-
1
-
-
77957743452
-
Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: Long-term clinical and MRD results of the German CLL Study Group CLL3X trial
-
20595516 10.1182/blood-2010-03-275420 1:CAS:528:DC%2BC3cXhtlyqt7nI This is a prospective multicenter phase 2 study investigating the long-term outcome of reduced-intensity conditioning allogeneic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia
-
• Dreger P, Dohner H, Ritgen M, et al. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood. 2010;116:2438-47. This is a prospective multicenter phase 2 study investigating the long-term outcome of reduced-intensity conditioning allogeneic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia.
-
(2010)
Blood
, vol.116
, pp. 2438-2447
-
-
Dreger, P.1
Dohner, H.2
Ritgen, M.3
-
2
-
-
84865997474
-
Comparing efficacy of reduced-toxicity allogeneic hematopoietic cell transplantation with conventional chemo-(immuno) therapy in patients with relapsed or refractory CLL: A Markov decision analysis
-
Kharfan-Dabaja MA, Pidala J, Kumar A, et al. Comparing efficacy of reduced-toxicity allogeneic hematopoietic cell transplantation with conventional chemo-(immuno) therapy in patients with relapsed or refractory CLL: a Markov decision analysis. Bone Marrow Transplant. 2012.
-
(2012)
Bone Marrow Transplant
-
-
Kharfan-Dabaja, M.A.1
Pidala, J.2
Kumar, A.3
-
3
-
-
54449093967
-
Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning
-
18794548 10.1200/JCO.2007.15.4757
-
Sorror ML, Storer BE, Sandmaier BM, et al. Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. J Clin Oncol. 2008;26:4912-20.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4912-4920
-
-
Sorror, M.L.1
Storer, B.E.2
Sandmaier, B.M.3
-
4
-
-
34247509369
-
Graft-versus-leukaemia effect after non-myeloablative haematopoietic transplantation can overcome the unfavourable expression of ZAP-70 in refractory chronic lymphocytic leukaemia
-
17456058 10.1111/j.1365-2141.2007.06591.x 1:CAS:528:DC%2BD2sXntVSntb0%3D
-
Khouri IF, Saliba RM, Admirand J, et al. Graft-versus-leukaemia effect after non-myeloablative haematopoietic transplantation can overcome the unfavourable expression of ZAP-70 in refractory chronic lymphocytic leukaemia. Br J Haematol. 2007;137:355-63.
-
(2007)
Br J Haematol
, vol.137
, pp. 355-363
-
-
Khouri, I.F.1
Saliba, R.M.2
Admirand, J.3
-
5
-
-
58149384550
-
Graft-versus-leukemia effects of transplantation and donor lymphocytes
-
19029455 10.1182/blood-2008-03-077974 1:CAS:528:DC%2BD1cXhsVCltbzO
-
Kolb HJ. Graft-versus-leukemia effects of transplantation and donor lymphocytes. Blood. 2008;112:4371-83.
-
(2008)
Blood
, vol.112
, pp. 4371-4383
-
-
Kolb, H.J.1
-
6
-
-
0026602322
-
Donor leukocyte infusions for chronic myeloid leukemia in relapse after allogeneic bone marrow transplantation
-
1536963 1:STN:280:DyaK387mtlWisQ%3D%3D
-
Cullis JO, Jiang YZ, Schwarer AP, et al. Donor leukocyte infusions for chronic myeloid leukemia in relapse after allogeneic bone marrow transplantation. Blood. 1992;79:1379-81.
-
(1992)
Blood
, vol.79
, pp. 1379-1381
-
-
Cullis, J.O.1
Jiang, Y.Z.2
Schwarer, A.P.3
-
7
-
-
0027437385
-
Salvage immunotherapy using donor leukocyte infusions as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: Efficacy and toxicity of a defined T-cell dose
-
8400284 1:STN:280:DyaK2c%2Fgtlaqtw%3D%3D
-
Drobyski WR, Keever CA, Roth MS, et al. Salvage immunotherapy using donor leukocyte infusions as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: efficacy and toxicity of a defined T-cell dose. Blood. 1993;82:2310-8.
-
(1993)
Blood
, vol.82
, pp. 2310-2318
-
-
Drobyski, W.R.1
Keever, C.A.2
Roth, M.S.3
-
8
-
-
0028037976
-
Complete remission following donor leukocyte infusion in ALL relapsing after haploidentical bone marrow transplantation
-
7994252 1:STN:280:DyaK2M%2Fos1Cmug%3D%3D
-
Ferster A, Bujan W, Mouraux T, et al. Complete remission following donor leukocyte infusion in ALL relapsing after haploidentical bone marrow transplantation. Bone Marrow Transplant. 1994;14:331-2.
-
(1994)
Bone Marrow Transplant
, vol.14
, pp. 331-332
-
-
Ferster, A.1
Bujan, W.2
Mouraux, T.3
-
9
-
-
0025678601
-
Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients
-
2265242 1:STN:280:DyaK3M%2FptFCrsQ%3D%3D
-
Kolb HJ, Mittermuller J, Clemm C, et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood. 1990;76:2462-5.
-
(1990)
Blood
, vol.76
, pp. 2462-2465
-
-
Kolb, H.J.1
Mittermuller, J.2
Clemm, C.3
-
10
-
-
0030815867
-
Donor leukocyte infusions are effective in relapsed multiple myeloma after allogeneic bone marrow transplantation
-
9354693 1:CAS:528:DyaK2sXnt12qsro%3D
-
Lokhorst HM, Schattenberg A, Cornelissen JJ, et al. Donor leukocyte infusions are effective in relapsed multiple myeloma after allogeneic bone marrow transplantation. Blood. 1997;90:4206-11.
-
(1997)
Blood
, vol.90
, pp. 4206-4211
-
-
Lokhorst, H.M.1
Schattenberg, A.2
Cornelissen, J.J.3
-
11
-
-
0029030250
-
Immunotherapy with donor leukocyte infusions for patients with relapsed acute myeloid leukemia following partially mismatched related donor bone marrow transplantation
-
7581101 1:STN:280:DyaK28%2Fot1Ogsg%3D%3D
-
Pati AR, Godder K, Lamb L, et al. Immunotherapy with donor leukocyte infusions for patients with relapsed acute myeloid leukemia following partially mismatched related donor bone marrow transplantation. Bone Marrow Transplant. 1995;15:979-81.
