Structure of fcγri in complex with Fc reveals the importance of glycan recognition for high-affinity gG binding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 3, 2015, Pages 833-838

  Lu, Jinghua ^a   Chu, Jonathan ^a   Zou, Zhongcheng ^a   Hamacher, Nels B ^b   Rixon, Mark W ^b   Sun, Peter D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

CD64 |; Crystal structure |; FcgRI |; Glycan recognition; IgG recognition |

Indexed keywords

CARBOHYDRATE; FC GAMMA RECEPTOR I; FC RECEPTOR; GLYCAN; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG; FCGR1A PROTEIN, HUMAN; POLYSACCHARIDE;

ANTIGEN BINDING; ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; CRYSTAL STRUCTURE; CRYSTALLIZATION; HINGE REGION; HYDROGEN BOND; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; HUMAN; MOLECULAR GENETICS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY;

BACTERIA (MICROORGANISMS); MAMMALIA;

AMINO ACID SEQUENCE; BINDING SITES; HUMANS; IMMUNOGLOBULIN G; MOLECULAR SEQUENCE DATA; POLYSACCHARIDES; PROTEIN CONFORMATION; RECEPTORS, IGG; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84922360962     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1418812112     Document Type: Article

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