The design strategy of selective PTP1B inhibitors over TCPTP

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 16, 2016, Pages 3343-3352

  Li, XiangQian ^a,b   Wang, LiJun ^a,b   Shi, DaYong ^a,b  

^a INSTITUTE OF OCEANOLOGY   (China)

^b QINGDAO NATIONAL LABORATORY FOR MARINE SCIENCE AND TECHNOLOGY   (China)

Author keywords

Design strategy; Diabetes; PTP1B inhibitor; Selectivity; TCPTP

Indexed keywords

LEUCINE; LYSINE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; TYROSINE; ENZYME INHIBITOR; PROTEIN TYROSINE PHOSPHATASE 1B;

CRYSTAL STRUCTURE; DIABETES MELLITUS; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; IC50; MOLECULAR DOCKING; OBESITY; REVIEW; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY;

DRUG DESIGN; ENZYME INHIBITORS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84977659381     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.06.035     Document Type: Review

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