-
2
-
-
4143110232
-
Secular trends in cardiovascular disease mortality, incidence, and case fatality rates in adults in the United States
-
A. Ergin Secular trends in cardiovascular disease mortality, incidence, and case fatality rates in adults in the United States Am. J. Med 117 2004 219 227
-
(2004)
Am. J. Med
, vol.117
, pp. 219-227
-
-
Ergin, A.1
-
3
-
-
43049159738
-
Antioxidants in cardiovascular health and disease: Key lessons from epidemiologic studies
-
B.J. Willcox, J.D. Curb, and B.L. Rodriguez Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies Am. J. Cardiol. 101 2008 75D 86D
-
(2008)
Am. J. Cardiol.
, vol.101
-
-
Willcox, B.J.1
Curb, J.D.2
Rodriguez, B.L.3
-
4
-
-
33847378451
-
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
-
G. Bjelakovic Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis JAMA 297 2007 842 857
-
(2007)
JAMA
, vol.297
, pp. 842-857
-
-
Bjelakovic, G.1
-
5
-
-
20044383911
-
Effects of long-term vitamin e supplementation on cardiovascular events and cancer: A randomized controlled trial
-
E. Lonn Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial JAMA 293 2005 1338 1347
-
(2005)
JAMA
, vol.293
, pp. 1338-1347
-
-
Lonn, E.1
-
6
-
-
53449101213
-
Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2
-
A.L. Eggler, K.A. Gay, and A.D. Mesecar Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2 Mol. Nutr. Food Res 52 Suppl. 1 2008 S84 S94
-
(2008)
Mol. Nutr. Food Res
, vol.52
, Issue.SUPPL. 1
-
-
Eggler, A.L.1
Gay, K.A.2
Mesecar, A.D.3
-
7
-
-
81855204961
-
Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
-
B.M. Hybertson Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation Mol. Aspects Med. 32 2011 234 246
-
(2011)
Mol. Aspects Med.
, vol.32
, pp. 234-246
-
-
Hybertson, B.M.1
-
8
-
-
56249106571
-
Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
-
Y.J. Surh, J.K. Kundu, and H.K. Na Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals Planta Med 74 2008 1526 1539
-
(2008)
Planta Med
, vol.74
, pp. 1526-1539
-
-
Surh, Y.J.1
Kundu, J.K.2
Na, H.K.3
-
9
-
-
1942455887
-
Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles
-
K. Itoh, K.I. Tong, and M. Yamamoto Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles Free Radic. Biol. Med. 36 2004 1208 1213
-
(2004)
Free Radic. Biol. Med.
, vol.36
, pp. 1208-1213
-
-
Itoh, K.1
Tong, K.I.2
Yamamoto, M.3
-
10
-
-
67650453921
-
Targeting the Nrf2 pathway against cardiovascular disease
-
J. Li Targeting the Nrf2 pathway against cardiovascular disease Expert Opin. Ther. Targets 13 2009 785 794
-
(2009)
Expert Opin. Ther. Targets
, vol.13
, pp. 785-794
-
-
Li, J.1
-
11
-
-
33750052885
-
DJ-1, a cancer- and Parkinson's disease-associated protein stabilizes the antioxidant transcriptional master regulator
-
C.M. Clements DJ-1, a cancer- and Parkinson's disease-associated protein stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. USA 103 2006 15091 15096
-
(2006)
Nrf2. Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 15091-15096
-
-
Clements, C.M.1
-
12
-
-
34548429119
-
Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells
-
S. Pugazhenthi Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells Am. J. Physiol. Endocrinol. Metab 293 2007 E645 655
-
(2007)
Am. J. Physiol. Endocrinol. Metab
, vol.293
, pp. 645-655
-
-
Pugazhenthi, S.1
-
13
-
-
28844469924
-
Molecular mechanism of Nrf2 activation by oxidative stress
-
K.W. Kang, S.J. Lee, and S.G. Kim Molecular mechanism of Nrf2 activation by oxidative stress Antioxid. Redox Signaling 7 2005 1664 1673
-
(2005)
Antioxid. Redox Signaling
, vol.7
, pp. 1664-1673
-
-
Kang, K.W.1
Lee, S.J.2
Kim, S.G.3
-
14
-
-
1942520367
-
Nrf2 signaling in coordinated activation of antioxidant gene expression
-
A.K. Jaiswal Nrf2 signaling in coordinated activation of antioxidant gene expression Free Radic. Biol. Med. 36 2004 1199 1207
-
(2004)
Free Radic. Biol. Med.
