 84877319910 scopus 로고    scopus 로고
    • Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides
    • C. Liu et al. Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides J. Endocrinol. 217 2013 185 196
    • (2013) J. Endocrinol. , vol.217 , pp. 185-196
    • Liu, C.1
  • 63
    • 84863467061 scopus 로고    scopus 로고
    • Effects of ginsenoside on pacemaker potentials of cultured interstitial cells of Cajal clusters from the small intestine of mice
    • S. Han et al. Effects of ginsenoside on pacemaker potentials of cultured interstitial cells of Cajal clusters from the small intestine of mice Mol. Cells 33 2012 243 249
    • (2012) Mol. Cells , vol.33 , pp. 243-249
    • Han, S.1
  • 64
    • 80052585518 scopus 로고    scopus 로고
    • Chemical composition of natural and polyphenol-free apple pomace and the effect of this dietary ingredient on intestinal fermentation and serum lipid parameters in rats
    • M. Kosmala et al. Chemical composition of natural and polyphenol-free apple pomace and the effect of this dietary ingredient on intestinal fermentation and serum lipid parameters in rats J. Agric. Food Chem. 59 2011 9177 9185
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 9177-9185
    • Kosmala, M.1
  • 65
    • 84882573263 scopus 로고    scopus 로고
    • Soybean oligosaccharides alter colon short-chain fatty acid production and microbial population in vitro
    • X.L. Zhou et al. Soybean oligosaccharides alter colon short-chain fatty acid production and microbial population in vitro J. Anim. Sci. 90 Suppl. 4 2012 37 39
    • (2012) J. Anim. Sci. , vol.90 , Issue.SUPPL. 4 , pp. 37-39
    • Zhou, X.L.1
  • 66
    • 84878810790 scopus 로고    scopus 로고
    • Pathways in microbe-induced obesity
    • L.M. Cox, and M.J. Blaser Pathways in microbe-induced obesity Cell Metab. 17 2013 883 894
    • (2013) Cell Metab. , vol.17 , pp. 883-894
    • Cox, L.M.1    Blaser, M.J.2
  • 67
    • 84055199781 scopus 로고    scopus 로고
    • Modernization: One step at a time
    • Z. Xu Modernization: one step at a time Nature 480 2011 S90 S92
    • (2011) Nature , vol.480
    • Xu, Z.1
  • 68
    • 84887409743 scopus 로고    scopus 로고
    • Pharmacological tools for the development of traditional Chinese medicine
    • X. Liu et al. Pharmacological tools for the development of traditional Chinese medicine Trends Pharmacol. Sci. 34 2013 620 628
    • (2013) Trends Pharmacol. Sci. , vol.34 , pp. 620-628
    • Liu, X.1
  • 69
    • 1542781600 scopus 로고    scopus 로고
    • A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR
    • W. Huang et al. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR J. Clin. Invest. 113 2004 137 143
    • (2004) J. Clin. Invest. , vol.113 , pp. 137-143
    • Huang, W.1
  • 70
    • 42449161986 scopus 로고    scopus 로고
    • Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
    • L. Wang et al. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia Proc. Natl. Acad. Sci. U.S.A. 105 2008 4826 4831
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 4826-4831
    • Wang, L.1
  • 71
    • 77950826446 scopus 로고    scopus 로고
    • Arsenic trioxide controls the fate of the PML-RARα oncoprotein by directly binding PML
    • X.W. Zhang et al. Arsenic trioxide controls the fate of the PML-RARα oncoprotein by directly binding PML Science 328 2010 240 243
    • (2010) Science , vol.328 , pp. 240-243
    • Zhang, X.W.1
  • 72
    • 47949093788 scopus 로고    scopus 로고
    • Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine
    • T. Lu et al. Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine Drug Metab. Dispos. 36 2008 1578 1586
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 1578-1586
    • Lu, T.1
  • 73
    • 84861016285 scopus 로고    scopus 로고
    • Sulfotanshinone sodium injection for unstable angina pectoris: A systematic review of randomized controlled trials
    • http://dx.doi.org/10.1155/2012/715790
    • X. Qiu et al. Sulfotanshinone sodium injection for unstable angina pectoris: a systematic review of randomized controlled trials Evid. Based Complement. Alternat. Med. 2012 2012 http://dx.doi.org/10.1155/2012/715790
    • (2012) Evid. Based Complement. Alternat. Med. , vol.2012
    • Qiu, X.1
  • 74
    • 84876414806 scopus 로고    scopus 로고
    • The gut microbiota - Masters of host development and physiology
    • F. Sommer, and F. Backhed The gut microbiota - masters of host development and physiology Nat. Rev. Microbiol. 11 2013 227 238
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 227-238
    • Sommer, F.1    Backhed, F.2
  • 75
    • 84863085673 scopus 로고    scopus 로고
    • Multi-target drugs: The trend of drug research and development
