Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia-reperfusion injury

Toxicology and Applied Pharmacology

Volumn 273, Issue 2, 2013, Pages 345-354

  Funk, Jason A ^a   Schnellmann, Rick G ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

Acute kidney injury; Ischemia reperfusion; Mitochondrial biogenesis; Mitochondrial dysfunction; Proximal tubule; SRT1720

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ATP SYNTHASE BETA; CREATININE; CYCLOOXYGENASE 1; DYNAMIN I; ENZYME ACTIVATOR; KIDNEY INJURY MOLECULE 1; MITOFUSIN 2; NDUFB8 PROTEIN; OUTER MEMBRANE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SIRTUIN 1; SRT 1720; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOSOL; DEACETYLATION; IMMUNOBLOTTING; IMMUNOREACTIVITY; KIDNEY CORTEX; KIDNEY TUBULE; LIGATION; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; RAT; REPERFUSION INJURY; RESPIRATORY CHAIN;

ACUTE KIDNEY INJURY; ATP SYNTHASE SUBUNIT Β; ATPΒ; COX I; CYTOCHROME C OXIDASE SUBUNIT I; DRP1; DYNAMIN RELATED PROTEIN 1; ISCHEMIA-REPERFUSION; KIDNEY INJURY MOLECULE 1; KIM-1; MFN2; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL DYSFUNCTION; MITOFUSIN-2; NADH DEHYDROGENASE (UBIQUINONE) 1 BETA SUBCOMPLEX 8; NDUFB8; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Γ COACTIVATOR-1Α; PGC-1Α; PROXIMAL TUBULE; SCR; SERUM CREATININE; SIRT1; SIRTUIN 1; SRT1720;

ANIMALS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HOMEOSTASIS; KIDNEY; KIDNEY TUBULES; MALE; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; REPERFUSION INJURY; SIRTUIN 1; TRANSCRIPTION FACTORS;

RATTUS;

EID: 84888203219     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.09.026     Document Type: Article

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