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Volumn 132, Issue 2, 2005, Pages 267-277

Targeted activation of β-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia

Author keywords

catenin; Basal epithelial cell; Hyperplasia; Mammary gland; Mouse; Progenitor cell

Indexed keywords

BETA CATENIN; CYCLIN D1; KERATIN; MYC PROTEIN; PROTEIN P63; PROTEINASE; PROTEINASE INHIBITOR;

EID: 13944259795     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01583     Document Type: Article
Times cited : (142)

References (61)
  • 1
    • 0030454231 scopus 로고    scopus 로고
    • Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene
    • Alexander, C. M., Howard, E. W., Bissell, M. J. and Werb, Z. (1996). Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene. J. Cell Biol. 135, 1669-1677.
    • (1996) J. Cell Biol. , vol.135 , pp. 1669-1677
    • Alexander, C.M.1    Howard, E.W.2    Bissell, M.J.3    Werb, Z.4
  • 3
    • 0038274074 scopus 로고    scopus 로고
    • Stem cells in the skin: Waste not, Wnt not
    • Alonso, L. and Fuchs, E. (2003). Stem cells in the skin: waste not, Wnt not. Genes Dev. 17, 1189-1200.
    • (2003) Genes Dev. , vol.17 , pp. 1189-1200
    • Alonso, L.1    Fuchs, E.2
  • 4
    • 0036278690 scopus 로고    scopus 로고
    • Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: A new cell biological concept
    • Bocker, W., Moll, R., Poremba, C., Holland, R., van Diest, P. J., Dervan, P., Burger, H., Wai, D., Ina Diallo, R., Brandt, B. et al. (2002). Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab. Invest. 82, 737-746.
    • (2002) Lab. Invest. , vol.82 , pp. 737-746
    • Bocker, W.1    Moll, R.2    Poremba, C.3    Holland, R.4    van Diest, P.J.5    Dervan, P.6    Burger, H.7    Wai, D.8    Ina Diallo, R.9    Brandt, B.10
  • 5
    • 0029114329 scopus 로고
    • Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice
    • Bradbury, J. M., Edwards, P. A., Niemeyer, C. C. and Dale, T. C. (1995). Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice. Dev. Biol. 170 553-563.
    • (1995) Dev. Biol. , vol.170 , pp. 553-563
    • Bradbury, J.M.1    Edwards, P.A.2    Niemeyer, C.C.3    Dale, T.C.4
  • 7
    • 0027415380 scopus 로고
    • Localization and quantification of Wnt-2 gene expression in mouse mammary development
    • Buhler, T. A., Dale, T. C., Kieback, C., Humphreys, R. C. and Rosen, J. M. (1993). Localization and quantification of Wnt-2 gene expression in mouse mammary development. Dev. Biol. 155, 87-96.
    • (1993) Dev. Biol. , vol.155 , pp. 87-96
    • Buhler, T.A.1    Dale, T.C.2    Kieback, C.3    Humphreys, R.C.4    Rosen, J.M.5
  • 8
    • 2342427631 scopus 로고    scopus 로고
    • Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
    • Celso, C. L., Prowse, D. M. and Watt, F. M. (2004). Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development 131, 1787-1799.
    • (2004) Development , vol.131 , pp. 1787-1799
    • Celso, C.L.1    Prowse, D.M.2    Watt, F.M.3
  • 9
    • 1242318518 scopus 로고    scopus 로고
    • p53 protein variants: Structural and functional similarities with p63 and p73 isoforms
    • Courtois, S., de Fromentel, C. C. and Hainaut, P. (2004). p53 protein variants: structural and functional similarities with p63 and p73 isoforms. Oncogene 23, 631-638.
    • (2004) Oncogene , vol.23 , pp. 631-638
    • Courtois, S.1    de Fromentel, C.C.2    Hainaut, P.3
  • 10
    • 0037064573 scopus 로고    scopus 로고
    • EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties
    • Deugnier, M. A., Faraldo, M. M., Janji, B., Rousselle, P., Thiery, J. P. and Glukhova, M. A. (2002a). EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties. J. Cell Biol. 159, 453-463.
    • (2002) J. Cell Biol. , vol.159 , pp. 453-463
    • Deugnier, M.A.1    Faraldo, M.M.2    Janji, B.3    Rousselle, P.4    Thiery, J.P.5    Glukhova, M.A.6
  • 13
    • 0032567078 scopus 로고    scopus 로고
    • De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
    • Gat, U., DasGupta, R., Degenstein, L. and Fuchs, E. (1998). De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95, 605-614.
