Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 13, 2011, Pages 3892-3900

  He, Xiao Peng ^a,c   Deng, Qiong ^a   Gao, Li Xin ^b   Li, Cui ^a   Zhang, Wei ^b   Zhou, Yu Bo ^b   Tang, Yun ^a   Shi, Xiao Xin ^a   Xie, Juan ^c   Li, Jia ^b   Chen, Guo Rong ^a   Chen, Kaixian ^a,b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c Ecole Normale Superieure de Cachan   (France)

Author keywords

Amino acid; Click chemistry; MTT assay; PTP inhibitor; Sugar template

Indexed keywords

2 (TERT BUTOXYCARBONYLAMINO) 3 [[1 [[3,4,5 TRIS(BENZYLOXY) 6 METHOXYTETRAHYDRO 2H PYRAN 2 YL]METHYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PROPANOATE BENZYL ETHER; 2 [(TERT BUTOXYCARBONYL)AMINO] 3 [[1 [3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 2YL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PROPANOIC ACID; 2 [(TERT BUTOXYCARBONYL)AMINO] 3 [[1 [3,4,5 TRIS(BENZYLOXY) 6 [(BENZYLOXY)METHYL]TETRAHYDRO 2H PYRAN 2Y] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]BUTANOIC ACID; 2 [(TERT BUTOXYCARBONYL)AMINO] 3 [[1 [3,4,5 TRIS(BENZYLOXY) 6 [(BENZYLOXY)METHYL]TETRAHYDRO 2H PYRAN 2Y] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PROPANOIC ACID; 2 [(TERT BUTOXYCARBONYL)AMINO] 3 [[1 [[3,4,5 TRIS(BENZYLOXY) 6 METHOXYTETRAHYDRO 2H PYRAN 2YL]METHYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]BUTANOIC ACID; 2 [(TERT BUTOXYCARBONYL)AMINO] 3 [[1 [[3,4,5 TRIS(BENZYLOXY) 6 METHOXYTETRAHYDRO 2H PYRAN 2YL]METHYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PROPANOIC ACID; ANTINEOPLASTIC AGENT; BENZYL 2 [(TERT BUTOXYCARBONYL)AMINO] 3 [[1 [3,4,5 TRIS(BENZYLOXY) 6 [(BENZYLOXY)METHYL]TETRAHYDRO 2H PYRAN 2YL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]BUTANOATE; BENZYL 2 [(TERT BUTOXYCARBONYL)AMINO] 3 [[1 [3,4,5 TRIS(BENZYLOXY) 6 [(BENZYLOXY)METHYL]TETRAHYDRO 2H PYRAN 2YL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PROPANOATE; BENZYL 2 [(TERT BUTOXYCARBONYL)AMINO] 3 [[1 [[3,4,5 TRIS(BENZYLOXY) 6 METHOXYTETRAHYDRO 2H PYRAN 2 YL]METHYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]BUTANOATE; BENZYL 2 [(TERT BUTOXYCARBONYL)AMINO] 3 [[1 [[3,4,5 TRIS(BENZYLOXY) 6 METHOXYTETRAHYDRO 2H PYRAN 2 YL]METHYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]PROPANOATE; GALACTOSE; GALACTOSYL 6 TRIAZOLOSERINE; MONOSACCHARIDE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; SERINE DERIVATIVE; SUGAR; THREONINE; TRIAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CLICK CHEMISTRY; COMPUTER SIMULATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MONOSACCHARIDES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; SERINE; THREONINE;

EID: 79959494618     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.049     Document Type: Article

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