Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice

Diabetes

Volumn 61, Issue 8, 2012, Pages 2016-2029

  Rezania, Alireza ^a   Bruin, Jennifer E ^b   Riedel, Michael J ^b,c   Mojibian, Majid ^b   Asadi, Ali ^b   Xu, Jean ^a   Gauvin, Rebecca ^a   Narayan, Kavitha ^a   Karanu, Francis ^a   O'Neil, John J ^a   Ao, Ziliang ^b   Warnock, Garth L ^b   Kieffer, Timothy J ^b  

^a JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c STEMCELL Technologies   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; INSULIN; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL POPULATION; CONTROLLED STUDY; CULTURE OPTIMIZATION; DIABETES MELLITUS; EMBRYONIC STEM CELL; FETUS DEVELOPMENT; GENE EXPRESSION PROFILING; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; INSULIN TREATMENT; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREATIC PROGENITOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; STEM CELL TRANSPLANTATION; STREPTOZOCIN DIABETES; TREATMENT OUTCOME;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; EMBRYONIC STEM CELLS; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; PANCREAS; PROPROTEIN CONVERTASES; RATS; STEM CELLS; TRANS-ACTIVATORS;

EID: 84864390303     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1711     Document Type: Article

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