Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Ma, Ting ^a   Fan, Bo Yi ^a   Zhang, Chao ^a   Zhao, Hui Jun ^a   Han, Chao ^a   Gao, Cai Yun ^a   Luo, Jian Guang ^a   Kong, Ling Yi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; PHYSAPUBENOLIDE; PROTEIN KINASE B; PROTEIN P53; WITHANOLIDE;

APOPTOSIS; BIOLOGICAL MODEL; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; GLYCOLYSIS; HEP-G2 CELL LINE; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; METABOLOMICS; MITOCHONDRION; PATHOLOGY; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; GLYCOLYSIS; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; METABOLOMICS; MITOCHONDRIA; MODELS, BIOLOGICAL; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; WITHANOLIDES;

EID: 84978639741     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep29926     Document Type: Article

References (49)

1. Zhang, D. et al. 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer letters 355, 176-183 (2014).
2. Vander Heiden, M. G., Cantley, L. C., Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
3. Meng, M. B. et al. Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo. Cancer letters 356, 985-993 (2015).
4. Mi, Y. J. et al. Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells. PloS one 10, e0120426 (2015).
5. Annibaldi, A., Widmann, C. Glucose metabolism in cancer cells. Current opinion in clinical nutrition and metabolic care 13, 466-470 (2010).
6. Won, K. Y. et al. Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer. Human pathology 43, 221-228 (2012).
7. Eleftheriadis, T. et al. Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation. International immunology 26, 673-684 (2014).
8. Elstrom, R. L. et al. Akt stimulates aerobic glycolysis in cancer cells. Cancer research 64, 3892-3899,(2004).
9. Abraham, A. G., O'Neill, E. PI3K/Akt-mediated regulation of p53 in cancer. Biochemical Society transactions 42, 798-803 (2014).
10. Koek, M. M., Jellema, R. H., van der Greef, J., Tas, A. C., Hankemeier, T. Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives. Metabolomics: Official journal of the Metabolomic Society 7, 307-328 (2011).
11. Zhang, A. et al. Metabolomics in diagnosis and biomarker discovery of colorectal cancer. Cancer letters 345, 17-20 (2014).
12. Guan, Y. Z., Shan, S. M., Zhang, W., Luo, J. G., Kong, L. Y. Withanolides from Physalis minima and their inhibitory effects on nitric oxide production. Steroids 82, 38-43 (2014).
13. Singh, A., Duggal, S., Singh, H., Singh, J., Katekhaye, S. Withanolides: Phytoconstituents with significant pharmacological activities. International Journal of Green Pharmacy 4, 229-237 (2010).
14. Mesaik, M. A. et al. Biological and molecular docking studies on coagulin-H: Human IL-2 novel natural inhibitor. Molecular immunology 43, 1855-1863 (2006).
15. Glotter, E., Sahai, M., Kirson, I., Gottlieb, H. E. ChemInform Abstract: Physapubenolide and Pubescenin, Two New Ergostanetype Steroids from Physalis pubescens L. Journal of the Chemical Society Perkin Transactions 17, 2241-2245 (1985).
16. Lingyi, K., Jianguang, L., Wenna, Z Inventors; China Pharmaceutical University, assignee. Withanolides type compound and antitumor application thereof. Chinese patent CN 1,033,964,470. 2013 Nov 20.
17. Zhuo, B. et al. PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma. Biochemical and biophysical research communications 464, 401-406 (2015).
18. Gogvadze, V., Orrenius, S., Zhivotovsky, B. Mitochondria in cancer cells: what is so special about them Trends in cell biology 18, 165-173 (2008).
19. Chen, L. X., He, H., Qiu, F. Natural withanolides: an overview. Natural product reports 28, 705-740 (2011).
20. Vyas, A. R., Singh, S. V. Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone. The AAPS journal 16, 1-10 (2014).
21. Cao, B. et al. Metabolomic approach to evaluating adriamycin pharmacodynamics and resistance in breast cancer cells. Metabolomics: Official journal of the Metabolomic Society 9, 960-973 (2013).
22. Dang, N. H., Singla, A. K., Mackay, E. M., Jirik, F. R., Weljie, A. M. Targeted cancer therapeutics: biosynthetic and energetic pathways characterized by metabolomics and the interplay with key cancer regulatory factors. Current pharmaceutical design 20, 2637-2647 (2014).
