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Volumn 745, Issue , 2014, Pages 152-165

Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway

Author keywords

Akt pathway; Insulin resistance; Palmitic acid; Polydatin; STZ

Indexed keywords

ANTIDIABETIC AGENT; CHOLESTEROL; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATE; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOSYLATED HEMOGLOBIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POLYDATIN; PROTEIN KINASE B; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84918801138     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.09.047     Document Type: Article
Times cited : (68)

References (52)
  • 1
    • 15744394674 scopus 로고    scopus 로고
    • Fructose, insulin resistance, and metabolic dyslipidemia
    • H. Basciano, L. Federico, and K. Adeli Fructose, insulin resistance, and metabolic dyslipidemia Nutr. Metab. 2 2005 5
    • (2005) Nutr. Metab. , vol.2 , pp. 5
    • Basciano, H.1    Federico, L.2    Adeli, K.3
  • 2
    • 79952451443 scopus 로고    scopus 로고
    • Obesity, insulin resistance and free fatty acids
    • G. Boden Obesity, insulin resistance and free fatty acids Curr. Opin. Endocrinol. Diabetes Obes. 18 2011 139 143
    • (2011) Curr. Opin. Endocrinol. Diabetes Obes. , vol.18 , pp. 139-143
    • Boden, G.1
  • 3
    • 8844255630 scopus 로고    scopus 로고
    • Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and beta-cell dysfunction
    • G. Boden, and G.I. Shulman Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction Eur. J. Clin. Investig. 32 Suppl 3 2002 S14 S23
    • (2002) Eur. J. Clin. Investig. , vol.32 , pp. 14-S23
    • Boden, G.1    Shulman, G.I.2
  • 4
    • 0028845430 scopus 로고
    • The glucose-6-phosphatase system in human development
    • A. Burchell, and R. Hume The glucose-6-phosphatase system in human development Histol. Histopathol. 10 1995 979 993
    • (1995) Histol. Histopathol. , vol.10 , pp. 979-993
    • Burchell, A.1    Hume, R.2
  • 5
    • 0034055787 scopus 로고    scopus 로고
    • Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4
    • E. Carvalho, C. Rondinone, and U. Smith Insulin resistance in fat cells from obese Zucker rats - evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4 Mol. Cell. Biochem. 206 2000 7 16
    • (2000) Mol. Cell. Biochem. , vol.206 , pp. 7-16
    • Carvalho, E.1    Rondinone, C.2    Smith, U.3
  • 6
    • 84880572450 scopus 로고    scopus 로고
    • Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinase
    • W. Chang, M. Zhang, J. Li, Z. Meng, S. Wei, H. Du, L. Chen, and G.M. Hatch Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinase Metabolism 62 2013 1159 1167
    • (2013) Metabolism , vol.62 , pp. 1159-1167
    • Chang, W.1    Zhang, M.2    Li, J.3    Meng, Z.4    Wei, S.5    Du, H.6    Chen, L.7    Hatch, G.M.8
  • 7
    • 84877870604 scopus 로고    scopus 로고
    • Effect of TangMaiJiaoTai on regulating the glycolipid metabolism and the production of glucokinase and low density lipoprotrein receptor protein in diabetic rats with hyperlipmia
    • X. Chang, J. Li, X. Xie, K. Huang, and H. Huang Effect of TangMaiJiaoTai on regulating the glycolipid metabolism and the production of glucokinase and low density lipoprotrein receptor protein in diabetic rats with hyperlipmia Chin. Pharmacol. Bull. 29 2013 234 237
    • (2013) Chin. Pharmacol. Bull. , vol.29 , pp. 234-237
    • Chang, X.1    Li, J.2    Xie, X.3    Huang, K.4    Huang, H.5
