High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

Journal of Biological Chemistry

Volumn 276, Issue 9, 2001, Pages 6591-6604

  Shields, Robert L ^a   Namenuk, Angela K ^a   Hong, Kyu ^a   Meng, Y Gloria ^a   Rae, Julie ^a   Briggs, John ^a   Xie, Dong ^a   Lai, Jadine ^a   Stadlen, Andrew ^a   Li, Betty ^a   Fox, Judith A ^a   Presta, Leonard G ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; IMMUNOLOGY;

CYTOTOXICITY;

ANTIBODIES;

FC RECEPTOR; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G;

ARTICLE; BINDING AFFINITY; BINDING SITE; EFFECTOR CELL; GENE EXPRESSION; HUMAN; IMMUNE RESPONSE; IMMUNOTHERAPY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MUTAGENESIS; PRIORITY JOURNAL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; CHEMISTRY; CLASSIFICATION; CRYSTALLIZATION; GLYCOSYLATION; METABOLISM; PROTEIN ENGINEERING; STRUCTURE ACTIVITY RELATION;

ANTIBODY-DEPENDENT CELL CYTOTOXICITY; BINDING SITES; CRYSTALLIZATION; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN G; PROTEIN ENGINEERING; RECEPTORS, IGG; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035794194     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009483200     Document Type: Article

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