Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon

ACS Chemical Biology

Volumn 11, Issue 7, 2016, Pages 1852-1861

  Chen, Wentao ^a,b   Kong, Leopold ^a   Connelly, Stephen ^a   Dendle, Julia M ^a   Liu, Yu ^a   Wilson, Ian A ^a   Powers, Evan T ^a   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; FC RECEPTOR IIA; FC RECEPTOR IIIA; FC RECEPTOR IIIB; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; UNCLASSIFIED DRUG; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANTIBODY ENGINEERING; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENHANCED AROMATIC SEQUON; FUCOSYLATION; GLYCOSYLATION; HUMAN; IMMUNOLOGICAL PARAMETERS; MELTING POINT; MOLECULAR INTERACTION; PH; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR BINDING; WILD TYPE; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; PROCEDURES; PROTEIN ENGINEERING; PROTEIN STABILITY;

ANTIBODIES, MONOCLONAL; CALORIMETRY, DIFFERENTIAL SCANNING; PROTEIN ENGINEERING; PROTEIN STABILITY; RECEPTORS, IGG; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84978483848     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b01035     Document Type: Article

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