Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

Journal of Cell Biology

Volumn 204, Issue 5, 2014, Pages 669-682

  Harada, Takamasa ^a   Swift, Joe ^a   Irianto, Jerome ^a   Shin, Jae Won ^a   Spinler, Kyle R ^a   Athirasala, Avathamsa ^a   Diegmiller, Rocky ^a   Dingal, P C Dave P ^a   Ivanovska, Irena L ^a   Discher, Dennis E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

MMP, matrix metalloproteinase; MS, mass spectrometry; MSC, mesenchymal stem cell; PMN, polymorphonuclear leukocyte; siLMNA, short interfering LMNA

Indexed keywords

CASPASE 3; FIBRONECTIN; LAMIN A; LAMIN B; SMALL INTERFERING RNA; TANESPIMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW; CELL COUNT; CELL DEATH; CELL MIGRATION; CELL NUCLEUS MEMBRANE; CELL SELECTION; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GENOMIC INSTABILITY; HARDNESS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG CARCINOMA; MASS SPECTROMETRY; MESENCHYMAL STEM CELL; MICROPORE FILTER; MOUSE; NONHUMAN; NUCLEAR LAMINA; NUCLEAR SHAPE; NUCLEAR SIZE; PRIMARY CELL CULTURE; PRIORITY JOURNAL; RIGIDITY; STOICHIOMETRY; SUBCUTANEOUS TISSUE; TRANSIENT TRANSFECTION; TUMOR XENOGRAFT; VISCOELASTICITY;

APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL NUCLEUS; CELL NUCLEUS SHAPE; CELL SURVIVAL; GENE KNOCKDOWN TECHNIQUES; HUMANS; LAMIN TYPE A; LAMIN TYPE B; PROTEIN STRUCTURE, TERTIARY;

EID: 84895746552     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201308029     Document Type: Article

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