Physiologic endpoints (efficacy) for acute renal failure studies

Current Opinion in Critical Care

Volumn 8, Issue 6, 2002, Pages 519-525

  Murray, Patrick T ^a,f   Le Gall, Jean Roger ^b   Miranda, Dinis Dos Reis ^c   Pinsky, Michael R ^d   Tetta, Ciro ^e  

^a UNIVERSITY OF CHICAGO   (United States)

^b SAINT LOUIS HOSPITAL   (France)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e Cyberonics Inc   (Italy)

^f UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE KIDNEY FAILURE; CLINICAL RESEARCH; CLINICAL TRIAL; CONFERENCE PAPER; DISEASE ASSOCIATION; DISEASE MARKER; GLOMERULUS FILTRATION RATE; HUMAN; INTENSIVE CARE; KIDNEY BLOOD FLOW; KIDNEY TRANSPLANTATION; MORTALITY; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; URINE VOLUME;

BIOLOGICAL MARKERS; CLINICAL TRIALS; ENDPOINT DETERMINATION; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY FAILURE, ACUTE; RENAL CIRCULATION; RENAL DIALYSIS; URINALYSIS;

EID: 0036892377     PISSN: 10705295     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075198-200212000-00007     Document Type: Conference Paper

References (69)

1. Tepel M, van der Giet M, Schwartzfeld C, et al.: Prevention of radiographic contrast agent-induced reductions in renal function by acetylcysteine. N Engl J Med 2000, 343:180-184.
2. Diaz-Sandoval LJ, Kosowsky BD, Losordo DW: Acetylcysteine to prevent angioplasty-related renal tissue injury (the APART Trial). Am J Cardiol 2002, 89:356-358.
3. Rahman SN, Kim GE, Mathew AS, et al,: Effects of atrial natriuretic peptide in clinical acute renal failure. Kidney Int 1994, 45:1731-1738.
4. Franklin SC, Moulton M, Sicard G, et al.: Insulin-like growth factor-1 preserves renal function postoperatively. Am J Physiol 1997, 272:F257-F259.
5. Allgren RL, Marbury TC, Rahman SN, et al.: Anaritide atrial natriuretic peptide in acute tubular necrosis. N Engl J Med 1997, 336:828-834.
6. Lewis J, Salem MM, Chertow GM, et al.: Atrial natriuretic factor in oliguric acute renal failure. Anaritide Acute Renal Failure Study Group. Am J Kidney Dis 2000, 36:767-774.
7. Hirschberg R, Kopple J, Lipsett P, et al.: Multicenter trial of recombinant insulin-like growth factor-1 in patients with acute renal failure. Kidney Int 1999, 55:2423-2432.
8. Star RA: Treatment of acute renal failure. Kidney Int 1998, 54:1817-1831.
9. Van Herten LM, Gunning-Schepers LJ: Targets as a tool in health policy, I: Lessons learned. Health Policy 2000, 53:1-11.
10. Erley CM, Brader BD, Berger ED, et al.: Plasma clearance of iodine contrast media as a measure of glomerular filtration rate in critically ill patients. Crit Care Med 2001, 29:1544-1550.
11. 2 analogue mitigates the progression rate of renal dysfunction improving renal blood flow without glomerular hyper-filtration in patients with chronic renal insufficiency. Prostaglandins Leukot Essent Fatty Acids 2001, 65:223-227.
12. Leoncini G, Martinoli C, Viazzi F, et al.: Changes in renal resistance index and urinary albumin excretion in hypertensive patients under long-term treatment with lisinopril or nifedipine GITS. Nephron 2002, 90:169-173.
13. Ryckwaert F, Colson P, Ribstein J, et al.: Hemodynamic and renal effects of intravenous enalaprilat during coronary artery bypass graft surgery in patients with ischaemic heart dysfunction. Br J Anaesth 2001, 86:169-175.
14. Corrigan G, Ramaswamy D, Kwon O, et al.: PAH extraction and estimation of plasma flow in human postischemic acute renal failure. Am J Physiol 1999, 277:F312-F318.
15. Ronco C, Kellum J, Mehta R: Acute Dialysis Quality Initiative: The New York conference. Curr Opin Crit Care 2002, 8:502-504.
16. Bellomo R, Chapman M, Finfer S, et al.: Low-dose dopamine in patients with early renal dysfunction: A placebo-controlled randomised trial. Australian and New Zealand (ANZICS) Clinical Trials Group. Lancet 2000, 356:2139-2143. A well-designed and conducted, landmark, negative study demonstrating the lack of efficacy of low-dose dopamine therapy for ARF in ICU patients.
17. Wang A, Holcslaw T, Bashore TM, et al.: Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism. Kidney Int 2000, 57:1675-1680.
18. Palevsky PM, Metnitz PGH, Piccinni P, et al.: Selection of endpoints for clinical trials of acute renal failure in critically ill patients. Curr Opin Crit Care 2002, 8:515-518.