-
(1995)
Bone Marrow Transplant
, vol.15
, pp. 979-981
-
-
Pati, A.R.1
Godder, K.2
Lamb, L.3
-
12
-
-
68049118980
-
Loss of mismatched HLA in leukemia after stem-cell transplantation
-
19641204 10.1056/NEJMoa0811036 1:CAS:528:DC%2BD1MXpt1CrsLc%3D
-
Vago L, Perna SK, Zanussi M, et al. Loss of mismatched HLA in leukemia after stem-cell transplantation. N Engl J Med. 2009;361:478-88.
-
(2009)
N Engl J Med
, vol.361
, pp. 478-488
-
-
Vago, L.1
Perna, S.K.2
Zanussi, M.3
-
13
-
-
16844379997
-
Immunosuppressive networks in the tumour environment and their therapeutic relevance
-
15776005 10.1038/nrc1586 1:CAS:528:DC%2BD2MXivVars7g%3D
-
Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer. 2005;5:263-74.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 263-274
-
-
Zou, W.1
-
14
-
-
34548485103
-
Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains
-
17685852 10.1089/hum.2007.028 1:CAS:528:DC%2BD2sXpsV2kurw%3D
-
Wang J, Jensen M, Lin Y, et al. Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains. Hum Gene Ther. 2007;18:712-25.
-
(2007)
Hum Gene Ther
, vol.18
, pp. 712-725
-
-
Wang, J.1
Jensen, M.2
Lin, Y.3
-
15
-
-
65249101637
-
The promise and potential pitfalls of chimeric antigen receptors
-
19327974 10.1016/j.coi.2009.02.009 1:CAS:528:DC%2BD1MXlsVCgtLc%3D
-
Sadelain M, Brentjens R, Riviere I. The promise and potential pitfalls of chimeric antigen receptors. Curr Opin Immunol. 2009;21:215-23.
-
(2009)
Curr Opin Immunol
, vol.21
, pp. 215-223
-
-
Sadelain, M.1
Brentjens, R.2
Riviere, I.3
-
16
-
-
33845294816
-
CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells
-
17108138 10.1158/0008-5472.CAN-06-0160 1:CAS:528:DC%2BD2sXivVyqt70%3D
-
Kowolik CM, Topp MS, Gonzalez S, et al. CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res. 2006;66:10995-1004.
-
(2006)
Cancer Res
, vol.66
, pp. 10995-11004
-
-
Kowolik, C.M.1
Topp, M.S.2
Gonzalez, S.3
-
17
-
-
78649461928
-
The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor
-
20702778 10.1182/blood-2010-05-283309 1:CAS:528:DC%2BC3cXhsFGgtbvO Study targeting the novel B-cell tumor associated antigen ROR 1 with chimeric antigen receptor expressing T-cells
-
• Hudecek M, Schmitt TM, Baskar S, et al. The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. Blood. 2010;116:4532-41. Study targeting the novel B-cell tumor associated antigen ROR 1 with chimeric antigen receptor expressing T-cells.
-
(2010)
Blood
, vol.116
, pp. 4532-4541
-
-
Hudecek, M.1
Schmitt, T.M.2
Baskar, S.3
-
18
-
-
10844296758
-
Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells
-
15604287 10.1158/0008-5472.CAN-04-0454 1:CAS:528:DC%2BD2cXhtVOmsb7E
-
Kahlon KS, Brown C, Cooper LJ, et al. Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells. Cancer Res. 2004;64:9160-6.
-
(2004)
Cancer Res
, vol.64
, pp. 9160-9166
-
-
Kahlon, K.S.1
Brown, C.2
Cooper, L.J.3
-
19
-
-
3042551216
-
Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
-
14961035 10.1038/sj.leu.2403302 1:CAS:528:DC%2BD2cXisVyru7Y%3D
-
Imai C, Mihara K, Andreansky M, et al. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia. 2004;18:676-84.
-
(2004)
Leukemia
, vol.18
, pp. 676-684
-
-
Imai, C.1
Mihara, K.2
Andreansky, M.3
-
20
-
-
76749120309
-
A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity
-
19843940 10.4049/jimmunol.0900447 1:CAS:528:DC%2BD1MXht1ymtbzI
-
Zhao Y, Wang QJ, Yang S, et al. A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity. J Immunol. 2009;183:5563-74.
-
(2009)
J Immunol
, vol.183
, pp. 5563-5574
-
-
Zhao, Y.1
Wang, Q.J.2
Yang, S.3
-
21
-
-
0025998529
-
T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins
-
1833767 10.1073/pnas.88.20.8905 1:CAS:528:DyaK3MXmsFelu7o%3D
-
Letourneur F, Klausner RD. T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins. Proc Natl Acad Sci U S A. 1991;88:8905-9.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 8905-8909
-
-
Letourneur, F.1
Klausner, R.D.2
-
22
-
-
0034526330
-
Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors
-
11191112 10.1038/sj.neo.7900108 1:CAS:528:DC%2BD3MXjtFyktQ%3D%3D
-
Yun CO, Nolan KF, Beecham EJ, et al. Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors. Neoplasia. 2000;2:449-59.
-
(2000)
Neoplasia
, vol.2
, pp. 449-459
-
-
Yun, C.O.1
Nolan, K.F.2
Beecham, E.J.3
-
23
-
-
0041677653
-
Immune response manipulation: Recombinant immunoreceptors endow T-cells with predefined specificity
-
12871185 10.2174/1381612033454289 1:CAS:528:DC%2BD3sXms1Wltbk%3D
-
Abken H, Hombach A, Heuser C. Immune response manipulation: recombinant immunoreceptors endow T-cells with predefined specificity. Curr Pharm Des. 2003;9:1992-2001.
