Jejunal leptin-PI3K signaling lowers glucose production

Cell Metabolism

Volumn 19, Issue 1, 2014, Pages 155-161

  Rasmussen, Brittany A ^a,b   Breen, Danna M ^a,b   Duca, Frank A ^a,b   Côté, Clémence D ^a,b   Tahmasebi, Melika Zadeh ^a,b   Filippi, Beatrice M ^a,b   Lam, Tony K T ^a,b,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GLUCOSE; INSULIN; LEPTIN; LEPTIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; STAT3 PROTEIN; STREPTOZOCIN; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BYPASS SURGERY; CONTROLLED STUDY; DIABETES MELLITUS; DUODENAL JEJUNAL BYPASS SURGERY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; INSULIN BLOOD LEVEL; INTESTINE SURGERY; JEJUNUM; LIPID DIET; MALE; MOUSE; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

RODENTIA;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; DIGESTIVE SYSTEM SURGICAL PROCEDURES; GLUCOSE; HYPOGLYCEMIC AGENTS; JEJUNUM; LEPTIN; MALE; MICE; MICE, INBRED C57BL; NERVE NET; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84891852494     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.11.014     Document Type: Article

References (46)

1. T.E. Adrian, G.L. Ferri, A.J. Bacarese-Hamilton, H.S. Fuessl, J.M. Polak, and S.R. Bloom Human distribution and release of a putative new gut hormone, peptide YY Gastroenterology 89 1985 1070 1077 (Pubitemid 16231572)
2. A. Bado, S. Levasseur, S. Attoub, S. Kermorgant, J.P. Laigneau, M.N. Bortoluzzi, L. Moizo, T. Lehy, M. Guerre-Millo, Y. Le Marchand-Brustel, and M.J. Lewin The stomach is a source of leptin Nature 394 1998 790 793 (Pubitemid 28391644)
3. A.S. Banks, S.M. Davis, S.H. Bates, and M.G. Myers Jr. Activation of downstream signals by the long form of the leptin receptor J. Biol. Chem. 275 2000 14563 14572 (Pubitemid 30339746)
4. J. Barrenetxe, A.C. Villaro, L. Guembe, I. Pascual, M. Muñoz-Navas, A. Barber, and M.P. Lostao Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes Gut 50 2002 797 802 (Pubitemid 34539041)
5. D.M. Breen, B.A. Rasmussen, A. Kokorovic, R. Wang, G.W. Cheung, and T.K. Lam Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes Nat. Med. 18 2012 950 955
6. C. Buettner, A. Pocai, E.D. Muse, A.M. Etgen, M.G. Myers Jr., and L. Rossetti Critical role of STAT3 in leptin's metabolic actions Cell Metab. 4 2006 49 60 (Pubitemid 43942253)
7. M. Buyse, M.L. Ovesjö, H. Goïot, S. Guilmeau, G. Péranzi, L. Moizo, F. Walker, M.J. Lewin, B. Meister, and A. Bado Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve Eur. J. Neurosci. 14 2001 64 72 (Pubitemid 32738475)
8. P. Cammisotto, and M. Bendayan A review on gastric leptin: the exocrine secretion of a gastric hormone Anat Cell Biol 45 2012 1 16
9. M. Chari, C.K. Lam, P.Y. Wang, and T.K. Lam Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance Diabetes 57 2008 836 840
10. G.W. Cheung, A. Kokorovic, C.K. Lam, M. Chari, and T.K. Lam Intestinal cholecystokinin controls glucose production through a neuronal network Cell Metab. 10 2009 99 109
11. N. Chinookoswong, J.L. Wang, and Z.Q. Shi Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat Diabetes 48 1999 1487 1492 (Pubitemid 29297316)
12. G. de Lartigue, G. Lur, R. Dimaline, A. Varro, H. Raybould, and G.J. Dockray EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons Endocrinology 151 2010 3589 3599
13. G. de Lartigue, C. Barbier de la Serre, E. Espero, J. Lee, and H.E. Raybould Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons Am. J. Physiol. Endocrinol. Metab. 301 2011 E187 E195
14. P. Duggal, X. Guo, R. Haque, K.M. Peterson, S. Ricklefs, D. Mondal, F. Alam, Z. Noor, H.P. Verkerke, and C. Marie et al. A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children J. Clin. Invest. 121 2011 1191 1198
15. B.M. Filippi, C.S. Yang, C. Tang, and T.K. Lam Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production Cell Metab. 16 2012 500 510
16. T. Fujikawa, J.C. Chuang, I. Sakata, G. Ramadori, and R. Coppari Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice Proc. Natl. Acad. Sci. USA 107 2010 17391 17396
17. J.P. German, J.P. Thaler, B.E. Wisse, S. Oh-I, D.A. Sarruf, M.E. Matsen, J.D. Fischer, G.J. Taborsky Jr., M.W. Schwartz, and G.J. Morton Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia Endocrinology 152 2011 394 404
18. Y. Gong, R. Ishida-Takahashi, E.C. Villanueva, D.C. Fingar, H. Münzberg, and M.G. Myers Jr. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms J. Biol. Chem. 282 2007 31019 31027 (Pubitemid 350035238)
19. S. Guilmeau, M. Buyse, A. Tsocas, J.P. Laigneau, and A. Bado Duodenal leptin stimulates cholecystokinin secretion: evidence of a positive leptin-cholecystokinin feedback loop Diabetes 52 2003 1664 1672 (Pubitemid 36792454)