    • J.J. Lu et al. Multi-target drugs: the trend of drug research and development PLoS ONE 7 2012 e40262
    • (2012) PLoS ONE , vol.7 , pp. 40262
    • Lu, J.J.1
  • 76
    • 84879097012 scopus 로고    scopus 로고
    • Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi)
    • Z. Hu et al. Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi) Drug Metab. Dispos. 41 2013 1457 1469
    • (2013) Drug Metab. Dispos. , vol.41 , pp. 1457-1469
    • Hu, Z.1
  • 77
    • 62749106838 scopus 로고    scopus 로고
    • Non-digestible food ingredients, colonic microbiota and the impact on gut health and immunity: A role for metabolomics
    • D.M. Jacobs et al. Non-digestible food ingredients, colonic microbiota and the impact on gut health and immunity: a role for metabolomics Curr. Drug Metab. 10 2009 41 54
    • (2009) Curr. Drug Metab. , vol.10 , pp. 41-54
    • Jacobs, D.M.1
  • 78
    • 84866005625 scopus 로고    scopus 로고
    • Compatibility art of traditional Chinese medicine: From the perspective of herb pairs
    • S. Wang et al. Compatibility art of traditional Chinese medicine: from the perspective of herb pairs J. Ethnopharmacol. 143 2012 412 423
    • (2012) J. Ethnopharmacol. , vol.143 , pp. 412-423
    • Wang, S.1
  • 79
    • 37349022457 scopus 로고    scopus 로고
    • Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats
    • M. Xu et al. Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats J. Ethnopharmacol. 115 2008 483 488
    • (2008) J. Ethnopharmacol. , vol.115 , pp. 483-488
    • Xu, M.1
  • 80
    • 84892940228 scopus 로고    scopus 로고
    • Oral tetra-arsenic tetra-sulfide formula versus intravenous arsenic trioxide as first-line treatment of acute promyelocytic leukemia: A multicenter randomized controlled trial
    • H.H. Zhu et al. Oral tetra-arsenic tetra-sulfide formula versus intravenous arsenic trioxide as first-line treatment of acute promyelocytic leukemia: a multicenter randomized controlled trial J. Clin. Oncol. 31 2013 4215 4221
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4215-4221
    • Zhu, H.H.1
  • 81
    • 67249159825 scopus 로고    scopus 로고
    • Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets
    • (in Chinese)
    • H.P. Hao et al. Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets Yao Xue Xue Bao 44 2009 270-275 (in Chinese)
    • (2009) Yao Xue Xue Bao , vol.44 , pp. 270-275
    • Hao, H.P.1
  • 82
    • 59949083512 scopus 로고    scopus 로고
    • Diagnostic fragment-ion-based extension strategy for rapid screening and identification of serial components of homologous families contained in traditional Chinese medicine prescription using high-resolution LC-ESI-IT-TOF/MS: Shengmai injection as an example
    • C. Zheng et al. Diagnostic fragment-ion-based extension strategy for rapid screening and identification of serial components of homologous families contained in traditional Chinese medicine prescription using high-resolution LC-ESI-IT-TOF/MS: Shengmai injection as an example J. Mass Spectrom. 44 2009 230 244
    • (2009) J. Mass Spectrom. , vol.44 , pp. 230-244
    • Zheng, C.1
  • 83
    • 55549122656 scopus 로고    scopus 로고
    • Global detection and identification of nontarget components from herbal preparations by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a strategy
    • H. Hao et al. Global detection and identification of nontarget components from herbal preparations by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a strategy Anal. Chem. 80 2008 8187 8194
    • (2008) Anal. Chem. , vol.80 , pp. 8187-8194
    • Hao, H.1
  • 84
    • 84880514182 scopus 로고    scopus 로고
    • An integral strategy toward the rapid identification of analogous nontarget compounds from complex mixtures
    • L. Wu et al. An integral strategy toward the rapid identification of analogous nontarget compounds from complex mixtures J. Chromatogr. A 1303 2013 39 47
    • (2013) J. Chromatogr. A , vol.1303 , pp. 39-47
    • Wu, L.1
  • 85
    • 84863356951 scopus 로고    scopus 로고
    • Chemicalome and metabolome matching approach to elucidating biological metabolic networks of complex mixtures
    • P. Gong et al. Chemicalome and metabolome matching approach to elucidating biological metabolic networks of complex mixtures Anal. Chem. 84 2012 2995 3002
    • (2012) Anal. Chem. , vol.84 , pp. 2995-3002
    • Gong, P.1
  • 86
    • 79961007572 scopus 로고    scopus 로고
    • Trends in the exploitation of novel drug targets
    • M. Rask-Andersen et al. Trends in the exploitation of novel drug targets Nat. Rev. Drug Discov. 10 2011 579 590
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 579-590
    • Rask-Andersen, M.1


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