-
(2003)
Curr Pharm des
, vol.9
, pp. 1992-2001
-
-
Abken, H.1
Hombach, A.2
Heuser, C.3
-
24
-
-
70349439277
-
Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells
-
19737958 10.1158/1078-0432.CCR-08-3163 1:CAS:528:DC%2BD1MXhtFars73F
-
Yvon E, Del Vecchio M, Savoldo B, et al. Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells. Clin Cancer Res. 2009;15:5852-60.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5852-5860
-
-
Yvon, E.1
Del Vecchio, M.2
Savoldo, B.3
-
25
-
-
77955510549
-
Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans
-
Jensen MC, Popplewell L, Cooper LJ, et al. Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans. Biol Blood Marrow Transplant. 16:1245-56.
-
Biol Blood Marrow Transplant
, vol.16
, pp. 1245-1256
-
-
Jensen, M.C.1
Popplewell, L.2
Cooper, L.J.3
-
26
-
-
50549096284
-
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
-
18509084 10.1182/blood-2007-12-128843 1:CAS:528:DC%2BD1cXhtFCrurjL
-
Till BG, Jensen MC, Wang J, et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood. 2008;112:2261-71.
-
(2008)
Blood
, vol.112
, pp. 2261-2271
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
-
27
-
-
33947265424
-
Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
-
17299405 1:CAS:528:DC%2BD2sXhtVejtLfF
-
Park JR, Digiusto DL, Slovak M, et al. Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther. 2007;15:825-33.
-
(2007)
Mol Ther
, vol.15
, pp. 825-833
-
-
Park, J.R.1
Digiusto, D.L.2
Slovak, M.3
-
28
-
-
55549145071
-
Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
-
18978797 10.1038/nm.1882 1:CAS:528:DC%2BD1cXhtlCjtLrF
-
Pule MA, Savoldo B, Myers GD, et al. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 2008;14:1264-70.
-
(2008)
Nat Med
, vol.14
, pp. 1264-1270
-
-
Pule, M.A.1
Savoldo, B.2
Myers, G.D.3
-
29
-
-
0032531091
-
Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
-
9743337 1:CAS:528:DyaK1cXmtVKjt78%3D
-
Finney HM, Lawson AD, Bebbington CR, et al. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol. 1998;161:2791-7.
-
(1998)
J Immunol
, vol.161
, pp. 2791-2797
-
-
Finney, H.M.1
Lawson, A.D.2
Bebbington, C.R.3
-
30
-
-
0035576250
-
Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule
-
11714771 1:CAS:528:DC%2BD3MXovVCjtrg%3D
-
Hombach A, Wieczarkowiecz A, Marquardt T, et al. Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule. J Immunol. 2001;167:6123-31.
-
(2001)
J Immunol
, vol.167
, pp. 6123-6131
-
-
Hombach, A.1
Wieczarkowiecz, A.2
Marquardt, T.3
-
31
-
-
0033857630
-
An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood t cells to specific lysis of carcinoembryonic antigen-positive tumor cells
-
10962448 10.1002/1097-0215(20001001)88:1<115: AID-IJC18>3.0.CO;2-E 1:CAS:528:DC%2BD3cXmslSntbw%3D
-
Hombach A, Schneider C, Sent D, et al. An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood t cells to specific lysis of carcinoembryonic antigen-positive tumor cells. Int J Cancer. 2000;88:115-20.
-
(2000)
Int J Cancer
, vol.88
, pp. 115-120
-
-
Hombach, A.1
Schneider, C.2
Sent, D.3
-
32
-
-
70349438847
-
Engineering lymphocyte subsets: Tools, trials and tribulations
-
19859065 10.1038/nri2635 1:CAS:528:DC%2BD1MXhtFOhs77K
-
June CH, Blazar BR, Riley JL. Engineering lymphocyte subsets: tools, trials and tribulations. Nat Rev Immunol. 2009;9:704-16.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 704-716
-
-
June, C.H.1
Blazar, B.R.2
Riley, J.L.3
-
33
-
-
77956535599
-
Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor
-
Jena B, Dotti G, Cooper LJ. Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor. Blood 116:1035-44.
-
Blood
, vol.116
, pp. 1035-1044
-
-
Jena, B.1
Dotti, G.2
Cooper, L.J.3
-
34
-
-
0024988334
-
Gene transfer into humans-immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction
-
2381442 10.1056/NEJM199008303230904 1:CAS:528:DyaK3MXhsl2ls7c%3D
-
Rosenberg SA, Aebersold P, Cornetta K, et al. Gene transfer into humans-immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med. 1990;323:570-8.
-
(1990)
N Engl J Med
, vol.323
, pp. 570-578
-
-
Rosenberg, S.A.1
Aebersold, P.2
Cornetta, K.3
-
35
-
-
4143074668
-
Human gammadelta T cells as mediators of chimaeric-receptor redirected anti-tumour immunity
-
15287953 10.1111/j.1365-2141.2004.05077.x 1:CAS:528:DC%2BD2cXnsF2qu7g%3D
-
Rischer M, Pscherer S, Duwe S, et al. Human gammadelta T cells as mediators of chimaeric-receptor redirected anti-tumour immunity. Br J Haematol. 2004;126:583-92.
-
(2004)
Br J Haematol
, vol.126
, pp. 583-592
-
-
Rischer, M.1
Pscherer, S.2
Duwe, S.3
-
36
-
-
14844322786
-
Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor
-
15538730 10.1002/jgm.647 1:CAS:528:DC%2BD2MXis1Kju7Y%3D
-
Turatti F, Figini M, Alberti P, et al. Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor. J Gene Med. 2005;7:158-70.
-
(2005)
J Gene Med
, vol.7
, pp. 158-170
-
-
Turatti, F.1
Figini, M.2
Alberti, P.3
-
37
-
-
70350726110
-
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo
-
19384291 10.1038/mt.2009.83 1:CAS:528:DC%2BD1MXkvVWqsLk%3D
-
Milone MC, Fish JD, Carpenito C, et al. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol Ther. 2009;17:1453-64.
