Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo

Cancer Letters

Volumn 356, Issue 2, 2015, Pages 985-993

  Meng, Mao Bin ^a   Wang, Huan Huan ^a   Guo, Wen Hao ^b   Wu, Zhi Qiang ^a   Zeng, Xian Liang ^a   Zaorsky, Nicholas G ^c   Shi, Hua Shan ^b   Qian, Dong ^a   Niu, Zhi Min ^a   Jiang, Bo ^a   Zhao, Lu Jun ^a   Yuan, Zhi Yong ^a   Wang, Ping ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

Apoptosis; Autophagy; Ionizing radiation; Pyruvate kinase M2 isoform; RNA interfering

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PLASMID VECTOR; PROTEIN KINASE B; PYRUVATE KINASE; PYRUVATE KINASE M2; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CANCER RADIOTHERAPY; CANCER STEM CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPRESSION VECTOR; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO GENE TRANSFER; IN VIVO STUDY; IONIZING RADIATION; LIPOSOMAL GENE DELIVERY SYSTEM; LUNG CANCER CELL LINE; MALE; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PKM2 GENE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; RANDOMIZED CONTROLLED TRIAL; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG SCREENING; ENZYME IMMUNOASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; LUNG NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; RADIATION DOSE; RADIATION RESPONSE; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; MICE; MICE, NUDE; PYRUVATE KINASE; RADIATION TOLERANCE; RADIATION, IONIZING; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84919430934     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.11.016     Document Type: Article

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