Cellular and molecular mechanisms of AKI

Journal of the American Society of Nephrology

Volumn 27, Issue 5, 2016, Pages 1288-1299

  Agarwal, Anupam ^a   Dong, Zheng ^b   Harris, Raymond ^c   Murray, Patrick ^d   Parikh, Samir M ^e   Rosner, Mitchell H ^f   Kellum, John A ^g   Ronco, Claudio ^h  

^a University of Alabama at Birmingham   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF VIRGINIA   (United States)

^g UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^h SAN BORTOLO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CELL SURFACE RECEPTOR;

ACUTE KIDNEY FAILURE; ANIMAL MODEL; CELL CYCLE; CELL FUNCTION; CELL INTERACTION; CELL MEMBRANE; CELL NUCLEUS; CLINICAL PRACTICE; CLINICAL TRIAL (TOPIC); CONSENSUS; CYTOSKELETON; ENDOPLASMIC RETICULUM; HUMAN; KIDNEY INJURY; LYSOSOME; MITOCHONDRION; MOLECULAR PATHOLOGY; NONHUMAN; PEROXISOME; PRECLINICAL STUDY; PRIORITY JOURNAL; REVIEW; SECONDARY PREVENTION; ACUTE KIDNEY INJURY; ANIMAL; DISEASE MODEL; KIDNEY; METABOLISM; PATHOLOGY; ULTRASTRUCTURE;

ACUTE KIDNEY INJURY; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; KIDNEY;

EID: 84977524014     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2015070740     Document Type: Review

References (115)

1. Zager RA: Plasma membrane cholesterol: a critical determinant of cellular energetics and tubular resistance to attack. Kidney Int 58: 193-205, 2000
2. Zager RA, Kalhorn TF: Changes in free and esterified cholesterol: hallmarks of acute renal tubular injury and acquired cytoresistance. AmJ Pathol 157: 1007-1016, 2000
3. Lorz C,Ortiz A, Justo P,González-Cuadrado S, Duque N, Gómez-Guerrero C, Egido J: Proapoptotic Fas ligand is expressed by normal kidney tubular epithelium and injured glomeruli. J Am Soc Nephrol 11: 1266-1277, 2000
4. Mahmoudi M, Willgoss D, Cuttle L, Yang T, Pat B, Winterford C, Endre Z, Johnson DW, Gobé GC: In vivo and in vitro models demonstrate a role for caveolin-1 in the pathogenesis of ischaemic acute renal failure. J Pathol 200: 396-405, 2003
5. Fujigaki Y, Sakakima M, Sun Y, Goto T, Ohashi N, Fukasawa H, Tsuji T, Yamamoto T, Hishida A: Immunohistochemical study on caveolin-1alpha in regenerating process of tubular cells in gentamicin-induced acute tubular injury in rats. Virchows Arch 450: 671-681, 2007
6. Kwon TH, Frøkiaer J, Han JS, Knepper MA, Nielsen S: Decreased abundance of major Na(+) transporters in kidneys of rats with ischemia-induced acute renal failure. Am J Physiol Renal Physiol 278: F925-F939, 2000
7. Peters E, van Elsas A, Heemskerk S, Jonk L, van der Hoeven J, Arend J, Masereeuw R, Pickkers P: Alkaline phosphatase as a treatment of sepsis-associated acute kidney injury. J Pharmacol Exp Ther 344: 2-7, 2013
8. Kaushal GP, Haun RS, Herzog C, Shah SV: Meprin A metalloproteinase and its role in acute kidney injury. Am J Physiol Renal Physiol 304: F1150-F1158, 2013
9. Cantaluppi V, Gatti S, Medica D, Figliolini F, Bruno S, Deregibus MC, Sordi A, Biancone L, Tetta C, Camussi G: Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells. Kidney Int 82: 412-427, 2012
10. Bruno S, Grange C, Collino F, Deregibus MC, Cantaluppi V, Biancone L, Tetta C, Camussi G: Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One 7: e33115, 2012
11. Linkermann A, Chen G, Dong G, Kunzendorf U, Krautwald S, Dong Z: Regulated cell death in AKI. J Am Soc Nephrol 25: 2689-2701, 2014
12. Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, BasavarajappaD, Radmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR,O'Donnell VB, Kagan VE, Schick JA, Conrad M: Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16: 1180-1191, 2014
13. Bhatt K, Wei Q, Pabla N, Dong G, Mi QS, Liang M, Mei C, Dong Z: MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol 26: 1588-1596, 2015
