Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells

European Journal of Medicinal Chemistry

Volumn 71, Issue , 2014, Pages 112-127

  Ottanà, Rosaria ^a   Maccari, Rosanna ^a   Mortier, Jérémie ^b   Caselli, Anna ^c   Amuso, Simona ^a   Camici, Guido ^c,d   Rotondo, Archimede ^e   Wolber, Gerhard ^b   Paoli, Paolo ^c  

^a UNIVERSITY OF MESSINA   (Italy)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF FLORENCE   (Italy)

^d Andrology Unit   (Italy)

^e UNIVERSITY OF MESSINA   (Italy)

Author keywords

4 (5 Arylidene 4 oxo 2 phenylimino oxothiazolidin 3 yl)methyl benzoic acids; 5 Arylidene 4 thiazolidinone derivatives; Enzyme inhibitors; Insulinomimetic effects; Molecular docking; Protein tyrosine phosphatases

Indexed keywords

(Z) 4 [(5 ARYLIDENE 2,4 DIOXOTHIAZOLIDIN 3 YL)METHYL]BENZOIC ACID; BENZOIC ACID DERIVATIVE; DEOXYGLUCOSE; INSULIN; LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; TRODUSQUEMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; IC 50; INSULIN METABOLISM; INSULIN SENSITIVITY; MOLECULAR DOCKING; MOUSE; MUSCLE CELL; NONHUMAN; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; STRUCTURE ACTIVITY RELATION;

2-DEOXYGLUCOSE; 2-DOG; 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE; 4-[(5-ARYLIDENE-4-OXO-2-PHENYLIMINO/OXOTHIAZOLIDIN-3-YL)METHYL]BENZOIC ACIDS; 5-ARYLIDENE-4-THIAZOLIDINONE DERIVATIVES; ENZYME INHIBITORS; INSULIN RECEPTOR; INSULINOMIMETIC EFFECTS; IR; LMW-PTP; LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE; MALDI-TOF MS; MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS; MOLECULAR DOCKING; MTT; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASES; PTP; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; STAT; T CELL PROTEIN TYROSINE PHOSPHATASE; T2DM; TCPTP; TYPE 2 DIABETES MELLITUS;

ANIMALS; BENZOIC ACID; CELL LINE; HUMANS; INSULIN; INSULIN RESISTANCE; MICE; MOLECULAR DOCKING SIMULATION; MUSCLE, SKELETAL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTEIN TYROSINE PHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888176367     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.11.001     Document Type: Article

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