-
1
-
-
78651276631
-
Diagnosis and Classification of Diabetes Mellitus
-
American Diabetes Association
-
American Diabetes Association Diagnosis and Classification of Diabetes Mellitus Diabetes Care 34 Suppl. 1 2011 S62 S69
-
(2011)
Diabetes Care
, vol.34
, Issue.SUPPL. 1
-
-
-
2
-
-
58849149063
-
Recent and emerging anti diabetes targets
-
M.L. Mohler Recent and emerging anti diabetes targets Med. Res. Rev. 29 2009 125 195
-
(2009)
Med. Res. Rev.
, vol.29
, pp. 125-195
-
-
Mohler, M.L.1
-
3
-
-
68449104156
-
Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: A cohort study
-
L.G. Hemkens Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study Diabetologia 52 2009 1732 1744
-
(2009)
Diabetologia
, vol.52
, pp. 1732-1744
-
-
Hemkens, L.G.1
-
4
-
-
41149159084
-
Insulin resistance and hyperinsulinemia: Is hyperinsulinemia the cart or the horse?
-
M.H. Shanik Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse? Diabetes Care 31 Suppl. 2 2008 S262 S268
-
(2008)
Diabetes Care
, vol.31
, Issue.SUPPL. 2
-
-
Shanik, M.H.1
-
5
-
-
0035091266
-
Recent advances in our understanding of insulin action and insulin resistance
-
D. Le Roith, and Y. Zick Recent advances in our understanding of insulin action and insulin resistance Diabetes Care 24 2001 588 597 (Pubitemid 32198431)
-
(2001)
Diabetes Care
, vol.24
, Issue.3
, pp. 588-597
-
-
Le Roith, D.1
Zick, Y.2
-
6
-
-
0033968126
-
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
-
K. Cusi Insulin resistance differentially affects the PI 3-kinase-and MAP kinase-mediated signaling in human muscle J. Clin. Invest. 105 2000 311 320 (Pubitemid 30094451)
-
(2000)
Journal of Clinical Investigation
, vol.105
, Issue.3
, pp. 311-320
-
-
Cusi, K.1
Maezono, K.2
Osman, A.3
Pendergrass, M.4
Patti, M.E.5
Pratipanawatr, T.6
DeFronzo, R.A.7
Kahn, C.R.8
Mandarino, L.J.9
-
7
-
-
0023665173
-
Insulin-mimetic effect of trypsin on the insulin receptor tyrosine kinase in intact adipocytes
-
J.W. Leef, and J. Larner Insulin-mimetic effect of trypsin on the insulin receptor tyrosine kinase in intact adipocytes J. Biol. Chem. 262 1987 14837 14842
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 14837-14842
-
-
Leef, J.W.1
Larner, J.2
-
8
-
-
0035787076
-
Discovery of a small molecule insulin receptor activator
-
G.M. Salituro Discovery of a small molecule insulin receptor activator Recent Prog. Horm. Res. 56 2001 107 126
-
(2001)
Recent Prog. Horm. Res.
, vol.56
, pp. 107-126
-
-
Salituro, G.M.1
-
9
-
-
0033532347
-
Discovery of a small molecule insulin mimetic with antidiabetic activity in mice
-
DOI 10.1126/science.284.5416.974
-
B. Zhang Discovery of a small molecule insulin mimetic with antidiabetic activity in mice Science 284 1999 974 977 (Pubitemid 29288438)
-
(1999)
Science
, vol.284
, Issue.5416
, pp. 974-977
-
-
Zhang, B.1
Salituro, G.2
Szalkowski, D.3
Li, Z.4
Zhang, Y.5
Royo, I.6
Vilella, D.7
Diez, M.T.8
Pelaez, F.9
Ruby, C.10
Kendall, R.L.11
Mao, X.12
Griffin, P.13
Calaycay, J.14
Zierath, J.R.15
Heck, J.V.16
Smith, R.G.17
Moller, D.E.18
-
10
-
-
0037598588
-
Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator
-
DOI 10.1002/cbic.200200468
-
N.J.G. Webster Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator Chembiochem 4 2003 379 385 (Pubitemid 36604322)
-
(2003)
ChemBioChem
, vol.4
, Issue.5
, pp. 379-385
-
-
Webster, N.J.G.1
Park, K.2
Pirrung, M.C.3
-
11
-
-
0033635999
-
A novel insulin mimetic without a proliferative effect on vascular smooth muscle cells
-
M.A. Weber A novel insulin mimetic without a proliferative effect on vascular smooth muscle cells J. Vasc. Surg. 32 2000 1118 1126
-
(2000)
