Competing aggregation pathways for monoclonal antibodies

FEBS Letters

Volumn 588, Issue 6, 2014, Pages 936-941

  Wu, Haixia ^a,b   Kroe Barrett, Rachel ^b   Singh, Sanjaya ^b   Robinson, Anne S ^a,c   Roberts, Christopher J ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c Tulane University   (United States)

Author keywords

Aggregation; Hot spot; MAb

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY;

ARTICLE; COMPARATIVE STUDY; HIGH TEMPERATURE; IMMUNOGLOBULIN AGGREGATE; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN UNFOLDING;

AGGREGATION; HOT-SPOT; MAB;

ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIGENS, CD40; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, GEL; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; KINETICS; MICE; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEOLYSIS;

EID: 84896086830     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.01.051     Document Type: Article

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