20. X. Guo, M.R. Roberts, S.M. Becker, B. Podd, Y. Zhang, S.C. Chua Jr., M.G. Myers Jr., P. Duggal, E.R. Houpt, and W.A. Petri Jr. Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica Mucosal Immunol. 4 2011 294 303
21. M.R. Hayes, K.P. Skibicka, T.M. Leichner, D.J. Guarnieri, R.J. DiLeone, K.K. Bence, and H.J. Grill Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation Cell Metab. 11 2010 77 83
22. A. Heldsinger, G. Grabauskas, I. Song, and C. Owyang Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways: implications for leptin as a regulator of short term satiety J. Biol. Chem. 286 2011 11707 11715
23. C. Herrmann, R. Göke, G. Richter, H.C. Fehmann, R. Arnold, and B. Göke Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients Digestion 56 1995 117 126
24. J.K. Howard, B.J. Cave, L.J. Oksanen, I. Tzameli, C. Bjørbaek, and J.S. Flier Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3 Nat. Med. 10 2004 734 738 (Pubitemid 38937639)
25. J. Iqbal, X. Li, B.H.J. Chang, L. Chan, G.J. Schwartz, S.C. Chua Jr., and M.M. Hussain An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption J. Lipid Res. 51 2010 1929 1942
26. J. Jiao, E.J. Bae, G. Bandyopadhyay, J. Oliver, C. Marathe, M. Chen, J.Y. Hsu, Y. Chen, H. Tian, J.M. Olefsky, and M. Saberi Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats Diabetes 62 2013 1074 1083
27. R.A. Liddle, I.D. Goldfine, M.S. Rosen, R.A. Taplitz, and J.A. Williams Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction J. Clin. Invest. 75 1985 1144 1152 (Pubitemid 15087139)
28. G.J. Morton, and M.W. Schwartz Leptin and the central nervous system control of glucose metabolism Physiol. Rev. 91 2011 389 411
29. N.M. Morton, V. Emilsson, Y.L. Liu, and M.A. Cawthorne Leptin action in intestinal cells J. Biol. Chem. 273 1998 26194 26201 (Pubitemid 28475857)
30. G.J. Morton, R.W. Gelling, K.D. Niswender, C.D. Morrison, C.J. Rhodes, and M.W. Schwartz Leptin regulates insulin sensitivity via phosphatidylinositol- 3-OH kinase signaling in mediobasal hypothalamic neurons Cell Metab. 2 2005 411 420
31. G.J. Morton, D.E. Cummings, D.G. Baskin, G.S. Barsh, and M.W. Schwartz Central nervous system control of food intake and body weight Nature 443 2006 289 295 (Pubitemid 44435142)
32. M.G. Myers Jr., and D.P. Olson Central nervous system control of metabolism Nature 491 2012 357 363
33. L.M. Patterson, H. Zheng, and H.R. Berthoud Vagal afferents innervating the gastrointestinal tract and CCKA-receptor immunoreactivity Anat. Rec. 266 2002 10 20 (Pubitemid 34027831)
34. D.J. Pournaras, C. Glicksman, R.P. Vincent, S. Kuganolipava, J. Alaghband-Zadeh, D. Mahon, J.H. Bekker, M.A. Ghatei, S.R. Bloom, and J.R. Walters et al. The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control Endocrinology 153 2012 3613 3619
35. B.A. Rasmussen, D.M. Breen, P. Luo, G.W. Cheung, C.S. Yang, B. Sun, A. Kokorovic, W. Rong, and T.K. Lam Duodenal activation of cAMP-dependent protein kinase induces vagal afferent firing and lowers glucose production in rats Gastroenterology 142 2012 834 843 e3
36. F. Rubino, and J. Marescaux Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease Ann. Surg. 239 2004 1 11 (Pubitemid 38176365)
37. M.W. Schwartz, and D. Porte Jr. Diabetes, obesity, and the brain Science 307 2005 375 379 (Pubitemid 40139972)
38. H. Sheng, J. Shao, C.M. Townsend Jr., and B.M. Evers Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells Gut 52 2003 1472 1478 (Pubitemid 37176728)
39. S. Shioda, H. Funahashi, S. Nakajo, T. Yada, O. Maruta, and Y. Nakai Immunohistochemical localization of leptin receptor in the rat brain Neurosci. Lett. 243 1998 41 44 (Pubitemid 28109406)
40. Q. Tong, N. Gamper, J.L. Medina, M.S. Shapiro, and J.D. Stockand Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase J. Biol. Chem. 279 2004 22654 22663 (Pubitemid 38679466)
41. S. Troy, M. Soty, L. Ribeiro, L. Laval, S. Migrenne, X. Fioramonti, B. Pillot, V. Fauveau, R. Aubert, and B. Viollet et al. Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice Cell Metab. 8 2008 201 211
42. A. Waget, C. Cabou, M. Masseboeuf, P. Cattan, M. Armanet, M. Karaca, J. Castel, C. Garret, G. Payros, and A. Maida et al. Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice Endocrinology 152 2011 3018 3029
43. J. Wang, S. Obici, K. Morgan, N. Barzilai, Z. Feng, and L. Rossetti Overfeeding rapidly induces leptin and insulin resistance Diabetes 50 2001 2786 2791 (Pubitemid 33733130)
44. M.Y. Wang, L. Chen, G.O. Clark, Y. Lee, R.D. Stevens, O.R. Ilkayeva, B.R. Wenner, J.R. Bain, M.J. Charron, C.B. Newgard, and R.H. Unger Leptin therapy in insulin-deficient type I diabetes Proc. Natl. Acad. Sci. USA 107 2010 4813 4819
45. J. Zhang, and P.J. Scarpace The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo Br. J. Pharmacol. 158 2009 475 482
46. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425 432 (Pubitemid 24365442)