PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma

Biochemical and Biophysical Research Communications

Volumn 464, Issue 2, 2015, Pages 401-406

  Zhuo, Baobiao ^a   Li, Yuan ^a   Li, Zhengwei ^a   Qin, Haihui ^a   Sun, Qingzeng ^a   Zhang, Fengfei ^a   Shen, Yang ^a   Shi, Yingchun ^a   Wang, Rong ^b  

^a The Children's Hospital of Xuzhou City   (China)

^b XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Growth; Hexokinase 2; Pediatric osteosarcoma; PI3K Akt signaling

Indexed keywords

DEOXYGLUCOSE; GLUCOSE; GLUCOSE 6 PHOSPHATE; HEXOKINASE; HEXOKINASE 2; KI 67 ANTIGEN; LACTIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AEROBIC METABOLISM; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GLUCOSE INTAKE; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; BONE TUMOR; CHILD; ENZYMOLOGY; METABOLISM; PATHOLOGY;

APOPTOSIS; BONE NEOPLASMS; CHILD; HEXOKINASE; HUMANS; OSTEOSARCOMA; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84938422948     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.06.092     Document Type: Article

References (35)

1. M.L. Broadhead, J.C. Clark, D.E. Myers, C.R. Dass, and P.F. Choong The molecular pathogenesis of osteosarcoma: a review Sarcoma 2011 2011 959248
2. R. Gorlick Current concepts on the molecular biology of osteosarcoma Cancer Treat. Res. 152 2009 467 478
3. J. PosthumaDeBoer, M.A. Witlox, G.J. Kaspers, and B.J. van Royen Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature Clin. Exp. Metastasis 28 2011 493 503
4. J.P. He, Y. Hao, X.L. Wang, X.J. Yang, J.F. Shao, F.J. Guo, and J.X. Feng Review of the molecular pathogenesis of osteosarcoma Asian Pac J. Cancer Prev. 15 2014 5967 5976
5. C.L. Haddox, G. Han, L. Anijar, O. Binitie, G.D. Letson, M.M. Bui, and D.R. Reed Osteosarcoma in pediatric patients and young adults: a single institution retrospective review of presentation, therapy, and outcome Sarcoma 2014 2014 402509
6. J. Zhang, X.H. Yu, Y.G. Yan, C. Wang, and W.J. Wang PI3K/Akt signaling in osteosarcoma Clin. Chim. Acta 444 2015 182 192
7. F. Pompetti, P. Rizzo, R.M. Simon, B. Freidlin, D.J. Mew, H.I. Pass, P. Picci, A.S. Levine, and M. Carbone Oncogene alterations in primary, recurrent, and metastatic human bone tumors J. Cell. Biochem. 63 1996 37 50
8. S. Takagi, A. Takemoto, M. Takami, T. Oh-Hara, and N. Fujita Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis Cancer Sci. 105 2014 983 988
9. P. D'Arcy, W. Maruwge, B. Wolahan, L. Ma, and B. Brodin Oncogenic functions of the cancer-testis antigen SSX on the proliferation, survival, and signaling pathways of cancer cells PLoS One 9 2014 e95136
10. L. Ding, S. He, and X. Sun HSP70 desensitizes osteosarcoma cells to baicalein and protects cells from undergoing apoptosis Apoptosis 19 2014 1269 1280
11. A. Nakanishi, Y. Wada, Y. Kitagishi, and S. Matsuda Link between PI3K/AKT/PTEN pathway and NOX proteinin diseases Aging Dis. 5 2014 203 211
12. Y.S. Guo, R. Zhao, J. Ma, W. Cui, Z. Sun, B. Gao, S. He, Y.H. Han, J. Fan, L. Yang, J. Tang, and Z.J. Luo betaig-h3 promotes human osteosarcoma cells metastasis by interacting with integrin alpha2beta1 and activating PI3K signaling pathway PLoS One 9 2014 e90220
13. A. Klotzsche-von Ameln, I. Prade, M. Grosser, A. Kettelhake, M. Rezaei, T. Chavakis, I. Flamme, B. Wielockx, and G. Breier PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-alpha Mol. Cancer Res. 11 2013 1337 1348
14. G. Zhao, C. Cai, T. Yang, X. Qiu, B. Liao, W. Li, Z. Ji, J. Zhao, H. Zhao, M. Guo, Q. Ma, C. Xiao, Q. Fan, and B. Ma MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma PLoS One 8 2013 e53906
