Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 22, 2003, Pages 3947-3950

  Xin, Zhili ^a   Liu, Gang ^a   Abad Zapatero, Cele ^a   Pei, Zhonghua ^a   Szczepankiewicz, Bruce G ^a   Li, Xiaofeng ^a   Zhang, Tianyuan ^a   Hutchins, Charles W ^a   Hajduk, Philip J ^a   Ballaron, Stephen J ^a   Stashko, Michael A ^a   Lubben, Thomas H ^a   Trevillyan, James M ^a   Jirousek, Michael R ^a,b  

^a ABBOTT LABORATORIES   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; ENZYME INHIBITOR; PHOSPHORIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL LINE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; NONHUMAN; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 10744232193     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.064     Document Type: Article

References (15)

1. (a) Saltiel A.R., Kahn C.R. Nature. 414:2001;799 (b) Evans J.L., Jallal B. Exp. Opin. Invest. Drugs. 8:1999;139.
2. (a) Saltiel A.R., Kahn C.R. Nature. 414:2001;799 (b) Evans J.L., Jallal B. Exp. Opin. Invest. Drugs. 8:1999;139.
3. Cheng A., Dube N., Gu F., Tremblay M.L. Eur. J. Biochem. 269:2002;1050.
4. Blaskovich M.A., Kim H.-O. Exp. Opin. Ther. Pat. 12:2002;871.
5. Ripka, W. C. In Annual Reports in Medicinal Chemistry; Doherty, A. M., Ed.; Academic: San Diego, CA, 2000; Vol. 35, p 231.
6. Johnson T.O., Ermolieff J., Jirousek M. Nat. Rev. Drug Discov. 1:2000;696.
7. Burke T.R. Jr., Kole H.K., Roller P.P. Biochem. Biophys. Res. Commun. 204:1994;129.
8. Andersen H.S., Iversen L.F., Jeppesen C.B., Branner S., Norris K., Rasmussen H.B., Møller K.B., Møller N.P.H. J. Biol. Chem. 275:2000;7101.
9. Larsen S.D., Barf T., Liljebris C., May P.D., Ogg D., O'Sullivan T.J., Palazuk B.J., Schostarez H.J., Stevens F.C., Bleasdale J.E. J. Med. Chem. 45:2002;598.
10. Liljebris C., Larsen S.D., Ogg D., Palazuk B.J., Bleasdale J.E. J. Med. Chem. 45:2002;1785.
11. Gao Y., Wu L., Luo J.H., Guo R., Yang D., Zhang Z.-Y., Burke T.R. Jr. Bioorg. Med. Chem. Lett. 10:2000;923.
12. Liu G., Xin Z., Liang H., Abad-Zapatero C., Hadjuk P.J., Janowick D.A., Szczepankiewicz B.G., Pei Z., Hutchins C.W., Ballaron S.J., Stashko M.A., Lubben T., Berg C.E., Rondinone C.M., Trevillyan J.M., Jirousek M.R. J. Med. Chem. 46:2003;3437.
13. Puius Y.A., Zhao Y., Sullivan M., Lawrence D.S., Almo S.C., Zhang Z.-Y. Proc. Natl. Acad. Sci. U.S.A. 94:1997;13420.
14. Beaulieu P.L., Cameron D.R., Ferland J.-M., Gauthier J., Ghiro E., Gillard J., Gorys V., Poirier M., Rancourt J., Wernic D., Llinas-Brunet M. J. Med. Chem. 42:1999;1757.
15. Refined crystallographic coordinates for the structure of hPTP1B complexed with compound 20 have been deposited with the Protein Data Bank ( www.rcsb.org ) with entry code 1QXK.