Crosstalk of the Wnt/β-catenin pathway with other pathways in cancer cells

Genes and Diseases

Volumn 3, Issue 1, 2016, Pages 41-47

  Morris, Saint Aaron L ^a   Huang, Suyun ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Cell signaling; Glioma stem cell; Tumorigenicity; Wnt; catenin

Indexed keywords

ALPHA 2 MACROGLOBULIN; AXIN; AXIN 1; BETA CATENIN; DICKKOPF 1 PROTEIN; DISHEVELLED PROTEIN; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NOTCH RECEPTOR; PROTEIN; PROTEIN FOXM1; PROTEIN P53; PROTEIN PLAGL2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; UNCLASSIFIED DRUG; WNT PROTEIN; ZINC FINGER PROTEIN;

CANCER CELL; CARCINOGENICITY; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; DOWN REGULATION; EPIGENETICS; HUMAN; MITOSIS RATE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; WNT SIGNALING PATHWAY;

EID: 84978128638     PISSN: None     EISSN: 23523042     Source Type: Journal    
DOI: 10.1016/j.gendis.2015.12.003     Document Type: Review

References (73)

1. Cox R.T., Kirkpatrick C., Peifer M. Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis. J Cell Biol 1996, 134:133-148.
2. Wodarz A., Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 1998, 14:59-88.
3. Hulsken J., Birchmeier W., Behrens J. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol 1994, 127:2061-2069.
4. He T.C., Sparks A.B., Rago C., Hermeking H., Zawel L., da Costa L.T. Identification of c-MYC as a target of the APC pathway. Science 1998, 281:1509-1512.
5. Koleske A.J., Baltimore D., Lisanti M.P. Reduction of caveolin and caveolae in oncogenically transformed cells. Proc Natl Acad Sci USA 1995, 280:119-133.
6. Okamoto T., Schlegel A., Scherer P.E., Lisanti M.P. Caveolins a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem 1998, 273(10):5419-5422.
7. Aberle H., Bauer A., Stappert J., Kispert A., Kemler R. Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997, 16:3797-3804.
8. Behrens J., Jerchow B.A., Wurtele M., et al. Functional interaction of axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 1998, 280:596-599.
9. Ikeda S., Kishida S., Yamamoto H., Murai H., Koyama S., Kikuchi A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J 1998, 17:1371-1384.
10. Orford K., Orford C.C., Byers S.W. Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, and radiation-induced cell cycle arrest. J Cell Biol 1999, 146:855-868.
11. Rubinfeld B., Albert I., Porfiri E., Fiol C., Munemitsu S., Polakis P. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 1996, 272:1023-1026.
12. Yost C., Torres M., Miller J.R., Huang E., Kimelman D., Moon R.T. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev 1996, 10:1443-1454.
13. Reya T., Clevers H. Wnt signalling in stem cells and cancer. Nature 2005, 434:843-850.
14. Takebe N., Miele L., Harris P.J., et al. Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat Rev Clin Oncol 2015, 12:445-464.
15. Roarty K., Rosen J.M. Wnt and mammary stem cells: hormones cannot fly wingless. Curr Opin Pharmacol 2010, 10:643-649.
16. Teulière J., Faraldo M.M., Deugnier M.A., et al. Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia. Development 2005, 132:267-277.
17. van Amerongen R., Bowman A.N., Nusse R. Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 2012, 11:387-400.
18. Zeng Y.A., Nusse R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 2010, 6:568-577.
19. Polakis P. Wnt signaling and cancer. Genes Dev 2000, 14:1837-1851.
20. Peifer M., Polakis P. Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus. Science 2000, 287:1606-1609.
21. Morin P.J. Beta-catenin signaling and cancer. Bioessays 1999, 21:1021-1030.
22. Ashihara K., Saito T., Mizumoto H., et al. Mutation of beta-catenin gene in endometrial cancer but not in associated hyperplasia. Med Electron Microsc 2002, 35:9-15.
23. Rimm D.L., Caca K., Hu G., Harrison F.B., Fearon E.R. Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. Am J Pathol 1999, 154:325-329.
24. de La Coste A., Romagnolo B., Billuart P., et al. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 1998, 95:8847-8851.
25. Satoh S., Daigo Y., Furukawa Y., et al. Axin1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of Axin1. Nat Genet 2000, 24:245-250.
26. Miyoshi Y., Iwao K., Nagasawa Y., et al. Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res 1998, 58:2524-2527.
27. Ihara A., Koizumi H., Hashizume R., Uchikoshi T. Expression of epithelial cadherin and alpha- and beta-catenins in nontumoral livers and hepatocellular carcinomas. Hepatology 1996, 23:1441-1447.
28. Paraf F., Jothy S., Van Meir E.G. Brain tumor-polyposis syndrome: two genetic diseases?. J Clin Oncol 1997, 15:2744-2758.
29. Fang D., Hawke D., Zheng Y., et al. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem 2007, 282:11221-11229.
30. Lu Z., Ghosh S., Wang Z., Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell 2003, 4:499-515.
31. Zhang N., Wei P., Gong A., et al. FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 2011, 20:427-442.
32. Kalani M.Y., Cheshier S.H., Cord B.J., et al. Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci USA 2008, 105:16970-16975.
33. Lie D.C., Colamarino S.A., Song H.J., et al. Wnt signalling regulates adult hippocampal neurogenesis. Nature 2005, 437:1370-1375.
34. Woodhead G.J., Mutch C.A., Olson E.C., Chenn A. Cell-autonomous beta-catenin signaling regulates cortical precursor proliferation. J Neurosci 2006, 26:12620-12630.
35. Wharton K.A. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev Biol 2003, 253:1-17.
36. Pulvirenti T., Van Der Heijden M., Droms L.A., et al. Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas. Cancer Res 2011, 71:7280-7290.