19. Hermeida J, Romero R, Tutor JC: Serum cystatin C-immunoglobulin high-molecular-weight complexes in kidney and liver transplant recipients. Kidney Int 2001, 60:1561-1564.
20. Desjars P, Pinaud M, Bugnon D, et al.: Norepinephrine therapy has no deleterious renal effects in human septic shock. Crit Care Med 1989, 17:426-429.
21. Redl-Wenzl EM, Armbruster C, Edelmann G, et al.: The effects of norepinephrine on hemodynamics and renal function in severe septic shock states. Intensive Care Med 1993, 19:151-154.
22. Bersten AD, Holt AW: Vasoactive drugs and the importance of renal perfusion pressure. New Horiz 1995, 3:650-661. An excellent review of a neglected, crucial topic.
23. Brenner M, Schaer GL, Mallory DL, et al.: Detection of renal blood flow abnormalities in septic and critically ill patients using a newly designed indwelling thermodilution renal vein catheter. Chest 1990, 98:170-179.
24. Izumi M, Sugiura T, Nakamura H, et al.: Differential diagnosis of prerenal azotemia from acute tubular necrosis and prediction of recovery by Doppler ultrasound. Am J Kidney Dis 2000, 35:713-719.
25. Weisberg LS, Kurnik PB, Kurnik BR: Radiocontrast-induced nephropathy in humans: Role of renal vasoconstriction. Kidney Int 1992, 41:1408-1415.
26. Liss P, Nygren A, Erikson U, et al.: Injection of low and iso-osmolar contrast medium decreases oxygen tension in the renal medulla. Kidney Int 1998, 53:698-702.
27. Heyman SN, Brezis M, Epstein FH, et al.: Early renal medullary hypoxic injury from radiocontrast and indomethacin. Kidney Int 1991, 40:632-642.
28. Prasad PV, Edelman RR, Epstein FH: Noninvasive evaluation of intrarenal oxygenation with BOLD MRI. Circulation 1996, 94:3721-3775.
29. Aronson S, Thistlethwaite RJ, Walker R, et al.: Safety and feasibility of renal blood flow determination during kidney transplant surgery with perfusion ultrasonography. Anesth Analg 1995, 80:353-359.
30. Miller TR, Anderson RJ, Linas SL, et al.: Urinary diagnostic indices in acute renal failure: A prospective study. Arch Int Med 1978, 89:47-50. A landmark study of the diagnostic utility of urine chemistries in ARF.
31. Zarich S, Fang LS, Diamond JR: Fractional excretion of sodium: Exceptions to its diagnostic value. Arch Intern Med 1985, 145:108-112.
32. Hilberman M, Derby GC, Spencer RJ, et al.: Sequential pathophysiological changes characterizing the progression from renal dysfunction to acute renal failure following cardiac operation. J Thorac Cardiovasc Surg 1980, 79:838-844.
33. Brown R, Babcock R, Talbert J, et al.: Renal function in critically ill postoperative patients: Sequential assessment of creatinine, osmolar, and free water clearance. Crit Care Med 1980, 8:68-72.
34. Marcussen N, Schumann J, Campbell P, et al.: Cytodiagnostic urinalysis is very useful in the differential diagnosis of acute renal failure and can predict the severity. Ren Fail 1995, 17:721-729.
35. Sumeray M, Robertson C, Lapsley M, et al.: Low dose dopamine infusion reduces renal tubular injury following cardiopulmonary bypass surgery. J Nephrol 2001, 14:397-402.
36. Ichimura T, Bonventre JV, Bailly V, et al.: Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem 1998, 273:4135-4142.
37. Nedelkov D, Nelson RW: Analysis of human urine protein biomarkers via bio-molecular interaction analysis mass spectrometry. Am J Kidney Dis 2001, 38:481-487.
38. Murray P, Hall JB: Renal replacement therapy for acute renal failure. Am J Respir Crit Care Med 2000, 162:777-781.
39. Mallie JP, Ait-Djaffer Z, Laroche F, et al.: Variations in plasma sodium concentration in postoperative patients depend on an electrolyte-free water balance, part of tonicity balance. Clin Nephrol 1998, 49:287-292.
40. Le Gall JR, Klar J, Lemeshow S, et al.: The Logistic Organ Dysfunction system: A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group. JAMA 1996, 276:802-810. A key study linking physiologic data to clinical outcomes.
41. Reis Miranda D, Ryan DW, Schaufeli WB, et al. (eds): Organisation and Management of Intensive Care: A Prospective Study in 12 European Countries. Berlin: Springer; 1998.
42. Lowell JA, Schifferdecker C, Driscoll DF, et al.: Postoperative fluid overload: Not a benign problem. Crit Care Med 1990, 18:728-733.
43. Himmelfarb J, Evanson J, Hakim RM, et al.: Urea volume of distribution exceeds total body water in patients with acute renal failure. Kidney Int 2002, 61:317-323.