14. Wei Q, Bhatt K, He HZ, Mi QS, Haase VH, Dong Z: Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury. J Am Soc Nephrol 21: 756-761, 2010
15. Zhdanov DD, Fahmi T, Wang X, Apostolov EO, Sokolov NN, Javadov S, Basnakian AG: Regulation of Apoptotic Endonucleases by EndoG. DNA Cell Biol 34: 316-326, 2015
16. Molitoris BA: Actin cytoskeleton in ischemic acute renal failure. Kidney Int 66: 871-883, 2004
17. Humphreys BD, Cantaluppi V, Portilla D, Singbartl K, Yang L, Rosner MH, Kellum JA, Ronco C, and Acute Dialysis Quality Initiative XIII Work Group: Targeting Endogenous Repair Pathways after AKI. J Am Soc Nephrol 27: XXX-XXX, 2016
18. Hodeify R,Megyesi J, Tarcsafalvi A, Mustafa HI, Hti Lar Seng NS, Price PM: Gender differences control the susceptibility to ER stress-induced acute kidney injury. Am J Physiol Renal Physiol 304: F875-F882, 2013
19. Taniguchi M, Yoshida H: Endoplasmic reticulum stress in kidney function and disease. Curr Opin Nephrol Hypertens 24: 345-350, 2015
20. Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK: A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-123, 2008
21. Trump BF, Valigorsky JM, Jones RT, Mergner WJ, Garcia JH, Cowley RA: The application of electron microscopy and cellular biochemistry to the autopsy. Observations on cellular changes in human shock. Hum Pathol 6: 499-516, 1975
22. Takasu O, Gaut JP, Watanabe E, To K, Fagley RE, Sato B, Jarman S, Efimov IR, Janks DL, Srivastava A, Bhayani SB, Drewry A, Swanson PE, Hotchkiss RS: Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med 187: 509-517, 2013
23. Perazella MA: Tenofovir-induced kidney disease: an acquired renal tubular mitochondriopathy. Kidney Int 78: 1060-1063, 2010
24. Parekh DJ, Weinberg JM, Ercole B, Torkko KC, Hilton W, Bennett M, Devarajan P, Venkatachalam MA: Tolerance of the human kidney to isolated controlled ischemia. J Am Soc Nephrol 24: 506-517, 2013
25. Brooks C, Wei Q, Cho SG, Dong Z: Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest 119: 1275-1285, 2009
26. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM: PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest 121: 4003-4014, 2011
27. Zsengellér ZK, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, Pacher P: Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. J Histochem Cytochem 60: 521-529, 2012
28. Zamzami N, KroemerG: Themitochondrion in apoptosis: how Pandora's boxopens. Nat Rev Mol Cell Biol 2: 67-71, 2001
29. Dare AJ, Bolton EA, Pettigrew GJ, Bradley JA, Saeb-Parsy K, Murphy MP: Protection against renal ischemia-reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ. Redox Biol 5: 163-168, 2015
30. Szeto HH, Liu S, Soong Y, Wu D, Darrah SF, Cheng FY, Zhao Z, GangerM, Tow CY, Seshan SV:Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury. J Am Soc Nephrol 22: 1041-1052, 2011
31. Mewton, N, Cung, TT, Morel, O, Cayla, G, Bonnefoy-Cudraz, E, Rioufol, G, Angoulvant, D, Guerin, P, Elbaz, M, Delarche, N, Coste, P, Vanzetto, G, Metge, M, Aupetit, JF, Jouve, B, Motreff, P, Tron, C, Labeque, JN, Steg, PG, Cottin, Y, Range, G, Clerc, J, Coussement, P, Prunier, F, Moulin, F, Roth, O, Belle, L, Dubois, P, Barragan, P, Gilard, M, Piot, C, Colin, P, Morice, MC, Monassier, JP, Ider, O, Dubois-Rande, JL, Unterseeh, T, Lebreton, H, Beard, T, Blanchard, D, Grollier, G, Malquarti, V, Staat, P, Sudre, A, Hansson, MJ, Elmer, E, Boussaha, I, Jossan, C, Torner, A, Claeys, M, Garcia-Dorado, D, Ovize, M, and CIRCUS Study Investigators: Rationale and design of the Cyclosporine to ImpRove Clinical oUtcome in ST-elevation myocardial infarction patients (the CIRCUS trial). Am Heart J 169(6): 758-766.e6, 2015
32. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM: A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92: 829-839, 1998