J. Vasc. Surg.
, vol.32
, pp. 1118-1126
-
-
Weber, M.A.1
-
12
-
-
0036310723
-
2+] and insulin secretion from pancreatic β-cells
-
2+] and insulin secretion from pancreatic β-cells Diabetes 51 Suppl. 1 2002 S43 S49
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 1
-
-
Roper, M.G.1
-
13
-
-
0036174499
-
Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity
-
DOI 10.1038/nm0202-179
-
E.L. Air Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity Nat. Med. 8 2002 179 183 (Pubitemid 34155130)
-
(2002)
Nature Medicine
, vol.8
, Issue.2
, pp. 179-183
-
-
Air, E.L.1
Strowski, M.Z.2
Benoit, S.C.3
Conarello, S.L.4
Salituro, G.M.5
Guan, X.-M.6
Liu, K.7
Woods, S.C.8
Zhang, B.B.9
-
14
-
-
0034699358
-
Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor
-
K. Liu Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor J. Med. Chem. 43 2000 3487 3494
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3487-3494
-
-
Liu, K.1
-
15
-
-
0036797873
-
Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator
-
DOI 10.1042/BJ20020708
-
V.D.H. Ding Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator Biochem. J. 367 2002 301 306 (Pubitemid 35176919)
-
(2002)
Biochemical Journal
, vol.367
, Issue.1
, pp. 301-306
-
-
Ding, V.D.H.1
Qureshi, S.A.2
Szalkowski, D.3
Li, Z.4
Biazzo-Ashnault, D.E.5
Xie, D.6
Liu, K.7
Jones, A.B.8
Moller, D.E.9
Zhang, B.B.10
-
16
-
-
0037195656
-
Synthesis of 2,5-dihydroxy-3-(indol-3-yl)benzoquinones by acid-catalyzed condensation of indoles with 2,5-dichlorobenzoquinone
-
DOI 10.1021/jo0204597
-
M.C. Pirrung Synthesis of 2,5-dihydroxy-3-(indol-3-yl)benzoquinones by acid-catalysed condensation of indoles with 2,5-dichlorobenzoquinone J. Org. Chem. 67 2002 8374 8388 (Pubitemid 35402983)
-
(2002)
Journal of Organic Chemistry
, vol.67
, Issue.24
, pp. 8374-8388
-
-
Pirrung, M.C.1
Deng, L.2
Li, Z.3
Park, K.4
-
17
-
-
35549002671
-
Identification of novel orally available small molecule insulin mimetics
-
DOI 10.1124/jpet.107.126102
-
B. Lin Identification of novel orally available small molecule insulin mimetics J. Pharmacol. Exp. Ther. 323 2007 579 585 (Pubitemid 350005119)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.323
, Issue.2
, pp. 579-585
-
-
Lin, B.1
Li, Z.2
Park, K.3
Deng, L.4
Pai, A.5
Zhong, L.6
Pirrung, M.C.7
Webster, N.J.G.8
-
18
-
-
39049091984
-
Anti-infective quinone derivatives of recent patents
-
J. Koyama Anti-infective quinone derivatives of recent patents Recent Pat. Anti-infect. Drug Discov. 1 2006 113 125
-
(2006)
Recent Pat. Anti-infect. Drug Discov.
, vol.1
, pp. 113-125
-
-
Koyama, J.1
-
19
-
-
84861954901
-
Cytotoxicity of quinone drugs on highly proliferative human leukemia T cells: Reactive oxygen species generation and inactive shortened SOD1 isoform implications
-
J.I. Aguilo Cytotoxicity of quinone drugs on highly proliferative human leukemia T cells: reactive oxygen species generation and inactive shortened SOD1 isoform implications Chem. Biol. Interact. 198 2012 18 28
-
(2012)
Chem. Biol. Interact.
