A flexible reporter system for direct observation and isolation of cancer stem cells

Stem Cell Reports

Volumn 4, Issue 1, 2015, Pages 155-169

  Tang, Binwu ^a   Raviv, Asaf ^a   Esposito, Dominic ^b   Flanders, Kathleen C ^a   Daniel, Catherine ^a   Nghiem, Bao Tram ^a   Garfield, Susan ^a   Lim, Langston ^a   Mannan, Poonam ^a   Robles, Ana I ^a   Smith, William I ^c   Zimmerberg, Joshua ^d   Ravin, Rea ^d   Wakefield, Lalage M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c SUBURBAN HOSPITAL   (United States)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 4; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; ANTINEOPLASTIC AGENT; PROTEIN BINDING; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; ASYMMETRIC CELL DIVISION; CANCER CELL; CANCER STEM CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL INVASION; CELL ISOLATION; CELL POPULATION; CELL RENEWAL; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYONIC STEM CELL; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TIME-LAPSE VIDEO MICROSCOPY; ANIMAL; CELL MOTION; CELL TRACKING; CELL TRANSFORMATION; CYTOLOGY; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION; GENE ORDER; GENE VECTOR; GENETICS; IMMUNOPHENOTYPING; METABOLISM; PATHOLOGY; REPORTER GENE; TUMOR CELL CULTURE; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; ASYMMETRIC CELL DIVISION; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; CELL TRACKING; CELL TRANSFORMATION, NEOPLASTIC; DRUG RESISTANCE, NEOPLASM; EMBRYONIC STEM CELLS; GENE EXPRESSION; GENE ORDER; GENES, REPORTER; GENETIC VECTORS; HETEROGRAFTS; HUMANS; IMMUNOPHENOTYPING; MICE; NEOPLASTIC STEM CELLS; PHENOTYPE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RESPONSE ELEMENTS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 84920883783     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2014.11.002     Document Type: Article

References (42)