, vol.36
, pp. 1199-1207
-
-
Jaiswal, A.K.1
-
15
-
-
33845442925
-
Mechanistic studies of the Nrf2-Keap1 signaling pathway
-
D.D. Zhang Mechanistic studies of the Nrf2-Keap1 signaling pathway Drug Metab. Rev. 38 2006 769 789
-
(2006)
Drug Metab. Rev.
, vol.38
, pp. 769-789
-
-
Zhang, D.D.1
-
16
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
A.T. Dinkova-Kostova Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants Proc. Natl. Acad. Sci. USA 99 2002 11908 11913
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
-
17
-
-
1542335553
-
Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol
-
D. Martin Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol J. Biol. Chem 279 2004 8919 8929
-
(2004)
J. Biol. Chem
, vol.279
, pp. 8919-8929
-
-
Martin, D.1
-
18
-
-
58149328569
-
Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1
-
C.A. Piantadosi Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1 Circ. Res 103 2008 1232 1240
-
(2008)
Circ. Res
, vol.103
, pp. 1232-1240
-
-
Piantadosi, C.A.1
-
19
-
-
1642368362
-
Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: A new therapeutic approach for the treatment of inflammatory diseases
-
X.L. Chen, and C. Kunsch Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases Curr. Pharm. Des 10 2004 879 891
-
(2004)
Curr. Pharm. des
, vol.10
, pp. 879-891
-
-
Chen, X.L.1
Kunsch, C.2
-
20
-
-
79953236274
-
Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis
-
T.M. Stepkowski, and M.K. Kruszewski Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis Free Radic. Biol. Med. 50 2011 1186 1195
-
(2011)
Free Radic. Biol. Med.
, vol.50
, pp. 1186-1195
-
-
Stepkowski, T.M.1
Kruszewski, M.K.2
-
21
-
-
84862278246
-
Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge
-
E.L. Donovan Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge Oxid. Med. Cell. Longevity 2012 2012 132931
-
(2012)
Oxid. Med. Cell. Longevity
, vol.2012
, pp. 132931
-
-
Donovan, E.L.1
-
22
-
-
73549096170
-
Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice
-
C.P. Judkins Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice Am. J. Physiol. Heart Circ. Physiol 298 2010 H24 32
-
(2010)
Am. J. Physiol. Heart Circ. Physiol
, vol.298
, pp. 24-32
-
-
Judkins, C.P.1
-
23
-
-
0021984681
-
Oxygen-derived free radicals in postischemic tissue injury
-
J.M. McCord Oxygen-derived free radicals in postischemic tissue injury N. Engl. J. Med. 312 1985 159 163
-
(1985)
N. Engl. J. Med.
, vol.312
, pp. 159-163
-
-
McCord, J.M.1
-
24
-
-
84856491833
-
The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion
-
K. Raedschelders, D.M. Ansley, and D.D. Chen The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion Pharmacol. Ther. 133 2012 230 255
-
(2012)
Pharmacol. Ther.
, vol.133
, pp. 230-255
-
-
Raedschelders, K.1
Ansley, D.M.2
Chen, D.D.3
-
25
-
-
80054099715
-
The effects of vitamin C and nitric oxide synthase inhibition on coronary flow and oxidative stress markers in isolated rat heart
-
V. Jakovljevic, D.Z. Djordjevic, and D.M. Djuric The effects of vitamin C and nitric oxide synthase inhibition on coronary flow and oxidative stress markers in isolated rat heart Gen. Physiol. Biophys 30 2011 293 300
-
(2011)
Gen. Physiol. Biophys
, vol.30
, pp. 293-300
-
-
Jakovljevic, V.1
Djordjevic, D.Z.2
Djuric, D.M.3
-
26
-
-
85027908010
-
Vitamin C compromises cardiac resuscitability in a rat model of ventricular fibrillation
-
(in press)
-
Motl, J.; et al. Vitamin C compromises cardiac resuscitability in a rat model of ventricular fibrillation. Am. J. Ther. (in press); 2012.