  • 8
    • 84877870604 scopus 로고    scopus 로고
    • Effect of TangMaiJiaoTai on regulating the glycolipid metabolism and the production of glucokinase and low density lipoprotrein receptor protein in diabetic rats with hyperlipmia
    • X. Chang, J. Li, X. Xie, K. Huang, and H. Huang Effect of TangMaiJiaoTai on regulating the glycolipid metabolism and the production of glucokinase and low density lipoprotrein receptor protein in diabetic rats with hyperlipmia Chin. Pharmacol. Bull. 29 2013 234 237
    • (2013) Chin. Pharmacol. Bull. , vol.29 , pp. 234-237
    • Chang, X.1    Li, J.2    Xie, X.3    Huang, K.4    Huang, H.5
  • 9
    • 33748470087 scopus 로고    scopus 로고
    • Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury
    • Y. Cheng, H. Zhang, L. Sun, S. Guo, S. Ouyang, Y. Zhang, and J. Xu Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury Brain Res. 1110 2006 193 200
    • (2006) Brain Res. , vol.1110 , pp. 193-200
    • Cheng, Y.1    Zhang, H.2    Sun, L.3    Guo, S.4    Ouyang, S.5    Zhang, Y.6    Xu, J.7
  • 10
    • 84866122780 scopus 로고    scopus 로고
    • Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
    • K.D. Copps, and M.F. White Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 Diabetologia 55 2012 2565 2582
    • (2012) Diabetologia , vol.55 , pp. 2565-2582
    • Copps, K.D.1    White, M.F.2
  • 11
    • 67349165065 scopus 로고    scopus 로고
    • Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters
    • J. Du, L.N. Sun, W.W. Xing, B.K. Huang, M. Jia, J.Z. Wu, H. Zhang, and L.P. Qin Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters Phytomedicine 16 2009 652 658
    • (2009) Phytomedicine , vol.16 , pp. 652-658
    • Du, J.1    Sun, L.N.2    Xing, W.W.3    Huang, B.K.4    Jia, M.5    Wu, J.Z.6    Zhang, H.7    Qin, L.P.8
  • 12
    • 77956921023 scopus 로고    scopus 로고
    • The effects of palmitate on hepatic insulin resistance are mediated by NADPH oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways
    • D. Gao, S. Nong, X. Huang, Y. Lu, H. Zhao, Y. Lin, Y. Man, S. Wang, J. Yang, and J. Li The effects of palmitate on hepatic insulin resistance are mediated by NADPH oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways J. Biol. Chem. 285 2010 29965 29973
    • (2010) J. Biol. Chem. , vol.285 , pp. 29965-29973
    • Gao, D.1    Nong, S.2    Huang, X.3    Lu, Y.4    Zhao, H.5    Lin, Y.6    Man, Y.7    Wang, S.8    Yang, J.9    Li, J.10
  • 13
    • 77956702315 scopus 로고    scopus 로고
    • Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse and pressure-overload rat models
    • J.P. Gao, C.X. Chen, W.L. Gu, Q. Wu, Y. Wang, and J. Lu Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse and pressure-overload rat models Fitoterapia 81 2010 953 960
    • (2010) Fitoterapia , vol.81 , pp. 953-960
    • Gao, J.P.1    Chen, C.X.2    Gu, W.L.3    Wu, Q.4    Wang, Y.5    Lu, J.6
  • 16
    • 84893051766 scopus 로고    scopus 로고
    • Insulin signaling, resistance, and the metabolic syndrome: Insights from mouse models into disease mechanisms
    • S. Guo Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms J. Endocrinol. 220 2014 T1 T23
    • (2014) J. Endocrinol. , vol.220 , pp. 1-T23
    • Guo, S.1
  • 17
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Investig. 109 2002 1125 1131
    • (2002) J. Clin. Investig. , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 18
    • 84882777501 scopus 로고    scopus 로고
    • Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway
    • M. Ishikawa, K. Yoshida, H. Okamura, K. Ochiai, H. Takamura, N. Fujiwara, and K. Ozaki Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway Biochim. Biophys. Acta 1832 2013 2035 2043
    • (2013) Biochim. Biophys. Acta , vol.1832 , pp. 2035-2043
    • Ishikawa, M.1    Yoshida, K.2    Okamura, H.3    Ochiai, K.4    Takamura, H.5    Fujiwara, N.6    Ozaki, K.7
  • 19
    • 0034329593 scopus 로고    scopus 로고
    • Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase
    • P. Iynedjian, R. Roth, M. Fleischmann, and A. Gjinovci Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase Biochem. J. 351 2000 621 627
    • (2000) Biochem. J. , vol.351 , pp. 621-627
    • Iynedjian, P.1    Roth, R.2    Fleischmann, M.3    Gjinovci, A.4
  • 20
    • 84155166813 scopus 로고    scopus 로고
    • Polydatin modulates inflammation by decreasing NF-k B activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain
    • H. Ji, X. Zhang, Y. Du, H. Liu, S. Li, and L. Li Polydatin modulates inflammation by decreasing NF-k B activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain Brain Res. Bull. 87 2012 50 59
    • (2012) Brain Res. Bull. , vol.87 , pp. 50-59
    • Ji, H.1    Zhang, X.2    Du, Y.3    Liu, H.4    Li, S.5    Li, L.6
  • 21
    • 33745116619 scopus 로고    scopus 로고
    • Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis
    • E. Karaskov, C. Scott, L. Zhang, T. Teodoro, M. Ravazzola, and A. Volchuk Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis Endocrinology 147 2006 3398 3407
    • (2006) Endocrinology , vol.147 , pp. 3398-3407
    • Karaskov, E.1    Scott, C.2    Zhang, L.3    Teodoro, T.4    Ravazzola, M.5    Volchuk, A.6
  • 22
    • 0019468569 scopus 로고
    • Glycosylated serum protein and hemoglobin A1 levels to measure control of glycemia
    • A.L. Kennedy, and T.J. Merimee Glycosylated serum protein and hemoglobin A1 levels to measure control of glycemia Ann. Intern. Med. 95 1981 56 58
    • (1981) Ann. Intern. Med. , vol.95 , pp. 56-58
    • Kennedy, A.L.1    Merimee, T.J.2
  • 23
    • 77956339397 scopus 로고    scopus 로고
    • Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway
    • T. Lan, X. Shen, P. Liu, W. Liu, S. Xu, X. Xie, Q. Jiang, W. Li, and H. Huang Berberine ameliorates renal injury in diabetic C57BL/6 mice: involvement of suppression of SphK-S1P signaling pathway Arch. Biochem. Biophys. 502 2010 112 120
    • (2010) Arch. Biochem. Biophys. , vol.502 , pp. 112-120
    • Lan, T.1    Shen, X.2    Liu, P.3    Liu, W.4    Xu, S.5    Xie, X.6    Jiang, Q.7    Li, W.8    Huang, H.9
  • 24
    • 70350417158 scopus 로고    scopus 로고
    • Akt2 is required for hepatic lipid accumulation in models of insulin resistance
    • K.F. Leavens, R.M. Easton, G.I. Shulman, S.F. Previs, and M.J. Birnbaum Akt2 is required for hepatic lipid accumulation in models of insulin resistance Cell Metab. 10 2009 405 418
    • (2009) Cell Metab. , vol.10 , pp. 405-418
    • Leavens, K.F.1    Easton, R.M.2    Shulman, G.I.3    Previs, S.F.4    Birnbaum, M.J.5
  • 25
    • 34547691071 scopus 로고    scopus 로고
    • The role of GSK3 in glucose homeostasis and the development of insulin resistance
    • J. Lee, and M.S. Kim The role of GSK3 in glucose homeostasis and the development of insulin resistance Diabetes Res. Clin. Pract. 77 Suppl 1 2007 S49 S57
    • (2007) Diabetes Res. Clin. Pract. , vol.77 , pp. 49-S57
    • Lee, J.1    Kim, M.S.2