-
(2009)
Mol Ther
, vol.17
, pp. 1453-1464
-
-
Milone, M.C.1
Fish, J.D.2
Carpenito, C.3
-
38
-
-
0029996147
-
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
-
8602510 10.1126/science.272.5259.263 1:CAS:528:DyaK28Xit1KqsLw%3D
-
Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 1996;272:263-7.
-
(1996)
Science
, vol.272
, pp. 263-267
-
-
Naldini, L.1
Blomer, U.2
Gallay, P.3
-
39
-
-
61849185275
-
Genetic engineering of T cells for adoptive immunotherapy
-
18841331 10.1007/s12026-008-8057-6
-
Varela-Rohena A, Carpenito C, Perez EE, et al. Genetic engineering of T cells for adoptive immunotherapy. Immunol Res. 2008;42:166-81.
-
(2008)
Immunol Res
, vol.42
, pp. 166-181
-
-
Varela-Rohena, A.1
Carpenito, C.2
Perez, E.E.3
-
40
-
-
79956149133
-
Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies
-
21558388 10.1158/0008-5472.CAN-10-3843 1:CAS:528:DC%2BC3MXmtVGlt70%3D
-
Singh H, Figliola MJ, Dawson MJ, et al. Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies. Cancer Res. 2011;71:3516-27.
-
(2011)
Cancer Res
, vol.71
, pp. 3516-3527
-
-
Singh, H.1
Figliola, M.J.2
Dawson, M.J.3
-
41
-
-
0033639189
-
Design of retroviral vectors and helper cells for gene therapy
-
11121508 1:CAS:528:DC%2BD3MXislWksg%3D%3D
-
Hu WS, Pathak VK. Design of retroviral vectors and helper cells for gene therapy. Pharmacol Rev. 2000;52:493-511.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 493-511
-
-
Hu, W.S.1
Pathak, V.K.2
-
42
-
-
0037481021
-
Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence
-
12649146 10.1182/blood-2003-01-0297 1:CAS:528:DC%2BD3sXlslGitrY%3D
-
Cavalieri S, Cazzaniga S, Geuna M, et al. Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence. Blood. 2003;102:497-505.
-
(2003)
Blood
, vol.102
, pp. 497-505
-
-
Cavalieri, S.1
Cazzaniga, S.2
Geuna, M.3
-
43
-
-
33745108790
-
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
-
16732270 10.1038/nbt1216 1:CAS:528:DC%2BD28XlsVCjsrs%3D
-
Montini E, Cesana D, Schmidt M, et al. Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol. 2006;24:687-96.
-
(2006)
Nat Biotechnol
, vol.24
, pp. 687-696
-
-
Montini, E.1
Cesana, D.2
Schmidt, M.3
-
44
-
-
55249087037
-
Resistance of mature T cells to oncogene transformation
-
18566328 10.1182/blood-2007-12-128751 1:CAS:528:DC%2BD1cXhtFCrurnO
-
Newrzela S, Cornils K, Li Z, et al. Resistance of mature T cells to oncogene transformation. Blood. 2008;112:2278-86.
-
(2008)
Blood
, vol.112
, pp. 2278-2286
-
-
Newrzela, S.1
Cornils, K.2
Li, Z.3
-
45
-
-
84856374598
-
Engineered T-cell therapy shows efficacy in blood cancer
-
21997612 10.1038/nbt1011-853 1:CAS:528:DC%2BC3MXhtlWlu7zM
-
Frantz S. Engineered T-cell therapy shows efficacy in blood cancer. Nat Biotechnol. 2011;29:853-5.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 853-855
-
-
Frantz, S.1
-
46
-
-
0042700227
-
Gene transfer into genomes of human cells by the sleeping beauty transposon system
-
12842434 10.1016/S1525-0016(03)00099-6 1:CAS:528:DC%2BD3sXkvFGnu7g%3D
-
Geurts AM, Yang Y, Clark KJ, et al. Gene transfer into genomes of human cells by the sleeping beauty transposon system. Mol Ther. 2003;8:108-17.
-
(2003)
Mol Ther
, vol.8
, pp. 108-117
-
-
Geurts, A.M.1
Yang, Y.2
Clark, K.J.3
-
47
-
-
39849086801
-
Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies
-
18227839 10.1038/sj.mt.6300404 1:CAS:528:DC%2BD1cXisFOrsrs%3D
-
Huang X, Guo H, Kang J, et al. Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies. Mol Ther. 2008;16:580-9.
-
(2008)
Mol Ther
, vol.16
, pp. 580-589
-
-
Huang, X.1
Guo, H.2
Kang, J.3
-
48
-
-
0033655529
-
Human T lymphocyte genetic modification with naked DNA
-
10933911 10.1006/mthe.1999.0012 1:CAS:528:DC%2BD38XhvF2itL0%3D
-
Jensen MC, Clarke P, Tan G, et al. Human T lymphocyte genetic modification with naked DNA. Mol Ther. 2000;1:49-55.
-
(2000)
Mol Ther
, vol.1
, pp. 49-55
-
-
Jensen, M.C.1
Clarke, P.2
Tan, G.3
-
49
-
-
0037441593
-
T-cell clones can be rendered specific for CD19: Toward the selective augmentation of the graft-versus-B-lineage leukemia effect
-
12393484 10.1182/blood-2002-07-1989 1:CAS:528:DC%2BD3sXht1ans7s%3D
-
Cooper LJ, Topp MS, Serrano LM, et al. T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B- lineage leukemia effect. Blood. 2003;101:1637-44.
-
(2003)
Blood
, vol.101
, pp. 1637-1644
-
-
Cooper, L.J.1
Topp, M.S.2
Serrano, L.M.3
-
50
-
-
42349088534
-
Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system
-
18413766 10.1158/0008-5472.CAN-07-5600 1:CAS:528:DC%2BD1cXks1Ghsrw%3D
-
Singh H, Manuri PR, Olivares S, et al. Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system. Cancer Res. 2008;68:2961-71.
-
(2008)
Cancer Res
, vol.68
, pp. 2961-2971
-
-
Singh, H.1
Manuri, P.R.2
Olivares, S.3
-
51
-
-
70349320475
-
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system
-
19414858 10.1182/blood-2009-03-210005 1:CAS:528:DC%2BD1MXhtVGhu7vP
-
Xue X, Huang X, Nodland SE, et al. Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system. Blood. 2009;114:1319-30.