-
(2012)
Am. J. Ther.
-
-
Motl, J.1
-
27
-
-
84864008286
-
17β-estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation
-
J. Yu 17β-estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation J. Biochem. Mol. Toxicol 26 2012 264 269
-
(2012)
J. Biochem. Mol. Toxicol
, vol.26
, pp. 264-269
-
-
Yu, J.1
-
28
-
-
84855451533
-
Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium
-
V.R. Muthusamy Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium Free Radic. Biol. Med 52 2012 366 376
-
(2012)
Free Radic. Biol. Med
, vol.52
, pp. 366-376
-
-
Muthusamy, V.R.1
-
29
-
-
0032539911
-
HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
-
W.C. Claycomb HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte Proc. Natl. Acad. Sci. USA 95 1998 2979 2984
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2979-2984
-
-
Claycomb, W.C.1
-
30
-
-
58149086400
-
Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim
-
K. Velmurugan Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim Free Radic. Biol. Med 46 2009 430 440
-
(2009)
Free Radic. Biol. Med
, vol.46
, pp. 430-440
-
-
Velmurugan, K.1
-
31
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method
-
K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method Methods 25 2001 402 408
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
32
-
-
0036240610
-
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: Role of antioxidant response element-like sequences in the Nrf2 promoter
-
M.K. Kwak Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the Nrf2 promoter Mol. Cell. Biol 22 2002 2883 2892
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 2883-2892
-
-
Kwak, M.K.1
-
33
-
-
84858964113
-
Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis
-
S.K. Niture, and A.K. Jaiswal Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis J. Biol. Chem. 287 2012 9873 9886
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 9873-9886
-
-
Niture, S.K.1
Jaiswal, A.K.2
-
34
-
-
0013282861
-
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: Degradation of Nrf2 by the 26 S proteasome
-
T. Nguyen Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: degradation of Nrf2 by the 26 S proteasome J. Biol. Chem 278 2003 4536 4541
-
(2003)
J. Biol. Chem
, vol.278
, pp. 4536-4541
-
-
Nguyen, T.1
-
35
-
-
77957282419
-
Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on Kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver
-
C.I. Schwer Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on Kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver Int. J. Biochem. Cell. Biol 42 2010 1876 1883
-
(2010)
Int. J. Biochem. Cell. Biol
, vol.42
, pp. 1876-1883
-
-
Schwer, C.I.1
-
36
-
-
4744360664
-
NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells
-
S. Papaiahgari NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells J. Biol. Chem 279 2004 42302 42312
-
(2004)
J. Biol. Chem
, vol.279
, pp. 42302-42312
-
-
Papaiahgari, S.1
-
37
-
-
0034623211
-
Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells: Role of p38 kinase and Nrf2 transcription factor
-
J. Alam Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells: role of p38 kinase and Nrf2 transcription factor J. Biol. Chem 275 2000 27694 27702
-
(2000)
J. Biol. Chem
, vol.275
, pp. 27694-27702
-
-
Alam, J.1
-
38
-
-
33745986025
-
Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein
-
C.C. Wu Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein Toxicol. Appl. Pharmacol 214 2006 244 252
-
(2006)
Toxicol. Appl. Pharmacol
, vol.214
, pp. 244-252
-
-
Wu, C.C.1
-
39
-
-
0033731182
-
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
-
H.C. Huang, T. Nguyen, and C.B. Pickett Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2 Proc. Natl. Acad. Sci. USA 97 2000 12475 12480
