Potential use of biomarkers in acute kidney injury: Report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference

Kidney International

Volumn 85, Issue 3, 2014, Pages 513-521

  Murray, Patrick T ^a   Mehta, Ravindra L ^b   Shaw, Andrew ^c   Ronco, Claudio ^d   Endre, Zoltan ^e,f   Kellum, John A ^g   Chawla, Lakhmir S ^h   Cruz, Dinna ^d,i   Ince, Can ^j   Okusa, Mark D ^k  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d SAN BORTOLO HOSPITAL   (Italy)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

^f UNIVERSITY OF OTAGO   (New Zealand)

^g SCHOOL OF MEDICINE   (United States)

^h GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

ⁱ International Renal Research Institute (IRRIV)   (Italy)

^j ERASMUS MEDICAL CENTER   (Netherlands)

^k UNIVERSITY OF VIRGINIA   (United States)

more..

Author keywords

acute; acute kidney injury; biomarkers; diagnosis; differential diagnosis; prognosis; surveillance

Indexed keywords

BIOLOGICAL MARKER; BETA 2 MACROGLOBULIN; CREATININE; CYSTATIN C; FATTY ACID BINDING PROTEIN; GLUTATHIONE TRANSFERASE; INTERLEUKIN 18; KIDNEY INJURY MOLECULE 1; MACROGLOBULIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; CONFERENCE PAPER; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISEASE COURSE; FUNCTIONAL ASSESSMENT; HUMAN; KIDNEY DYSFUNCTION; KIDNEY INJURY; MANAGED CARE; PATIENT IDENTIFICATION; PATIENT MONITORING; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; ARTICLE; CLINICAL PRACTICE; CREATININE BLOOD LEVEL; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; ECHOGRAPHY; GLOMERULUS FILTRATION RATE; MEDICAL EXPERT; MEDICAL LITERATURE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT CARE; PRACTICE GUIDELINE; SENSITIVITY AND SPECIFICITY; STAGING; SYSTEMATIC REVIEW; URINE VOLUME; ACUTE KIDNEY INJURY; RENAL REPLACEMENT THERAPY; STATISTICAL ANALYSIS;

ACUTE KIDNEY INJURY; BIOLOGICAL MARKERS; DATA INTERPRETATION, STATISTICAL; HUMANS; RENAL DIALYSIS;

EID: 84895097820     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.374     Document Type: Conference Paper

References (38)

