Classification and characterization of therapeutic antibody aggregates

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 25118-25133

  Joubert, Marisa K ^a   Luo, Quanzhou ^a   Nashed Samuel, Yasser ^a   Wypych, Jette ^a   Narhi, Linda O ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPLIED STRESS; CLASSIFICATION SYSTEM; COPPER CONTENT; DEGREE OF DISORDER; DIVERSE STRESS; HETEROGENEOUS POPULATIONS; HIGHER-ORDER STRUCTURE; MECHANICAL STRESS; METAL CONTENT; PARTICLE COUNTS; PROTEIN AGGREGATES; PROTEIN AGGREGATION; PROTEIN PARTICLES; SECONDARY AND TERTIARY STRUCTURES; STRESS PROCESS; SURFACE HYDROPHOBICITY; THERAPEUTIC ANTIBODIES;

AGGREGATES; CHEMICAL MODIFICATION; MONOCLONAL ANTIBODIES; MORPHOLOGY; PROTEINS; SURFACE STRUCTURE; THERMAL STRESS; THERMOELASTICITY;

AGGLOMERATION;

COPPER; IMMUNOGLOBULIN G MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G1 MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G2 MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY STRUCTURE; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; HYDROPHOBICITY; MECHANICAL STRESS; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN AGGREGATION; TEMPERATURE STRESS;

ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; CATALYSIS; COPPER; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G;

EID: 79960128166     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.160457     Document Type: Article

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