33. Funk JA, Schnellmann RG: Persistent disruption of mitochondrial homeostasis after acute kidney injury. Am J Physiol Renal Physiol 302: F853-F864, 2012
34. Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P: Mitochondrialtargeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radic Biol Med 52: 497-506, 2012
35. Brooks C, Cho SG, Wang CY, Yang T, Dong Z: Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis. AmJ Physiol Cell Physiol 300: C447-C455, 2011
36. Youle RJ, van der Bliek AM: Mitochondrial fission, fusion, and stress. Science 337: 1062-1065, 2012
37. Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Horino T, Fujieda M, Fujimoto S, Terada Y: Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury. Am J Physiol Renal Physiol 305: F495-F509, 2013
38. Gall JM,Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG: Role of mitofusin 2 in the renal stress response. PLoS One 7: e31074, 2012
39. Gall JM, Wang Z, Bonegio RG, Havasi A, Liesa M, Vemula P, Borkan SC: Conditional knockout of proximal tubule mitofusin 2 accelerates recovery and improves survival after renal ischemia. J Am Soc Nephrol 26: 1092-1102, 2015
40. Gewin L, Vadivelu S, Neelisetty S, Srichai MB, Paueksakon P, Pozzi A, Harris RC, Zent R: Deleting the TGF-b receptor attenuates acute proximal tubule injury. J Am Soc Nephrol 23: 2001-2011, 2012
41. GentleME, Shi S, Daehn I, Zhang T, Qi H, Yu L, D'Agati VD, Schlondorff DO, Bottinger EP: Epithelial cell TGFb signaling induces acute tubular injury and interstitial inflammation. J Am Soc Nephrol 24: 787-799, 2013
42. Chen J, Chen JK,Harris RC: Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury. Kidney Int 82: 45-52, 2012
43. Zhou D, Tan RJ, Lin L, Zhou L, Liu Y: Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury. Kidney Int 84: 509-520, 2013
44. Okusa MD, Lynch KR: Targeting sphingosine 1 phosphate receptor type 1 receptors in acute kidney injury. Drug Discov Today Dis Mech 4: 55-59, 2007
45. Ranganathan P, JayakumarC,Navankasattusas S, Li DY, Kim IM, Ramesh G: UNC5B receptor deletion exacerbates tissue injury in response to AKI. J Am Soc Nephrol 25: 239-249, 2014
46. Rabb H, Griffin MD, McKay DB, Swaminathan S, Pickkers P, RosnerMH, Kellum JA, Ronco C, and AcuteDialysis Quality Initiative Consensus XIII Work Group: Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps. J Am Soc Nephrol 27: XXX-XXX, 2016
47. Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV: Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 16: 535-543, 1p, 143, 2010
48. Bonventre JV, Yang L: Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 121: 4210-4221, 2011
49. Megyesi J, Safirstein RL, Price PM: Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatininduced acute renal failure. J Clin Invest 101: 777-782, 1998
50. Megyesi J, Udvarhelyi N, Safirstein RL, Price PM: The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure. Am J Physiol 271: F1211-F1216, 1996
51. Zhang D, Liu Y, Wei Q, Huo Y, Liu K, Liu F, Dong Z: Tubular p53 regulates multiple genes tomediate acute kidney injury. J Am Soc Nephrol 25: 2278-2289, 2014
52. Price PM, Safirstein RL, Megyesi J: Protection of renal cells from cisplatin toxicity by cell cycle inhibitors. Am J Physiol Renal Physiol 286: F378-F384, 2004
53. JiangM, Yi X, Hsu S,Wang CY, Dong Z: Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity. Am J Physiol Renal Physiol 287: F1140-F1147, 2004
54. Kelly KJ, Plotkin Z, Vulgamott SL, Dagher PC: P53 mediates the apoptotic response to GTP depletion after renal ischemiareperfusion: protective role of a p53 inhibitor. J AmSocNephrol 14: 128-138, 2003
55. Pabla N, Huang S,Mi QS, Daniel R, Dong Z: ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatininduced apoptosis. J Biol Chem 283: 6572-6583, 2008
56. Pabla N, Ma Z, McIlhatton MA, Fishel R, Dong Z: hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. J Biol Chem 286: 10411-10418, 2011