, vol.198
, pp. 18-28
-
-
Aguilo, J.I.1
-
20
-
-
84881186374
-
-
Merck and Co. Inc., Rahway, NJ (US). USP 6,596,760 B1
-
Chen, S.S.T. et al. Antidiabetic 4-hydroxy-2-furoic acids. Merck and Co. Inc., Rahway, NJ (US). USP 6,596,760 B1
-
Antidiabetic 4-hydroxy-2-furoic Acids
-
-
Chen, S.S.T.1
-
21
-
-
69449098665
-
A novel hydroxyfuroic acid compound as an insulin receptor activator. Structure and activity relationship of a prenylindole moiety to insulin receptor activation
-
H.J. Tsai, and S.Y. Chou A novel hydroxyfuroic acid compound as an insulin receptor activator. Structure and activity relationship of a prenylindole moiety to insulin receptor activation J. Biomed. Sci. 16 2009 68
-
(2009)
J. Biomed. Sci.
, vol.16
, pp. 68
-
-
Tsai, H.J.1
Chou, S.Y.2
-
22
-
-
48249090087
-
Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice
-
S. Belmadani Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice Diabetes 57 2008 1629 1637
-
(2008)
Diabetes
, vol.57
, pp. 1629-1637
-
-
Belmadani, S.1
-
23
-
-
61649100307
-
The FGF family: Biology, pathophysiology and therapy
-
A. Beenken, and M. Mohammadi The FGF family: biology, pathophysiology and therapy Nat. Rev. Drug Discov. 8 2009 235 253
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 235-253
-
-
Beenken, A.1
Mohammadi, M.2
-
25
-
-
59849103075
-
A target based therapeutic approach towards diabetes mellitus using medicinal plants
-
P.K. Prabhakar, and M. Doble A target based therapeutic approach towards diabetes mellitus using medicinal plants Curr. Diabetes Rev. 4 2008 291 308
-
(2008)
Curr. Diabetes Rev.
, vol.4
, pp. 291-308
-
-
Prabhakar, P.K.1
Doble, M.2
-
26
-
-
33847631240
-
α-lipoic acid as a directly binding activator of the insulin receptor: Protection from hepatocyte apoptosis
-
DOI 10.1021/bi602547m
-
B. Diesel α-Lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis Biochemistry 46 2007 2146 2155 (Pubitemid 46355324)
-
(2007)
Biochemistry
, vol.46
, Issue.8
, pp. 2146-2155
-
-
Diesel, B.1
Kulhanek-Heinze, S.2
Holtje, M.3
Brandt, B.4
Holtje, H.-D.5
Vollmar, A.M.6
Kiemer, A.K.7
-
27
-
-
79955087504
-
Insulin-mimetic action of rhoifolin and cosmosiin isolated from Citrus grandis (L.) Osbeck leaves: Enhanced adiponectin secretion and insulin receptor phosphorylation in 3T3-L1 cells
-
Y.K. Rao Insulin-mimetic action of rhoifolin and cosmosiin isolated from Citrus grandis (L.) Osbeck leaves: enhanced adiponectin secretion and insulin receptor phosphorylation in 3T3-L1 cells Evidence-Based Complement. Alternat. Med. 2011 2009 1 9
-
(2009)
Evidence-Based Complement. Alternat. Med.
, vol.2011
, pp. 1-9
-
-
Rao, Y.K.1
-
28
-
-
13244259179
-
Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells
-
X. Liu Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells J. Nutr. 135 2005 165 171 (Pubitemid 40194473)
-
(2005)
Journal of Nutrition
, vol.135
, Issue.2
, pp. 165-171
-
-
Liu, X.1
Kim, J.-K.2
Li, Y.3
Li, J.4
Liu, F.5
Chen, X.6
-
29
-
-
0141955261
-
Activation of insulin receptors by lagerstroemin
-
DOI 10.1254/jphs.93.69
-
K. Hattori Activation of insulin receptors by lagerstroemin J. Pharmacol. Sci. 93 2003 69 73 (Pubitemid 37254269)
-
(2003)
Journal of Pharmacological Sciences
, vol.93
, Issue.1
, pp. 69-73
-
-
Hattori, K.1
Sukenobu, N.2
Sasaki, T.3
Takasuga, S.4
Hayashi, T.5
Kasai, R.6
Yamasaki, K.7
Hazeki, O.8
-
30
-
-
34247115917
-
Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator
-
DOI 10.1042/BJ20061123
-
S.H. Jung Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator Biochem. J. 403 Pt 2 2007 243 250 (Pubitemid 46596579)
-
(2007)
Biochemical Journal
, vol.403
, Issue.2
, pp. 243-250
-
-
Jung, S.H.1
Ha, Y.J.2
Shim, E.K.3
Choi, S.Y.4
Jin, J.L.5
Yun-Choi, H.S.6
Lee, J.R.7
-
31
-
-
0000659206
-
Vanadium compounds as insulin mimics
-
K.H. Thompson Vanadium compounds as insulin mimics Chem. Rev. 99 1999 2561 2572
-
(1999)
Chem. Rev.