  • 26
    • 84874495104 scopus 로고    scopus 로고
    • Clinical significance of glycosylated serum protein in patients with diabetic nephropathy
    • P.L. Li, R. Yang, Y. Zhou, H. Chen, and D.H. Cai Clinical significance of glycosylated serum protein in patients with diabetic nephropathy J. South. Med. Univ. 31 2011 1093 1094
    • (2011) J. South. Med. Univ. , vol.31 , pp. 1093-1094
    • Li, P.L.1    Yang, R.2    Zhou, Y.3    Chen, H.4    Cai, D.H.5
  • 28
    • 79959962745 scopus 로고    scopus 로고
    • Hormonal regulation of hepatic glucose production in health and disease
    • H.V. Lin, and D. Accili Hormonal regulation of hepatic glucose production in health and disease Cell Metab. 14 2011 9 19
    • (2011) Cell Metab. , vol.14 , pp. 9-19
    • Lin, H.V.1    Accili, D.2
  • 29
    • 80055004410 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contrib-ute to polydatin-induced apoptosis in human nasopharyngeal carcinoma CNE cells
    • H. Liu, S. Zhao, Y. Zhang, J. Wu, H. Peng, J. Fan, and J. Liao Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contrib-ute to polydatin-induced apoptosis in human nasopharyngeal carcinoma CNE cells J. Cell. Biochem. 112 2011 3695 3703
    • (2011) J. Cell. Biochem. , vol.112 , pp. 3695-3703
    • Liu, H.1    Zhao, S.2    Zhang, Y.3    Wu, J.4    Peng, H.5    Fan, J.6    Liao, J.7
  • 30
    • 77953537219 scopus 로고    scopus 로고
    • Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury
    • W. Liu, X. Zhang, P. Liu, X. Shen, T. Lan, W. Li, Q. Jiang, X. Xie, and H. Huang Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury Eur. J. Pharmacol. 638 2010 150 155
    • (2010) Eur. J. Pharmacol. , vol.638 , pp. 150-155
    • Liu, W.1    Zhang, X.2    Liu, P.3    Shen, X.4    Lan, T.5    Li, W.6    Jiang, Q.7    Xie, X.8    Huang, H.9
  • 31
    • 0028914922 scopus 로고
    • Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities
    • H. Maegawa, R. Ide, M. Hasegawa, S. Ugi, K. Egawa, M. Iwanishi, R. Kikkawa, Y. Shigeta, and A. Kashiwagi Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities J. Biol. Chem. 270 1995 7724 7730
    • (1995) J. Biol. Chem. , vol.270 , pp. 7724-7730
    • Maegawa, H.1    Ide, R.2    Hasegawa, M.3    Ugi, S.4    Egawa, K.5    Iwanishi, M.6    Kikkawa, R.7    Shigeta, Y.8    Kashiwagi, A.9
  • 32
    • 34547444891 scopus 로고    scopus 로고
    • Mechanistic insights into diabetes mellitus and oxidative stress
    • K. Maiese, Z.Z. Chong, and Y.C. Shang Mechanistic insights into diabetes mellitus and oxidative stress Curr. Med. Chem. 14 2007 1729 1738
    • (2007) Curr. Med. Chem. , vol.14 , pp. 1729-1738
    • Maiese, K.1    Chong, Z.Z.2    Shang, Y.C.3
  • 33
    • 0036724133 scopus 로고    scopus 로고
    • Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition
    • G. Patane, M. Anello, S. Piro, R. Vigneri, F. Purrello, and A.M. Rabuazzo Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition Diabetes 51 2002 2749 2756
    • (2002) Diabetes , vol.51 , pp. 2749-2756
    • Patane, G.1    Anello, M.2    Piro, S.3    Vigneri, R.4    Purrello, F.5    Rabuazzo, A.M.6
  • 34
    • 84865293359 scopus 로고    scopus 로고
    • Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-κB signaling pathway in rat glomerular mesangial cells
    • J. Peng, X. Xie, K. Huang, J. Huang, X. Shen, P. Liu, and H. Huang Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-κB signaling pathway in rat glomerular mesangial cells Mol. Cell. Endocrinol. 362 2012 183 193