57. Zhang D, Liu Y, Wei Q, Huo Y, Liu K, Liu F, Dong Z: Tubular p53 regulates multiple genes to mediate AKI. J Am Soc Nephrol 25: 2278-2289, 2014
58. Jiang M, Dong Z: Regulation and pathological role of p53 in cisplatin nephrotoxicity. J Pharmacol Exp Ther 327: 300-307, 2008
59. Chawla LS, Kimmel PL: Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. Kidney Int 82: 516-524, 2012
60. Venkatachalam MA,GriffinKA,LanR,GengH, Saikumar P, Bidani AK: Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol 298: F1078-F1094, 2010
61. Kashani K, Al-Khafaji A, Ardiles T, Artigas A, Bagshaw SM, Bell M, Bihorac A, Birkhahn R, Cely CM, Chawla LS, DavisonDL, Feldkamp T, Forni LG, Gong MN, Gunnerson KJ, HaaseM, Hackett J, Honore PM, Hoste EA, Joannes-Boyau O, Joannidis M, Kim P, Koyner JL, Laskowitz DT, Lissauer ME, Marx G, McCullough PA, Mullaney S, Ostermann M, RimmeléT,ShapiroNI, ShawAD, Shi J, Sprague AM, Vincent JL, Vinsonneau C, Wagner L, Walker MG, Wilkerson RG, Zacharowski K, Kellum JA:Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care 17(1): R25, 2013
62. Livingston MJ, Dong Z: Autophagy in acute kidney injury. Semin Nephrol 34: 17-26, 2014
63. Suzuki C, Isaka Y, Takabatake Y, Tanaka H, Koike M, Shibata M, Uchiyama Y, Takahara S, Imai E: Participation of autophagy in renal ischemia/reperfusion injury. Biochem Biophys Res Commun 368: 100-106, 2008
64. Chien CT, Shyue SK, Lai MK: Bcl-xL augmentation potentially reduces ischemia/reperfusion induced proximal and distal tubular apoptosis and autophagy. Transplantation 84: 1183-1190, 2007
65. JiangM, Liu K, Luo J, Dong Z: Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Am J Pathol 176: 1181-1192, 2010
66. Bolisetty S, Traylor AM, Kim J, Joseph R, Ricart K, Landar A, Agarwal A: Heme oxygenase-1 inhibits renal tubular macroautophagy in acute kidney injury. J Am Soc Nephrol 21: 1702-1712, 2010
67. Periyasamy-Thandavan S, Jiang M, Wei Q, Smith R, Yin XM, Dong Z: Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Kidney Int 74: 631-640, 2008
68. Jiang M,Wei Q, Dong G, Komatsu M, Su Y, Dong Z: Autophagy in proximal tubules protects against acute kidney injury. Kidney Int 82: 1271-1283, 2012
69. Li L, Zepeda-Orozco D, Black R, Lin F: Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol 176: 1767-1778, 2010
70. Koesters R, Kaissling B, Lehir M, Picard N, Theilig F, Gebhardt R, Glick AB, Hähnel B, Hosser H, Gröne HJ, Kriz W: Tubular overexpression of transforming growth factorbeta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol 177: 632-643, 2010
71. Lan R, Geng H, Polichnowski AJ, Singha PK, Saikumar P, McEwen DG, Griffin KA, Koesters R, Weinberg JM, Bidani AK, Kriz W, Venkatachalam MA: PTEN loss defines a TGF-b-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis. Am J Physiol Renal Physiol 302: F1210-F1223, 2012
72. Hasegawa K, Wakino S, Yoshioka K, Tatematsu S,Hara Y,Minakuchi H, Sueyasu K, Washida N, Tokuyama H, Tzukerman M, Skorecki K, Hayashi K, Itoh H: Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. J Biol Chem 285: 13045-13056, 2010
73. Sander JD, Joung JK: CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol 32: 347-355, 2014
74. Heyman SN, Brezis M, Reubinoff CA, Greenfeld Z, Lechene C, Epstein FH, Rosen S: Acute renal failure with selective medullary injury in the rat. J Clin Invest 82: 401-412, 1988
75. Miyaji T, Hu X, Yuen PS, Muramatsu Y, Iyer S, Hewitt SM, Star RA: Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int 64: 1620-1631, 2003
76. Doi K, Leelahavanichkul A, Yuen PS, Star RA: Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest 119: 2868-2878, 2009
77. Leelahavanichkul A, Huang Y, Hu X, Zhou H, Tsuji T,Chen R,Kopp JB, Schnermann J, Yuen PS, Star RA: Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasingHighMobilityGroup Box Protein-1. Kidney Int 80: 1198-1211, 2011