    • (1998) Cell , vol.95 , pp. 605-614
    • Gat, U.1    DasGupta, R.2    Degenstein, L.3    Fuchs, E.4
  • 14
    • 0026780763 scopus 로고
    • Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland
    • Gavin, B. J. and McMahon, A. P. (1992). Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol. Cell. Biol. 12, 2418-2423.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2418-2423
    • Gavin, B.J.1    McMahon, A.P.2
  • 15
    • 0038359353 scopus 로고    scopus 로고
    • Caught up in a Wnt storm: Wnt signaling in cancer
    • Giles, R. H., van Es, J. H. and Clevers, H. (2003). Caught up in a Wnt storm: Wnt signaling in cancer. Biochim. Biophys. Acta 1653, 1-24.
    • (2003) Biochim. Biophys. Acta , vol.1653 , pp. 1-24
    • Giles, R.H.1    van Es, J.H.2    Clevers, H.3
  • 16
    • 0037087738 scopus 로고    scopus 로고
    • Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties
    • Gudjonsson, T., Villadsen, R., Nielsen, H. L., Ronnov-Jessen, L., Bissell, M. J. and Petersen, O. W. (2002). Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev. 16 693-706.
    • (2002) Genes Dev. , vol.16 , pp. 693-706
    • Gudjonsson, T.1    Villadsen, R.2    Nielsen, H.L.3    Ronnov-Jessen, L.4    Bissell, M.J.5    Petersen, O.W.6
  • 17
    • 0035110730 scopus 로고    scopus 로고
    • Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice
    • Ha, H. Y., Moon, H. B., Nam, M. S., Lee, J. W., Ryoo, Z. Y., Lee, T. H., Lee, K. K., So, B. J., Sato, H., Seiki, M. et al. (2001). Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice. Cancer Res. 61, 984-990.
    • (2001) Cancer Res. , vol.61 , pp. 984-990
    • Ha, H.Y.1    Moon, H.B.2    Nam, M.S.3    Lee, J.W.4    Ryoo, Z.Y.5    Lee, T.H.6    Lee, K.K.7    So, B.J.8    Sato, H.9    Seiki, M.10
  • 19
    • 0035842902 scopus 로고    scopus 로고
    • Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice
    • Hsu, W., Shakya, R. and Costantini, F. (2001). Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J. Cell Biol. 155, 1055-1064.
    • (2001) J. Cell Biol. , vol.155 , pp. 1055-1064
    • Hsu, W.1    Shakya, R.2    Costantini, F.3
  • 20
    • 0035972159 scopus 로고    scopus 로고
    • Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland
    • Imbert, A., Eelkema, R., Jordan, S., Feiner, H. and Cowin, P. (2001). Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J. Cell Biol. 153, 555-568.
    • (2001) J. Cell Biol. , vol.153 , pp. 555-568
    • Imbert, A.1    Eelkema, R.2    Jordan, S.3    Feiner, H.4    Cowin, P.5
  • 21
    • 0035734285 scopus 로고    scopus 로고
    • Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
    • Jonkers, J., Meuwissen, R., van der Gulden, H., Peterse, H., van der Valk, M. and Berns, A. (2001). Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat. Genet. 29, 418-425.
    • (2001) Nat. Genet. , vol.29 , pp. 418-425
    • Jonkers, J.1    Meuwissen, R.2    van der Gulden, H.3    Peterse, H.4    van der Valk, M.5    Berns, A.6
  • 22
    • 0942301281 scopus 로고    scopus 로고
    • p63 is the molecular switch for initiation of an epithelial stratification program
    • Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J. and Roop, D. R. (2004). p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 18, 126-131.
    • (2004) Genes Dev. , vol.18 , pp. 126-131
    • Koster, M.I.1    Kim, S.2    Mills, A.A.3    DeMayo, F.J.4    Roop, D.R.5
  • 23
    • 0035105088 scopus 로고    scopus 로고
    • The mammary myoepithelial cell-Cinderella or ugly sister?
    • Lakhani, S. R. and O'Hare, M. J. (2001). The mammary myoepithelial cell-Cinderella or ugly sister? Breast Cancer Res. 3, 1-4.
    • (2001) Breast Cancer Res. , vol.3 , pp. 1-4
    • Lakhani, S.R.1    O'Hare, M.J.2
  • 24
    • 0030613905 scopus 로고    scopus 로고
    • Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice
    • Lane, T. F. and Leder, P. (1997). Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice. Oncogene 15, 2133-2144.
