Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK

Biochemical Pharmacology

Volumn 81, Issue 7, 2011, Pages 891-909

  Das, Joydeep ^a   Ghosh, Jyotirmoy ^a   Manna, Prasenjit ^a   Sil, Parames C ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Antioxidant; Apoptosis; Cardiac oxidative stress; Cell survival; Doxorubicin; NF B and MAPK; p53; PI3 K Akt; Reactive oxygen species; Taurine

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 CHLORO 8 NICOTINAMIDO BETA CARBOLINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CALCIUM; CASPASE 12; CASPASE 3; CASPASE 9; CREATINE KINASE; DOXORUBICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TAURINE;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CARDIOTOXICITY; CELL CULTURE; CELL VIABILITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; HEART MUSCLE CELL; HEART PROTECTION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; DOXORUBICIN; HEART; MALE; MICE; OXIDATIVE STRESS; POLYPLOIDY; PROTEIN KINASE INHIBITORS; RATS; TAURINE; UP-REGULATION;

EID: 79952575620     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.01.008     Document Type: Article

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