78. Peng J, Li X, Zhang D, Chen JK, Su Y, Smith SB, Dong Z: Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney Int 87: 137-150, 2015
79. Pabla N, Dong G, Jiang M, Huang S, Kumar MV, Messing RO, Dong Z: Inhibition of PKCd reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. J Clin Invest 121: 2709-2722, 2011
80. Faubel S, Chawla LS, ChertowGM, Goldstein SL, Jaber BL, Liu KD; Acute Kidney Injury Advisory Group of the American Society of Nephrology: Ongoing clinical trials in AKI. Clin J Am Soc Nephrol 7: 861-873, 2012
81. Palevsky PM,Molitoris BA,OkusaMD, Levin A, Waikar SS, Wald R, Chertow GM, Murray PT, Parikh CR, Shaw AD, Go AS, Faubel SG, Kellum JA, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene T, Mehta RL, Stokes JB, Thompson AM, Thompson BT,WestenfelderCS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA: Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology. Clin J Am Soc Nephrol 7: 844-850, 2012
82. Murray PT: Acute kidney injury biomarkers and endpoints for clinical trials. Contrib Nephrol 171: 208-212, 2011
83. Murray PT, Mehta RL, ShawA, Ronco C, Endre Z, Kellum JA, Chawla LS, Cruz D, Ince C, OkusaMD;ADQI10workgroup: Potential use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference. Kidney Int 85: 513-521, 2014
84. Murray PT, Le Gall JR, Dos Reis Miranda D, Pinsky MR, Tetta C: Physiologic endpoints (efficacy) for acute renal failure studies. Curr Opin Crit Care 8: 519-525, 2002
85. Palevsky PM, Metnitz PG, Piccinni P, VinsonneauC: Selectionofendpoints for clinical trials of acute renal failure in critically ill patients. Curr Opin Crit Care 8: 515-518, 2002
86. Bajwa A, Jo SK, Ye H, Huang L, Dondeti KR, Rosin DL, Haase VH, Macdonald TL, Lynch KR,OkusaMD: Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J Am Soc Nephrol 21: 955-965, 2010
87. Lien YH, Yong KC, Cho C, Igarashi S, Lai LW: S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure. Kidney Int 69: 1601-1608, 2006
88. Park SW, KimJY, HamA, Brown KM, Kim M, D'Agati VD, Lee HT: A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury. AmJ Physiol Renal Physiol 303: F721-F732, 2012
89. Delbridge MS, Shrestha BM, Raftery AT, El Nahas AM, Haylor JL: Reduction of ischemia-reperfusion injury in the rat kidney by FTY720, a synthetic derivative of sphingosine. Transplantation 84: 187-195, 2007
90. Boffa JJ, Just A, Coffman TM, Arendshorst WJ: Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemicmice. J AmSoc Nephrol 15: 2358-2365, 2004
91. Kramer HJ, Mohaupt MG, Pinoli F, Bäcker A, Meyer-Lehnert H, Schlebusch H: Effects of thromboxane A2 receptor blockade on oliguric ischemic acute renal failure in conscious rats. J AmSoc Nephrol 4: 50-57, 1993
92. Duffield JS, Hong S, Vaidya VS, Lu Y, Fredman G, Serhan CN, Bonventre JV: Resolvin D series and protectin D1 mitigate acute kidney injury. J Immunol 177: 5902-5911, 2006
93. Kong D, Zhuo L, Gao C, Shi S, Wang N, Huang Z, Li W, Hao L: Erythropoietin protects against cisplatin-induced nephrotoxicity by attenuating endoplasmic reticulum stress-induced apoptosis. J Nephrol 26: 219-227, 2013
94. Khan MA, Liu J, Kumar G, Skapek SX, Falck JR, Imig JD: Novel orally active epoxyeicosatrienoic acid (eet) analogs attenuate cisplatin nephrotoxicity. FASEB J 27: 2946-2956, 2013
95. Wang J,Wei Q, Wang CY, HillWD, Hess DC, Dong Z: Minocycline up-regulates bcl-2 and protects against cell death in mitochondria. J Biol Chem279: 19948-19954, 2004
96. Wang Z, Gall JM, Bonegio R, Havasi A, Illanes K, Schwartz JH, Borkan SC: Nucleophosmin, a critical bax cofactor in ischemiainduced cell death. Mol Cell Biol 33: 1916-1924, 2013
97. Funk JA, Schnellmann RG: Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1a activation following ischemia-reperfusion injury. Toxicol Appl Pharmacol 273: 345-354, 2013
