Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells

Journal of Bone and Mineral Metabolism

Volumn 33, Issue 6, 2015, Pages 615-624

  Zou, Wanjing ^a   Yang, Shu ^a   Zhang, Tie ^a   Sun, Haimei ^a   Wang, Yuying ^a   Xue, Hong ^a   Zhou, Deshan ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle arrest; Glucocorticoid; Hypoxia; Osteoblast

Indexed keywords

CASPASE 3; CYCLIN D1; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; METHYLPREDNISOLONE SODIUM SUCCINATE; MONOMER; P21 ACTIVATED KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; PROTEIN P85; METHYLPREDNISOLONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE NECROSIS; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DOWN REGULATION; FLOW CYTOMETRY; HYPOXIA; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CYCLE CHECKPOINT; CELL HYPOXIA; DRUG EFFECTS; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL HYPOXIA; CELL LINE; GLUCOCORTICOIDS; METHYLPREDNISOLONE; MICE; OSTEOBLASTS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION;

EID: 84944739334     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-014-0627-1     Document Type: Article

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