23. Gao, F. et al. Epigallocatechin gallate inhibits human tongue carcinoma cells via HK2mediated glycolysis. Oncology reports 33, 1533-1539 (2015).
24. Wang, Z. et al. Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism. Molecular medicine reports 11, 1917-1924 (2015).
25. Huang, S. W. et al. Targeting aerobic glycolysis and HIF-1alpha expression enhance imiquimod-induced apoptosis in cancer cells. Oncotarget 5, 1363-1381 (2014).
26. Jason, C. et al. Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth. Oncotarget 5, 6670-6686 (2014).
27. Hirschhaeuser, F., Sattler, U. G., Mueller-Klieser, W. Lactate: a metabolic key player in cancer. Cancer research 71, 6921-6925 (2011).
28. Wang, Y. H. et al. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell 158, 1309-1323 (2014).
29. Kaushik, N. et al. Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells. Scientific reports 5, 8726 (2015).
30. Huang, W. W. et al. Bufalin induces G0/G1 phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells. Mutation research 732, 26-33 (2012).
31. Geng, Y. D. et al. Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma. Cancer letters 366, 19-31 (2015).
32. Zhang, Y. S., Shen, Q., Li, J. Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy. Acta pharmacologica Sinica 37, 295-302 (2016).
33. Weinberg, S. E., Chandel, N. S. Targeting mitochondria metabolism for cancer therapy. Nature chemical biology 11, 9-15 (2015).
34. Xie, D. et al. Association of p53/p21 expression and cigarette smoking with tumor progression and poor prognosis in non-small cell lung cancer patients. Oncology reports 32, 2517-2526 (2014).
35. Li, Y. et al. Expression of p53, p21(CIP1/WAF1) and eIF4E in the adjacent tissues of oral squamous cell carcinoma: establishing the molecular boundary and a cancer progression model. International journal of oral science 7, 161-168 (2015).
36. Gu, Z. T. et al. Heat stress induced apoptosis is triggered by transcription-independent p53, Ca(2+ ) dyshomeostasis and the subsequent Bax mitochondrial translocation. Scientific reports 5, 11497 (2015).
37. Miyashita, T. et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9, 1799-1805 (1994).
38. Tian, X., Zeng, G., Li, X., Wu, Z., Wang, L. Cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamous cell carcinoma through suppression of miR-214 and regulation of p53 and Bcl-2/Bax. Oncology reports 33, 3061-3068 (2015).
39. Li, L., Fath, M. A., Scarbrough, P. M., Watson, W. H., Spitz, D. R. Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer. Redox biology 4, 127-135 (2015).
40. Hao, J. et al. Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway. European journal of pharmacology 745, 152-165 (2014).
41. Das, J., Ghosh, J., Manna, P., Sil, P. C. Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK. Biochemical pharmacology 81, 891-909 (2011).
42. Zou, W. et al. Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells. Journal of bone and mineral metabolism 33, 615-624 (2015).
43. Ogawara, Y. et al. Akt enhances Mdm2-mediated ubiquitination and degradation of p53. The Journal of biological chemistry 277, 21843-21850 (2002).
44. Lee, M. H., Lozano, G. Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins. Seminars in cancer biology 16, 225-234 (2006).
45. Jonsson, P. et al. High-throughput data analysis for detecting and identifying differences between samples in GC/MS-based metabolomic analyses. Anal Chem 77, 5635-5642 (2005).
46. Kim, S. R. et al. Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor kappaB activation. The Journal of allergy and clinical immunology 132, 1397-1408 (2013).
47. Trygg, J., Holmes, E., Lundstedt, T. Chemometrics in metabonomics. Journal of Proteome Research 6, 469-479 (2007).
48. Shaffer, R. E. Multi-and Megavariate Data Analysis. Principles and Applications, I. Eriksson, E. Johansson, N. Kettaneh-Wold and S. Wold, Umetrics Academy, Umeå, 2001, Journal of Chemometrics 16, 261-262 ISBN 91-973730-1-X, 533pp. (2002).
49. Xia, J., Psychogios, N., Young, N., Wishart, D. S. MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucleic Acids Research 37, W652-W660 (2009).