98. Whitaker RM, Wills LP, Stallons LJ, Schnellmann RG: cGMP-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury. J Pharmacol Exp Ther 347: 626-634, 2013
99. Jung YJ, Kim DH, Lee AS, Lee S, Kang KP, Lee SY, Jang KY, Sung MJ, Park SK, Kim W: Peritubular capillary preservation with COMP-angiopoietin-1 decreases ischemiareperfusion-induced acute kidney injury. Am J Physiol Renal Physiol 297: F952-F960, 2009
100. Kumpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park JK, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, Shushakova N: The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care 15: R261, 2011
101. Rabadi MM, Ghaly T, Goligorksy MS, Ratliff BB: HMGB1 in renal ischemic injury. Am J Physiol Renal Physiol 303: F873-F885, 2012
102. Li J, Gong Q, Zhong S, Wang L, Guo H, Xiang Y, Ichim TE,Wang CY, Chen S, Gong F, Chen G: Neutralization of the extracellular HMGB1 released by ischaemic damaged renal cells protects against renal ischaemia-reperfusion injury. Nephrol Dial Transplant 26: 469-478, 2011
103. Wu H, Steenstra R, de Boer EC, Zhao CY, Ma J, van der Stelt JM, Chadban SJ: Preconditioning with recombinant highmobility group box 1 protein protects the kidney against ischemia-reperfusion injury in mice. Kidney Int 85: 824-832, 2014
104. Sadis C, Teske G, Stokman G, Kubjak C, ClaessenN,Moore F, Loi P,Diallo B, Barvais L, Goldman M, Florquin S, Le Moine A: Nicotine protects kidney fromrenal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway. PLoS One 2: e469, 2007
105. Gigliotti JC, Huang L, Ye H, Bajwa A, Chattrabhuti K, Lee S, Klibanov AL, Kalantari K, Rosin DL, Okusa MD: Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic antiinflammatory pathway. J AmSoc Nephrol 24: 1451-1460, 2013
106. Yeboah MM, Xue X, Duan B, Ochani M, Tracey KJ, Susin M, Metz CN: Cholinergic agonists attenuate renal ischemiareperfusion injury in rats. Kidney Int 74: 62-69, 2008
107. Chatterjee PK, Yeboah MM, Dowling O, Xue X, Powell SR, Al-Abed Y, Metz CN: Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity. PLoS One 7: e35361, 2012
108. Fan H, Goodwin AJ, Chang E, Zingarelli B, Borg K, Guan S, Halushka PV, Cook JA: Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis. Am J Respir Crit Care Med 189: 1509-1519, 2014
109. Roux S, Qiu C, Sprecher U, Osterwalder R, Clozel JP: Protective effects of endothelin receptor antagonists in dogs with aortic cross-clamping. J Cardiovasc Pharmacol 34: 199-205, 1999
110. Gellai M, Jugus M, Fletcher T, DeWolf R, Nambi P: Reversal of postischemic acute renal failure with a selective endothelin A receptor antagonist in the rat. J Clin Invest 93: 900-906, 1994
111. Knoll T, Schult S, Birck R, Braun C, Michel MS, Bross S, Juenemann KP, Kirchengast M, Rohmeiss P: Therapeutic administration of an endothelin-A receptor antagonist after acute ischemic renal failure dosedependently improves recovery of renal function. J Cardiovasc Pharmacol 37: 483-488, 2001
112. Wilhelm SM, Stowe NT, Robinson AV, Schulak JA: The use of the endothelin receptor antagonist, tezosentan, before or after renal ischemia protects renal function. Transplantation 71: 211-216, 2001
113. Ding H, Kopple JD, Cohen A, Hirschberg R: Recombinant human insulin-like growth factor-I accelerates recovery and reduces catabolism in rats with ischemic acute renal failure. J Clin Invest 91: 2281-2287, 1993
114. Miller SB,Martin DR, Kissane J, Hammerman MR: Insulin-like growth factor I accelerates recovery fromischemic acute tubular necrosis in the rat. ProcNatlAcadSciUSA89: 11876-11880, 1992
115. Franklin SC, Moulton M, Sicard GA, Hammerman MR, Miller SB: Insulin-like growth factor I preserves renal function postoperatively. Am J Physiol 272: F257-F259, 1997