1. M.R. Alison, W.R. Lin, S.M. Lim, and L.J. Nicholson Cancer stem cells: in the line of fire Cancer Treat. Rev. 38 2012 589 598
2. K. Arnold, A. Sarkar, M.A. Yram, J.M. Polo, R. Bronson, S. Sengupta, M. Seandel, N. Geijsen, and K. Hochedlinger Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice Cell Stem Cell 9 2011 317 329
3. Y. Atlasi, S.J. Mowla, S.A. Ziaee, P.J. Gokhale, and P.W. Andrews OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells Stem Cells 26 2008 3068 3074
4. A.S. Beltran, A.G. Rivenbark, B.T. Richardson, X. Yuan, H. Quian, J.P. Hunt, E. Zimmerman, L.M. Graves, and P. Blancafort Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor Breast Cancer Res. 13 2011 R94
5. I. Ben-Porath, M.W. Thomson, V.J. Carey, R. Ge, G.W. Bell, A. Regev, and R.A. Weinberg An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors Nat. Genet. 40 2008 499 507
6. T. Brabletz, A. Jung, S. Spaderna, F. Hlubek, and T. Kirchner Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression Nat. Rev. Cancer 5 2005 744 749
7. H. Clevers The cancer stem cell: premises, promises and challenges Nat. Med. 17 2011 313 319
8. M.J. Conboy, A.O. Karasov, and T.A. Rando High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny PLoS Biol. 5 2007 e102
9. S.J. Conley, E. Gheordunescu, P. Kakarala, B. Newman, H. Korkaya, A.N. Heath, S.G. Clouthier, and M.S. Wicha Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia Proc. Natl. Acad. Sci. USA 109 2012 2784 2789
10. P. Corish, and C. Tyler-Smith Attenuation of green fluorescent protein half-life in mammalian cells Protein Eng. 12 1999 1035 1040
11. T.X. Cui, I. Kryczek, L. Zhao, E. Zhao, R. Kuick, M.H. Roh, L. Vatan, W. Szeliga, Y. Mao, and D.G. Thomas Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2 Immunity 39 2013 611 621
12. C.M. Fillmore, and C. Kuperwasser Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy Breast Cancer Res. 10 2008 R25
13. R.M. Gangemi, F. Griffero, D. Marubbi, M. Perera, M.C. Capra, P. Malatesta, G.L. Ravetti, G.L. Zona, A. Daga, and G. Corte SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity Stem Cells 27 2009 40 48
14. C. Ginestier, M.H. Hur, E. Charafe-Jauffret, F. Monville, J. Dutcher, M. Brown, J. Jacquemier, P. Viens, C.G. Kleer, and S. Liu ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome Cell Stem Cell 1 2007 555 567
15. K. Hochedlinger, Y. Yamada, C. Beard, and R. Jaenisch Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues Cell 121 2005 465 477
16. A. Hotta, A.Y. Cheung, N. Farra, K. Vijayaragavan, C.A. Séguin, J.S. Draper, P. Pasceri, I.A. Maksakova, D.L. Mager, and J. Rossant Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency Nat. Methods 6 2009 370 376
17. Y. Hu, and G.K. Smyth ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays J. Immunol. Methods 347 2009 70 78
18. I. Ibarra, Y. Erlich, S.K. Muthuswamy, R. Sachidanandam, and G.J. Hannon A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells Genes Dev. 21 2007 3238 3243
19. P. Kabos, J.M. Haughian, X. Wang, W.W. Dye, C. Finlayson, A. Elias, K.B. Horwitz, and C.A. Sartorius Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopulation in luminal breast cancers Breast Cancer Res. Treat. 128 2011 45 55
20. H. Korkaya, S. Liu, and M.S. Wicha Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots Clin. Cancer Res. 17 2011 6125 6129
21. H. Korkaya, G.I. Kim, A. Davis, F. Malik, N.L. Henry, S. Ithimakin, A.A. Quraishi, N. Tawakkol, R. D'Angelo, and A.K. Paulson Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population Mol. Cell 47 2012 570 584
22. T. Kuroda, M. Tada, H. Kubota, H. Kimura, S.Y. Hatano, H. Suemori, N. Nakatsuji, and T. Tada Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression Mol. Cell. Biol. 25 2005 2475 2485
23. C. Lagadec, E. Vlashi, L. Della Donna, C. Dekmezian, and F. Pajonk Radiation-induced reprogramming of breast cancer cells Stem Cells 30 2012 833 844
24. C.J. Lengner, G.G. Welstead, and R. Jaenisch The pluripotency regulator Oct4: a role in somatic stem cells? Cell Cycle 7 2008 725 728
25. P.P. Levings, S.V. McGarry, T.P. Currie, D.M. Nickerson, S. McClellan, S.C. Ghivizzani, D.A. Steindler, and C.P. Gibbs Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma Cancer Res. 69 2009 5648 5655
26. X. Li, X. Zhao, Y. Fang, X. Jiang, T. Duong, C. Fan, C.C. Huang, and S.R. Kain Generation of destabilized green fluorescent protein as a transcription reporter J. Biol. Chem. 273 1998 34970 34975
27. M. Locke, M. Heywood, S. Fawell, and I.C. Mackenzie Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines Cancer Res. 65 2005 8944 8950
28. J.A. Magee, E. Piskounova, and S.J. Morrison Cancer stem cells: impact, heterogeneity, and uncertainty Cancer Cell 21 2012 283 296
29. S.A. Mani, W. Guo, M.J. Liao, E.N. Eaton, A. Ayyanan, A.Y. Zhou, M. Brooks, F. Reinhard, C.C. Zhang, and M. Shipitsin The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 2008 704 715
30. G.B. Pierce, and W.C. Speers Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation Cancer Res. 48 1988 1996 2004
31. S.R. Pine, B.M. Ryan, L. Varticovski, A.I. Robles, and C.C. Harris Microenvironmental modulation of asymmetric cell division in human lung cancer cells Proc. Natl. Acad. Sci. USA 107 2010 2195 2200
32. D.F. Quail, and J.A. Joyce Microenvironmental regulation of tumor progression and metastasis Nat. Med. 19 2013 1423 1437
33. S.J. Santner, P.J. Dawson, L. Tait, H.D. Soule, J. Eliason, A.N. Mohamed, S.R. Wolman, G.H. Heppner, and F.R. Miller Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells Breast Cancer Res. Treat. 65 2001 101 110
34. R. Schmidt, and K. Plath The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation Genome Biol. 13 2012 251
35. M. Schober, and E. Fuchs Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling Proc. Natl. Acad. Sci. USA 108 2011 10544 10549
36. S. Schwitalla, A.A. Fingerle, P. Cammareri, T. Nebelsiek, S.I. Göktuna, P.K. Ziegler, O. Canli, J. Heijmans, D.J. Huels, and G. Moreaux Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties Cell 152 2013 25 38
37. F.L. Shaw, H. Harrison, K. Spence, M.P. Ablett, B.M. Simões, G. Farnie, and R.B. Clarke A detailed mammosphere assay protocol for the quantification of breast stem cell activity J. Mammary Gland Biol. Neoplasia 17 2012 111 117
38. T.C. Somervaille, C.J. Matheny, G.J. Spencer, M. Iwasaki, J.L. Rinn, D.M. Witten, H.Y. Chang, S.A. Shurtleff, J.R. Downing, and M.L. Cleary Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells Cell Stem Cell 4 2009 129 140
39. B. Tang, M. Vu, T. Booker, S.J. Santner, F.R. Miller, M.R. Anver, and L.M. Wakefield TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression J. Clin. Invest. 112 2003 1116 1124
40. J.E. Visvader, and G.J. Lindeman Cancer stem cells: current status and evolving complexities Cell Stem Cell 10 2012 717 728
41. E. Vlashi, K. Kim, C. Lagadec, L.D. Donna, J.T. McDonald, M. Eghbali, J.W. Sayre, E. Stefani, W. McBride, and F. Pajonk In vivo imaging, tracking, and targeting of cancer stem cells J. Natl. Cancer Inst. 101 2009 350 359
42. R.A. Young Control of the embryonic stem cell state Cell 144 2011 940 954