, vol.99
, pp. 2561-2572
-
-
Thompson, K.H.1
-
32
-
-
78650202507
-
Trace elements in glucometabolic disorders: An update
-
N. Wiernsperger, and J. Rapin Trace elements in glucometabolic disorders: an update Diabetol. Metab. Syndr. 19 2010 70
-
(2010)
Diabetol. Metab. Syndr.
, vol.19
, pp. 70
-
-
Wiernsperger, N.1
Rapin, J.2
-
33
-
-
0037298297
-
Historic perspective and recent developments on the insulin-like actions of vanadium; Toward developing vanadium-based drugs for diabetes
-
Y. Shechter Historic perspective and recent developments on the insulin-like actions of vanadium; toward developing vanadium-based drugs for diabetes Coord. Chem. Rev. 237 2003 3 11
-
(2003)
Coord. Chem. Rev.
, vol.237
, pp. 3-11
-
-
Shechter, Y.1
-
34
-
-
0023219921
-
Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Characterization and mode of action
-
J. Meyerovitch Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Characterization and mode of action J. Biol. Chem. 262 1987 6658 6662 (Pubitemid 17104143)
-
(1987)
Journal of Biological Chemistry
, vol.262
, Issue.14
, pp. 6658-6662
-
-
Meyerovitch, J.1
Farfel, Z.2
Sack, J.3
Shechter, Y.4
-
35
-
-
0024443899
-
Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats
-
S.M. Brichard Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats Endocrinology 125 1989 2510 2516 (Pubitemid 19279438)
-
(1989)
Endocrinology
, vol.125
, Issue.5
, pp. 2510-2516
-
-
Brichard, S.M.1
Pottier, A.M.2
Henquin, J.C.3
-
36
-
-
0025779733
-
Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus
-
J. Meyerovitch Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus J. Clin. Invest. 87 1991 1286 1294
-
(1991)
J. Clin. Invest.
, vol.87
, pp. 1286-1294
-
-
Meyerovitch, J.1
-
38
-
-
0031022433
-
Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate
-
DOI 10.1074/jbc.272.2.843
-
G. Huyer Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate J. Biol. Chem. 272 1997 843 851 (Pubitemid 27034572)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.2
, pp. 843-851
-
-
Huyer, G.1
Liu, S.2
Kelly, J.3
Moffat, J.4
Payette, P.5
Kennedy, B.6
Tsaprailis, G.7
Gresser, M.J.8
Ramachandran, C.9
-
39
-
-
0027480758
-
Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes
-
A. Shisheva, and Y. Shechter Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes J. Biol. Chem. 268 1993 6463 6469 (Pubitemid 23099344)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.9
, pp. 6463-6469
-
-
Shisheva, A.1
Shechter, Y.2
-
40
-
-
0030724164
-
Vanadate activates membranous nonreceptor protein tyrosine kinase in rat adipocytes
-
G. Elberg Vanadate activates membranous nonreceptor protein tyrosine kinase in rat adipocytes Diabetes 46 1997 1684 1690 (Pubitemid 27456398)
-
(1997)
Diabetes
, vol.46
, Issue.11
, pp. 1684-1690
-
-
Elberg, G.1
He, Z.2
Li, J.3
Sekar, N.4
Shechter, Y.5
-
41
-
-
0028136598
-
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics
-
B.I. Posner Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics J. Biol. Chem. 269 1994 4596 4604
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 4596-4604
-
-
Posner, B.I.1
-
42
-
-
34247362854
-
PTP1B as a drug target: Recent developments in PTP1B inhibitor discovery
-
DOI 10.1016/j.drudis.2007.03.011, PII S1359644607001365
-
S. Zhang, and Z.Y. Zhang PTP1B as a drug target: recent developments in PTP1B inhibitor discovery Drug Discov. Today 12 2007 373 381 (Pubitemid 46636379)
-
(2007)
Drug Discovery Today
, vol.12
, Issue.9-10
, pp. 373-381
-
-
Zhang, S.1
Zhang, Z.-Y.2
-
43
-
-
0036181649
-
Protein tyrosine phosphatases: Structure and function, substrate specificity, and inhibitor development
-
Z.Y. Zhang Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development Annu. Rev. Pharmacol. Toxicol. 42 2002 209 234
-
(2002)
Annu. Rev. Pharmacol. Toxicol.