    • (1997) Oncogene , vol.15 , pp. 2133-2144
    • Lane, T.F.1    Leder, P.2
  • 25
    • 9144269759 scopus 로고    scopus 로고
    • Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    • Li, Y., Welm, B., Podsypanina, K., Huang, S., Chamorro, M., Zhang, X., Rowlands, T., Egeblad, M., Cowin, P., Werb, Z. et al. (2003). Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc. Natl. Acad. Sci. USA 100, 15853-15858.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15853-15858
    • Li, Y.1    Welm, B.2    Podsypanina, K.3    Huang, S.4    Chamorro, M.5    Zhang, X.6    Rowlands, T.7    Egeblad, M.8    Cowin, P.9    Werb, Z.10
  • 26
    • 1642570244 scopus 로고    scopus 로고
    • The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    • Liu, B. Y., McDermott, S. P., Khwaja, S. S. and Alexander, C. M. (2004). The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc. Natl. Acad. Sci. USA 101, 4158-4163.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4158-4163
    • Liu, B.Y.1    McDermott, S.P.2    Khwaja, S.S.3    Alexander, C.M.4
  • 27
    • 0036467391 scopus 로고    scopus 로고
    • The p53 and Mdm2 families in cancer
    • Michael, D. and Oren, M. (2002). The p53 and Mdm2 families in cancer. Curr. Opin. Genet. Dev. 12, 53-59.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 53-59
    • Michael, D.1    Oren, M.2
  • 28
    • 0035939818 scopus 로고    scopus 로고
    • Beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland
    • Michaelson, J. S. and Leder, P. (2001). beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland. Oncogene 20, 5093-5099.
    • (2001) Oncogene , vol.20 , pp. 5093-5099
    • Michaelson, J.S.1    Leder, P.2
  • 29
    • 0033594491 scopus 로고    scopus 로고
    • p63 is a p53 homologue required for limb and epidermal morphogenesis
    • Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R. and Bradley, A. (1999). p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398, 708-713.
    • (1999) Nature , vol.398 , pp. 708-713
    • Mills, A.A.1    Zheng, B.2    Wang, X.J.3    Vogel, H.4    Roop, D.R.5    Bradley, A.6
  • 30
    • 0037103985 scopus 로고    scopus 로고
    • Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors
    • Miyoshi, K., Rosner, A., Nozawa, M., Byrd, C., Morgan, F., Landesman-Bollag, E., Xu, X., Seldin, D. C., Schmidt, E. V., Taketo, M. M. et al. (2002a). Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors. Oncogene 21, 5548-5556.
    • (2002) Oncogene , vol.21 , pp. 5548-5556
    • Miyoshi, K.1    Rosner, A.2    Nozawa, M.3    Byrd, C.4    Morgan, F.5    Landesman-Bollag, E.6    Xu, X.7    Seldin, D.C.8    Schmidt, E.V.9    Taketo, M.M.10
  • 32
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • Nelson, W. J. and Nusse, R. (2004). Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303, 1483-1487.
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 33
    • 0038460529 scopus 로고    scopus 로고
    • Human mammary luminal epithelial cells contain progenitors to myoepithelial cells
    • Pechoux, C., Gudjonsson, T., Ronnov-Jessen, L., Bissell, M. J. and Petersen, O. W. (1999). Human mammary luminal epithelial cells contain progenitors to myoepithelial cells. Dev. Biol. 206 88-99.
    • (1999) Dev. Biol. , vol.206 , pp. 88-99
    • Pechoux, C.1    Gudjonsson, T.2    Ronnov-Jessen, L.3    Bissell, M.J.4    Petersen, O.W.5
  • 35
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis, P. (2000). Wnt signaling and cancer. Genes Dev. 14, 1837-1851.
    • (2000) Genes Dev. , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 36
    • 0037393850 scopus 로고    scopus 로고
    • A novel function for tissue inhibitor of metalloproteinases-3 (Timp3): Inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2
    • Qi, J. H., Ebrahem, Q., Moore, N., Murphy, G., Claesson-Welsh, L., Bond, M., Baker, A. and Anand-Apte, B. (2003). A novel function for tissue inhibitor of metalloproteinases-3 (Timp3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nat. Med. 9, 407-415.
    • (2003) Nat. Med. , vol.9 , pp. 407-415
    • Qi, J.H.1    Ebrahem, Q.2    Moore, N.3    Murphy, G.4    Claesson-Welsh, L.5    Bond, M.6    Baker, A.7    Anand-Apte, B.8
  • 37
    • 0027973880 scopus 로고
    • Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development
    • Ramirez, A., Bravo, A., Jorcano, J. L. and Vidal, M. (1994). Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development. Differentiation 58, 53-64.
