Structural determinants of unique properties of human IgG4-Fc

Journal of Molecular Biology

Volumn 426, Issue 3, 2014, Pages 630-644

  Davies, Anna M ^a,b   Rispens, Theo ^c,d   Ooijevaar De Heer, Pleuni ^c,d   Gould, Hannah J ^a,b   Jefferis, Roy ^e   Aalberse, Rob C ^c,d   Sutton, Brian J ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c SANQUIN RESEARCH   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

antibody; C1q; Fab arm exchange; Fc receptor; immunoglobulin

Indexed keywords

CD16 ANTIGEN; COMPLEMENT COMPONENT C1Q; FC RECEPTOR IIA; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; FC RECEPTOR; METHYL GROUP; RECOMBINANT PROTEIN;

ANTIGEN BINDING; ARTICLE; COMPLEMENT FIXATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; GLYCOSYLATION; HINGE REGION; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; POINT MUTATION; PRIORITY JOURNAL; STATIC ELECTRICITY; CONSENSUS SEQUENCE; CONTROLLED STUDY; GENE DISRUPTION; IMMUNOGLOBULIN STRUCTURE; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SERUM; SURFACE PROPERTY;

4-MORPHOLINEETHANESULFONIC ACID; ANTIBODY; C1Q; FAB-ARM EXCHANGE; FAE; FC RECEPTOR; IGG4-RD; IGG4-RELATED DISEASE; IMMUNOGLOBULIN; MES; RECOMBINANT IGG4-FC; RFC; SDFC; SERUM-DERIVED IGG4-FC;

ANTIBODIES, MONOCLONAL; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IGG; RECOMBINANT PROTEINS;

EID: 84892525003     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.10.039     Document Type: Article

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