Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice

Science

Volumn 334, Issue 6059, 2011, Pages 1133-1137

  Czupryn, Artur ^a,b,c,d   Zhou, Yu Dong ^b,e,f   Chen, Xi ^b   McNay, David ^b,g   Anderson, Matthew P ^b,e   Flier, Jeffrey S ^b   Macklis, Jeffrey D ^a,b  

^a Harvard University   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^g UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LEPTIN; LEPTIN RECEPTOR;

BIOENGINEERING; BRAIN; CYTOLOGY; GLUCOSE; HOMEOSTASIS; HORMONE; MAMMAL; NEUROLOGY; OBESITY; PHYSIOLOGY; PROTEIN; SIGNALING;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL POPULATION; EXCITATORY JUNCTION POTENTIAL; HYPERGLYCEMIA; MORBID OBESITY; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR POTENTIAL; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 82255169467     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1209870     Document Type: Article

References (34)

1. J. M. Friedman, J. L. Halaas, Nature 395, 763 (1998).
2. J. S. Flier, Cell 116, 337 (2004).
3. P. Cohen et al., J. Clin. Invest. 108, 1113 (2001).
4. T. J. Kowalski, S. M. Liu, R. L. Leibel, S. C. Chua Jr., Diabetes 50, 425 (2001).
5. M. V. Kokoeva, H. Yin, J. S. Flier, Science 310, 679 (2005).
6. M. V. Kokoeva, H. Yin, J. S. Flier, J. Comp. Neurol. 505, 209 (2007).
7. E. van de Wall et al., Endocrinology 149, 1773 (2008).
8. Materials and methods are available as supporting material on Science Online.
9. P. H. Ozdinler, J. D. Macklis, Nat. Neurosci. 9, 1371 (2006).
10. C. S. Hernit-Grant, J. D. Macklis, Exp. Neurol. 139, 131 (1996).
11. J. J. Shin et al., J. Neurosci. 20, 7404 (2000).
12. R. A. Fricker-Gates, J. J. Shin, C. C. Tai, L. A. Catapano, J. D. Macklis, J. Neurosci. 22, 4045 (2002).
13. C. Scharff, J. R. Kirn, M. Grossman, J. D. Macklis, F. Nottebohm, Neuron 25, 481 (2000).
14. H. van Praag et al., Nature 415, 1030 (2002).
15. U. S. Sohur, J. G. Emsley, B. D. Mitchell, J. D. Macklis, Philos. Trans. R. Soc. Lond. B Biol. Sci. 361, 1477 (2006).
16. D. E. McNay, M. Pelling, S. Claxton, F. Guillemot, S. L. Ang, Mol. Endocrinol. 20, 1623 (2006).
17. M. Shimada, T. Nakamura, Exp. Neurol. 41, 163 (1973).
18. S. L. Padilla, J. S. Carmody, L. M. Zeltser, Nat. Med. 16, 403 (2010).
19. Y. D. Zhou et al., Nat. Med. 15, 1208 (2009).
20. D. Burdakov, F. M. Ashcroft, J. Neurosci. 22, 6380 (2002).
21. T. Miki et al., Nat. Neurosci. 4, 507 (2001).
22. Y. H. Jo, D. Wiedl, L. W. Role, J. Neurosci. 25, 11133 (2005).
23. N. Ibrahim et al., Endocrinology 144, 1331 (2003).
24. S. H. Bates et al., Nature 421, 856 (2003).
25. H. Münzberg, L. Huo, E. A. Nillni, A. N. Hollenberg, C. Bjørbaek, Endocrinology 144, 2121 (2003).
26. C. Li, J. M. Friedman, Proc. Natl. Acad. Sci. U.S.A. 96, 9677 (1999).
27. M. A. Cowley et al., Nature 411, 480 (2001).
28. M. van den Top, K. Lee, A. D. Whyment, A. M. Blanks, D. Spanswick, Nat. Neurosci. 7, 493 (2004).
29. M. Claret et al., J. Clin. Invest. 117, 2325 (2007).
30. L. E. Parton et al., Nature 449, 228 (2007).
31. X. Fioramonti et al., Diabetes 56, 1219 (2007).
32. S. A. Bayer, J. Altman, Neocortical Development (Raven Press, New York, 1991).
33. H. Dhillon et al., Neuron 49, 191 (2006).
34. J. W. Hill et al., Cell Metab. 11, 286 (2010).