Immunoglobulin G1 Fc domain motions: Implications for Fc engineering

Journal of Molecular Biology

Volumn 426, Issue 8, 2014, Pages 1799-1811

  Frank, Martin ^a   Walker, Ross C ^b,c   Lanzilotta, William N ^d   Prestegard, James H ^e   Barb, Adam W ^f  

^a BIOGNOS AB   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Iowa State University ^*  (United States)

^e UNIVERSITY OF GEORGIA   (United States)

^f IOWA STATE UNIVERSITY   (United States)

Author keywords

glycoprotein; molecular dynamics; N glycan; x ray crystallography

Indexed keywords

CARBOHYDRATE; GLYCAN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN HEAVY CHAIN; MONOMER; POLYPEPTIDE;

ADAPTIVE IMMUNITY; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; HOST PATHOGEN INTERACTION; IMMUNE SYSTEM; IMMUNOGLOBULIN STRUCTURE; MOLECULAR DYNAMICS; OPSONIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

GLYCOPROTEIN; MOLECULAR DYNAMICS; N-GLYCAN; X-RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; POLYSACCHARIDES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IGG; STATIC ELECTRICITY;

EID: 84897110175     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.01.011     Document Type: Article

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