Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents

Journal of Medicinal Chemistry

Volumn 58, Issue 13, 2015, Pages 5242-5255

  Peng, Shoujiao ^a   Zhang, Baoxin ^a   Meng, Xianke ^a   Yao, Juan ^a   Fang, Jianguo ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 (3,4 DIMETHOXYPHENYL)ACRYLOYL)PYRROLIDIN 2 ONE; 1 (3 (3,4,5 TRIMETHOXYPHENYL)ACRYLOYL) 5,6 DIHYDROPYRIDIN 2(1H) ONE; 1 (3 (3,4,5 TRIMETHOXYPHENYL)ACRYLOYL)AZEPAN 2 ONE; 1 (3 (3,4,5 TRIMETHOXYPHENYL)ACRYLOYL)PIPERIDIN 2 ONE; 1 (3 (3,4,5 TRIMETHOXYPHENYL)PROPANOYL)PIPERIDIN 2 ONE; 1 (3 (4 (TRIFLUOROMETHYL)PHENYL)ACRYLOYL)AZEPAN 2 ONE; 1 (3 (4 (TRIFLUOROMETHYL)PHENYL)ACRYLOYL)PIPERIDIN 2 ONE; 1 (3 (4 (TRIFLUOROMETHYL)PHENYL)ACRYLOYL)PYRROLIDIN 2 ONE; 1 (3 (4 BROMOPHENYL)ACRYLOYL)PIPERIDIN 2 ONE; 1 (3 (4 BROMOPHENYL)ACRYLOYL)PYRROLIDIN 2 ONE; 1 (3 (4 HYDROXYPHENYL)ACRYLOYL)PYRROLIDIN 2 ONE; 1 (3 (4 METHOXYPHENYL)ACRYLOYL)PIPERIDIN 2 ONE; 1 (3 (4 METHOXYPHENYL)ACRYLOYL)PYRROLIDIN 2 ONE; 1 (3 (4 NITROPHENYL)ACRYLOYL)AZEPAN 2 ONE; 1 (3 (4 NITROPHENYL)ACRYLOYL)PIPERIDIN 2 ONE; 1 CINNAMOYLAZEPAN 2 ONE; 1 CINNAMOYLPIPERIDIN 2 ONE; 1 CINNAMOYLPYRROLIDIN 2 ONE; 4 (3 OXO 3 (2 OXOPYRROLIDIN 1 YL)PROP 1 EN 1 YL)PHENYL ACETATE; GLUTATHIONE; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENT; NUCLEAR FACTOR ERYTHROID 2 RELATED FACTOR 2 ACTIVATOR; OXIDOPAMINE; PIPERLONGUMINE ANALOGUE; SHORT HAIRPIN RNA; THIOREDOXIN 1; THIOREDOXIN REDUCTASE 1; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; 1-(3-(3,4,5-TRIMETHOXYPHENYL)ACRYLOYL)PIPERIDIN-2-ONE; 1-(3-(4-METHOXYPHENYL)ACRYLOYL)PYRROLIDIN-2-ONE; ANTIOXIDANT; CINNAMIC ACID DERIVATIVE; COUMARIC ACID; MESSENGER RNA; PIPERIDONE DERIVATIVE; PIPERLONGUMININE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; FOLLOW UP; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PC12 CELL LINE; RAT; STRUCTURE ACTIVITY RELATION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYNTHESIS; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; CINNAMATES; COUMARIC ACIDS; CYTOPROTECTION; DIOXOLANES; HYDROGEN PEROXIDE; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PC12 CELLS; PIPERIDONES; RATS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937396199     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00410     Document Type: Article

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