    • (2012) Mol. Cell. Endocrinol. , vol.362 , pp. 183-193
    • Peng, J.1    Xie, X.2    Huang, K.3    Huang, J.4    Shen, X.5    Liu, P.6    Huang, H.7
  • 35
    • 57149123016 scopus 로고    scopus 로고
    • Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium
    • S.V. Penumathsa, M. Thirunavukkarasu, L. Zhan, G. Maulik, V.P. Menon, D. Bagchi, and N. Maulik Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium J. Cell. Mol. Med. 12 2008 2350 2361
    • (2008) J. Cell. Mol. Med. , vol.12 , pp. 2350-2361
    • Penumathsa, S.V.1    Thirunavukkarasu, M.2    Zhan, L.3    Maulik, G.4    Menon, V.P.5    Bagchi, D.6    Maulik, N.7
  • 36
    • 4544242908 scopus 로고    scopus 로고
    • Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells
    • D.J. Powell, S. Turban, A. Gray, E. Hajduch, and H.S. Hundal Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells Biochem. J. 382 2004 619 629
    • (2004) Biochem. J. , vol.382 , pp. 619-629
    • Powell, D.J.1    Turban, S.2    Gray, A.3    Hajduch, E.4    Hundal, H.S.5
  • 37
    • 77957962451 scopus 로고    scopus 로고
    • Risk factors for microvascular complications of diabetes among South Indian subjects with type 2 diabetes - The Chennai urban rural epidemiology study (CURES) eye study-5
    • R. Pradeepa, R.M. Anjana, R. Unnikrishnan, A. Ganesan, V. Mohan, and M. Rema Risk factors for microvascular complications of diabetes among South Indian subjects with type 2 diabetes - the Chennai urban rural epidemiology study (CURES) eye study-5 Diabetes Technol. Ther. 12 2010 755 761
    • (2010) Diabetes Technol. Ther. , vol.12 , pp. 755-761
    • Pradeepa, R.1    Anjana, R.M.2    Unnikrishnan, R.3    Ganesan, A.4    Mohan, V.5    Rema, M.6
  • 39
    • 84874411482 scopus 로고    scopus 로고
    • High-fat diet obesity associated with insulin resistance increases cell proliferation, estrogen receptor, and PI3K proteins in rat ventral prostate
    • D.L. Ribeiro, M.E. Pinto, A. Rafacho, J.R. Bosqueiro, S.Y. Maeda, J.A. Anselmo-Franci, S.R. Taboga, and R.M. Goes High-fat diet obesity associated with insulin resistance increases cell proliferation, estrogen receptor, and PI3K proteins in rat ventral prostate J. Androl. 33 2012 854 865
    • (2012) J. Androl. , vol.33 , pp. 854-865
    • Ribeiro, D.L.1    Pinto, M.E.2    Rafacho, A.3    Bosqueiro, J.R.4    Maeda, S.Y.5    Anselmo-Franci, J.A.6    Taboga, S.R.7    Goes, R.M.8
  • 40
    • 0032765342 scopus 로고    scopus 로고
    • Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus
    • C.M. Rondinone, E. Carvalho, C. Wesslau, and U.P. Smith Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus Diabetologia 42 1999 819 825
    • (1999) Diabetologia , vol.42 , pp. 819-825
    • Rondinone, C.M.1    Carvalho, E.2    Wesslau, C.3    Smith, U.P.4
  • 42
    • 77649144555 scopus 로고    scopus 로고
    • Pioglitazone: Side effect and safety profile
    • P. Shah, and S. Mudaliar Pioglitazone: side effect and safety profile Expert Opin. Drug Saf. 9 2010 347 354
    • (2010) Expert Opin. Drug Saf. , vol.9 , pp. 347-354
    • Shah, P.1    Mudaliar, S.2
  • 43
    • 23844504364 scopus 로고    scopus 로고
    • Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening
    • K. Srinivasan, B. Viswanad, L. Asrat, C.L. Kaul, and P. Ramarao Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening Pharmacol. Res. 52 2005 313 320
    • (2005) Pharmacol. Res. , vol.52 , pp. 313-320
