Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole core

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 16, 2016, Pages 3540-3547

  Xu, Li Li ^a   Zhang, Xian ^a   Jiang, Zheng Yu ^a   You, Qi Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

ARE inducers; Nrf2 activator; Oxadiazole core

Indexed keywords

1,2,4 OXADIAZOLE; CHEMICAL COMPOUND; DDO 7204; HYDROGEN PEROXIDE; M416 0271; PYRROLE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; NFE2L2 PROTEIN, HUMAN; OXADIAZOLE DERIVATIVE;

ARTICLE; CELL LINE; CELL PROTECTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; GAMMA GCS GENE; GENE; HCT116 CELL LINE; HO 1 GENE; L02 CELL LINE; LUCIFERASE ASSAY; MOLECULAR MODEL; NCM460 CELL LINE; NQO1 GENE; PC12 CELL LINE; PROCESS OPTIMIZATION; PROTEIN LOCALIZATION; REPORTER GENE; STRUCTURE ANALYSIS; UPREGULATION; AGONISTS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MOLECULAR STRUCTURE; NF-E2-RELATED FACTOR 2; OXADIAZOLES;

EID: 84978198820     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.05.056     Document Type: Article

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