    • (1994) Differentiation , vol.58 , pp. 53-64
    • Ramirez, A.1    Bravo, A.2    Jorcano, J.L.3    Vidal, M.4
  • 38
    • 0141816802 scopus 로고    scopus 로고
    • Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia
    • Rowlands, T. M., Pechenkina, I. V., Hatsell, S. J., Pestell, R. G. and Cowin, P. (2003). Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia. Proc. Natl. Acad. Sci. USA 100, 11400-11405.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 11400-11405
    • Rowlands, T.M.1    Pechenkina, I.V.2    Hatsell, S.J.3    Pestell, R.G.4    Cowin, P.5
  • 39
    • 0344413420 scopus 로고    scopus 로고
    • Live and let die in the intestinal epithelium
    • Sancho, E., Batlle, E. and Clevers, H. (2003). Live and let die in the intestinal epithelium. Curr. Opin. Cell Biol. 15 763-770.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 763-770
    • Sancho, E.1    Batlle, E.2    Clevers, H.3
  • 40
    • 85020344705 scopus 로고    scopus 로고
    • TAp63gamma (p51A) and dNp63alpha (p73L), two major isoforms of the p63 gene, exert opposite effects on the vascular endothelial growth factor (VEGF) gene expression
    • Senoo, M., Matsumura, Y. and Habu, S. (2002). TAp63gamma (p51A) and dNp63alpha (p73L), two major isoforms of the p63 gene, exert opposite effects on the vascular endothelial growth factor (VEGF) gene expression. Oncogene 21, 2455-2465.
    • (2002) Oncogene , vol.21 , pp. 2455-2465
    • Senoo, M.1    Matsumura, Y.2    Habu, S.3
  • 42
    • 0242667837 scopus 로고    scopus 로고
    • Stem cells and breast cancer: A field in transit
    • Smalley, M. and Ashworth, A. (2003). Stem cells and breast cancer: a field in transit. Nat. Rev. Cancer 3, 832-844.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 832-844
    • Smalley, M.1    Ashworth, A.2
  • 43
    • 0032757453 scopus 로고    scopus 로고
    • Differentiation of separated mouse mammary luminal epithelial and myoepithelial cells cultured on EHS matrix analyzed by indirect immunofluorescence of cytoskeletal antigens
    • Smalley, M. J., Titley, J., Paterson, H., Perusinghe, N., Clarke, C. and O'Hare, M. J. (1999). Differentiation of separated mouse mammary luminal epithelial and myoepithelial cells cultured on EHS matrix analyzed by indirect immunofluorescence of cytoskeletal antigens. J. Histochem. Cytochem. 47, 1513-1524.
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 1513-1524
    • Smalley, M.J.1    Titley, J.2    Paterson, H.3    Perusinghe, N.4    Clarke, C.5    O'Hare, M.J.6
  • 44
    • 0346244046 scopus 로고    scopus 로고
    • Mammary epithelial stem cells: Transplantation and self-renewal analysis
    • Smith, G. H. and Boulanger, C. A. (2003). Mammary epithelial stem cells: transplantation and self-renewal analysis. Cell Prolif. 36, 3-15.
    • (2003) Cell Prolif. , vol.36 , pp. 3-15
    • Smith, G.H.1    Boulanger, C.A.2
  • 45
    • 0023889974 scopus 로고
    • A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland
    • Smith, G. H. and Medina, D. (1988). A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland. J. Cell Sci. 90, 173-183.
    • (1988) J. Cell Sci. , vol.90 , pp. 173-183
    • Smith, G.H.1    Medina, D.2
  • 49
    • 0028302990 scopus 로고
    • Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression
    • Sympson, C. J., Talhouk, R. S., Alexander, C. M., Chin, J. R., Clift, S. M., Bissell, M. J. and Werb, Z. (1994). Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J. Cell Biol. 125, 681-693.
    • (1994) J. Cell Biol. , vol.125 , pp. 681-693
    • Sympson, C.J.1    Talhouk, R.S.2    Alexander, C.M.3    Chin, J.R.4    Clift, S.M.5    Bissell, M.J.6    Werb, Z.7
  • 50
    • 0037444482 scopus 로고    scopus 로고
    • A beta-catenin survival signal is required for normal lobular development in the mammary gland
    • Tepera, S. B., McCrea, P. D. and Rosen, J. M. (2003). A beta-catenin survival signal is required for normal lobular development in the mammary gland. J. Cell Sci. 116, 1137-1149.