-
(2009)
Blood
, vol.114
, pp. 1319-1330
-
-
Xue, X.1
Huang, X.2
Nodland, S.E.3
-
52
-
-
77950953208
-
PiggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies
-
Manuri PV, Wilson MH, Maiti SN, et al. piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies. Hum Gene Ther. 21:427-37.
-
Hum Gene Ther
, vol.21
, pp. 427-437
-
-
Manuri, P.V.1
Wilson, M.H.2
Maiti, S.N.3
-
53
-
-
70349696650
-
Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes
-
19752751 10.1097/CJI.0b013e3181ad762b 1:CAS:528:DC%2BD1MXhtFGksbvK
-
Nakazawa Y, Huye LE, Dotti G, et al. Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes. J Immunother. 2009;32:826-36.
-
(2009)
J Immunother
, vol.32
, pp. 826-836
-
-
Nakazawa, Y.1
Huye, L.E.2
Dotti, G.3
-
54
-
-
25144492340
-
Sleeping beauty transposon-mediated gene therapy for prolonged expression
-
16096013 10.1016/S0065-2660(05)54009-4 1:CAS:528:DC%2BD1cXivFWrt7k%3D
-
Hackett PB, Ekker SC, Largaespada DA, et al. Sleeping beauty transposon-mediated gene therapy for prolonged expression. Adv Genet. 2005;54:189-232.
-
(2005)
Adv Genet
, vol.54
, pp. 189-232
-
-
Hackett, P.B.1
Ekker, S.C.2
Largaespada, D.A.3
-
55
-
-
0030662074
-
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
-
9390559 10.1016/S0092-8674(00)80436-5 1:CAS:528:DyaK2sXnsFGlsbk%3D
-
Ivics Z, Hackett PB, Plasterk RH, et al. Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell. 1997;91:501-10.
-
(1997)
Cell
, vol.91
, pp. 501-510
-
-
Ivics, Z.1
Hackett, P.B.2
Plasterk, R.H.3
-
56
-
-
70349779189
-
Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors
-
19615447 10.1016/j.ymeth.2009.07.001 1:CAS:528:DC%2BD1MXht1ymsLnM
-
Izsvak Z, Chuah MK, Vandendriessche T, et al. Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors. Methods. 2009;49:287-97.
-
(2009)
Methods
, vol.49
, pp. 287-297
-
-
Izsvak, Z.1
Chuah, M.K.2
Vandendriessche, T.3
-
57
-
-
77950525914
-
A transposon and transposase system for human application
-
Hackett PB, Largaespada DA, Cooper LJ. A transposon and transposase system for human application. Mol Ther. 18:674-83.
-
Mol Ther
, vol.18
, pp. 674-683
-
-
Hackett, P.B.1
Largaespada, D.A.2
Cooper, L.J.3
-
58
-
-
77956668327
-
Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges
-
Izsvak Z, Hackett PB, Cooper LJ, et al. Translating Sleeping Beauty transposition into cellular therapies: victories and challenges. Bioessays 32:756-67.
-
Bioessays
, vol.32
, pp. 756-767
-
-
Izsvak, Z.1
Hackett, P.B.2
Cooper, L.J.3
-
59
-
-
80051775476
-
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
-
21832238 10.1126/scitranslmed.3002842 1:CAS:528:DC%2BC3MXhtFOisL3N Trial showing impressive clinical activity in 3 patients with relapsed/refractory chronic lymphocytic leukemia who received treatment with chimeric antigen receptor modified T cells
-
•• Kalos M, Levine BL, Porter DL, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med. 2011;3:95ra73. Trial showing impressive clinical activity in 3 patients with relapsed/refractory chronic lymphocytic leukemia who received treatment with chimeric antigen receptor modified T cells.
-
(2011)
Sci Transl Med
, vol.3
-
-
Kalos, M.1
Levine, B.L.2
Porter, D.L.3
-
60
-
-
80051720194
-
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
-
21830940 10.1056/NEJMoa1103849 1:CAS:528:DC%2BC3MXhtV2lu7nP Study showing long-term persistence of engineered T cells in-vivo
-
•• Porter DL, Levine BL, Kalos M, et al. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011;365:725-33. Study showing long-term persistence of engineered T cells in-vivo.
-
(2011)
N Engl J Med
, vol.365
, pp. 725-733
-
-
Porter, D.L.1
Levine, B.L.2
Kalos, M.3
-
61
-
-
77950480974
-
Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: Case report of an unforeseen adverse event in a phase i clinical trial
-
20357779 10.1038/mt.2010.31 1:CAS:528:DC%2BC3cXktVGju74%3D Unforseen adverse event in a patient treated with genetically engineered T-cells
-
• Brentjens R, Yeh R, Bernal Y, et al. Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial. Mol Ther. 2010;18:666-8. Unforseen adverse event in a patient treated with genetically engineered T-cells.
-
(2010)
Mol Ther
, vol.18
, pp. 666-668
-
-
Brentjens, R.1
Yeh, R.2
Bernal, Y.3
-
62
-
-
80455179612
-
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
-
21849486 10.1182/blood-2011-04-348540 1:CAS:528:DC%2BC3MXhsVOgsrjL
-
Brentjens RJ, Riviere I, Park JH, et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood. 2011;118:4817-28.
-
(2011)
Blood
, vol.118
, pp. 4817-4828
-
-
Brentjens, R.J.1
Riviere, I.2
Park, J.H.3
-
63
-
-
78549278144
-
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
-
20668228 10.1182/blood-2010-04-281931 1:CAS:528:DC%2BC3cXhsFCiu7fK
-
Kochenderfer JN, Wilson WH, Janik JE, et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood. 2010;116:4099-102.
-
(2010)
Blood
, vol.116
, pp. 4099-4102
-
-
Kochenderfer, J.N.1
Wilson, W.H.2
Janik, J.E.3
-
64
-
-
84858804212
-
Good T cells for bad B cells
-
22442331 10.1182/blood-2011-12-398719 1:CAS:528:DC%2BC38XkvFalt74%3D
-
Cooper LJ, Jena B, Bollard CM. Good T cells for bad B cells. Blood. 2012;119:2700-2.