37. Jin X., Jeon H.Y., Joo K.M., et al. Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation. Cancer Res 2011, 71:3066-3075.
38. Zheng H., Ying H., Wiedemeyer R., et al. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 2010, 17:497-509.
39. Liu M., Dai B., Kang S.H., et al. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res 2006, 66:3593-3602.
40. Hodgson J.G., Yeh R.F., Ray A., et al. Comparative analyses of gene copy number and mRNA expression in GBM tumors and GBM xenografts. Neuro Oncol 2009, 11:477-487.
41. Thorpe C.J., Weidinger G., Moon R.T. Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development 2005, 132:1763-1772.
42. Jiang X., Yu Y., Yang H.W., Agar N.Y., Frado L., Johnson M.D. The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth. J Biol Chem 2010, 285:8472-8480.
43. Kohda T., Asai A., Kuroiwa Y., et al. Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. Genes Cells 2001, 6:237-247.
44. Liu J., Stevens J., Rote C.A., et al. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 2001, 7:927-936.
45. Fedi P., Bafico A., Nieto Soria A., et al. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem 1999, 274:19465-19472.
46. Schiefer L., Visweswaran M., Perumal V., et al. Epigenetic regulation of the secreted frizzled-related protein family in human glioblastoma multiforme. Cancer Gene Ther 2014, 21:297-303.
47. Uren A., Reichsman F., Anest V., et al. Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling. J Biol Chem 2000, 275:4374-4382.
48. Bafico A., Gazit A., Pramila T., et al. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J Biol Chem 1999, 274:16180-16187.
49. Bhuvanalakshmi G., Arfuso F., Millward M., Dharmarajan A., Warrier S. Secreted frizzled-related protein 4 inhibits glioma stem-like cells by reversing epithelial to mesenchymal transition, inducing apoptosis and decreasing cancer stem cell properties. PLoS One 2015, 10:1-21.
50. Warrier S., Balu S.K., Kumar A.P., Millward M., Dharmarajan A. Wnt antagonist, secreted frizzled-related protein 4 (sFRP4), increases chemotherapeutic response of glioma stem-like cells. Oncol Res 2013, 21:93-102.
51. Padmasekar M., Nandigama R., Wartenberg M., Schluter K.D., Sauer H. The acute phase protein α2-macroglobulin induces rat ventricular cardiomyocyte hypertrophy via ERK1,2 and PI3-kinase/Akt pathways. Cardiovasc Res 2007, 75:118-128.
52. Arandjelovic S., Freed T.A., Gonias S.L. Growth factor-binding sequence in human α2-macroglobulin targets the receptor-binding site in transforming growth factor-β. Biochemistry 2003, 42:6121-6127.
53. Lindner I., Hemdan N.Y., Buchold M., et al. Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling. Cancer Res 2010 1, 70:277-287.
54. Li V.S., Ng S.S., Boersema P.J., et al. Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell 2012, 149:1245-1256.
55. Azzolin L., Panciera T., Soligo S., et al. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell 2014, 158:157-170.
56. Tetsu O., McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398:422-426.
57. Inoki K., Ouyang H., Zhu T., et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006, 126:955-968.
58. Bouras T., Pal B., Vaillant F., et al. Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 2008, 3:429-441.
59. Buono K.D., Robinson G.W., Martin C., et al. The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy. Dev Biol 2006, 293:565-580.
60. Raouf A., Zhao Y., To K., Stingl J., et al. Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell 2008, 3:109-118.
61. Gu B., Watanabe K., Dai X. Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. Cell Cycle 2012, 11:79-87.
62. Gu B., Watanabe K., Sun P., Fallahi M., Dai X. Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells. Cell Stem Cell 2013, 13:48-61.
63. Fuccillo M., Joyner A.L., Fishell G. Morphogen to mitogen: the multiple roles of hedgehog signaling in vertebrate neural development. Nat Rev Neurosci 2006, 7:772-783.
64. Lee E.Y., Ji H., Ouyang Z., et al. Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci USA 2010, 107:9736-9741.
65. Stecca B., Ruiz i Altaba A. Brain as a paradigm of organ growth: hedgehog-Gli signaling in neural stem cells and brain tumors. J Neurobiol 2005, 64:476-490.
66. Kim J.H., Shin H.S., Lee S.H., et al. Contrasting activity of Hedgehog and Wnt pathways according to gastric cancer cell differentiation: relevance of crosstalk mechanisms. Cancer Sci 2010, 101:328-335.
67. Pöschl J., Bartels M., Ohli J., et al. Wnt/β-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma. Acta Neuropathol 2014, 127:605-607.
68. Zinke J., Schneider F.T., Harter P.N., et al. β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma. Mol Cancer 2015, 14:17.
69. Sharov A.A., Mardaryev A.N., Sharova T.Y., et al. Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Am J Pathol 2009, 175:1303-1314.
70. Mishra S. CSNK1A1 and Gli2 as Novel targets identified through an integrative analysis of gene expression data, protein-protein interaction and pathways networks in glioblastoma tumors: can these two be antagonistic proteins?. Cancer Inf 2014, 13:93-108.
71. Uchida H., Arita K., Yunoue S., et al. Role of sonic hedgehog signaling in migration of cell lines established from CD133-positive malignant glioma cells. J Neurooncol 2011, 104:697-704.
72. Kamino M., Kishida M., Kibe T., et al. Wnt-5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and MMP-2. Cancer Sci 2011, 102:540-548.
73. Lo H.W., Zhu H., Cao X., Aldrich A., Ali-Osman F. A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. Cancer Res 2009, 69:6790-6798.