Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Chang, ZeNan L ^a,b   Silver, Pamela A ^c   Chen, Yvonne Y ^a  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CD19 CAR T cell; Chimeric antigen receptor; PD 1; T cell immunotherapy

Indexed keywords

CHIMERIC ANTIGEN RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; LYMPHOCYTE SURFACE MARKER; PROGRAMMED DEATH 1 RECEPTOR; CD274 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 LIGAND 1;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CELL EXPANSION; CELL SELECTION; CELL THERAPY; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOCYTOSIS; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPOIESIS; MEMORY T LYMPHOCYTE; PHENOTYPIC VARIATION; PROCESS OPTIMIZATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RECEPTOR UPREGULATION; STIMULUS RESPONSE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TARGET CELL; CELL PROLIFERATION; CYTOLOGY; GENE DOSAGE; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; METABOLISM; PHENOTYPE; TRANSGENE; TUMOR CELL LINE; UPREGULATION;

ANTIGENS, CD; ANTIGENS, CD274; CELL LINE, TUMOR; CELL PROLIFERATION; GENE DOSAGE; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; PHENOTYPE; PROGRAMMED CELL DEATH 1 RECEPTOR; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; TRANSGENES; UP-REGULATION;

EID: 84938983902     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0519-8     Document Type: Article

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