-
(2012)
Blood
, vol.119
, pp. 2700-2702
-
-
Cooper, L.J.1
Jena, B.2
Bollard, C.M.3
-
65
-
-
84863337890
-
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
-
22160384 10.1182/blood-2011-10-384388 1:CAS:528:DC%2BC38XkvFalt7o%3D
-
Kochenderfer JN, Dudley ME, Feldman SA, et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood. 2012;119:2709-20.
-
(2012)
Blood
, vol.119
, pp. 2709-2720
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Feldman, S.A.3
-
66
-
-
77955510549
-
Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans
-
20304086 10.1016/j.bbmt.2010.03.014 1:CAS:528:DC%2BC3cXpvVOhtr4%3D
-
Jensen MC, Popplewell L, Cooper LJ, et al. Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans. Biol Blood Marrow Transplant. 2010;16:1245-56.
-
(2010)
Biol Blood Marrow Transplant
, vol.16
, pp. 1245-1256
-
-
Jensen, M.C.1
Popplewell, L.2
Cooper, L.J.3
-
67
-
-
79955517235
-
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
-
21540550 10.1172/JCI46110 1:CAS:528:DC%2BC3MXlvFKnt7o%3D
-
Savoldo B, Ramos CA, Liu E, et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J Clin Invest. 2011;121:1822-6.
-
(2011)
J Clin Invest
, vol.121
, pp. 1822-1826
-
-
Savoldo, B.1
Ramos, C.A.2
Liu, E.3
-
68
-
-
84861674447
-
Infusing CD19-directed T cells to augment disease control in patients undergoing autologous hematopoietic stem-cell transplantation for advanced B-lymphoid malignancies
-
22107246 10.1089/hum.2011.167 1:CAS:528:DC%2BC38XnslKmsL0%3D
-
Kebriaei P, Huls H, Jena B, et al. Infusing CD19-directed T cells to augment disease control in patients undergoing autologous hematopoietic stem-cell transplantation for advanced B-lymphoid malignancies. Hum Gene Ther. 2012;23:444-50.
-
(2012)
Hum Gene Ther
, vol.23
, pp. 444-450
-
-
Kebriaei, P.1
Huls, H.2
Jena, B.3
-
69
-
-
84860333968
-
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: Pilot clinical trial results
-
22308288 10.1182/blood-2011-10-387969 1:CAS:528:DC%2BC38Xms1alt7w%3D
-
Till BG, Jensen MC, Wang J, et al. CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results. Blood. 2012;119:3940-50.
-
(2012)
Blood
, vol.119
, pp. 3940-3950
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
-
70
-
-
33845256434
-
T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
-
16926291 10.1182/blood-2006-04-017061 1:CAS:528:DC%2BD28Xht1Kgs73F
-
Vera J, Savoldo B, Vigouroux S, et al. T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells. Blood. 2006;108:3890-7.
-
(2006)
Blood
, vol.108
, pp. 3890-3897
-
-
Vera, J.1
Savoldo, B.2
Vigouroux, S.3
-
71
-
-
79955980426
-
In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor
-
Giordano Attianese GM, Marin V, Hoyos V, et al. In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor. Blood. 2011;117:4736-45.
-
(2011)
Blood
, vol.117
, pp. 4736-4745
-
-
Giordano Attianese, G.M.1
Marin, V.2
Hoyos, V.3
-
72
-
-
84863251015
-
ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth
-
22403610 10.1371/journal.pone.0031127 1:CAS:528:DC%2BC38XjvFajtbw%3D
-
Zhang S, Chen L, Cui B, et al. ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS One. 2012;7:e31127.
-
(2012)
PLoS One
, vol.7
, pp. 31127
-
-
Zhang, S.1
Chen, L.2
Cui, B.3
-
73
-
-
84863384604
-
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
-
22439932 10.1016/j.ccr.2012.02.008 1:CAS:528:DC%2BC38Xkt1ygt78%3D
-
Yamaguchi T, Yanagisawa K, Sugiyama R, et al. NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma. Cancer Cell. 2012;21:348-61.
-
(2012)
Cancer Cell
, vol.21
, pp. 348-361
-
-
Yamaguchi, T.1
Yanagisawa, K.2
Sugiyama, R.3
-
74
-
-
84866888649
-
Dramatic Regression of Chronic Lymphocytic Leukemia in the First Patient Treated with Donor-Derived Genetically-Engineered Anti-CD19-Chimeric-Antigen- Receptor-Expressing T Cells after Allogeneic Hematopoietic Stem Cell Transplantation
-
AffiliationsNational Cancer Institute B, MD, MED et al
-
Kochenderfer JN, AffiliationsNational Cancer Institute B, MD, MED, et al. Dramatic Regression of Chronic Lymphocytic Leukemia in the First Patient Treated With Donor-Derived Genetically-Engineered Anti-CD19-Chimeric-Antigen- Receptor-Expressing T Cells After Allogeneic Hematopoietic Stem Cell Transplantation. BBMT. 2011;17:S158.
-
(2011)
BBMT
, vol.17
, pp. 158
-
-
Kochenderfer, J.N.1
-
75
-
-
84874251759
-
Outcomes of CD19-directed multivirus specific cytotoxic T lymphocyte therapy for patients with relapsed B cell malignancies after allogeneic haematopoietic stem cell transplantation
-
Bollard C, Cruz C, Savoldo B, et al. Outcomes of CD19-directed multivirus specific cytotoxic T lymphocyte therapy for patients with relapsed B cell malignancies after allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplantation. 2012;47:S56.
-
(2012)
Bone Marrow Transplantation
, vol.47
, pp. 56
-
-
Bollard, C.1
Cruz, C.2
Savoldo, B.3
-
76
-
-
80053997259
-
A human memory T cell subset with stem cell-like properties
-
21926977 10.1038/nm.2446 1:CAS:528:DC%2BC3MXhtFyls7bJ
-
Gattinoni L, Lugli E, Ji Y, et al. A human memory T cell subset with stem cell-like properties. Nat Med. 2011;17:1290-7.