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 12475-12480
-
-
Huang, H.C.1
Nguyen, T.2
Pickett, C.B.3
-
40
-
-
41549085759
-
Characteristics of catechin- and theaflavin-mediated cardioprotection
-
H. Dreger Characteristics of catechin- and theaflavin-mediated cardioprotection Exp. Biol. Med. (Maywood) 233 2008 427 433
-
(2008)
Exp. Biol. Med. (Maywood)
, vol.233
, pp. 427-433
-
-
Dreger, H.1
-
41
-
-
30344461640
-
The induction of human superoxide dismutase and catalase in vivo: A fundamentally new approach to antioxidant therapy
-
S.K. Nelson The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy Free Radic. Biol. Med 40 2006 341 347
-
(2006)
Free Radic. Biol. Med
, vol.40
, pp. 341-347
-
-
Nelson, S.K.1
-
42
-
-
0141885079
-
Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway
-
J. Alam, and J.L. Cook Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway Curr. Pharm. Des 9 2003 2499 2511
-
(2003)
Curr. Pharm. des
, vol.9
, pp. 2499-2511
-
-
Alam, J.1
Cook, J.L.2
-
43
-
-
84868560352
-
A novel small molecule N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6- trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: Therapeutic implications for ALS
-
T. Kanno A novel small molecule N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2, 4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS Free Radic. Biol. Med 53 2012 2028 2042
-
(2012)
Free Radic. Biol. Med
, vol.53
, pp. 2028-2042
-
-
Kanno, T.1
-
44
-
-
79952585899
-
Haem oxygenase-1 and cardiovascular disease: Mechanisms and therapeutic potential
-
K.H. Chan, M.K. Ng, and R. Stocker Haem oxygenase-1 and cardiovascular disease: mechanisms and therapeutic potential Clin. Sci. (London) 120 2011 493 504
-
(2011)
Clin. Sci. (London)
, vol.120
, pp. 493-504
-
-
Chan, K.H.1
Ng, M.K.2
Stocker, R.3
-
45
-
-
35349023691
-
Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway
-
A.S. Pachori Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway J. Mol. Cell. Cardiol 43 2007 580 592
-
(2007)
J. Mol. Cell. Cardiol
, vol.43
, pp. 580-592
-
-
Pachori, A.S.1
-
46
-
-
4644226200
-
The role of heme oxygenase-1 promoter polymorphisms in human disease
-
M. Exner The role of heme oxygenase-1 promoter polymorphisms in human disease Free Radic. Biol. Med 37 2004 1097 1104
-
(2004)
Free Radic. Biol. Med
, vol.37
, pp. 1097-1104
-
-
Exner, M.1
-
47
-
-
33746874131
-
Dual role of VEGF-induced heme-oxygenase-1 in angiogenesis
-
B. Bussolati, and J.C. Mason Dual role of VEGF-induced heme-oxygenase-1 in angiogenesis Antioxid. Redox Signaling 8 2006 1153 1163
-
(2006)
Antioxid. Redox Signaling
, vol.8
, pp. 1153-1163
-
-
Bussolati, B.1
Mason, J.C.2
-
49
-
-
84857624825
-
Exercise protects cardiac mitochondria against ischemia-reperfusion injury
-
Y. Lee Exercise protects cardiac mitochondria against ischemia-reperfusion injury Med. Sci. Sports Exerc. 44 2012 397 405
-
(2012)
Med. Sci. Sports Exerc.
, vol.44
, pp. 397-405
-
-
Lee, Y.1
-
50
-
-
14644433145
-
Calcium antagonist reduces oxidative stress by upregulating Cu/Zn superoxide dismutase in stroke-prone spontaneously hypertensive rats
-
S. Umemoto Calcium antagonist reduces oxidative stress by upregulating Cu/Zn superoxide dismutase in stroke-prone spontaneously hypertensive rats Hypertens. Res 27 2004 877 885
-
(2004)
Hypertens. Res
, vol.27
, pp. 877-885
-
-
Umemoto, S.1
-
51
-
-
5344280431
-
Genetically altered mice to evaluate glutathione homeostasis in health and disease
-
T.P. Dalton Genetically altered mice to evaluate glutathione homeostasis in health and disease Free Radic. Biol. Med. 37 2004 1511 1526
-
(2004)
Free Radic. Biol. Med.
, vol.37
, pp. 1511-1526
-
-
Dalton, T.P.1
|