, vol.42
, pp. 209-234
-
-
Zhang, Z.Y.1
-
44
-
-
21244444303
-
Inhibitors of protein tyrosine phosphatases: Next-generation drugs?
-
DOI 10.1002/anie.200461517
-
L. Bialy, and H. Waldmann Inhibitors of protein tyrosine phosphatases: next generation drugs? Angew. Chem. Int. Ed. 44 2005 3814 3839 (Pubitemid 40885689)
-
(2005)
Angewandte Chemie - International Edition
, vol.44
, Issue.25
, pp. 3814-3839
-
-
Bialy, L.1
Waldmann, H.2
-
45
-
-
0031457541
-
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design
-
Y.A. Puius Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design Proc. Natl. Acad. Sci. U.S.A. 94 1997 13420 13425
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 13420-13425
-
-
Puius, Y.A.1
-
46
-
-
0035861668
-
Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure
-
K. Shen Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure J. Biol. Chem. 276 2001 47311 47319
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47311-47319
-
-
Shen, K.1
-
47
-
-
10744228071
-
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors
-
DOI 10.1016/j.bmcl.2003.11.076
-
C.K. Lau Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors Bioorg. Med. Chem. Lett. 14 2004 1043 1048 (Pubitemid 38167639)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.4
, pp. 1043-1048
-
-
Lau, C.K.1
Bayly, C.I.2
Gauthier, J.Y.3
Li, C.S.4
Therien, M.5
Asante-Appiah, E.6
Cromlish, W.7
Boie, Y.8
Forghani, F.9
Desmarais, S.10
Wang, Q.11
Skorey, K.12
Waddleton, D.13
Payette, P.14
Ramachandran, C.15
Kennedy, B.P.16
Scapin, G.17
-
49
-
-
0041842685
-
Selective protein tyrosine phosphatase 1B inhibitors: Targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands
-
DOI 10.1021/jm034088d
-
G. Liu Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands J. Med. Chem. 46 2003 3437 3440 (Pubitemid 36909816)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.16
, pp. 3437-3440
-
-
Liu, G.1
Xin, Z.2
Liang, H.3
Abad-Zapatero, C.4
Hajduk, P.J.5
Janowick, D.A.6
Szczepankiewicz, B.G.7
Pei, Z.8
Hutchins, C.W.9
Ballaron, S.J.10
Stashko, M.A.11
Lubben, T.H.12
Berg, C.E.13
Rondinone, C.M.14
Trevillyan, J.M.15
Jirousek, M.R.16
-
50
-
-
34648833338
-
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: From the active site to the second phosphotyrosine binding site
-
DOI 10.1021/jm0702478
-
D.P. Wilson Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site J. Med. Chem. 50 2007 4681 4698 (Pubitemid 47463242)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.19
, pp. 4681-4698
-
-
Wilson, D.P.1
Wan, Z.-K.2
Xu, W.-X.3
Kirincich, S.J.4
Follows, B.C.5
Joseph-McCarthy, D.6
Foreman, K.7
Moretto, A.8
Wu, J.9
Zhu, M.10
Binnun, E.11
Zhang, Y.-L.12
Tam, M.13
Erbe, D.V.14
Tobin, J.15
Xu, X.16
Leung, L.17
Shilling, A.18
Tam, S.Y.19
Mansour, T.S.20
Lee, J.21
more..