    • Srinivasan, K.1    Viswanad, B.2    Asrat, L.3    Kaul, C.L.4    Ramarao, P.5
  • 44
    • 33646148946 scopus 로고    scopus 로고
    • Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta
    • C. Taniguchi, T. Kondo, M. Sajan, J. Luo, R. Bronson, T. Asano, R. Farese, L. Cantley, and C. Kahn Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta Cell Metab. 3 2006 343 353
    • (2006) Cell Metab. , vol.3 , pp. 343-353
    • Taniguchi, C.1    Kondo, T.2    Sajan, M.3    Luo, J.4    Bronson, R.5    Asano, T.6    Farese, R.7    Cantley, L.8    Kahn, C.9
  • 45
    • 0030903085 scopus 로고    scopus 로고
    • Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene
    • L. Tappy, P. Dussoix, P. Iynedjian, S. Henry, P. Schneiter, G. Zahnd, E. Jequier, and J. Philippe Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene Diabetes 46 1997 204 208
    • (1997) Diabetes , vol.46 , pp. 204-208
    • Tappy, L.1    Dussoix, P.2    Iynedjian, P.3    Henry, S.4    Schneiter, P.5    Zahnd, G.6    Jequier, E.7    Philippe, J.8
  • 46
    • 0035432971 scopus 로고    scopus 로고
    • Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities
    • F. Tremblay, C. Lavigne, H. Jacques, and A. Marette Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities Diabetes 50 2001 1901 1910
    • (2001) Diabetes , vol.50 , pp. 1901-1910
    • Tremblay, F.1    Lavigne, C.2    Jacques, H.3    Marette, A.4
  • 47
    • 68049084636 scopus 로고    scopus 로고
    • Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits
    • W. Xing, J. Wu, M. Jia, J. Du, H. Zhang, and L. Qin Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits Biomed. Pharmacother. 63 2009 457 462
    • (2009) Biomed. Pharmacother. , vol.63 , pp. 457-462
    • Xing, W.1    Wu, J.2    Jia, M.3    Du, J.4    Zhang, H.5    Qin, L.6
  • 48
    • 0034698030 scopus 로고    scopus 로고
    • Measurement of glucose uptake and intracellular calcium concentration in single, living pancreatic β-cells
    • K. Yamada, M. Nakata, N. Horimoto, M. Saito, H. Matsuoka, and N. Inagaki Measurement of glucose uptake and intracellular calcium concentration in single, living pancreatic β-cells J. Biol. Chem. 275 2000 22278 22283
    • (2000) J. Biol. Chem. , vol.275 , pp. 22278-22283
    • Yamada, K.1    Nakata, M.2    Horimoto, N.3    Saito, M.4    Matsuoka, H.5    Inagaki, N.6
  • 49
    • 0036833480 scopus 로고    scopus 로고
    • Effects of berberine on glucose metabolism in vitro
    • J. Yin, R. Hu, M. Chen, J. Tang, F. Li, Y. Yang, and J. Chen Effects of berberine on glucose metabolism in vitro Metabolism 51 2002 1439 1443
    • (2002) Metabolism , vol.51 , pp. 1439-1443
    • Yin, J.1    Hu, R.2    Chen, M.3    Tang, J.4    Li, F.5    Yang, Y.6    Chen, J.7
  • 50
    • 14944381279 scopus 로고    scopus 로고
    • Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications
    • J. Zdychova, and R. Komers Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications Physiol. Res. 54 2005 1 16
    • (2005) Physiol. Res. , vol.54 , pp. 1-16
    • Zdychova, J.1    Komers, R.2
  • 52
    • 25844526509 scopus 로고    scopus 로고
    • 2-NBDG as a fluorescent indicator for direct glucose uptake measurement
    • C. Zou, Y. Wang, and Z. Shen 2-NBDG as a fluorescent indicator for direct glucose uptake measurement J. Biochem. Biophys. Methods 64 2005 207 215
    • (2005) J. Biochem. Biophys. Methods , vol.64 , pp. 207-215
    • Zou, C.1    Wang, Y.2    Shen, Z.3


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