44. Dhondt A, Vanholder R, Van Biesen W, et al.: The removal of uremic toxins. Kidney Int Suppl 2000, 76:S47-S59.
45. National Kidney Foundation: NKF-DOQI clinical practice guidelines for hemodialysis adequacy. Am J Kidney Dis 1997, 30:515-566.
46. Schneditz D, Daugirdas JT: Compartment effects in hemodialysis. Semin Dial 2001, 14:271-277.
47. Evanson JA, Himmelfarb J, Wingard R, et al.: Prescribed versus delivered dialysis in acute renal failure patients. Am J Kidney Dis 1998, 32:731-738. A simple, elegantly reported study exposing the inadequacy of modern intermittent hemodialysis prescription and delivery in ARF.
48. Evanson JA, Ikizler TA, Wingard R, et al.: Measurement of delivery of dialysis in acute renal failure. Kidney Int 1999, 55:1501-1508.
49. Schiffl H, Lang S, Fischer R: Daily hemodialysis and the outcome of acute renal failure. N Engl J Med 2002, 346:305-310. A flawed but important study showing the superiority of frequent, inadequate, intermittent hemodialysis over infrequent, intermittent hemodialysis in ICU ARF.
50. Paganini EP, Tapolyai M, Goormastic M, et al.: Establishing a dialysis therapy/patient outcome link in intensive care unit acute dialysis for patients with acute renal failure. Am J Kidney Dis 1996, 28:S81-S89.
51. Clark WR, Mueller BA, Kraus MA, et al.: Extracorporeal therapy requirements for patients with acute renal failure. J Am Soc Nephrol 1997, 8:802-812.
52. Ronco C, Bellomo R, Homel P, et al.: Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: A prospective randomised trial. Lancet 2000, 356:26-30. The first conclusive, prospective demonstration of a dose-response relationship to mortality in acute RRT
53. Casino FG, Lopez T: The equivalent renal urea clearance: A new parameter to assess dialysis dose. Nephrol Dial Transplant 1996, 11:1574-1581.
54. Kellum JA, Johnson JP, Kramer D, et al.: Diffusive vs. convective therapy: Effects on mediators of inflammation in patients with severe systemic inflammatory response syndrome. Crit Care Med 1998, 26:1995-2000.
55. Cavaillon JM, Adib-Conquy M, Cloez-Tayarani I, et al.: Immunosuppression in sepsis and SIRS assessed by ex-vivo cytokine production is not a generalized phenomenon: A review. J Endotoxin Res 2001, 7:85-93.
56. Munoz C, Carlet J, Fitting C, et al.: Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 1991, 88:1747-1754.
57. Randow F, Syrbe V, Meisel C, et al.: Mechanism of endotoxin desensitization: Involvement of interleukin-10 and transforming growth factor. J Exp Med 1995, 181:1887-1892.
58. Brandtzaeg P, Osnes L, Ostebo R, et al.: Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: Identification of interleukin-10 as a major functional deactivator of human monocytes. J Exp Med 1996, 184:51-60.
59. Botha AJ, Moore FA, Moore EE, et al.: Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure. Br J Surg 1996, 83:1407-1412.
60. Yaffe MB, Xu J, Burke PA, et al.: Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. Surgery 1999, 126:248-254.
61. Horl WH, Schafer RM, Horl M, et al.: Neutrophil activation in acute renal failure and sepsis. Arch Surg 1990, 125:651-654.
62. Botha AJ, Moore FA, Moore EE, et al.: Postinjury neutrophil priming and activation: An early vulnerable window. Surgery 1995, 118:358-365.
63. Moore EE, Moore FA, Franciose RJ, et al.: The postischemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure. J Trauma 1994, 37:881-887.
64. Mariano F, Tetta C, Guida GE, et al.: Hemofiltration reduces the serum priming activity on neutrophil chemiluminescence in septic patients. Kidney Int 2001, 60:1598-1605.
65. Martin-Malo A, Carracedo J, Ramirez R, et al.: Effect of uremia and dialysis modality on mononuclear cell apoptosis. J Am Soc Nephrol 2000, 11:936-942.
66. Carracedo J, Ramirez R, Martin-Malo A, et al.: Role of adhesion molecules in mononuclear cell apoptosis induced by cuprophan hemodialysis membranes. Nephron 2001, 89:186-193.
67. Carracedo J, Ramirez R, Madueno JA, et al.: Cell apoptosis and hemodialysis-induced inflammation. Kidney Int 2002, 61 (suppl 80):89-93.
68. Adrie C, Bachelet M, Vayssier-Taussat M, et al.: Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis. Am J Respir Crit Care Med 2001, 164:389-395.
69. Joashi U, Tibby SM, Turner C, et al.: Soluble Fas may be a proinflammatory marker after cardiopulmonary bypass in children. J Thorac Cardiovasc Surg 2002, 123:137-144.