-
(2011)
Nat Med
, vol.17
, pp. 1290-1297
-
-
Gattinoni, L.1
Lugli, E.2
Ji, Y.3
-
77
-
-
79953106580
-
A non-human primate model for analysis of safety, persistence, and function of adoptively transferred T cells
-
Berger C, Berger M, Anderson D, et al.: A non-human primate model for analysis of safety, persistence, and function of adoptively transferred T cells. J Med Primatol.
-
J Med Primatol
-
-
Berger, C.1
Berger, M.2
Anderson, D.3
-
78
-
-
70350458112
-
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity
-
19805141 10.1073/pnas.0907448106 1:CAS:528:DC%2BD1MXhs1WktrfI
-
Hinrichs CS, Borman ZA, Cassard L, et al. Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity. Proc Natl Acad Sci U S A. 2009;106:17469-74.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 17469-17474
-
-
Hinrichs, C.S.1
Borman, Z.A.2
Cassard, L.3
-
79
-
-
0037085804
-
Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: Potential for improved immunotherapy
-
11877273 10.1182/blood.V99.6.2009 1:CAS:528:DC%2BD38XitF2ntLw%3D
-
Rossig C, Bollard CM, Nuchtern JG, et al. Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy. Blood. 2002;99:2009-16.
-
(2002)
Blood
, vol.99
, pp. 2009-2016
-
-
Rossig, C.1
Bollard, C.M.2
Nuchtern, J.G.3
-
80
-
-
13544273197
-
Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTLs by cotransfer of T cells modified to present influenza MP1
-
15507526 10.1182/blood-2004-03-1208 1:CAS:528:DC%2BD2MXhsVChur8%3D
-
Cooper LJ, Al-Kadhimi Z, Serrano LM, et al. Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTLs by cotransfer of T cells modified to present influenza MP1. Blood. 2005;105:1622-31.
-
(2005)
Blood
, vol.105
, pp. 1622-1631
-
-
Cooper, L.J.1
Al-Kadhimi, Z.2
Serrano, L.M.3
-
81
-
-
36849021712
-
T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection
-
18026115 10.1038/nm1676 1:CAS:528:DC%2BD2sXhtl2gs7nJ
-
Stephan MT, Ponomarev V, Brentjens RJ, et al. T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Nat Med. 2007;13:1440-9.
-
(2007)
Nat Med
, vol.13
, pp. 1440-1449
-
-
Stephan, M.T.1
Ponomarev, V.2
Brentjens, R.J.3
-
82
-
-
27744566329
-
A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
-
15979412 10.1016/j.ymthe.2005.04.016 1:CAS:528:DC%2BD2MXhtFKmtLjK
-
Pule MA, Straathof KC, Dotti G, et al. A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther. 2005;12:933-41.
-
(2005)
Mol Ther
, vol.12
, pp. 933-941
-
-
Pule, M.A.1
Straathof, K.C.2
Dotti, G.3
-
83
-
-
84869446716
-
Immune responses to transgene and retroviral vector in patients treated with ex vivo engineered T cells
-
Lamers CH, Willemsen R, van Elzakker P, et al. Immune responses to transgene and retroviral vector in patients treated with ex vivo engineered T cells. Blood 2010.
-
(2010)
Blood
-
-
Lamers, C.H.1
Willemsen, R.2
Van Elzakker, P.3
-
84
-
-
33750699642
-
A phase i study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
-
17062687 10.1158/1078-0432.CCR-06-1183 1:CAS:528:DC%2BD28XhtFWhsbnL
-
Kershaw MH, Westwood JA, Parker LL, et al. A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res. 2006;12:6106-15.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6106-6115
-
-
Kershaw, M.H.1
Westwood, J.A.2
Parker, L.L.3
-
85
-
-
70449726875
-
Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts
-
19704119 10.1182/blood-2009-03-212134 1:CAS:528:DC%2BD1MXhsVSmsbzK
-
Cui Y, Zhang H, Meadors J, et al. Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts. Blood. 2009;114:3831-40.
-
(2009)
Blood
, vol.114
, pp. 3831-3840
-
-
Cui, Y.1
Zhang, H.2
Meadors, J.3
-
86
-
-
84858759305
-
Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
-
22354001 10.1182/blood-2011-12-400044 1:CAS:528:DC%2BC38XmvV2rsLg%3D
-
Pegram HJ, Lee JC, Hayman EG, et al. Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood. 2012;119:4133-41.
-
(2012)
Blood
, vol.119
, pp. 4133-4141
-
-
Pegram, H.J.1
Lee, J.C.2
Hayman, E.G.3
-
87
-
-
77954590000
-
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
-
20428207 10.1038/leu.2010.75 1:CAS:528:DC%2BC3cXntFShs74%3D
-
Hoyos V, Savoldo B, Quintarelli C, et al. Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety. Leukemia. 2010;24:1160-70.
-
(2010)
Leukemia
, vol.24
, pp. 1160-1170
-
-
Hoyos, V.1
Savoldo, B.2
Quintarelli, C.3
-
88
-
-
84874285417
-
-
San Diego, California
-
P.R. Manuriso, N. Dara, M.J. Dawson, H. Huls, D.A. Lee, E.J. Shpall, R.E. Champlin, L.J.N. Cooper: A fully-human chimeric antigen receptor for redirecting specificity of T cells to B-lineage tumors American Society for Blood and Marrow Transplantation, Tandem Meetings. San Diego, California, 2008, pp 13-14
-
(2008)
A Fully-human Chimeric Antigen Receptor for Redirecting Specificity of T Cells to B-lineage Tumors American Society for Blood and Marrow Transplantation, Tandem Meetings
, pp. 13-14
-
-
Manuriso, P.R.1
Dara, N.2
Dawson, M.J.3
Huls, H.4
Lee, D.A.5
Shpall, E.J.6
Champlin, R.E.7
Cooper, L.J.N.8
-
89
-
-
0035186913
-
A phage display selected fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes
-
11894998 10.1038/sj.gt.3301570 1:CAS:528:DC%2BD3MXosVyqur0%3D
-
Willemsen RA, Debets R, Hart E, et al. A phage display selected fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes. Gene Ther. 2001;8:1601-8.