    • (2003) J. Cell Sci. , vol.116 , pp. 1137-1149
    • Tepera, S.B.1    McCrea, P.D.2    Rosen, J.M.3
  • 51
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu, O. and McCormick, F. (1999). Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422-426.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 52
    • 0024162530 scopus 로고
    • Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
    • Tsukamoto, A. S., Grosschedl, R., Guzman, R. C., Parslow, T. and Varmus, H. E. (1988). Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 55, 619-625.
    • (1988) Cell , vol.55 , pp. 619-625
    • Tsukamoto, A.S.1    Grosschedl, R.2    Guzman, R.C.3    Parslow, T.4    Varmus, H.E.5
  • 53
    • 0038625113 scopus 로고    scopus 로고
    • Transient activation of beta-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice
    • Van Mater, D., Kolligs, F. T., Dlugosz, A. A. and Fearon, E. R. (2003). Transient activation of beta-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev. 17, 1219-1224.
    • (2003) Genes Dev. , vol.17 , pp. 1219-1224
    • Van Mater, D.1    Kolligs, F.T.2    Dlugosz, A.A.3    Fearon, E.R.4
  • 54
    • 0028145283 scopus 로고
    • Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland
    • Weber-Hall, S. J., Phippard, D. J., Niemeyer, C. C. and Dale, T. C. (1994). Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland. Differentiation 57, 205-214.
    • (1994) Differentiation , vol.57 , pp. 205-214
    • Weber-Hall, S.J.1    Phippard, D.J.2    Niemeyer, C.C.3    Dale, T.C.4
  • 55
    • 0036570144 scopus 로고    scopus 로고
    • Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population
    • Welm, B. E., Tepera, S. B., Venezia, T., Graubert, T. A., Rosen, J. M. and Goodell, M. A. (2002). Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev. Biol. 245, 42-56.
    • (2002) Dev. Biol. , vol.245 , pp. 42-56
    • Welm, B.E.1    Tepera, S.B.2    Venezia, T.3    Graubert, T.A.4    Rosen, J.M.5    Goodell, M.A.6
  • 56
    • 3042813412 scopus 로고    scopus 로고
    • p63: Molecular complexity in development and cancer
    • Westfall, M. D. and Pietenpol, J. A. (2004). p63: molecular complexity in development and cancer. Carcinogenesis 25, 857-864.
    • (2004) Carcinogenesis , vol.25 , pp. 857-864
    • Westfall, M.D.1    Pietenpol, J.A.2
  • 57
    • 0037052448 scopus 로고    scopus 로고
    • Stromal effects on mammary gland development and breast cancer
    • Wiseman, B. S. and Werb, Z. (2002). Stromal effects on mammary gland development and breast cancer. Science 296, 1046-1049.
    • (2002) Science , vol.296 , pp. 1046-1049
    • Wiseman, B.S.1    Werb, Z.2
  • 58
    • 0028877124 scopus 로고
    • Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development
    • Witty, J. P., Wright, J. H. and Matrisian, L. M. (1995). Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development. Mol. Biol. Cell 6, 1287-1303.
    • (1995) Mol. Biol. Cell. , vol.6 , pp. 1287-1303
    • Witty, J.P.1    Wright, J.H.2    Matrisian, L.M.3
  • 59
    • 0037507296 scopus 로고    scopus 로고
    • DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development
    • Wu, G., Nomoto, S., Hoque, M. O., Dracheva, T., Osada, M., Lee, C. C., Dong, S. M., Guo, Z., Benoit, N., Cohen, Y. et al. (2003 . DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res. 63, 2351-2357.
    • (2003) Cancer Res. , vol.63 , pp. 2351-2357
    • Wu, G.1    Nomoto, S.2    Hoque, M.O.3    Dracheva, T.4    Osada, M.5    Lee, C.C.6    Dong, S.M.7    Guo, Z.8    Benoit, N.9    Cohen, Y.10
  • 60
    • 0032161624 scopus 로고    scopus 로고
    • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang, A., Kaghad, M., Wang, Y., Gillett, E., Fleming, M. D., Dotsch, V., Andrews, N. C., Caput, D. and McKeon, F. (1998). p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2 305-316.
    • (1998) Mol. Cell. , vol.2 , pp. 305-316
    • Yang, A.1    Kaghad, M.2    Wang, Y.3    Gillett, E.4    Fleming, M.D.5    Dotsch, V.6    Andrews, N.C.7    Caput, D.8    McKeon, F.9


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