Disrupted leptin signaling in the lateral hypothalamus and ventral premammillary nucleus alters insulin and glucagon secretion and protects against diet-induced obesity

Endocrinology

Volumn 157, Issue 7, 2016, Pages 2671-2685

  Denroche, Heather C ^a   Glavas, Maria M ^a   Tudurí, Eva ^a   Karunakaran, Subashini ^a   Quong, Whitney L ^a   Philippe, Marion ^a   Britton, Heidi M ^a   Clee, Susanne M ^a   Kieffer, Timothy J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; CRE RECOMBINASE; GLUCAGON; GLUCOSE; INSULIN; LEPTIN; LEPTIN RECEPTOR; STAT3 PROTEIN; SYNAPSIN; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; COMPARATIVE STUDY; CONTROLLED STUDY; DIET INDUCED OBESITY; DIET RESTRICTION; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; ENERGY EXPENDITURE; FAT MASS; FEMALE; FOOD INTAKE; GENETIC BACKGROUND; GLUCAGON BLOOD LEVEL; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; HYPERINSULINEMIA; HYPERLEPTINEMIA; HYPOGLYCEMIA; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOREACTIVITY; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN TOLERANCE TEST; LATERAL HYPOTHALAMUS; LIPID DIET; LIPID OXIDATION; LUNG GAS EXCHANGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLITARY TRACT NUCLEUS; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; THALAMUS VENTRAL NUCLEUS; VENTRAL PREMAMMILLARY NUCLEUS; WEIGHT GAIN; ANIMAL; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HYPOTHALAMUS; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; OBESITY; PHYSIOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ANIMALS; ARCUATE NUCLEUS OF HYPOTHALAMUS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; GLUCAGON; HYPOTHALAMIC AREA, LATERAL; HYPOTHALAMUS; INSULIN; LEPTIN; MICE; MICE, KNOCKOUT; NEURONS; OBESITY; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 84977085843     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2015-1998     Document Type: Article

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