1. Mehta RL, Kellum JA, Shah SV et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11: R31.
2. Singbartl K, Kellum JA. AKI in the ICU: definition, epidemiology, risk stratification, and outcomes. Kidney Int 2011; 81: 819-825.
3. Wang HE, Muntner P, Chertow GM et al. Acute kidney injury and mortality in hospitalized patients. Am J Nephrol 2012; 35: 349-355.
4. Nickolas TL, Schmidt-Ott KM, Canetta P et al. Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study. J Am Coll Cardiol 2012; 59: 246-255.
5. Stewart JFG, Smith N, Kelly K et al. Adding insult to injury: a review of the care of patients who died in hospital with a primary diagnosis of acute kidney injury (acute renal failure). A report by the National Confidential Enquiry into Patient Outcome and Death. http://www.ncepod.org.uk/ 2009aki.htm 2009.
6. Devarajan P. Biomarkers for the early detection of acute kidney injury. Curr Opin Pediatr 2011; 23: 194-200.
7. Bonventre JV, Vaidya VS, Schmouder R et al. Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol 2010; 28: 436-440.
8. Parikh CR, Garg AX. Acute kidney injury: better biomarkers and beyond. Kidney Int 2008; 73: 801-803.
9. Singer E, Elger A, Elitok S et al. Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney Int 2011; 80: 405-414.
10. Vaidya VS, Waikar SS, Ferguson MA et al. Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci 2008; 1: 200-208.
11. Katz R. Biomarkers and surrogate markers: an FDA perspective. NeuroRx 2004; 1: 189-195.
12. Chawla LS, Kellum JA. Acute kidney injury in 2011: Biomarkers are transforming our understanding of AKI. Nat Rev Nephrol 2012; 8: 68-70.
13. Vaidya VS, Bonventre JV. Mechanistic biomarkers for cytotoxic acute kidney injury. Expert Opin Drug Metab Toxicol 2006; 2: 697-713.
14. Srisawat N, Wen X, Lee M et al. Urinary biomarkers and renal recovery in critically ill patients with renal support. Clin J Am Soc Nephrol 2011; 6: 1815-1823.
15. Endre ZH, Walker RJ, Pickering JW et al. Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney Int 2010; 77: 1020-1030.
16. Mehta RL. Timed and targeted therapy for acute kidney injury: a glimpse of the future. Kidney Int 2010; 77: 947-949.
17. Siew ED, Ikizler TA, Gebretsadik T et al. Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Clin J Am Soc Nephrol 2010; 5: 1497-1505.
18. Parikh CR, Coca SG, Thiessen-Philbrook H et al. Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol 2011; 22: 1748-1757.
19. Coca SG, Yalavarthy R, Concato J et al. Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review. Kidney Int 2008; 73: 1008-1016.
20. Macedo E, Malhotra R, Claure-Del Granado R et al. Defining urine output criterion for acute kidney injury in critically ill patients. Nephrol Dial Transplant 2011; 26: 509-515.
21. Cruz DN, de Geus HR, Bagshaw SM. Biomarker strategies to predict need for renal replacement therapy in acute kidney injury. Semin Dial 2011; 24: 124-131.
22. Stillman IE, Lima EQ, Burdmann EA. Renal biopsies in acute kidney injury: who are we missing? Clin J Am Soc Nephrol 2008; 3: 647-648.
23. Davison DL, Patel K, Chawla LS. Hemodynamic monitoring in the critically ill: spanning the range of kidney function. Am J Kidney Dis 2012; 59: 715-723.
24. Sharfuddin AA, Sandoval RM, Molitoris BA. Imaging techniques in acute kidney injury. Nephron Clin Pract 2008; 109: c198-c204.
25. Bolignano D, Coppolino G, Campo S et al. Urinary neutrophil gelatinaseassociated lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients. Nephrol Dial Transplant 2008; 23: 414-416.
26. Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. Eur Heart J 2007; 28: 2525-2538.
27. Sistare FD, DeGeorge JJ. Promise of new translational safety biomarkers in drug development and challenges to regulatory qualification. Biomark Med 2011; 5: 497-514.
28. Ozer JS, Dieterle F, Troth S et al. A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function. Nat Biotechnol 2010; 28: 486-494.
29. Dieterle F, Sistare F, Goodsaid F et al. Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium. Nat Biotechnol 2010; 28: 455-462.
30. Schrier RW. Diagnostic value of urinary sodium, chloride, urea, and flow. J Am Soc Nephrol 2011; 22: 1610-1613.
31. Bagshaw SM, Bennett M, Haase M et al. Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intens Care Med 2010; 36: 452-461.
32. Yndestad A, Landro L, Ueland T et al. Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. Eur Heart J 2009; 30: 1229-1236.
33. Waikar SS, Sabbisetti VS, Bonventre JV. Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int 2010; 78: 486-494.
34. Kashani K, Al-Khafaji A, Ardiles T et al. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care 2013; 17: R25.
35. Uchino S, Bellomo R, Bagshaw SM et al. Transient azotaemia is associated with a high risk of death in hospitalized patients. Nephrol Dial Transplant 2010; 25: 1833-1839.
36. Mehta RL. Biomarker explorations in acute kidney injury: the journey continues. Kidney Int 2011; 80: 332-334.
37. Belcher JM, Parikh CR. Is it time to evolve past the prerenal azotemia versus acute tubular necrosis classification? Clin J Am Soc Nephrol 2011; 6: 2332-2334.
38. Briggs JP. The hunt for the perfect biomarker for acute kidney injury: back to gamma-trace? Kidney Int 2008; 74: 987-989.