-
(2001)
Gene Ther
, vol.8
, pp. 1601-1608
-
-
Willemsen, R.A.1
Debets, R.2
Hart, E.3
-
90
-
-
54049137681
-
Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow
-
18635810 10.1182/blood-2008-02-138040 1:CAS:528:DC%2BD1cXht1OmurzK
-
Palendira U, Chinn R, Raza W, et al. Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow. Blood. 2008;112:3293-302.
-
(2008)
Blood
, vol.112
, pp. 3293-3302
-
-
Palendira, U.1
Chinn, R.2
Raza, W.3
-
91
-
-
38449118049
-
Tumor-derived chemokine MCP-1/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells
-
17709550 1:CAS:528:DC%2BD2sXpt1SmtLo%3D
-
Brown CE, Vishwanath RP, Aguilar B, et al. Tumor-derived chemokine MCP-1/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells. J Immunol. 2007;179:3332-41.
-
(2007)
J Immunol
, vol.179
, pp. 3332-3341
-
-
Brown, C.E.1
Vishwanath, R.P.2
Aguilar, B.3
-
92
-
-
34249868241
-
Adoptive T cell therapy for cancer in the clinic
-
17549249 10.1172/JCI32446 1:CAS:528:DC%2BD2sXmsVWktb8%3D
-
June CH. Adoptive T cell therapy for cancer in the clinic. J Clin Invest. 2007;117:1466-76.
-
(2007)
J Clin Invest
, vol.117
, pp. 1466-1476
-
-
June, C.H.1
-
93
-
-
33749624177
-
Cancer regression in patients after transfer of genetically engineered lymphocytes
-
16946036 10.1126/science.1129003 1:CAS:528:DC%2BD28XhtVCiurrK
-
Morgan RA, Dudley ME, Wunderlich JR, et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science. 2006;314:126-9.
-
(2006)
Science
, vol.314
, pp. 126-129
-
-
Morgan, R.A.1
Dudley, M.E.2
Wunderlich, J.R.3
-
94
-
-
33646440024
-
Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: First clinical experience
-
16648493 10.1200/JCO.2006.05.9964
-
Lamers CH, Sleijfer S, Vulto AG, et al. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol. 2006;24:e20-2.
-
(2006)
J Clin Oncol
, vol.24
-
-
Lamers, C.H.1
Sleijfer, S.2
Vulto, A.G.3
-
95
-
-
77950475517
-
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
-
Morgan RA, Yang JC, Kitano M, et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther. 18:843-51.
-
Mol Ther
, vol.18
, pp. 843-851
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
-
96
-
-
51349090473
-
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
-
18688285 10.1172/JCI35700 1:CAS:528:DC%2BD1cXhtV2isbrK
-
Hacein-Bey-Abina S, Garrigue A, Wang GP, et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest. 2008;118:3132-42.
-
(2008)
J Clin Invest
, vol.118
, pp. 3132-3142
-
-
Hacein-Bey-Abina, S.1
Garrigue, A.2
Wang, G.P.3
-
97
-
-
33645451483
-
Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors
-
16544975 10.1089/hum.2006.17.253 1:CAS:528:DC%2BD28XisFWgu7o%3D
-
Baum C, Kustikova O, Modlich U, et al. Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors. Hum Gene Ther. 2006;17:253-63.
-
(2006)
Hum Gene Ther
, vol.17
, pp. 253-263
-
-
Baum, C.1
Kustikova, O.2
Modlich, U.3
-
98
-
-
0344511772
-
Safety of retroviral gene marking with a truncated NGF receptor
-
12669036 10.1038/nm0403-367 1:CAS:528:DC%2BD3sXisVOmt7Y%3D
-
Bonini C, Grez M, Traversari C, et al. Safety of retroviral gene marking with a truncated NGF receptor. Nat Med. 2003;9:367-9.
-
(2003)
Nat Med
, vol.9
, pp. 367-369
-
-
Bonini, C.1
Grez, M.2
Traversari, C.3
-
99
-
-
77956499908
-
A high throughput microelectroporation device to introduce a chimeric antigen receptor to redirect the specificity of human T cells
-
Choi Y, Yuen C, Maiti SN, et al. A high throughput microelectroporation device to introduce a chimeric antigen receptor to redirect the specificity of human T cells. Biomed Microdevices 12:855-63.
-
Biomed Microdevices
, vol.12
, pp. 855-863
-
-
Choi, Y.1
Yuen, C.2
Maiti, S.N.3
-
100
-
-
77954590000
-
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
-
Hoyos V, Savoldo B, Quintarelli C, et al. Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety. Leukemia 24:1160-70.
-
Leukemia
, vol.24
, pp. 1160-1170
-
-
Hoyos, V.1
Savoldo, B.2
Quintarelli, C.3
-
101
-
-
76249116978
-
Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice
-
19880489 10.1182/blood-2009-08-232967 1:CAS:528:DC%2BC3cXhtFejsA%3D%3D
-
James SE, Orgun NN, Tedder TF, et al. Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. Blood. 2009;114:5454-63.
-
(2009)
Blood
, vol.114
, pp. 5454-5463
-
-
James, S.E.1
Orgun, N.N.2
Tedder, T.F.3
-
102
-
-
34047271156
-
Combining adoptive cellular and immunocytokine therapies to improve treatment of B-lineage malignancy
-
17363611 10.1158/0008-5472.CAN-06-2283 1:CAS:528:DC%2BD2sXivV2nsbc%3D
-
Singh H, Serrano LM, Pfeiffer T, et al. Combining adoptive cellular and immunocytokine therapies to improve treatment of B-lineage malignancy. Cancer Res. 2007;67:2872-80.
-
(2007)
Cancer Res
, vol.67
, pp. 2872-2880
-
-
Singh, H.1
Serrano, L.M.2
Pfeiffer, T.3
|