15. K. Inoki, Y. Li, T. Zhu, J. Wu, and K.L. Guan TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nat. Cell. Biol. 4 2002 648 657
16. S.R. Boreddy, K.C. Pramanik, and S.K. Srivastava Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway Clin. Cancer Res. 17 2011 1784 1795
17. B. Faubert, G. Boily, S. Izreig, T. Griss, B. Samborska, Z. Dong, F. Dupuy, C. Chambers, B.J. Fuerth, B. Viollet, O.A. Mamer, D. Avizonis, R.J. DeBerardinis, P.M. Siegel, and R.G. Jones AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo Cell. Metab. 17 2013 113 124
18. K. Shibuya, M. Okada, S. Suzuki, M. Seino, S. Seino, H. Takeda, and C. Kitanaka Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells Oncotarget 6 2015 651 661
19. A.T. Ooi, and B.N. Gomperts Molecular pathways: targeting cellular energy metabolism in cancer via inhibition of SLC2A1 and LDHA Clin. Cancer Res. 21 11 2015 Jun 1 2440 2444
20. M. Shi, J. Cui, J. Du, D. Wei, Z. Jia, J. Zhang, Z. Zhu, Y. Gao, and K. Xie A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer Clin. Cancer Res. 20 2014 4370 4380
21. L.W. Finley, J. Zhang, J. Ye, P.S. Ward, and C.B. Thompson SnapShot: cancer metabolism pathways Cell. Metab. 17 2013 466 466 e462
22. K. Brand, S. Aichinger, S. Forster, S. Kupper, B. Neumann, W. Nurnberg, and G. Ohrisch Cell-cycle-related metabolic and enzymatic events in proliferating rat thymocytes Eur. J. Biochem. 172 1988 695 702
23. P.L. Pedersen, S. Mathupala, A. Rempel, J.F. Geschwind, and Y.H. Ko Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention Biochim. Biophys. Acta 1555 2002 14 20
24. H. Yoshino, H. Enokida, T. Itesako, S. Kojima, T. Kinoshita, S. Tatarano, T. Chiyomaru, M. Nakagawa, and N. Seki Tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma Cancer Sci. 104 2013 1567 1574
25. A. Wolf, S. Agnihotri, J. Micallef, J. Mukherjee, N. Sabha, R. Cairns, C. Hawkins, and A. Guha Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme J. Exp. Med. 208 2011 313 326
26. J. Chen, S. Zhang, Y. Li, Z. Tang, and W. Kong Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma Tumour Biol. 35 2014 3743 3753
27. C.V. Dang c-Myc target genes involved in cell growth, apoptosis, and metabolism Mol. Cell. Biol. 19 1999 1 11
28. S.P. Mathupala, Y.H. Ko, and P.L. Pedersen Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy Semin. Cancer Biol. 19 2009 17 24
29. J.E. Kim, B.C. Ahn, M.H. Hwang, Y.H. Jeon, S.Y. Jeong, S.W. Lee, and J. Lee Combined RNA interference of hexokinase II and (131)I-sodium iodide symporter gene therapy for anaplastic thyroid carcinoma J. Nucl. Med. 52 2011 1756 1763
30. K.J. Ahn, H.S. Hwang, J.H. Park, S.H. Bang, W.J. Kang, M. Yun, and J.D. Lee Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines J. Nucl. Med. 50 2009 1525 1532
31. Q. Peng, Q. Zhou, J. Zhou, D. Zhong, F. Pan, and H. Liang Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo Cancer Biol. Ther. 7 2008 1128 1135
32. E. Bustamante, H.P. Morris, and P.L. Pedersen Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding J. Biol. Chem. 256 1981 8699 8704
33. L. Sun, S. Shukair, T.J. Naik, F. Moazed, and H. Ardehali Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinases I and II Mol. Cell. Biol. 28 2008 1007 1017
34. R.A. Cairns, I.S. Harris, and T.W. Mak Regulation of cancer cell metabolism Nat. Rev. Cancer 11 2011 85 95
35. S. Ros, and A. Schulze Glycolysis back in the limelight: systemic targeting of HK2 blocks tumor growth Cancer Discov. 3 2013 1105 1107