-
51
-
-
0036336284
-
Synthesis and biological activity of a novel class of pyridazine analogues as non-competitive reversible inhibitors of protein tyrosine phosphatase 1B (PTP1B)
-
DOI 10.1016/S0968-0896(02)00176-1, PII S0968089602001761
-
C. Liljebris Synthesis and biological activity of a novel class of pyridazine analogues as non-competitive reversible inhibitors of protein tyrosine phosphatase 1B (PTP1B) Bioorg. Med. Chem. 10 2002 3197 3212 (Pubitemid 34855393)
-
(2002)
Bioorganic and Medicinal Chemistry
, vol.10
, Issue.10
, pp. 3197-3212
-
-
Liljebris, C.1
Martinsson, J.2
Tedenborg, L.3
Williams, M.4
Barker, E.5
Duffy, J.E.S.6
Nygren, A.7
James, S.8
-
52
-
-
3543017313
-
Allosteric inhibition of protein tyrosine phosphatase 1B
-
DOI 10.1038/nsmb803
-
C. Wiesmann Allosteric inhibition of protein tyrosine phosphatase 1B Nat. Struct. Mol. Biol. 11 2004 730 737 (Pubitemid 39014498)
-
(2004)
Nature Structural and Molecular Biology
, vol.11
, Issue.8
, pp. 730-737
-
-
Wiesmann, C.1
Barr, K.J.2
Kung, J.3
Zhu, J.4
Erlanson, D.A.5
Shen, W.6
Fahr, B.J.7
Zhong, M.8
Taylor, L.9
Randall, M.10
McDowell, R.S.11
Hansen, S.K.12
-
53
-
-
13044270997
-
PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3- d]thiophenes
-
DOI 10.1021/jm990260v
-
J. Wrobel PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo [b] naphtho [2,3-d] furans and 11-arylbenzo [b] naphtho [2,3-d] thiophenes J. Med. Chem. 42 1999 3199 3202 (Pubitemid 29409708)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.17
, pp. 3199-3202
-
-
Wrobel, J.1
Sredy, J.2
Moxham, C.3
Dietrich, A.4
Li, Z.5
Sawicki, D.R.6
Seestaller, L.7
Wu, L.8
Katz, A.9
Sullivan, D.10
Tio, C.11
Zhang, Z.-Y.12
-
54
-
-
19944427190
-
Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms
-
DOI 10.1124/mol.104.005553
-
D.V. Erbe Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms Mol. Pharmacol. 67 2005 69 77 (Pubitemid 40069967)
-
(2005)
Molecular Pharmacology
, vol.67
, Issue.1
, pp. 69-77
-
-
Erbe, D.V.1
Wang, S.2
Zhang, Y.-L.3
Harding, K.4
Kung, L.5
Tam, M.6
Stolz, L.7
Xing, Y.8
Furey, S.9
Qadri, A.10
Klaman, L.D.11
Tobin, J.F.12
-
56
-
-
43049126784
-
PTP1B and TC-PTP: Regulators of transformation and tumorigenesis
-
M. Stuible PTP1B and TC-PTP: regulators of transformation and tumorigenesis Cancer Metastasis Rev. 27 2008 215 230
-
(2008)
Cancer Metastasis Rev.
, vol.27
, pp. 215-230
-
-
Stuible, M.1
-
57
-
-
0030769147
-
Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice
-
DOI 10.1084/jem.186.5.683
-
K.E. You-Ten Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice J. Exp. Med. 186 1997 683 693 (Pubitemid 27381533)
-
(1997)
Journal of Experimental Medicine
, vol.186
, Issue.5
, pp. 683-693
-
-
You-Ten, K.E.1
Muise, E.S.2
Itie, A.3
Michaliszyn, E.4
Wagner, J.5
Jothy, S.6
Lapp, W.S.7
Tremblay, M.L.8
-
58
-
-
33646359443
-
Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase
-
DOI 10.1074/jbc.M511827200
-
E. Asante-Appiah Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase J. Biol. Chem. 281 2006 8010 8015 (Pubitemid 43847418)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.12
, pp. 8010-8015
-
-
Asante-Appiah, E.1
Patel, S.2
Desponts, C.3
Taylor, J.M.4
Lau, C.5
Dufresne, C.6
Therien, M.7
Friesen, R.8
Becker, J.W.9
Leblanc, Y.10
Kennedy, B.P.11
Scapin, G.12
-
59
-
-
0037143754
-
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice
-
DOI 10.1073/pnas.142298199
-
B.A. Zinker PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice Proc. Natl. Acad. Sci. U.S.A. 99 2002 11357 11362 (Pubitemid 34920930)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.17
, pp. 11357-11362
-
-
Zinker, B.A.1
Rondinone, C.M.2
Trevillyan, J.M.3
Gum, R.J.4
Clampit, J.E.5
Waring, J.F.6
Xie, N.7
Wilcox, D.8
Jacobson, P.9
Frost, L.10
Kroeger, P.E.11
Reilly, R.M.12
Koterski, S.13
Opgenorth, T.J.14
Ulrich, R.G.15
Crosby, S.16
Butler, M.17
Murray, S.F.18
McKay, R.A.19
Bhanot, S.20
Monia, B.P.21
Jirousek, M.R.22
more..
-
60
-
-
63849189635
-
Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys
-
M.M. Swarbrick Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys Endocrinology 150 2009 1670 1679
-
(2009)
Endocrinology
, vol.150
, pp. 1670-1679
-
-
Swarbrick, M.M.1
|